CN102415403A - Composite pesticidal composition containing dinotefuran and MTMC and application thereof - Google Patents

Composite pesticidal composition containing dinotefuran and MTMC and application thereof Download PDF

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Publication number
CN102415403A
CN102415403A CN2010102998851A CN201010299885A CN102415403A CN 102415403 A CN102415403 A CN 102415403A CN 2010102998851 A CN2010102998851 A CN 2010102998851A CN 201010299885 A CN201010299885 A CN 201010299885A CN 102415403 A CN102415403 A CN 102415403A
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mtmc
mti
pesticide compositions
compound pesticide
pesticidal composition
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CN102415403B (en
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杨寿海
张爱娟
陈志忠
韦琛鸿
刘小平
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Nanjing Huazhou Pharmaceutical Co Ltd
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Nanjing Huazhou Pharmaceutical Co Ltd
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Abstract

The invention discloses a composite pesticidal composition containing dinotefuran and MTMC ((meta-tolyl-N-methyl carbamate)) and an application thereof. The pesticidal composition comprises dinotefuran and MTMC as main effective ingredients, wherein, the weight ratio of dinotefuran to MTMC is 0.1-80:0.5-80. The pesticidal composition has high synergism, overcomes and postpones the drug resistance of insects, has rapid insecticidal speed and long persistent period, reduces drug costs, and has better control effect than single-ingredient pesticidal composition. The pesticidal composition can be used for controlling homoptera insects on crops, especially rice hopper and aphid.

