CN102451341A - Chinese medicine injection for relieving exterior syndrome of liver channel and lung channel and production method of Chinese medicine injection - Google Patents
Chinese medicine injection for relieving exterior syndrome of liver channel and lung channel and production method of Chinese medicine injection Download PDFInfo
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- CN102451341A CN102451341A CN2011104154753A CN201110415475A CN102451341A CN 102451341 A CN102451341 A CN 102451341A CN 2011104154753 A CN2011104154753 A CN 2011104154753A CN 201110415475 A CN201110415475 A CN 201110415475A CN 102451341 A CN102451341 A CN 102451341A
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- 239000003814 drug Substances 0.000 title claims abstract description 74
- 238000002347 injection Methods 0.000 title claims abstract description 22
- 239000007924 injection Substances 0.000 title claims abstract description 22
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 18
- 210000004185 liver Anatomy 0.000 title claims abstract description 15
- 210000004072 lung Anatomy 0.000 title claims abstract description 15
- 208000011580 syndromic disease Diseases 0.000 title abstract 3
- 238000001035 drying Methods 0.000 claims abstract description 25
- 238000001914 filtration Methods 0.000 claims abstract description 16
- 230000001954 sterilising effect Effects 0.000 claims abstract description 16
- 210000004243 sweat Anatomy 0.000 claims abstract description 8
- 238000011049 filling Methods 0.000 claims abstract description 7
- QQILFGKZUJYXGS-UHFFFAOYSA-N Indigo dye Chemical compound C1=CC=C2C(=O)C(C3=C(C4=CC=CC=C4N3)O)=NC2=C1 QQILFGKZUJYXGS-UHFFFAOYSA-N 0.000 claims abstract description 4
- 210000004027 cell Anatomy 0.000 claims description 24
- 238000007689 inspection Methods 0.000 claims description 24
- 238000012856 packing Methods 0.000 claims description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 21
- 239000000945 filler Substances 0.000 claims description 18
- 235000013312 flour Nutrition 0.000 claims description 12
- 210000004907 gland Anatomy 0.000 claims description 12
- 238000005406 washing Methods 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 11
- 241000628997 Flos Species 0.000 claims description 9
- 239000012153 distilled water Substances 0.000 claims description 9
- 229940079593 drug Drugs 0.000 claims description 9
- 239000000843 powder Substances 0.000 claims description 9
- 229940126678 chinese medicines Drugs 0.000 claims description 7
- 230000001939 inductive effect Effects 0.000 claims description 7
- 238000001802 infusion Methods 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 claims description 3
- 244000080767 Areca catechu Species 0.000 claims description 3
- 235000006226 Areca catechu Nutrition 0.000 claims description 3
- 241000255791 Bombyx Species 0.000 claims description 3
- 241000700605 Viruses Species 0.000 claims description 3
- 230000000844 anti-bacterial effect Effects 0.000 claims description 3
- 229940088710 antibiotic agent Drugs 0.000 claims description 3
- 210000002421 cell wall Anatomy 0.000 claims description 3
- 239000008187 granular material Substances 0.000 claims description 3
- 230000003834 intracellular effect Effects 0.000 claims description 3
- 238000003860 storage Methods 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims description 3
- 238000005303 weighing Methods 0.000 claims description 3
- 239000011148 porous material Substances 0.000 abstract description 10
- 208000026062 Tissue disease Diseases 0.000 abstract description 6
- 235000008216 herbs Nutrition 0.000 abstract 2
- 244000235603 Acacia catechu Species 0.000 abstract 1
- 235000006020 Acacia catechu Nutrition 0.000 abstract 1
- 241001529821 Agastache Species 0.000 abstract 1
- 241000205585 Aquilegia canadensis Species 0.000 abstract 1
- 241000255789 Bombyx mori Species 0.000 abstract 1
- 241000561734 Celosia cristata Species 0.000 abstract 1
