CN102283727A - Hole-type medicine coating bracket - Google Patents
Hole-type medicine coating bracket Download PDFInfo
- Publication number
- CN102283727A CN102283727A CN201110171677A CN201110171677A CN102283727A CN 102283727 A CN102283727 A CN 102283727A CN 201110171677 A CN201110171677 A CN 201110171677A CN 201110171677 A CN201110171677 A CN 201110171677A CN 102283727 A CN102283727 A CN 102283727A
- Authority
- CN
- China
- Prior art keywords
- bracket
- medicines
- holes
- hole
- concentration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Abstract
The invention discloses a hole-type medicine coating bracket. The bracket has a porous structure in which holes distributed in all linking ribs are decreased progressively along the axial direction of the bracket, and the decreasing tendency is described by the density ratio of the holes. The quantity of the holes in a first linking rib is supposed to be M, the quantity of the holes in a second linking rib is supposed to be N, and the M/N is between 1.2 and 2. Medicines carried by the bracket are filled into the holes. During clinical application, a doctor can put the bracket into a narrow or blocked blood vessel of a patient through a guide wire, and the bracket is arranged in the direction consistent with that of blood flow at the position. The concentration of the medicines in a bracket area with high original medicinal dose is relatively reduced due to the characteristics of a flow field at the position, and the concentration of the medicines on a downstream tail end part with low medicinal dose is relatively improved due to the obvious effect of convection current diffusion, so that the balance of medicinal concentration is achieved; therefore, the medicines are greatly saved, and the utilization rate of the medicines is improved, so that the cost is reduced, and the device has obvious clinical application value and economic benefits.
Description
Technical field
The present invention relates to the interventional therapy field of cardiovascular disease, belong to the cardiac stent category that carries medicine.
Background technology
Inserting endovascular stent in the blood vessel of narrow or obstruction is to be used for one of important method for the treatment of cardiovascular disease at present, and still, the restenosis problem after endovascular stent is implanted does not obtain at present fully and solves.The clinical practice of bracket for eluting medicament in recent years greatly reduce postoperative in stenosis rate.However still there are many deficiencies in bracket for eluting medicament, and high amount of drug can discharge at short notice after many pharmacokinetics studies show that the bracket for eluting medicament implant into body.Meanwhile, because the complexity of human vas set configuration, the medicine of release also non-uniform Distribution can occur at diseased region, and local patholoic change district blood drug level is too high or too low, causes the waste or the inefficacy of medicine.If the distribution that can come the reasonably optimizing medication coat at blood flow and drug level characteristic distributions will improve the utilization rate of bracket for eluting medicament greatly.
Summary of the invention
The objective of the invention is to have designed a kind of pass coating stent of medicine at the restenosis problem after the present endovascular stent implantation.This support is compared with traditional coating bracket, has the advantage on the pharmacokinetics.It can comply with the characteristics that distribute behind the drug release in the flow field, make after the support implantation, and it is close that the blood drug level of lesion region keeps as far as possible, improves the utilization rate of medicine.
Concrete scheme of the present invention is a kind of pass support of taking the dose alternation.The concrete graphic structure of this support such as the Fig. 1 in the Figure of description.
The hole number of entire bracket successively decreases vertically, and density ratio in hole is 3: 2, and its mesopore density is the hole count on every section dowel.
Adopt such scheme can reach following useful effect: utilize blood vessel flow field characteristics, the medicine reasonable distribution with discharging has improved utilization ratio of drug; When reaching identical therapeutic effect, reduced medicine and carried dosage
Description of drawings
Fig. 1 is a hole distribution schematic diagram of the present invention
Among Fig. 1: first dowel hole number M=3, second dowel number N=2
The specific embodiment
Below in conjunction with the accompanying drawing and the specific embodiment the present invention is described in further detail:
As shown in Figure 1: the present invention is made up of loose structure, distributes along the hole on the axial every link muscle of support and successively decreases.The trend of successively decreasing is described with hole density ratio.
Article one, link muscle hole number is M, and second is N, and then M/N is between 1.2～2.Its entrained medicine is filled among the hole.In clinical application, the doctor can put into the narrow or artery-clogging place of patient with this support by guide wire, and support placement direction and this place's blood flow direction are consistent.Owing to the flow field characteristic at this place, make that the high stent area drug level of pharmaceutical quantities decreases originally like this, the remarkable effect that the part that downstream tail end pharmaceutical quantities is low then spreads owing to convection current, concentration raises to some extent, reaches balance thus.This will save medicament greatly, improve utilization ratio of drug, thereby reduce cost, and have significant clinical value and economic benefit.
Claims (3)
1. a pass coating stent of medicine is characterized in that, the hole of described pass supporting structure distributes and successively decreases vertically.
2. a kind of pass coating stent of medicine according to claim 1 is characterized in that, the hole of this pass supporting structure distributes and successively decreases vertically, and its increasing or decreasing rule is recently weighed with hole density, in the description relevant for the concrete elaboration of hole density ratio.
