CN102448329A - Functional food using fresh juice or starch made from bora valley potato for patients with gastritis, gastric ulcer or duodenal ulcer - Google Patents
Functional food using fresh juice or starch made from bora valley potato for patients with gastritis, gastric ulcer or duodenal ulcer Download PDFInfo
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- CN102448329A CN102448329A CN200980159625XA CN200980159625A CN102448329A CN 102448329 A CN102448329 A CN 102448329A CN 200980159625X A CN200980159625X A CN 200980159625XA CN 200980159625 A CN200980159625 A CN 200980159625A CN 102448329 A CN102448329 A CN 102448329A
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- A—HUMAN NECESSITIES
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
- A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
- A23L29/212—Starch; Modified starch; Starch derivatives, e.g. esters or ethers
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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Abstract
The present invention relates to functional foods using the Bora valley potato (Solanum tuberosum L., cv. Bora valley), a new variety of potato, for use in preventing and treating gastric and duodenal ulcers, and more specifically to functional foods using the juice or the starch made from the Bora valley potato as a main or supplementary ingredient, or adding the fresh juice or starch to various favorite foods. According to the present invention, the fresh juice or starch of the Bora valley potato is shown to have significant inhibitory activity against gastritis, gastric ulcer and duodenal ulcer in various animal experiments, and can therefore be used advantageously in functional foods for preventing and treating gastritis, and gastric or duodenal ulcers.
Description
Technical field
The present invention relates to functional food (functional food); It uses potato new varieties Bao Laiweili (Bora valley) potato (Solanum tuberosum L.; Cv.Bora valley) is used for prevention and treatment gastritis, gastric ulcer or duodenal ulcer; More specifically, it relates to the bright juice of application Bao Laiweili potato preparation or the functional food of starch.
Background technology
The original producton location is the potato in Andean, South America (South Africa andes) area, is one to can be used as the useful crop of hardy plant (hardy plant).Potato raw is short for a long time, yield per unit area is high relatively, and has stronger adaptive capacity to environment, surplus the whole world 130, belongs in the crop that country is cultivating and is only second to one of the fourth-largest cereal crops in the world of paddy rice, wheat and corn.The relative rice of potato and other crop of wheat class, not only heat is low and contain abundant nutrition compositions such as the vitamin C that is similar to vegetables, B1, B2, nicotinic acid.Therefore, potato has been carried out more research to general nutrition analysis and anti-oxidant type (vitality of sulfation) physiologically active etc. has been arranged.Potato produces area and just is being trend of globalization growth, especially at undeveloped center.
Recently, the variation of international agricultural environment has increased the weight of the compressing to grain war or seed war, and grain (food) will become following weapon, and various countries carry out the protection work of relevant kind power with cereal crops with all strength.Korea S added the UPOV of UPOV in 2002, though the kind protection period is slightly different according to country variant, the shortest kind protection system from 18 years to 35 years has realized legalization.Based on this situation; The inventor develops multiple functional potato new varieties; Handled registration (state-run seed management institute, 15 new varieties and 4 application kinds) (Korea Seed & Variety Service, 15 new varieties and, 4 applied varieties) as national kind; Not only substituted external potato kind (beautiful (Superior)/u.s. variety, the earth/Japan cultivars, Da Xi (Atlantic)/u.s. variety) (Superior (U.S.A); Dejima (Japan), Atlantic (U.S.A)), also carried out experimental planting on the U.S., Canada, France, Russia, Mongolia, China, Kazakhstan, India and other places.
Potato is in part country even belong to the staple food crop, and is not only important and also be applied to make various converted products, and along with the continuous West Europeization of cooking culture, the consumption of potato is further growth trend.Increase based on this consumption, people come to realise the further necessity of the potato variety development of trend health of exploitation.
It is said that potato is applied to more kind disease treatment among the people.According to Republic of Korea's publication communique 2001-29185 number, can suppress through having antibacterium, antitumaous effect thereby mentioned potato to hypertension, heart disease, constipation, increment hepatitis and other microorganism, but its effect have no way of know.
