CN102423471A - Heart-stomach two-channel traditional Chinese drug injection without exterior syndrome relieving, and production method thereof - Google Patents
Heart-stomach two-channel traditional Chinese drug injection without exterior syndrome relieving, and production method thereof Download PDFInfo
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- CN102423471A CN102423471A CN2011104152692A CN201110415269A CN102423471A CN 102423471 A CN102423471 A CN 102423471A CN 2011104152692 A CN2011104152692 A CN 2011104152692A CN 201110415269 A CN201110415269 A CN 201110415269A CN 102423471 A CN102423471 A CN 102423471A
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- 238000002347 injection Methods 0.000 title claims abstract description 23
- 239000007924 injection Substances 0.000 title claims abstract description 23
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 19
- 239000003390 Chinese drug Substances 0.000 title abstract 8
- 208000011580 syndromic disease Diseases 0.000 title abstract 2
- 239000003814 drug Substances 0.000 claims abstract description 68
- 238000001035 drying Methods 0.000 claims abstract description 25
- 238000007689 inspection Methods 0.000 claims abstract description 25
- 238000001914 filtration Methods 0.000 claims abstract description 16
- 230000001954 sterilising effect Effects 0.000 claims abstract description 16
- 238000012545 processing Methods 0.000 claims abstract description 13
- 229940079593 drug Drugs 0.000 claims abstract description 11
- 239000000843 powder Substances 0.000 claims abstract description 10
- 210000004243 sweat Anatomy 0.000 claims abstract description 8
- 239000004863 Frankincense Substances 0.000 claims abstract description 4
- 210000004027 cell Anatomy 0.000 claims description 24
- 238000012856 packing Methods 0.000 claims description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 21
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- 235000013312 flour Nutrition 0.000 claims description 12
- 210000004907 gland Anatomy 0.000 claims description 12
- 210000000582 semen Anatomy 0.000 claims description 12
- 238000005406 washing Methods 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 11
- 210000002784 stomach Anatomy 0.000 claims description 11
- 239000012153 distilled water Substances 0.000 claims description 9
- 229940126678 chinese medicines Drugs 0.000 claims description 7
- 230000001939 inductive effect Effects 0.000 claims description 7
- 238000001802 infusion Methods 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- 241000717739 Boswellia sacra Species 0.000 claims description 3
- 241000218236 Cannabis Species 0.000 claims description 3
- 241000628997 Flos Species 0.000 claims description 3
- 241000700605 Viruses Species 0.000 claims description 3
- 230000000844 anti-bacterial effect Effects 0.000 claims description 3
- 229940088710 antibiotic agent Drugs 0.000 claims description 3
- 210000002421 cell wall Anatomy 0.000 claims description 3
- 239000008187 granular material Substances 0.000 claims description 3
- 230000003834 intracellular effect Effects 0.000 claims description 3
- 238000003860 storage Methods 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims description 3
- 238000005303 weighing Methods 0.000 claims description 3
- 239000011148 porous material Substances 0.000 abstract description 10
- 208000026062 Tissue disease Diseases 0.000 abstract description 6
- 208000008454 Hyperhidrosis Diseases 0.000 abstract description 4
- 208000004880 Polyuria Diseases 0.000 abstract description 4
- 230000037315 hyperhidrosis Effects 0.000 abstract description 4
- 238000011282 treatment Methods 0.000 abstract description 3
- 230000000694 effects Effects 0.000 abstract description 2
- 208000024891 symptom Diseases 0.000 abstract description 2
- 235000013399 edible fruits Nutrition 0.000 abstract 2
- MFYSUUPKMDJYPF-UHFFFAOYSA-N 2-[(4-methyl-2-nitrophenyl)diazenyl]-3-oxo-n-phenylbutanamide Chemical compound C=1C=CC=CC=1NC(=O)C(C(=O)C)N=NC1=CC=C(C)C=C1[N+]([O-])=O MFYSUUPKMDJYPF-UHFFFAOYSA-N 0.000 abstract 1
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- 244000025254 Cannabis sativa Species 0.000 abstract 1