- 241000207199 Citrus Species 0.000 abstract 1
- 235000018142 Hedysarum alpinum var americanum Nutrition 0.000 abstract 1
- 240000006461 Hedysarum alpinum var. americanum Species 0.000 abstract 1
- 241000488974 Loranthus Species 0.000 abstract 1
- 235000011755 Nepeta hederacea Nutrition 0.000 abstract 1
- 244000215554 Nepeta hederacea Species 0.000 abstract 1
- 235000018167 Reynoutria japonica Nutrition 0.000 abstract 1
- 240000001341 Reynoutria japonica Species 0.000 abstract 1
- 241001162994 Rugosus Species 0.000 abstract 1
- 241000205578 Thalictrum Species 0.000 abstract 1
- 239000001560 acacia catechu Substances 0.000 abstract 1
- 238000009924 canning Methods 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 235000020971 citrus fruits Nutrition 0.000 abstract 1
- 238000004140 cleaning Methods 0.000 abstract 1
- 210000001520 comb Anatomy 0.000 abstract 1
- 238000004806 packaging method and process Methods 0.000 abstract 1
- 230000003071 parasitic effect Effects 0.000 abstract 1
- 244000112814 pipewort Species 0.000 abstract 1
- 208000008454 Hyperhidrosis Diseases 0.000 description 3
- 208000004880 Polyuria Diseases 0.000 description 3
- 210000001035 gastrointestinal tract Anatomy 0.000 description 3
- 230000037315 hyperhidrosis Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a Chinese medicine injection for relieving exterior syndrome of the liver channel and the lung channel and a production method of the Chinese medicine injection. The Chinese medicine injection comprises the following Chinese medicinal herbs: 1g of pipewort, 1g of meadowrue root and rhizome, 1g of indigo naturalis, 0.5g of rhizoma bistortae, 0.5g of honeysuckle flower, 1g of cortex lycii radicis, 1g of rhizoma dioscoreae nipponicae, 1g of parasitic loranthus, 1g of agastache rugosus, 1g of cat's-foot, 1g of polygonum cuspidatum, 1g of citrus chirocarpus, 1g of caulis spatholobi, 1g of acacia catechu, 1g of cortex albiziae, 1g of stiff silkworm, 1g of liquorice root, 1g of gecko, 1g of radix changii and 1g of cockscomb. The production method comprises the steps of: burdening, cleaning, drying and sterilizing, crushing, carrying out cell rupture, multi-filtering, canning, filling in capsules, covering, lamp-checking, sticking specifications, packaging, storing and checking. The Chinese medicine injection has the advantages of no decoction, no passing of pores and sweat pores, and the like, and is suitable for patients suffering from tissue diseases of the liver channel and the lung channel, such as hidrosis, urorrhagia and multi-stagnation. The production method has the function of remaining medicine components in all Chinese medicinal herbs, and is used for producing a full-Chinese medicine injection for relieving the exterior syndrome of the liver channel and the lung channel.
Description
Technical field the present invention relates to a kind of not through inducing sweat, can treat liver, lung two Chinese medicine injection and the production method through tissue disease.
Background technology is known do not need high temperature decoct, need not be through digestive tract, can treat liver, lung two through the Chinese medicine of tissue disease inducing sweat property all; These Chinese medicines are through being got in the human body by pore, pore the inducing sweat effect of pore, pore; And then human liver, lung two treated through tissue disease; It can bring hyperhidrosis, polyuria, phenomenon such as stagnate more, thereby it is not suitable for the patient of hyperhidrosis, polyuria, symptoms such as stagnate more.
Summary of the invention the object of the invention is exactly in order to solve the shortcoming that above-mentioned Chinese medicine exists, and provide a kind of and need not decoct, not need through digestive tract, not need to the inducing sweat of pore, pore, can direct injection to intravenous, can treat liver, lung two Chinese medicine injection and production method through tissue disease.