The inventor once developed the new varieties potato through the improvement potato, and according to the new varieties potato of inventor's exploitation, every kind of new varieties all have different effects separately.Promptly; Republic of Korea's registered patent communique has announced that new varieties tie up beautiful potato (Bao Laiweili (Bora valley), fruit juice dimension beautiful (Juice Valley), Da Songweili (Dasom Valley), height collude Wei Li (Gogu Valley)) to strengthening the effect of human body intestinal canal function for No. 628417; Republic of Korea's registered patent communique has announced that the high peptide that separates in the potato (Solanum tuberosum L cv.Gogu Valley) of the beautiful kind of dimension that colludes has superpower antibiotic effect for No. 654231, and Republic of Korea's registered patent communique has announced that the peptide that separates in the potato (Solanum tuberosum L cv.Golden Valley) of Ge Dengweili (Golden Valley) kind has superpower antibiotic effect for No. 654232.And Republic of Korea's registered patent communique has been pointed out potato (the Solanum tuberosum L. of Bao Laiweili (Bora valley) kind for No. 583192; Cv Bora valley) anti-oxidant of extract; No. 709238 Bao Laiweili of Republic of Korea's registered patent communique (Bora valley) potato (Solanum tuberosum L.; Cv Bora valley) announced that ethanolic extract can suppress fat cell differentiation, be divided into the leptin (leptin) of fat cell through minimizing, thereby had the inhibition obesity action.
According to the present invention; Bao Laiweili (Bora valley) potato (Solanum tuberosum L.; CvBora valley) be to be purple by the interior earth that comprises that the inventor develops; Be to use the potato new varieties for the processing of purple-colored potato potato chips, the application kind protection of state-run seed management institute (application numbers: 2002-11), in official register in 2004 national kind (accession designation number: 1-5-2004-5).This kind is example with A87spx14-4, with gurmeys purple as copy (A87spx14-4 is the example and Gurmeys purple is the duplicate); After the artificial hybridization method that adopted non-genomic to handle in 1996 obtained real seed, spring, autumn had been implemented the seedling cultivation twice 1997 the fraction of the year.Implement formal detection and 1999-2001 in 1998 and implemented production capacity detection test and regional compatibility test (west, spring river, Jin Di face extensively alive, the horizontal small stream in mountain range, high point etc.) (in Chuncheon Seo-myeon; Gimje Gwanghwal-myeon, Daegwanryung Hoenggye etc.).The zone compatibility test is implemented in spring, summer, autumn, winter booth.Applied for the new varieties rights protection in 2002, the outstanding property of new varieties has been approved by state-run seed management institute after 2 years entrusted 3 places research institution of country to detect, and the processing of purple-colored potato potato chips is born in Korea S in 2004 with kind first thus.This kind demonstrates the applicability in multiple cooking and the food development with its purple gloss epidermis and dark purple yellowish pink.Bao Laiweili (Bora valley) potato has been honoured with Nobel prize item gold medal in the Innovation Awards field in the international potato fair that hold in Moscow in 2007, be one to receive the potato kind of whole world approval.
The potato that eats something rare that the inventor is conceived to spread in the ancient folkd therapy of Korea S has remarkable efficacy a bit to gastritis, enteritis; To said new varieties potato Bao Laiweili (Bora valley) potato (Solanum tuberosum L.; Cv Bora valley) in the research as the functional food purposes; Find that common potato and oral instructions effect are not inconsistent; Gastritis, gastric ulcer or duodenal ulcer are not shown any activity, and bright juice and the starch of having confirmed Bao Laiweili (Bora valley) potato have on the contrary been accomplished the present invention thus to having superpower effect such as above-mentioned gastritis, gastric ulcer and duodenal ulcer disease.