- 235000012766 Cannabis sativa ssp. sativa var. sativa Nutrition 0.000 abstract 1
- 235000012765 Cannabis sativa ssp. sativa var. spontanea Nutrition 0.000 abstract 1
- 244000241235 Citrullus lanatus Species 0.000 abstract 1
- 235000012828 Citrullus lanatus var citroides Nutrition 0.000 abstract 1
- 241000037740 Coptis chinensis Species 0.000 abstract 1
- 244000303040 Glycyrrhiza glabra Species 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 235000017443 Hedysarum boreale Nutrition 0.000 abstract 1
- 235000007858 Hedysarum occidentale Nutrition 0.000 abstract 1
- 241000208278 Hyoscyamus Species 0.000 abstract 1
- 241000234435 Lilium Species 0.000 abstract 1
- 241001448331 Liriope spicata Species 0.000 abstract 1
- 241000745390 Lophatherum Species 0.000 abstract 1
- 244000280244 Luffa acutangula Species 0.000 abstract 1
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- 235000008632 Santalum album Nutrition 0.000 abstract 1
- 241000304432 Sedum sarmentosum Species 0.000 abstract 1
- 241000219784 Sophora Species 0.000 abstract 1
- 244000178320 Vaccaria pyramidata Species 0.000 abstract 1
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- 240000004922 Vigna radiata Species 0.000 abstract 1
- 235000010721 Vigna radiata var radiata Nutrition 0.000 abstract 1
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- 244000273928 Zingiber officinale Species 0.000 abstract 1
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- 235000005607 chanvre indien Nutrition 0.000 abstract 1
- 235000008397 ginger Nutrition 0.000 abstract 1
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- 239000011487 hemp Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
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Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a heart-stomach two-channel traditional Chinese drug injection without exterior syndrome relieving, and a production method thereof. The formula of the injection comprises: 1 g of common lophatherum herb, 0.5 g of mung bean, 1 g of coptis chinensis, 0.5 g of lightyellow sophora root, 1 g of honeysuckle, 1 g of unprocessed rehmannia root, 0.5 g of hemp fruit, 1 g of loofah, 1 g of whitefruit amomum fruit, 1 g of watermelon peel, 1 g of stringy stonecrop herb, 1 g of dried ginger, 1 g of sandalwood, 1 g of malt, 1 g of frankincense, 1 g of cowherb seed, 1 g of henbane seed, 1 g of licorice root, 1 g of lily, 1 g of creeping liriope and 1 g of lotus seed. The production process comprises: material preparing, clean processing, drying and sterilization, crushing into powder, cell breaking, multiple filtering, filling, rubber plug filling, lid pressing, lamp examination, instruction pasting, packaging, storing and inspection. The traditional Chinese drug injection of the present invention has the following advantages that: the traditional Chinese drug injection does not require decocting, provides the effect without requirements of pores and sweat pores, and has other advantages; the traditional Chinese drug injection is applicable for treatments of patients with the heart-stomach two-channel tissue diseases, wherein the symptoms of the patients comprise hyperhidrosis, polyuria and multiple stagnation; the production of the traditional Chinese drug injection can remains all the drug components of the traditional Chinese drugs in the formula, and is the production of the heart-stomach two-channel traditional Chinese drug whole drug injection.
Description
Technical field the present invention relates to a kind of not through inducing sweat, can treat the heart, stomach two Chinese medicine injection and the production method through tissue disease.
Background technology is known do not need high temperature decoct, need not be through digestive tract, can treat the heart, stomach two through the Chinese medicine of tissue disease inducing sweat property all; These Chinese medicines are through being got in the human body by pore, pore the inducing sweat effect of pore, pore; And then people body-centered, stomach two treated through tissue disease; It can bring hyperhidrosis, polyuria, phenomenon such as stagnate more, thereby it is not suitable for the patient of hyperhidrosis, polyuria, symptoms such as stagnate more.