3. a kind of pass coating stent of medicine according to claim 1 is characterized in that, the hole of this pass supporting structure distributes and successively decreases vertically, the hole density of this pass support than scope between 1.2～2.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110171677A CN102283727A (en) | 2011-06-23 | 2011-06-23 | Hole-type medicine coating bracket |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110171677A CN102283727A (en) | 2011-06-23 | 2011-06-23 | Hole-type medicine coating bracket |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102283727A true CN102283727A (en) | 2011-12-21 |
Family
ID=45330671
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201110171677A Pending CN102283727A (en) | 2011-06-23 | 2011-06-23 | Hole-type medicine coating bracket |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102283727A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102579172A (en) * | 2012-02-15 | 2012-07-18 | 北京航空航天大学 | Drug-coating stent |
| CN109498850A (en) * | 2018-12-11 | 2019-03-22 | 上海七木医疗器械有限公司 | A kind of preparation method of Biodegradable fibers bracket |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050060022A1 (en) * | 2003-05-21 | 2005-03-17 | Felt Jeffrey C. | Polymer stent |
| US7169178B1 (en) * | 2002-11-12 | 2007-01-30 | Advanced Cardiovascular Systems, Inc. | Stent with drug coating |
| WO2008098418A1 (en) * | 2007-02-14 | 2008-08-21 | Shandong Intech Medical Technology Co., Ltd. | Intracoronary stent with asymmetric drug releasing controlled coating |
| CN101947351A (en) * | 2009-07-09 | 2011-01-19 | 科迪斯公司 | Rapamycin container FirebirdTM |
-
2011
- 2011-06-23 CN CN201110171677A patent/CN102283727A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7169178B1 (en) * | 2002-11-12 | 2007-01-30 | Advanced Cardiovascular Systems, Inc. | Stent with drug coating |
| US20050060022A1 (en) * | 2003-05-21 | 2005-03-17 | Felt Jeffrey C. | Polymer stent |
| WO2008098418A1 (en) * | 2007-02-14 | 2008-08-21 | Shandong Intech Medical Technology Co., Ltd. | Intracoronary stent with asymmetric drug releasing controlled coating |
| CN101947351A (en) * | 2009-07-09 | 2011-01-19 | 科迪斯公司 | Rapamycin container FirebirdTM |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102579172A (en) * | 2012-02-15 | 2012-07-18 | 北京航空航天大学 | Drug-coating stent |
| CN109498850A (en) * | 2018-12-11 | 2019-03-22 | 上海七木医疗器械有限公司 | A kind of preparation method of Biodegradable fibers bracket |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0578998A1 (en) | Implantable percutaneous endoprosthesis | |
| CN109966239A (en) | Paliperidone implantation material preparation | |
| CN203138758U (en) | Combined medical device composed of drug-coated balloon and bracket | |
| RU2015109296A (en) | MEDICINAL DELIVERY SYSTEMS AND METHODS FOR TREATMENT OF BLADDER CANCER, INCLUDING THE USE OF OXALIPLATIN | |
| US20150273089A1 (en) | Method of treating cancer | |
| CN103431931A (en) | Pulmonary artery support and pulmonary artery valve replacement device with same | |
| AU2011320829B2 (en) | Bare metal stent with drug eluting reservoirs having improved drug retention | |
| CN102283727A (en) | Hole-type medicine coating bracket | |
| CN203379235U (en) | Pulmonary artery support and pulmonary artery valve replacement device with thereof | |
| CN107106506A (en) | The injectable particulate that super localization for therapeutic agent discharges | |
| CN207822261U (en) | A kind of radioactive particle chain connected using high molecular polymer connecting tube | |
| CN107205939A (en) | Biodegradable medicament elution microballoon for treatment of solid tumors | |
| CN109330753A (en) | A kind of carried stent improving blood circulation | |
| van den Heuvel-Eibrink et al. | Steroids and risk of osteonecrosis in ALL: take a break | |
| CN204709090U (en) | Intravascular stent | |
| CN106727444B (en) | A kind of medicinal film | |
| CN216169073U (en) | Double-channel targeted coating drug stent | |
| WO2021128953A1 (en) | Knitted stent and knitted stent system | |
| CN108325050A (en) | A kind of novel cyclic sacculus and its application method | |
| CN205054514U (en) | Blood vessel bracket | |
| CN200973766Y (en) | Artificial lentis for preventing disease after cataract operation | |
| Phad et al. | Matrix tablet: as a sustained release drug delivery system | |
| CN107233150A (en) | A kind of mesoporous silicon oxide biodegradable stent and preparation method thereof | |
| CN2642341Y (en) | Memory alloy support | |
| CN215535350U (en) | Trachea medicine carrying support for graded medicine administration |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20111221 |