Summary of the invention
One of the object of the invention is to utilize potato new varieties Bao Laiweili potato (Solanum tuberosum L., cv Bora valley) that the functional food of a kind of prevention and treatment gastritis, gastric ulcer or duodenal ulcer is provided.
For realizing above-mentioned purpose; The present invention provides the application Bao Laiweili potato that can prevent and treat gastritis, gastric ulcer or duodenal ulcer (Solanum tuberosum L.; Cv Bora valley) functional food; More specifically, it provides the bright juice of application Bao Laiweili potato preparation or the functional food of starch.
The present invention utilizes juice extractor to make the method for bright juice after being provided at and removing Bao Laiweili (Bora valley) potato (Solanum tuberosum L., cv.Bora valley) bud position.
And; According to the present invention; Bao Laiweili (Bora valley) farina can be through the bright juice of normal temperature held Bao Laiweili (Bora valley) potato after about 10 minutes; Through isolated by vacuum filtration Bao Laiweili (Bora valley) farina layer and filtrate layers, again with Bao Laiweili (Bora valley) the said stratum granulosum of farina layer vacuum freezedrying or in 65 ℃ dry starch obtain dry farina.
Various food can be through following preparation: can be added on fancy food to bright juice of Bao Laiweili (Bora valley) potato or starch with common known method; Such as wheaten food classes such as instant noodles or living noodles, bean curd, cereal, Bread and Pastries, chewing gum, carbohydrate, Biscuits (snack class); And bright juice of Bao Laiweili (Bora valley) potato or starch can be realized formulationization by general formulation such as powder (pulvis), tablet, granule, pill, hard capsule, soft capsule or liquid dosage form; Can manufacture juice, packed, beverage or teas, other composition except that said composition can suitably be selected by those skilled in the art and mixes according to formulation (dispensing).
According to the present invention; Preparation can prevent and treat health care (heath) functional food of gastritis, gastric ulcer or duodenal ulcer; Can maybe can be added on Bao Laiweili potato (Solanum tuberosum L., cv.Bora valley) bright juice or starch in other food as the major and minor raw material manufacturing of food and make.The food auxiliary additive that can use bromatology to allow this moment.
Bao Laiweili of the present invention (Bora valley) potato (Solanum tuberosum L.; Cv.Bora valley) bright juice or starch are in the test of alcohol induced rat gastric ulcer model, and it is more outstanding with medicine Omeprazole (Omeprazole) preparation than the gastric ulcer prevention of market sale to have manifested preventive effect.
In the PGE2 determination test of bright juice of Bao Laiweili of the present invention (Bora valley) potato or the relevant gastritis model of starch; Show the obvious suppression rate, the health care property food that therefore contains it can better used aspect prevention and treatment gastritis, gastric ulcer or the duodenal ulcer.
Therefore; Bao Laiweili potato of the present invention (Solanum tuberosum L.; Cv.Bora valley) bright juice or starch are the brand-new functional food food materials for gastritis, gastric ulcer or duodenal ulcer patients, can be developed as the health care property food of prevention and treatment gastritis, gastric ulcer or duodenal ulcer.
Bao Laiweili potato of the present invention (Solanum tuberosum L., cv.Bora valley) bright juice or starch are fit to be added in the food and use according to The acute toxicity tests.
Bao Laiweili potato of the present invention (Solanum tuberosum L.; Cv Bora valley) in bright juice or the relative market of starch as the prevention of gastritis, gastric ulcer or duodenal ulcer and medicine sell the Omeprazole preparation; Suppress effect high (occurrence of gastric ulcer more than Omeprazole) than its performance gastric ulcer, obviously find out the effect that suppresses the PGE2 amount.
Therefore the present invention's health care property food that can be suitable as prevention and treatment gastritis, gastric ulcer or duodenal ulcer is applied.
Description of drawings
Fig. 1 has shown the picture in kind of Bao Laiweili of the present invention (Bora valley) potato (Solanum tuberosum L.cv.Bora valley).