Summary of the invention the object of the invention is exactly in order to solve the shortcoming that above-mentioned Chinese medicine exists, and provide a kind of and need not decoct, not need through digestive tract, not need to the inducing sweat of pore, pore, can direct injection to intravenous, can treat the heart, stomach two Chinese medicine injection and production method through tissue disease.
Chinese medicine preparation of the present invention is: Herba Lophatheri 1g, Semen phaseoli radiati 0.5g, Rhizoma Coptidis 1g, Radix Sophorae Flavescentis 0.5g, Flos Lonicerae 1g, Radix Rehmanniae 1g, Fructus Cannabis 0.5g, Retinervus Luffae Fructus 1g, Fructus Amomi Rotundus 1g, Exocarpium Citrulli 1g, Herba Sedi 1g, Rhizoma Zingiberis 1g, Lignum Santali Albi 1g, Fructus Hordei Germinatus 1g, Olibanum 1g, Semen Vaccariae 1g, Semen Hyoscyami 1g, Radix Glycyrrhizae 1g, Bulbus Lilii 1g, Radix Ophiopogonis 1g, Semen Nelumbinis 1g, production link of the present invention comprises batching, cleaningization processing, drying and sterilizing, flour, cell rupture, multi-filtering, fill, filler plug, gland, lamp inspection, subsides description, packing, storage, check etc., house of the present invention, facility, equipment comprise: a, batching use the room, prepare burden with equipment such as electronic scale, b, cleaningization processing room are arranged in the room; Equipment such as ultrasonic washing unit are arranged in the cleaningization processing room, and c, drying and sterilizing are used the room, and drying and sterilizing is with there being equipment such as microwave drying room in the room, and d, flour are used the room, and flour is with equipment such as Chinese medicine powder beater are arranged in the room; E, cell rupture are used the room, and cell rupture is with there being equipment such as ultrasonic cell disruptor in the room, and there are equipment such as particulate filter, liquid medicine filter, g, fill room in f, multi-filtering room in the multi-filtering room; Equipment such as automatic filling machine are arranged in the fill room, and there are equipment such as automatic filler plug machine in h, filler plug room in the filler plug room, and there are equipment such as automatic capping machine in i, gland room in the gland room; There are equipment such as computer lamp inspection machine in j, lamp inspection room in the lamp inspection room, k, paste the explanation study, and pasting in the explanation study has the equipment that pastes description, l, packing room; Equipment such as automatic packing machine are arranged in the packing room, m, warehouse, n, check room, concrete production method is: in batch house, take by weighing the various Chinese medicines in the above-mentioned prescription in proportion with electronic scale, various Chinese medicines are rubbed with the hands and are mixed; Be placed in the container, reached in the ultrasonic washing unit in the cleaningization processing room by conveyer belt, and in ultrasonic washing unit, pour pure water into, Chinese medicine is fully immersed in the pure water, opens ultrasonic washing unit; Clean after 20-30 minute, pour out pure water, put into distilled water again, Chinese medicine is carried out fine purifiation; After the Chinese medicine fine purifiation is clean, refund in the clean container, be sent in the microwave drying room in the drying and sterilizing room, the temperature in microwave drying room is transferred to 60 ℃ by conveyer belt; Open, drying and sterilizing is after 24 hours again, and Chinese medicine is reached in the Chinese medicine powder beater in the flour room by conveyer belt, opens; Repeat to pulverize 3-5 time, Chinese medicine is ground into Chinese medicine medicated powder, is sent to cell rupture with in the ultrasonic cell disruptor in the room by conveyer belt again, and pours distilled water in a small amount into; Open ultrasonic cell disruptor, after 24 hours, Chinese medicine cell rupture, intracellular matter dissolve in the water; Pour the distilled water of requirement again into, process middle drug solns, be sent in the multi-filtering room by pipeline again, through the multi-filtering of particulate filter, liquid medicine filter; Filtered granule in the middle drug solns, broken cell wall, and some antibacterials, virus, insoluble substance, middle drug solns has just become Chinese medicine injection, in pipeline is sent to the fill room, carries out fill by automatic filling machine again; After in Chinese medicine injection fill to the infusion bottle, mouth of infusion bottle is sealed by plastic sheeting, is transferred in the filler plug room by conveyer belt again, on plastic sheeting, fills in plug by automatic filler plug machine; And then be sent to the gland room by conveyer belt, and by automatic capping machine easy-open lid is covered on plug, be sent in the lamp inspection room by conveyer belt again, carry out lamp inspection by computer lamp inspection machine; Qualified products are reached by conveyer belt and paste in the explanation study, paste the Chinese medicine description that has lot number, are reached in the packing room, after the vanning by conveyer belt again; By the automatic packing machine packing, send into storehouse reservation again after packing is good, the inspection machine in the check room is tested to each link in this process, and each link in this process all meets the requirement of GMP.