Description

A kind of compound pesticide compositions that contains MTI-446 and MTMC and uses thereof
Technical field
The invention belongs to pesticide field, be specifically related to a kind of compound pesticide compositions that contains MTI-446 and MTMC and uses thereof.
Background technology
MTI-446 (dinotefuran), chemical name: 1-methyl-2-nitro-3-(tetrahydrochysene-3-furfuryl) guanidine, white crystal, 107.5 ℃ of fusing points, 94.5~101.5 ℃ of industrial goods, vapour pressure<1.7 * 10 -6Pa (30 ℃), density 1.33 (25 ℃).Solvability is water 40g/L, is insoluble in cyclohexane, solvent wet goods organic solvent.Structural formula is:
MTI-446 is fool proof to mammal, and its acute oral LD50 is male rat 2450mg/kg, female rats 2275mg/kg; Male mice 2840mg/kg, female mice 2000mg/kg.To rat acute through skin LD50>2000mg/kg (female, hero).No teratogenesis, carcinogenic and mutagenicity.MTI-446 is also fool proof to aquatile.The ichthyotoxin test shows that MTI-446 is to carp nm (48h)>1000mg/L, to water flea>1000mg/L; Equally, MTI-446 is also very low to birds toxicity, and through the honeybee test is learnt, MTI-446 is to honeybee safety to quail acute oral LD50>1000mg/kg., and do not influence honeybee producting honey.This medicament insecticidal spectrum is wide, has remarkable interior suction osmosis, and has promptly shown very high insecticidal activity at very low dosage.This medicament is fool proof to mammal, birds and aquatile, and crop is not had poisoning, can be used for numerous crops such as paddy rice, fruit tree, vegetables.
MTMC is a kind of carbamate insecticide.Chemical name is: a tolyl-N-methyl carbamate, and structural formula is:
MTMC has insect tags and fumigation action, and the power of knocking down is strong, holds to imitate weak point.Can be used to prevent and treat towering like a mountain peak lice, leafhopper, cotten aphid, thrips, cotton bollworm etc.; Control rice fulgorid, rice leafhopper, rice thrips etc. have special efficacy.To the people, animal moderate toxicity.
But rice fulgorid and aphid are under the condition of present long-term prescription, and resistance increases gradually, and the agent of agricultural chemicals list descends to the effect of control of insect gradually.The inventor finds that after deliberation the synergistic complex of agricultural chemicals is expanding prevention spectrum and the effective measures that improve preventive effect, does not find the Pesticidal combination of relevant MTI-446 and MTMC up to now as yet.
Summary of the invention
The purpose of this invention is to provide a kind of compound pesticide compositions that contains MTI-446 and MTMC, this Pesticidal combination is the multifunctional insecticide composition of control homoptera pest.
Another object of the present invention provides this Pesticidal combination and prevents and treats the application on the insecticidal materials of resistance homoptera pest in preparation, particularly the application on the insecticidal materials of preparation control plant hopper, aleyrodid or aphid.
The objective of the invention is to realize through following technical scheme:
A kind of compound pesticide compositions that contains MTI-446 and MTMC, this Pesticidal combination is main active ingredient with MTI-446 and MTMC, wherein, the weight ratio of MTI-446 and MTMC is 0.1~80: 0.5~80.Be preferably 0.5~50: 2~50, further be preferably 0.5~10: 4~30.Effective ingredient is present in the composition with the synergy effective dose in this Pesticidal combination.
In compound pesticide compositions of the present invention, the two weight percentage in this compound pesticide compositions of MTI-446 and MTMC is 3~80%.Be preferably 5~55%, most preferably 10~40%.
Pesticidal combination of the present invention is that main active ingredient and insecticides adjuvant and excipient are mixed with any one formulation that allows on the agricultural chemicals, the preferred emulsion of described formulation, suspending agent, wetting powder, aqueous emulsion, microemulsion and water dispersion granule with MTI-446 and MTMC.
Auxiliary agent can adopt calcium dodecyl benzene sulfonate, APES, polyoxyethylene polyoxy third rare block compound (like farming breast 33 #), NPE etc., excipient comprises isopropyl alcohol, vegetable oil, solvent naphtha, water, antifreezing agent (like propane diols), deionized water etc.Above auxiliary agent, excipient and other auxiliary material can singly be used or and use.
Pesticidal combination of the present invention has good preventive effect to the multiple homoptera pest that rice fulgorid and aphid etc. is easy to generate resistance; And the inhibition insect is to the pesticide resistance generation of single preparation (MTI-446 or MTMC are arbitrary).
Above-mentioned Pesticidal combination is prevented and treated the application on the insecticidal materials of resistance homoptera pest in preparation, especially the effect on the insecticidal materials of preparation control aleyrodid, rice fulgorid or aphid is remarkable.
Beneficial effect compared with prior art of the present invention: (1) is compared with single agent; Said composition antagonism homoptera pest such as rice fulgorid, aphid etc. have obvious synergistic function, overcome and have delayed pest resistance to insecticide, the expanding prevention spectrum; Desinsection speed is fast, has obviously improved control efficiency; (2) reduce control recruitment, drug cost; (3) alternative high-toxic pesticide; (4) have concurrently quick-acting and long-acting; (5) compare with the agent of MTMC list with MTI-446, produce and the use cost reduction; (6) suppress the resistance enhancing of homoptera pest to agricultural chemicals, its effect is used apparently higher than its single agent.
Embodiment
Below in conjunction with embodiment the present invention is described further:
Embodiment 1:
Taking by weighing MTI-446, MTMC, to adopt the conventional formulation method to be mixed with main active ingredient weight percentage by different proportion be 30% MTI-446 MTMC missible oil.Concrete ratio is seen table 1,2.
Adopt rice stem infusion process to carry out indoor synergy biologicall test, selecting the resistant rice plant hopper is target pest, every processing repetition 3 times, and every concentration is handled 60, calculates toxicity regression equation and the lethal concentration of 50 LC of each medicament antagonism rice fulgorid with probability value method 50, use LC 50Value is pressed the abundant method of Sun Yun and is calculated co-toxicity coefficient, and the result sees table 1:
The toxicity test of the composite and single agent antagonism of table 1 MTI-446 and MTMC rice fulgorid
Can be known that by table 1 MTI-446 and MTMC are composite, co-toxicity coefficient shows good synergistic effects all greater than 120.Wherein when MTI-446 and MTMC in the time of 1: 1 synergistic effect the most obvious.
Employing is soaked the leaf dip method and is carried out indoor synergy biologicall test, and selecting the resistance wheat aphid is target pest, and every processing repetition 3 times is with toxicity regression equation and the lethal concentration of 50 LC of each medicament antagonism rice fulgorid of probability value method calculating 50, use LC 50Value is pressed the abundant method of Sun Yun and is calculated co-toxicity coefficient, and the result sees table 2:
The toxicity test of the composite and single agent antagonism of table 2 MTI-446 and MTMC wheat aphid
Can know that by table 2 MTI-446 and MTMC are composite, the co-toxicity coefficient of wheat aphid all greater than 120, is shown good synergistic effects.Wherein when MTI-446 and MTMC in the time of 1: 1 synergistic effect the most obvious.
Embodiment 2:
Take by weighing 5g MTI-446,50g MTMC, phenethyl phenol polyethenoxy ether phosphate 3g, farming breast 33 #(alkylaryl polyoxyethylene polyoxypropylene ether) 2g, APES 1g, vegetable oil 13g adds water to 100g.Above raw material is dropped into the mixing kettle high speed by the method for routine preparation aqueous emulsion mix, form main active ingredient weight percentage and be 55% MTI-446 MTMC aqueous emulsion.
Embodiment 3:
Take by weighing 2g MTI-446,18g MTMC, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether phosphate 3g, farming breast (alkylaryl polyoxyethylene polyoxypropylene ether) 33 #2g, APES 1g, isopropyl alcohol 10g adds water to 100g.Above raw material dropped in the mixing kettle by the method for routine preparation microemulsion mix, form main active ingredient weight percentage and be 20% MTI-446 MTMC microemulsion.
Embodiment 3 is prevented and treated the paddy rice brown planthopper test of pesticide effectiveness, and the contrast medicament is 420% MTMC EC (missible oil) and 20% MTI-446 EW (aqueous emulsion), dilutes according to the extension rate of 3 li of forms; The consumption medication that 30Kg/ mu is pressed in the dilution back; Looked into behind the medicine 3 days, 7 days result, result is seen table 3:
Table 3: the composite field test results of MTI-446-MTMC to the paddy rice brown planthopper
Field efficacy is the result show, MTI-446 MTMC composition antagonism brown planthopper has good control efficiency, and control efficiency all is better than the effect that single agent kind is better than direct each Dan Pin of while.
Embodiment 3 is prevented and treated the wheat aphid field medicine effect test; The contrast medicament is 20% MTMC EC (missible oil) and 20% MTI-446 EW (aqueous emulsion); Extension rate according to 3 li of forms dilutes, and the consumption medication that 30Kg/ mu is pressed in the dilution back was looked into behind the medicine 3 days; 7 days result, result is seen table 4:
Table 4: the composite field test results of MTI-446-MTMC to wheat aphid
Field efficacy is the result show, MTI-446 MTMC composition antagonism wheat aphid has good control efficiency, and control efficiency all is better than the effect that single agent kind is better than direct each Dan Pin of while.
Embodiment 4:
Take by weighing 1g MTI-446,5g MTMC, calcium dodecyl benzene sulfonate 4g, phenethyl phenol polyethenoxy ether 3g, vegetable oil to 100g.Above raw material dropped in the mixing kettle by the method for routine preparation missible oil mix, form main active ingredient weight percentage and be 6% MTI-446 MTMC missible oil.
Embodiment 5: take by weighing 50g MTI-446,20g MTMC, calcium dodecyl benzene sulfonate 5g, phenethyl phenol polyethenoxy ether 2g, solvent naphtha are to 100g.Above raw material dropped in the mixing kettle by the method for routine preparation missible oil mix, form main active ingredient weight percentage and be 70% MTI-446 MTMC missible oil.
Embodiment 6: take by weighing 2g MTI-446,40g MTMC, calcium dodecyl benzene sulfonate 8g, phenethyl phenol polyethenoxy ether 5g, solvent naphtha are to 100g.Above raw material dropped in the mixing kettle by the method for routine preparation missible oil mix, form main active ingredient weight percentage and be 42% MTI-446 MTMC missible oil.
Embodiment 7: take by weighing 0.2g MTI-446,50g MTMC, calcium dodecyl benzene sulfonate 9g, phenethyl phenol polyethenoxy ether 8g, vegetable oil are to 100g.Above raw material dropped in the mixing kettle by the method for routine preparation missible oil mix, form main active ingredient weight percentage and be 50.2% MTI-446 MTMC missible oil.
Embodiment 8: take by weighing 5g MTI-446,0.5g MTMC, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether 7g, vegetable oil are to 100g.Above raw material dropped in the mixing kettle by the method for routine preparation missible oil mix, form main active ingredient weight percentage and be 5.5% MTI-446 MTMC missible oil.
Embodiment 9: take by weighing 5g MTI-446,30g MTMC, calcium dodecyl benzene sulfonate 4g, phenethyl phenol polyethenoxy ether 4g, vegetable oil are to 100g.Above raw material dropped in the mixing kettle by the method for routine preparation missible oil mix, form main active ingredient weight percentage and be MTI-446-MTMC missible oil of 35%.
Embodiment 10: take by weighing 20g MTI-446,5g MTMC, calcium dodecyl benzene sulfonate 7g, phenethyl phenol polyethenoxy ether 9g, vegetable oil are to 100g.Above raw material dropped in the mixing kettle by the method for routine preparation missible oil mix, form main active ingredient weight percentage and be 25% MTI-446 MTMC missible oil.
Embodiment 11: take by weighing 30g MTI-446,12g MTMC, sodium lignin sulfonate 2g, polyoxyethylene poly-oxygen propylene aether and sulphate 4g thereof; Xanthans 0.15g; Ethylene glycol 5g, silica ethane 0.10g, aluminium-magnesium silicate 0.5g; Water complements to 100g, and the main active ingredient weight percentage of formation is 42% MTI-446 MTMC suspending agent under the effect of sand mill.
Embodiment 12: take by weighing 2g MTI-446,5g MTMC; Sodium lignin sulfonate 8g, lauryl sodium sulfate 2g, ammonium sulfate 5g; Polyvinyl alcohol 5g; Borax 2g, diatomite 21g, it is 14% MTI-446 MTMC water dispersion granule that above raw material is formed main active ingredient weight percentage by the water dispersible granular agent method.
Embodiment 13: take by weighing 50g MTI-446,3g MTMC, calcium dodecyl benzene sulfonate 4g, phenethyl phenol polyethenoxy ether 3g, vegetable oil are to 100g.Above raw material dropped in the mixing kettle by the method for routine preparation missible oil mix, form main active ingredient weight percentage and be 53% MTI-446 MTMC missible oil.
Embodiment 14: take by weighing 2g MTI-446,18g MTMC; Sodium lignin sulfonate 10g, Negel 2g, add to 100g with diatomite; Above raw material is mixed in micronizer, form main active ingredient weight percentage and be 20% MTI-446 MTMC wetting powder.
Embodiment 15: take by weighing 7g MTI-446,70g MTMC, calcium dodecyl benzene sulfonate 4g, phenethyl phenol polyethenoxy ether 3g, solvent naphtha are to 100g.Above raw material dropped in the mixing kettle by the method for routine preparation missible oil mix, form main active ingredient weight percentage and be 77% MTI-446 MTMC missible oil.
Embodiment 16: take by weighing 60g MTI-446,5g MTMC, the 8g of wooden sodium sulfonate, lauryl sodium sulfate 2g, ammonium sulfate 5g; Polyvinyl alcohol 5g; Borax 2g; Kaolin 13g, it is 65% MTI-446 Tsumacide water dispersible granule that above raw material is formed main active ingredient weight percentage by the water dispersible granular agent method.