Chinese medicine preparation of the present invention is: Flos Eriocauli 1g, Radix et Rhizoma Thalictri 1g, Indigo Naturalis 1g, Rhizoma Bistortae 0.5g, Flos Lonicerae 0.5g, Cortex Lycii 1g, Rhizoma Dioscoreae Nipponicae 1g, Herba Taxilli 1g, Herba Pogostemonis 1g, Herba Glechomae 1g, Rhizoma Polygoni Cuspidati 1g, Fructus Citri Sarcodactylis 1g, Caulis Spatholobi 1g, catechu 1g, Cortex Albiziae 1g, Bombyx Batryticatus 1g, Radix Glycyrrhizae 1g, Gecko 1g, Radix Changii 1g, Flos Celosiae Cristatae 1g, production link of the present invention comprise batching, cleaningization processing, drying and sterilizing, flour, cell rupture, multi-filtering, fill, filler plug, gland, lamp inspection, subsides description, packing, storage, check etc., and house of the present invention, facility, equipment comprise: a, batching use the room, prepare burden with equipment such as electronic scale, b, cleaningization processing room are arranged in the room; Equipment such as ultrasonic washing unit are arranged in the cleaningization processing room, and c, drying and sterilizing are used the room, and drying and sterilizing is with there being equipment such as microwave drying room in the room, and d, flour are used the room, and flour is with equipment such as Chinese medicine powder beater are arranged in the room; E, cell rupture are used the room, and cell rupture is with there being equipment such as ultrasonic cell disruptor in the room, and there are equipment such as particulate filter, liquid medicine filter, g, fill room in f, multi-filtering room in the multi-filtering room; Equipment such as automatic filling machine are arranged in the fill room, and there are equipment such as automatic filler plug machine in h, filler plug room in the filler plug room, and there are equipment such as automatic capping machine in i, gland room in the gland room; There are equipment such as computer lamp inspection machine in j, lamp inspection room in the lamp inspection room, k, paste the explanation study, and pasting in the explanation study has the equipment that pastes description, l, packing room; Equipment such as automatic packing machine are arranged in the packing room, m, warehouse, n, check room, concrete production method is: in batch house, take by weighing the various Chinese medicines in the above-mentioned prescription in proportion with electronic scale, various Chinese medicines are rubbed with the hands and are mixed; Be placed in the container, reached in the ultrasonic washing unit in the cleaningization processing room by conveyer belt, and in ultrasonic washing unit, pour pure water into, Chinese medicine is fully immersed in the pure water, opens ultrasonic washing unit; Clean after 20-30 minute, pour out pure water, put into distilled water again, Chinese medicine is carried out fine purifiation; After the Chinese medicine fine purifiation is clean, refund in the clean container, be sent in the microwave drying room in the drying and sterilizing room, the temperature in microwave drying room is transferred to 60 ℃ by conveyer belt; Open, drying and sterilizing is after 24 hours again, and Chinese medicine is reached in the Chinese medicine powder beater in the flour room by conveyer belt, opens; Repeat to pulverize 3-5 time, Chinese medicine is ground into Chinese medicine medicated powder, is sent to cell rupture with in the ultrasonic cell disruptor in the room by conveyer belt again, and pours distilled water in a small amount into; Open ultrasonic cell disruptor, after 24 hours, Chinese medicine cell rupture, intracellular matter dissolve in the water; Pour the distilled water of requirement again into, process middle drug solns, be sent in the multi-filtering room by pipeline again, through the multi-filtering of particulate filter, liquid medicine filter; Filtered granule in the middle drug solns, broken cell wall, and some antibacterials, virus, insoluble substance, middle drug solns has just become Chinese medicine injection, in pipeline is sent to the fill room, carries out fill by automatic filling machine again; After in Chinese medicine injection fill to the infusion bottle, mouth of infusion bottle is sealed by plastic sheeting, is transferred in the filler plug room by conveyer belt again, on plastic sheeting, fills in plug by automatic filler plug machine; And then be sent to the gland room by conveyer belt, and by automatic capping machine easy-open lid is covered on plug, be sent in the lamp inspection room by conveyer belt again, carry out lamp inspection by computer lamp inspection machine; Qualified products are reached by conveyer belt and paste in the explanation study, paste the Chinese medicine description that has lot number, are reached in the packing room, after the vanning by conveyer belt again; By the automatic packing machine packing, send into storehouse reservation again after packing is good, the inspection machine in the check room is tested to each link in this process, and each link in this process all meets the requirement of GMP.
Compare through the Chinese medicine of tissue with present treatment liver, lung two; It with non-inducing sweat property liver, lung two through medicine, process injection and replace, make it to be applicable to treatment hyperhidrosis, polyuria, the liver that stagnates, lung two patient through tissue disease more, decoct without high temperature; Do not pass through digestive tract; Through pore, pore, its production can be saved all pharmaceutical compositions in the Chinese medicine from damage, is the production through the full medicine injection of prescription Chinese medicine of a kind of liver, lung two.