The specific embodiment
Specify the present invention through the embodiment of the invention below.Yet, below embodiment be preferred exemplary the present invention, do not represent content of the present invention to be limited to this embodiment.
<embodiment 1>
The manufacturing of the bright juice of Bao Laiweili (Bora valley) potato
After getting Bao Laiweili (Bora valley) potato (Solanum tuberosum L., cv.Bora valley) 55g and cleaning up and excise the bud position, utilize juice extractor to obtain the bright juice of Bao Laiweili (Bora valley) potato of about 50ml.
<embodiment 2>
The manufacturing of Bao Laiweili (Bora valley) farina
The bright juice 40ml of Bao Laiweili (Bora valley) potato of making among the said embodiment 1 placed 10 minutes at normal temperatures; After isolated by vacuum filtration became Bao Laiweili (Bora valley) farina layer and filtrate layers, dry Bao Laiweili in 65 ℃ (Bora valley) farina layer had obtained dry farina 6.4g.
<embodiment 3>
The manufacturing of Bao Laiweili (Bora valley) farina
The bright juice 40ml of Bao Laiweili (Bora valley) potato of making among the said embodiment 1 placed 10 minutes at normal temperatures; After isolated by vacuum filtration became Bao Laiweili (Bora valley) farina layer and filtrates, vacuum freezedrying Bao Laiweili (Bora valley) farina layer had obtained dry farina 7.4g.
<reference examples 1>
The manufacturing of the bright juice of common potato
Common potato 55g has obtained the bright juice of common potato of about 31ml according to the method manufacturing identical with embodiment 1.
<reference examples 2>
The manufacturing of common farina
The bright juice 30ml of the common potato of making in the reference examples has obtained the dry farina of about 8.8g according to after embodiment 2 identical methods are made.
<experimental example 1>
Ethanol induces the inhibition ability of potato in the rat gastric ulcer model to measure
Bright juice 0.5ml of the potato of making in embodiment 1,2 and the reference examples 1,2 and farina 10mg are dissolved in 0.1%CMC separately, and oral administration is in SD rat (150-200g buys from ORIENTBIO company for male, SPF).After this; For inducing gastric ulcer according to methods such as Rao (J.Ethnopharmacol.91; 243,2004), oral administration ethanol after 1 hour; After 4 hours, stomach is put to death, excised to rat again and be fixed on formalin, behind the measurement ulcer width its outcome record has been used the 5mg Omeprazole at table 1. as control group.
Table 1
The gastric ulcer inhibitory action of potato
N=6,
*: P<0.05, contrast ethanol administration crowd
As shown in table 1, can find out from embodiments of the invention 1 and embodiment 2, in the check experiment of market, shown higher gastric ulcer and suppressed effect as the Omeprazole of gastric ulcer prevention and therapeutic agent sale.
But reference examples of common potato 1 and reference examples 2 (beautiful, Superior, the U.S.) are different with the tradition biography, can find out gastric ulcer is not manifested effect.
Therefore, bright juice or the starch of new varieties Bao Laiweili (Bora valley) potato (Solanum tuberosum L., cv.Bora valley) are different with common potato, can have remarkable efficacy to gastritis, gastric ulcer or duodenal ulcer certainly.
<experimental example 2>
The obstruction ability of gastritis in model
Bright juice 0.5ml of the potato of making in embodiment 1,3 and the reference examples 1,2 and farina 10mg are dissolved in 0.1%CMC separately, and oral administration is in SD rat (150-200g buys from ORIENTBIO company for male, SPF).After 1 hour with 10mg/ rat capacity to SD rat oral administration indomethacin, after excision stomach after 5 hours divided with polytron homogenizer grinding, centrifugation had obtained first-class liquid again.After this extract the back drying with ethyl acetate.After this be dissolved in behind the methyl alcohol put into Sep-Pak C18column and flow out with methods such as Park (Eur.J.Pharmacol.425,153-157,2001) after, with after the N2 drying with the amount of the PGE2 of the quantitative inflammatory parameters of ELISA method, with its outcome record at table 2.