Claims (9)

1. a compound pesticide compositions that contains MTI-446 and MTMC is characterized in that this Pesticidal combination is main active ingredient with MTI-446 and MTMC, and wherein, the weight ratio of MTI-446 and MTMC is 0.1~80: 0.5~80.
2. the compound pesticide compositions that contains MTI-446 and MTMC according to claim 1, the weight ratio that it is characterized in that described MTI-446 and MTMC is 0.5~50: 2~50.
3. the compound pesticide compositions that contains MTI-446 and MTMC according to claim 2, the weight ratio that it is characterized in that described MTI-446 and MTMC is 0.5~10: 4~30.
4. the compound pesticide compositions that contains MTI-446 and MTMC according to claim 1 is characterized in that the two weight percentage in this compound pesticide compositions of MTI-446 and MTMC is 3%~80%.
5. the compound pesticide compositions that contains MTI-446 and MTMC according to claim 4 is characterized in that the two weight percentage in this compound pesticide compositions of MTI-446 and MTMC is 5%~55%.
6. the compound pesticide compositions that contains MTI-446 and MTMC according to claim 1 is characterized in that this compound pesticide compositions is that main active ingredient and insecticides adjuvant, excipients are mixed with any one formulation that allows on the agricultural chemicals with MTI-446 and MTMC.
7. the compound pesticide compositions that contains MTI-446 and MTMC according to claim 6 is characterized in that said formulation is missible oil, suspending agent, aqueous emulsion, wetting powder, microemulsion or water dispersion granule.
8. the described compound pesticide compositions that contains MTI-446 and MTMC of claim 1 is prevented and treated the application on the insecticidal materials of resistance homoptera pest in preparation.
9. the compound pesticide compositions that contains MTI-446 and MTMC according to claim 8 anti-ly eliminates aphis in preparation, the application on the insecticidal materials of aleyrodid or plant hopper.
CN 201010299885 2010-09-28 2010-09-28 Composite pesticidal composition containing dinotefuran and MTMC and application thereof Active CN102415403B (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101971855A (en) * 2010-11-29 2011-02-16 陕西韦尔奇作物保护有限公司 Synergistic insecticidal composite with dinotefuran

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1112556A (en) * 1993-10-26 1995-11-29 三井东压化学株式会社 Furanyl insecticide
CN101588719A (en) * 2007-01-30 2009-11-25 巴斯夫欧洲公司 Pesticide combination based on azoles and pyrimidine radicals amine derivative and insecticide
CN101801196A (en) * 2007-09-21 2010-08-11 拜尔农作物科学股份公司 Active ingredient combinations having insecticidal and acaricidal properties

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1112556A (en) * 1993-10-26 1995-11-29 三井东压化学株式会社 Furanyl insecticide
CN101588719A (en) * 2007-01-30 2009-11-25 巴斯夫欧洲公司 Pesticide combination based on azoles and pyrimidine radicals amine derivative and insecticide
CN101801196A (en) * 2007-09-21 2010-08-11 拜尔农作物科学股份公司 Active ingredient combinations having insecticidal and acaricidal properties

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101971855A (en) * 2010-11-29 2011-02-16 陕西韦尔奇作物保护有限公司 Synergistic insecticidal composite with dinotefuran
CN101971855B (en) * 2010-11-29 2013-10-09 陕西韦尔奇作物保护有限公司 Synergistic insecticidal composite with dinotefuran

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