Specific embodiment production of the present invention is the production through the full medicine injection of prescription Chinese medicine of a kind of liver, lung two, and production of the present invention is the improvement of present Chinese medicine injection production on prescription and method for distilling, and prescription of the present invention is: Flos Eriocauli 1g, Radix et Rhizoma Thalictri 1g, Indigo Naturalis 1g, Rhizoma Bistortae 0.5g, Flos Lonicerae 0.5g, Cortex Lycii 1g, Rhizoma Dioscoreae Nipponicae 1g, Herba Taxilli 1g, Herba Pogostemonis 1g, Herba Glechomae 1g, Rhizoma Polygoni Cuspidati 1g, Fructus Citri Sarcodactylis 1g, Caulis Spatholobi 1g, catechu 1g, Cortex Albiziae 1g, Bombyx Batryticatus 1g, Radix Glycyrrhizae 1g, Gecko 1g, Radix Changii 1g, Flos Celosiae Cristatae 1g, production link of the present invention comprise batching, cleaningization processing, drying and sterilizing, flour, cell rupture, multi-filtering, fill, filler plug, gland, lamp inspection, subsides description, packing, storage, check etc., and house of the present invention, facility, equipment comprise: a, batching are used the room; Batching is with there being equipment such as electronic scale in the room, there are equipment such as ultrasonic washing unit in b, cleaningization processing room in the cleaningization processing room, and c, drying and sterilizing are used the room, and drying and sterilizing is with equipment such as microwave drying room is arranged in the room; D, flour are used the room, and flour is with there being equipment such as Chinese medicine powder beater in the room, and e, cell rupture are used the room, and cell rupture is with equipment such as ultrasonic cell disruptor, f, multi-filtering room are arranged in the room; Particulate filter, the aperture equipment such as liquid medicine filter less than 2um are arranged in the multi-filtering room, and there are equipment such as automatic filling machine in g, fill room in the fill room, and there are equipment such as automatic filler plug machine in h, filler plug room in the filler plug room; There are equipment such as automatic capping machine in i, gland room in the gland room, there are equipment such as computer lamp inspection machine in j, lamp inspection room in the lamp inspection room, k, subsides explanation study; Pasting in the explanation study has the equipment that pastes description, and there are equipment such as automatic packing machine in l, packing room, m, warehouse, n, check room in the packing room; These rooms all are clean rooms, and structure meets the related request of GMP, in batch house, take by weighing the various Chinese medicines in the above-mentioned prescription in proportion with electronic scale, and various Chinese medicines are rubbed with the hands and mixed, and are placed in the container; Reached in the ultrasonic washing unit in the cleaningization processing room by conveyer belt, and in ultrasonic washing unit, pour pure water into, Chinese medicine is fully immersed in the pure water, opens ultrasonic washing unit, cleans after 20-30 minute; Pour out pure water, put into distilled water again, Chinese medicine is carried out fine purifiation, after the Chinese medicine fine purifiation is clean, refund in the clean container; Be sent in the microwave drying room in the drying and sterilizing room by conveyer belt, the temperature in microwave drying room is transferred to 60 ℃, open, drying and sterilizing is after 24 hours, and Chinese medicine is reached in the Chinese medicine powder beater in the flour room by conveyer belt; Open, repeat to pulverize 3-5 time, Chinese medicine is ground into Chinese medicine medicated powder, is sent to cell rupture with in the ultrasonic cell disruptor in the room by conveyer belt again, and pours distilled water in a small amount into; Open ultrasonic cell disruptor, after 24 hours, Chinese medicine cell rupture, intracellular matter dissolve in the water; Pour the distilled water of requirement again into, process middle drug solns, be sent in the multi-filtering room by pipeline again, through the multi-filtering of particulate filter, liquid medicine filter; Filtered granule in the middle drug solns, broken cell wall, and some antibacterials, virus, insoluble substance, middle drug solns has just become Chinese medicine injection, in pipeline is sent to the fill room, carries out fill by automatic filling machine again; After in Chinese medicine injection fill to the infusion bottle, mouth of infusion bottle is sealed by plastic sheeting, is transferred in the filler plug room by conveyer belt again, on plastic sheeting, fills in plug by automatic filler plug machine; And then be sent to the gland room by conveyer belt, and by automatic capping machine easy-open lid is covered on plug, be sent in the lamp inspection room by conveyer belt again, carry out lamp inspection by computer lamp inspection machine; Qualified products are reached by conveyer belt and paste in the explanation study, paste the Chinese medicine description that has lot number, are reached in the packing room, after the vanning by conveyer belt again; By the automatic packing machine packing, send into storehouse reservation again after packing is good, the inspection machine in the check room is tested to each link in this process, and each link in this process all meets the requirement of GMP.