Table 2
Indomethacin (indomathacin)-the induce inhibitory action of gastritis
N=6,
*: P<0.05, contrast ethanol administration crowd
As shown in table 2; Can find out from embodiments of the invention 1 and embodiment 3; The inhibitory action of PGE2 is very outstanding, but does not show the gastritis effect in traditional oral instructions as reference examples 1 and the reference examples 2 of common potato, can affirm that not manifesting PGE2 suppresses effect.
Therefore, bright juice or the starch of new varieties Bao Laiweili (Bora valley) potato (Solanum tuberosum L., cv.Bora valley) are different with common potato, can have remarkable efficacy to gastritis, gastric ulcer or duodenal ulcer certainly.
<experimental example 3>
Acute toxicity test
Checked acute toxicity according to food medicine Room guide at ICR mouse (male).Its as a result the bright juice of Bao Laiweili (Bora valley) potato till 5.0ml/kg, do not find any toxicity, Bao Laiweili (Bora valley) the farina toxicity that do not come to light till the 750mg/kg equally.
As stated, bright juice of Bao Laiweili (Bora valley) potato and starch are nontoxic in fact, and as the effective dose of said purpose, bright juice is that 0.1-5ml/kg, starch are 1mg-500mg/kg, took in 1st 1-3 time comparatively suitable.
Through this safety experiment, judge that bright juice of Bao Laiweili of the present invention (Bora valley) potato and starch do not have bad influence to human body.
Following Bao Laiweili of the present invention (Bora valley) potato (Solanum tuberosum L.; Cv Bora valley) extract can be added on and make prevention gastritis, gastric ulcer or duodenal ulcer in the various solid-state foods (particulates) such as wheaten food class, carbohydrate, Biscuits, cereal, Bread and Pastries of chewing gum, instant noodles etc. and function is improved functional food, and can manufacture tea and beverage.Example embodiment of the present invention hereinafter is detailed.
< make the manufacturing of example 1>biscuit
Self-raising flour (weak flour: the flour that biceps is weak) 1 grade of 19.59 percentage by weight, 1 grade of 22.22 percentage by weight of Plain flour, refined sugar 4.80 percentage by weights, salt 0.73 percentage by weight, glucose 0.78 percentage by weight, palm butter 11.15 percentage by weights, carbonic hydroammonium, 1.54 percentage by weights, sodium acid carbonate 0.17 percentage by weight, niter cake (sodium bisulfate) 0.16 percentage by weight, ground rice 1.45 percentage by weights, vitaminB10 .0001 percentage by weight, vitamin B2 0.0001 percentage by weight, frankincense 0.04 percentage by weight, water 21.3298 percentage by weights, whole milk powder 1.16 percentage by weights, substitute Bao Laiweili (Bora valley) potato dried powder 7 percentage by weights that cream (alternative milk powder) 0.29 percentage by weight, calcium dihydrogen phosphate 0.03 percentage by weight, salting (scattering salt) 0.29 weight percent are when made among spray oils (oil mist) 7.27 percentage by weights and the said embodiment 2, after allocating, made biscuit with usual method.
< make the manufacturing of example 2>chewing gum
Bao Laiweili (Bora valley) potato dried powder 7 percentage by weights that matrix 20 percentage by weights, sugared 70 percentage by weights, spices 1 weight percent are when made among water 2 percentage by weights and the said embodiment 2 have been made chewing gum with usual method after allocating.
The manufacturing of < making example 2>sugar
Bao Laiweili (Bora valley) potato dried powder 10 percentage by weights that sugar 50 percentage by weights, syrup 39.8 weight percent are when made among spices 0.2 percentage by weight and the said embodiment 2 have been made carbohydrate with usual method after allocating.
