CN102552289A - 一种治疗糖尿病的组合物及制备方法 - Google Patents
一种治疗糖尿病的组合物及制备方法 Download PDFInfo
- Publication number
- CN102552289A CN102552289A CN2012100319179A CN201210031917A CN102552289A CN 102552289 A CN102552289 A CN 102552289A CN 2012100319179 A CN2012100319179 A CN 2012100319179A CN 201210031917 A CN201210031917 A CN 201210031917A CN 102552289 A CN102552289 A CN 102552289A
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- CN
- China
- Prior art keywords
- glipizide
- dextrin
- starch
- magnesium stearate
- compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 35
- 238000002360 preparation method Methods 0.000 title claims description 15
- 206010012601 diabetes mellitus Diseases 0.000 title abstract description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 52
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims abstract description 52
- ZJJXGWJIGJFDTL-UHFFFAOYSA-N glipizide Chemical compound C1=NC(C)=CN=C1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCCCC2)C=C1 ZJJXGWJIGJFDTL-UHFFFAOYSA-N 0.000 claims abstract description 38
- 229960001381 glipizide Drugs 0.000 claims abstract description 38
- 229920001353 Dextrin Polymers 0.000 claims abstract description 33
- 239000004375 Dextrin Substances 0.000 claims abstract description 33
- 229920002472 Starch Polymers 0.000 claims abstract description 33
- 235000019425 dextrin Nutrition 0.000 claims abstract description 33
- 235000019698 starch Nutrition 0.000 claims abstract description 33
- 239000008107 starch Substances 0.000 claims abstract description 33
- 235000019359 magnesium stearate Nutrition 0.000 claims abstract description 26
- 239000000377 silicon dioxide Substances 0.000 claims abstract description 26
- 235000012239 silicon dioxide Nutrition 0.000 claims abstract description 19
- 239000005720 sucrose Substances 0.000 claims abstract description 15
- 229930006000 Sucrose Natural products 0.000 claims abstract description 14
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims abstract description 14
- 239000008187 granular material Substances 0.000 claims description 39
- 230000001476 alcoholic effect Effects 0.000 claims description 21
- 238000000034 method Methods 0.000 claims description 17
- 239000007779 soft material Substances 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- 238000005303 weighing Methods 0.000 claims description 14
- 239000008213 purified water Substances 0.000 claims description 7
- 238000001035 drying Methods 0.000 claims description 5
- 239000002245 particle Substances 0.000 claims description 4
- 229940006384 glipizide 2.5 mg Drugs 0.000 claims description 2
- 229940083580 glipizide 5 mg Drugs 0.000 claims description 2
- 229940126701 oral medication Drugs 0.000 claims description 2
- 238000004090 dissolution Methods 0.000 abstract description 17
- 239000000126 substance Substances 0.000 abstract 1
- 239000012535 impurity Substances 0.000 description 18
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 12
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
- 238000005550 wet granulation Methods 0.000 description 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 229940127003 anti-diabetic drug Drugs 0.000 description 1
- 239000003472 antidiabetic agent Substances 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 125000004836 hexamethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[*:1] 0.000 description 1
- 230000002218 hypoglycaemic effect Effects 0.000 description 1
- 210000004153 islets of langerhan Anatomy 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 229960005206 pyrazinamide Drugs 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 1
- 230000009967 tasteless effect Effects 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
样品 | 实施例1 | 实施例2 | 实施例3 | 对照例1 | 对照例2 | 对照例3 | 对照例4 |
溶出度% | 95.8 | 93.3 | 94.2 | 82.6 | 81.8 | 79.2 | 78.3 |
样品 | 实施例1 | 实施例2 | 实施例3 | 对照例1 | 对照例2 | 对照例3 | 对照例4 |