Compare through the Chinese medicine of tissue with the present treatment heart, stomach two; It with non-the inducing sweat property heart, stomach two through medicine, process injection and replace, make it to be applicable to treatment hyperhidrosis, polyuria, the heart that stagnates, stomach two patient through tissue disease more, decoct without high temperature; Do not pass through digestive tract; Through pore, pore, its production can be saved all pharmaceutical compositions in the Chinese medicine from damage, is the production through the full medicine injection of prescription Chinese medicine of a kind of heart, stomach two.
Specific embodiment production of the present invention is the production through the full medicine injection of prescription Chinese medicine of a kind of heart, stomach two, and production of the present invention is the improvement of present Chinese medicine injection production on prescription and method for distilling, and prescription of the present invention is: Herba Lophatheri 1g, Semen phaseoli radiati 0.5g, Rhizoma Coptidis 1g, Radix Sophorae Flavescentis 0.5g, Flos Lonicerae 1g, Radix Rehmanniae 1g, Fructus Cannabis 0.5g, Retinervus Luffae Fructus 1g, Fructus Amomi Rotundus 1g, Exocarpium Citrulli 1g, Herba Sedi 1g, Rhizoma Zingiberis 1g, Lignum Santali Albi 1g, Fructus Hordei Germinatus 1g, Olibanum 1g, Semen Vaccariae 1g, Semen Hyoscyami 1g, Radix Glycyrrhizae 1g, Bulbus Lilii 1g, Radix Ophiopogonis 1g, Semen Nelumbinis 1g, production link of the present invention comprises batching, cleaningization processing, drying and sterilizing, flour, cell rupture, multi-filtering, fill, filler plug, gland, lamp inspection, subsides description, packing, storage, check etc., house of the present invention, facility, equipment comprise: a, batching are used the room; Batching is with there being equipment such as electronic scale in the room, there are equipment such as ultrasonic washing unit in b, cleaningization processing room in the cleaningization processing room, and c, drying and sterilizing are used the room, and drying and sterilizing is with equipment such as microwave drying room is arranged in the room; D, flour are used the room, and flour is with there being equipment such as Chinese medicine powder beater in the room, and e, cell rupture are used the room, and cell rupture is with equipment such as ultrasonic cell disruptor, f, multi-filtering room are arranged in the room; Particulate filter, the aperture equipment such as liquid medicine filter less than 2um are arranged in the multi-filtering room, and there are equipment such as automatic filling machine in g, fill room in the fill room, and there are equipment such as automatic filler plug machine in h, filler plug room in the filler plug room; There are equipment such as automatic capping machine in i, gland room in the gland room, there are equipment such as computer lamp inspection machine in j, lamp inspection room in the lamp inspection room, k, subsides explanation study; Pasting in the explanation study has the equipment that pastes description, and there are equipment such as automatic packing machine in l, packing room, m, warehouse, n, check room in the packing room; These rooms all are clean rooms, and structure meets the related request of GMP, in batch house, take by weighing the various Chinese medicines in the above-mentioned prescription in proportion with electronic scale, and various Chinese medicines are rubbed with the hands and mixed, and are placed in the container; Reached in the ultrasonic washing unit in the cleaningization processing room by conveyer belt, and in ultrasonic washing unit, pour pure water into, Chinese medicine is fully immersed in the pure water, opens ultrasonic washing unit, cleans after 20-30 minute; Pour out pure water, put into distilled water again, Chinese medicine is carried out fine purifiation, after the Chinese medicine fine purifiation is clean, refund in the clean container; Be sent in the microwave drying room in the drying and sterilizing room by conveyer belt, the