< make the manufacturing of example 4>beverage
Bright juice 10 percentage by weights of Bao Laiweili (Bora valley) potato that honey 0.26 percentage by weight, lipozyme (thioctic acid amide) 0.0002 percentage by weight, niacinamide (nicotinamide) 0.0004 percentage by weight, Riboflavine sodium phosphate 0.0001 percentage by weight, puridoxine hydrochloride 0.0001 percentage by weight, inose (inositol) 0.001 percentage by weight, orotic acid (orotic acid) 0.002 weight percent are when made among water 89.7362 percentage by weights and the said embodiment 1 have been made beverage with usual method after allocating.
< make the manufacturing of example 5>tablet
Bao Laiweili (Bora valley) potato dried powder 200mg, VB11 5mg, vitamin B2 15mg, vitamin C 25mg, the Cobastab made among the embodiment 2
625mg, nicotine 15mg; Through mixing the back for after carrying out tablet formulation interpolation lactulose powder 200mg, sodium aluminosilicate 25mg, sucrose fatty ester 25mg, hydroxypropyl methylcellulose 25mg, fatty acid glyceride (Glycerin Esters of Fatty Acids) 15mg, zinc oxide 15mg, beta-schardinger dextrin-15mg, mixing is also made tablet with tablet machine.
< make the manufacturing of example 6>hard capsules
The dry 100mg of Bao Laiweili (Bora valley) potato of making among the embodiment 2, Cobastab
115mg, Cobastab
215mg, vitamin C 25mg, Cobastab
625mg, nicotine 15mg, citric acid (citric acid) 25mg, lactose 400mg and purify waste water and mix.Afterwards, said mixture is put into granulator and is shaped to graininess, after 40~50 ℃ air flow dryer drying, utilizes the sieve of 12~14 meshes to make impartial particle the particle of said moulding, it is filled in the hard capsules again.
Claims (6)
1. health care property food that is used to prevent and treat gastritis, gastric ulcer or duodenal ulcer contains the starch of Bao Laiweili (Bora valley) potato (Solanum tuberosum L.cv.Bora valley).
2. according to the food of claim 1, said health care property food is selected from the group of being made up of pulvis, tablet, granule, pill, hard capsule, soft capsule and liquid dosage form.
4. be used to prevent and treat the food additives of gastritis, gastric ulcer or duodenal ulcer, it contains the starch of Bao Laiweili potato (Solanum tuberosum L.cv.Bora valley).
5. be used to prevent and treat the health care property food of gastritis, gastric ulcer or duodenal ulcer, wherein be selected from the food additives that the fancy food of forming group (favorite foods) by chewing gum, candy class and Biscuits contains in the claim 4 to be limited.
6. be used to prevent and treat the health care property food of gastritis, gastric ulcer or duodenal ulcer, wherein be selected from the food additives that contain in the claim 4 to be limited by the food that comprises instant noodles (ramen) and give birth to the group that wheaten food class (noodles), bean curd, cereal, the Bread and Pastries of (wet) noodles form.
Applications Claiming Priority (1)
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PCT/KR2009/001759 WO2010117093A1 (en) | 2009-04-06 | 2009-04-06 | Functional food using fresh juice or starch made from bora valley potato for patients with gastritis, gastric ulcer or duodenal ulcer |
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CN101223986A (en) * | 2007-01-17 | 2008-07-23 | 马铃薯百利公司(株) | The healthy and functional foods for the obesity patients using purple-colored potato |
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KR100583192B1 (en) * | 2004-05-18 | 2007-04-12 | (주)포테이토밸리 | Method of anti-oxidative compound extracted from boravalley potato, functional foods and cosmetics containing thereof |
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2009
- 2009-04-06 CN CN200980159625XA patent/CN102448329A/en active Pending
- 2009-04-06 RU RU2011144816/13A patent/RU2011144816A/en not_active Application Discontinuation
- 2009-04-06 WO PCT/KR2009/001759 patent/WO2010117093A1/en active Application Filing
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WO2010117093A1 (en) | 2010-10-14 |
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