杂质I | 0.12 | 0.08 | 0.13 | 0.86 | 0.93 | 1.32 | 1.06 |
其他杂质 | 0.20 | 0.16 | 0.26 | 1.86 | 1.94 | 2.16 | 2.09 |
Claims (7)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 201210031917 CN102552289B (zh) | 2012-02-08 | 2012-02-08 | 一种治疗糖尿病的组合物及制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 201210031917 CN102552289B (zh) | 2012-02-08 | 2012-02-08 | 一种治疗糖尿病的组合物及制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102552289A true CN102552289A (zh) | 2012-07-11 |
CN102552289B CN102552289B (zh) | 2013-11-06 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN 201210031917 Active CN102552289B (zh) | 2012-02-08 | 2012-02-08 | 一种治疗糖尿病的组合物及制备方法 |
Country Status (1)
Country | Link |
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CN (1) | CN102552289B (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104997747A (zh) * | 2015-08-11 | 2015-10-28 | 瑞阳制药有限公司 | 格列吡嗪片及其制备方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1726916A (zh) * | 2004-07-27 | 2006-02-01 | 江西省药物研究所 | 一种降血糖口崩片及其制备方法 |
-
2012
- 2012-02-08 CN CN 201210031917 patent/CN102552289B/zh active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1726916A (zh) * | 2004-07-27 | 2006-02-01 | 江西省药物研究所 | 一种降血糖口崩片及其制备方法 |
Non-Patent Citations (2)
Title |
---|
张丽英等: "格列吡嗪胶囊制备工艺改进及对溶出度的影响", 《黑龙江医药》, vol. 9, no. 6, 31 December 1996 (1996-12-31), pages 325 - 326 * |
钱伟光等: "格列吡嗪制剂溶出曲线考察", 《药物分析杂志》, vol. 31, no. 7, 31 December 2011 (2011-12-31), pages 1364 - 1367 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104997747A (zh) * | 2015-08-11 | 2015-10-28 | 瑞阳制药有限公司 | 格列吡嗪片及其制备方法 |
CN104997747B (zh) * | 2015-08-11 | 2019-10-25 | 瑞阳制药有限公司 | 格列吡嗪片及其制备方法 |
Also Published As
Publication number | Publication date |
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CN102552289B (zh) | 2013-11-06 |
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SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20160805 Address after: 264205 No. 1 South Qingdao Road, Weihai economic and technological development, Shandong Patentee after: DISHA PHARMACEUTICAL GROUP Co.,Ltd. Patentee after: WEIHAI DISU PHARMACEUTICAL Co.,Ltd. Address before: 264205 No. 1 South Qingdao Road, Weihai economic and technological development, Shandong Patentee before: DISHA PHARMACEUTICAL GROUP Co.,Ltd. Patentee before: Shandong Disha Pharmaceutical Co.,Ltd., Disha Phamaceutical Group Patentee before: WEIHAI DISU PHARMACEUTICAL Co.,Ltd. |
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TR01 | Transfer of patent right |
Effective date of registration: 20200507 Address after: 264205 No. 1 South Qingdao Road, Weihai economic and Technological Development Zone, Shandong, China Co-patentee after: Dijia Pharmaceutical Group Co.,Ltd. Patentee after: DISHA PHARMACEUTICAL GROUP Co.,Ltd. Address before: 264205 No. 1 South Qingdao Road, Weihai economic and technological development, Shandong Co-patentee before: WEIHAI DISU PHARMACEUTICAL Co.,Ltd. Patentee before: DISHA PHARMACEUTICAL GROUP Co.,Ltd. |
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TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20210601 Address after: No.1 Qingdao South Road, Weihai Economic and Technological Development Zone, Shandong Province Patentee after: DISHA PHARMACEUTICAL GROUP Co.,Ltd. Address before: No.1 Qingdao South Road, Weihai Economic and Technological Development Zone, Shandong Province Patentee before: DISHA PHARMACEUTICAL GROUP Co.,Ltd. Patentee before: Dijia Pharmaceutical Group Co.,Ltd. |
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TR01 | Transfer of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A composition for treating diabetes and its preparation method Effective date of registration: 20220721 Granted publication date: 20131106 Pledgee: Bank of China Limited Weihai Branch Pledgor: DISHA PHARMACEUTICAL GROUP Co.,Ltd. Registration number: Y2022980010828 |
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