temperature in microwave drying room is transferred to 60 ℃, open, drying and sterilizing is after 24 hours, and Chinese medicine is reached in the Chinese medicine powder beater in the flour room by conveyer belt; Open, repeat to pulverize 3-5 time, Chinese medicine is ground into Chinese medicine medicated powder, is sent to cell rupture with in the ultrasonic cell disruptor in the room by conveyer belt again, and pours distilled water in a small amount into; Open ultrasonic cell disruptor, after 24 hours, Chinese medicine cell rupture, intracellular matter dissolve in the water; Pour the distilled water of requirement again into, process middle drug solns, be sent in the multi-filtering room by pipeline again, through the multi-filtering of particulate filter, liquid medicine filter; Filtered granule in the middle drug solns, broken cell wall, and some antibacterials, virus, insoluble substance, middle drug solns has just become Chinese medicine injection, in pipeline is sent to the fill room, carries out fill by automatic filling machine again; After in Chinese medicine injection fill to the infusion bottle, mouth of infusion bottle is sealed by plastic sheeting, is transferred in the filler plug room by conveyer belt again, on plastic sheeting, fills in plug by automatic filler plug machine; And then be sent to the gland room by conveyer belt, and by automatic capping machine easy-open lid is covered on plug, be sent in the lamp inspection room by conveyer belt again, carry out lamp inspection by computer lamp inspection machine; Qualified products are reached by conveyer belt and paste in the explanation study, paste the Chinese medicine description that has lot number, are reached in the packing room, after the vanning by conveyer belt again; By the automatic packing machine packing, send into storehouse reservation again after packing is good, the inspection machine in the check room is tested to each link in this process, and each link in this process all meets the requirement of GMP.
Claims (1)
1. the heart, stomach two are through non-Chinese medicine injection and the production method of inducing sweat, and prescription is: Herba Lophatheri 1g, Semen phaseoli radiati 0.5g, Rhizoma Coptidis 1g, Radix Sophorae Flavescentis 0.5g, Flos Lonicerae 1g, Radix Rehmanniae 1g, Fructus Cannabis 0.5g, Retinervus Luffae Fructus 1g, Fructus Amomi Rotundus 1g, Exocarpium Citrulli 1g, Herba Sedi 1g, Rhizoma Zingiberis 1g, Lignum Santali Albi 1g, Fructus Hordei Germinatus 1g, Olibanum 1g, Semen Vaccariae 1g, Semen Hyoscyami 1g, Radix Glycyrrhizae 1g, Bulbus Lilii 1g, Radix Ophiopogonis 1g, Semen Nelumbinis 1g, production link comprises: batching, cleaningization processing, drying and sterilizing, flour, cell rupture, multi-filtering, fill, filler plug, gland, lamp inspection, subsides description, packing, storage, check, house and equipment comprise: a, batching use the room, prepare burden with electronic scale is arranged in the room; B, cleaningization processing room, the cleaningization processing has ultrasonic washing unit in the room, and c, drying and sterilizing are used the room, and drying and sterilizing is with there being the microwave drying room in the room, and d, flour are used the room; Flour is with there being the Chinese medicine powder beater in the room, e, cell rupture are used the room, and cell rupture is with there being ultrasonic cell disruptor in the room, and there are particulate filter, liquid medicine filter in f, multi-filtering room in the multi-filtering room; G, fill room, fill has automatic filling machine in the room, and there is automatic filler plug machine in h, filler plug room, i, gland room in the filler plug room; Gland has automatic capping machine in the room, and there is computer lamp inspection machine in j, lamp inspection room in the lamp inspection room, k, subsides explanation study, and pasting in the explanation study has the equipment that pastes description; L, packing room, packing has automatic packing machine in the room, m, warehouse, n, check room is