Claims (1)
1. liver, lung two are through non-Chinese medicine injection and the production method of inducing sweat, and prescription is: Flos Eriocauli 1g, Radix et Rhizoma Thalictri 1g, Indigo Naturalis 1g, Rhizoma Bistortae 0.5g, Flos Lonicerae 0.5g, Cortex Lycii 1g, Rhizoma Dioscoreae Nipponicae 1g, Herba Taxilli 1g, Herba Pogostemonis 1g, Herba Glechomae 1g, Rhizoma Polygoni Cuspidati 1g, Fructus Citri Sarcodactylis 1g, Caulis Spatholobi 1g, catechu 1g, Cortex Albiziae 1g, Bombyx Batryticatus 1g, Radix Glycyrrhizae 1g, Gecko 1g, Radix Changii 1g, Flos Celosiae Cristatae 1g, and production link comprises: batching, cleaningization processing, drying and sterilizing, flour, cell rupture, multi-filtering, fill, filler plug, gland, lamp inspection, subsides description, packing, storage, check, house and equipment comprise: a, batching are used the room, and batching is with electronic scale is arranged in the room; B, cleaningization processing room, the cleaningization processing has ultrasonic washing unit in the room, and c, drying and sterilizing are used the room, and drying and sterilizing is with there being the microwave drying room in the room, and d, flour are used the room; Flour is with there being the Chinese medicine powder beater in the room, e, cell rupture are used the room, and cell rupture is with there being ultrasonic cell disruptor in the room, and there are particulate filter, liquid medicine filter in f, multi-filtering room in the multi-filtering room; G, fill room, fill has automatic filling machine in the room, and there is automatic filler plug machine in h, filler plug room, i, gland room in the filler plug room; Gland has automatic capping machine in the room, and there is computer lamp inspection machine in j, lamp inspection room in the lamp inspection room, k, subsides explanation study, and pasting in the explanation study has the equipment that pastes description; L, packing room, packing has automatic packing machine in the room, m, warehouse, n, check room is characterized in that: in batch house, take by weighing the various Chinese medicines in the above-mentioned prescription in proportion with electronic scale; Various Chinese medicines are rubbed with the hands and are mixed, and are placed in the container, are reached in the ultrasonic washing unit in the cleaningization processing room by conveyer belt, and in ultrasonic washing unit, pour pure water into, and Chinese medicine is fully immersed in the pure water; Open ultrasonic washing unit, clean after 20-30 minute, pour out pure water, put into distilled water again, Chinese medicine is carried out fine purifiation; After the Chinese medicine fine purifiation is clean, refund in the clean container, be sent in the microwave drying room in the drying and sterilizing room, the temperature in microwave drying room is transferred to 60 ℃ by conveyer belt; Open, drying and sterilizing is after 24 hours again, and Chinese medicine is reached in the Chinese medicine powder beater in the flour room by conveyer belt, opens; Repeat to pulverize 3-5 time, Chinese medicine is ground into Chinese medicine medicated powder, is sent to cell rupture with in the ultrasonic cell disruptor in the room by conveyer belt again, and pours distilled water in a small amount into; Open ultrasonic cell disruptor, after 24 hours, Chinese medicine cell rupture, intracellular matter dissolve in the water; Pour the distilled water of requirement again into, process middle drug solns, be sent in the multi-filtering room by pipeline again, through the multi-filtering of particulate filter, liquid medicine filter; Filtered granule in the middle drug solns, broken cell wall, and some antibacterials, virus, insoluble substance, middle drug solns has just become Chinese medicine injection, in pipeline is sent to the fill room, carries out fill by automatic filling machine again; After in Chinese medicine injection fill to the infusion bottle, mouth of infusion bottle is sealed by plastic sheeting, is transferred in the filler plug room by conveyer belt again, on plastic sheeting, fills in plug by automatic filler plug machine; And then be sent to the gland room by conveyer belt, and by automatic capping machine easy-open lid is covered on plug, be sent in the lamp inspection room by conveyer belt again, carry out lamp inspection by computer lamp inspection machine; Qualified products are reached by conveyer belt and paste in the explanation study, paste the Chinese medicine description that has lot number, are reached in the packing room, after the vanning by conveyer belt again; By the automatic packing machine packing, send into storehouse reservation again after packing is good, the inspection machine in the check room is tested to each link in this process, and each link in this process all meets the requirement of GMP.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011104154753A CN102451341A (en) | 2011-12-08 | 2011-12-08 | Chinese medicine injection for relieving exterior syndrome of liver channel and lung channel and production method of Chinese medicine injection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011104154753A CN102451341A (en) | 2011-12-08 | 2011-12-08 | Chinese medicine injection for relieving exterior syndrome of liver channel and lung channel and production method of Chinese medicine injection |
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| Publication Number | Publication Date |
|---|---|
| CN102451341A true CN102451341A (en) | 2012-05-16 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011104154753A Pending CN102451341A (en) | 2011-12-08 | 2011-12-08 | Chinese medicine injection for relieving exterior syndrome of liver channel and lung channel and production method of Chinese medicine injection |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102451341A (en) |
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2011
- 2011-12-08 CN CN2011104154753A patent/CN102451341A/en active Pending
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Application publication date: 20120516 |