characterized in that: in batch house, take by weighing the various Chinese medicines in the above-mentioned prescription in proportion with electronic scale; Various Chinese medicines are rubbed with the hands and are mixed, and are placed in the container, are reached in the ultrasonic washing unit in the cleaningization processing room by conveyer belt, and in ultrasonic washing unit, pour pure water into, and Chinese medicine is fully immersed in the pure water; Open ultrasonic washing unit, clean after 20-30 minute, pour out pure water, put into distilled water again, Chinese medicine is carried out fine purifiation; After the Chinese medicine fine purifiation is clean, refund in the clean container, be sent in the microwave drying room in the drying and sterilizing room, the temperature in microwave drying room is transferred to 60 ℃ by conveyer belt; Open, drying and sterilizing is after 24 hours again, and Chinese medicine is reached in the Chinese medicine powder beater in the flour room by conveyer belt, opens; Repeat to pulverize 3-5 time, Chinese medicine is ground into Chinese medicine medicated powder, is sent to cell rupture with in the ultrasonic cell disruptor in the room by conveyer belt again, and pours distilled water in a small amount into; Open ultrasonic cell disruptor, after 24 hours, Chinese medicine cell rupture, intracellular matter dissolve in the water; Pour the distilled water of requirement again into, process middle drug solns, be sent in the multi-filtering room by pipeline again, through the multi-filtering of particulate filter, liquid medicine filter; Filtered granule in the middle drug solns, broken cell wall, and some antibacterials, virus, insoluble substance, middle drug solns has just become Chinese medicine injection, in pipeline is sent to the fill room, carries out fill by automatic filling machine again; After in Chinese medicine injection fill to the infusion bottle, mouth of infusion bottle is sealed by plastic sheeting, is transferred in the filler plug room by conveyer belt again, on plastic sheeting, fills in plug by automatic filler plug machine; And then be sent to the gland room by conveyer belt, and by automatic capping machine easy-open lid is covered on plug, be sent in the lamp inspection room by conveyer belt again, carry out lamp inspection by computer lamp inspection machine; Qualified products are reached by conveyer belt and paste in the explanation study, paste the Chinese medicine description that has lot number, are reached in the packing room, after the vanning by conveyer belt again; By the automatic packing machine packing, send into storehouse reservation again after packing is good, the inspection machine in the check room is tested to each link in this process, and each link in this process all meets the requirement of GMP.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011104152692A CN102423471A (en) | 2011-12-08 | 2011-12-08 | Heart-stomach two-channel traditional Chinese drug injection without exterior syndrome relieving, and production method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011104152692A CN102423471A (en) | 2011-12-08 | 2011-12-08 | Heart-stomach two-channel traditional Chinese drug injection without exterior syndrome relieving, and production method thereof |
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| Publication Number | Publication Date |
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| CN102423471A true CN102423471A (en) | 2012-04-25 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011104152692A Pending CN102423471A (en) | 2011-12-08 | 2011-12-08 | Heart-stomach two-channel traditional Chinese drug injection without exterior syndrome relieving, and production method thereof |
Country Status (1)
| Country | Link |
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| CN (1) | CN102423471A (en) |
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- 2011-12-08 CN CN2011104152692A patent/CN102423471A/en active Pending
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Application publication date: 20120425 |