CN102274309B - Hair follicle transformation agent and preparation method thereof - Google Patents
Hair follicle transformation agent and preparation method thereof Download PDFInfo
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- CN102274309B CN102274309B CN 201110205967 CN201110205967A CN102274309B CN 102274309 B CN102274309 B CN 102274309B CN 201110205967 CN201110205967 CN 201110205967 CN 201110205967 A CN201110205967 A CN 201110205967A CN 102274309 B CN102274309 B CN 102274309B
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Abstract
The invention discloses a hair follicle transformation agent, which consists of a Chinese medicinal extract A and a synergistic agent B, wherein the Chinese medicinal extract A comprises the following raw material components A in part by weight: 10 to 20 parts of glossy privet fruit, 10 to 20 parts of yerbadetajo herb, 10 to 20 parts of Chinese taxillus twig, 8 to 15 parts of tuber of multiflower knotweed, 5 to 15 parts of raspberry, 8 to 15 parts of parslane herb, 8 to 15 parts of pink herb, 3 to 10 parts of Chinese angelica and 2 to 8 parts of mint; and the synergistic agent B comprises 4 to 6 parts of mixture of lysine, vitamin B5, vitamin B6, vitamin B12 and essence in any ratio. In the preparation method, Chinese medicinal clear paste is leached by a method of alcohol extract and water extract, and the synergistic agent B is prepared by crushing and grinding a synergistic solid medicine. The transformation agent can balance the secretion of scalp lipid, enhance trichotrophy, restore the vitality of the hair follicle, promote the dense growth of hair to improve the quality of new hair, and solve the problems of alopecia, withered and yellow hair, white hair and the like effectively. The hair follicle transformation agent avoids toxic and side effects, is wide in medicinal sources, low in price, easy to prepare, quick in response, wide in applicable diseases, convenient to use, safe and reliable, and is suitable for large-scale industrial production.
Description
Technical field
The invention belongs to daily-use chemical industry and Chinese medicine health-care technical field, particularly a kind of hair follicle is transformed agent and preparation method thereof.
Background technology
Hair is a tissue-partly, the organism of being made up of cell.The hair cell is in hair follicle, to divide, and increases with multiple, and newborn hair will be pushed the scalp skin surface to from hair follicle.It is the normal metabolic symptom that hair comes off below 30 every day, each hair follicle-year in make and can bear new hair.Have a pitch-black hair to make the people seem young, healthy and spiritual, so people hope oneself to have the hair color of a self-sow.Along with the development of society, the quickening that life joint gathers, people's work, life stress are also increasing, immunity is also along with decline, hair white with lose hair also more and more.Hair too much come off or the reason that bleaches a lot, go down closely related, simultaneously closely related with the bodily fuctions with heredity, psychentonia, brain overwork, malnutrition etc.The traditional Chinese medical science thinks, and is sad gloomy, can cause that Liver and kidney and spleen are all hindered, the nutrient blood imbalance, makes hair lose its nutrition, and hair bleaches or comes off and just can hardly be avoided like this.Lack necessary primary raw material 20 several amino acids of natural on-off cycles of hair growth for a long time, and hair forms necessary vitamin and trace element etc. and all can cause alopecia.Nervous and Mental Factors should not ignored the influence of alopecia yet, and the people alopecia can occur after long-term spirit is nervous.If it is hair cell growth albumen that hair lacks necessary reactive protein, just hair can each upgrade replacement after atrophy gradually, gradually by thick changes children, long to become the children short by the children, becomes the children again and carefully, atrophy forms daily being seen bareheaded symptom until white fine hair.
Experiment showed, the hair growth key at intrafollicular each cell, appropraite condition is sufficient supports part as long as cell has, and any cell division all capable of using and reaching is lived again.If can provide the activated protein of necessary growth to nourish the cell in the hair follicle, cell will divide naturally, increases with multiple, and newborn hair will be born.In the prior art, the product that is used for the hair care hair care is generally shampoo, nurses one's health daily hair treatment and hair conditioner, can only play the effect of hair care, can not fundamentally improve the cell in the hair follicle, thereby hair restoration is difficult to realize with changeing in vain to deceive.The Along with people's growth in the living standard has side effect and limitation to the hair growth promoter that chemical production is arranged because of it, and is eliminated gradually.For this reason, people have invented the regeneration that promotes hair with the medicament of oral or external.To retrieve relevant technologies takes passages as follows at present:
Chinese patent CN 200310112149.0, a kind of hair color hair growth promoting health medicine and preparation technology.The prescription of this invention is formed and proportioning (percent by weight): Chinese herbal medicine compound extracting thing a+b:20～60%, natural vitamin A 0.3～15%, silk peptide 0.3～15%, tyrosine 0.5～10%, cystine 0.5～10% and adjuvant: 10～30%.
The proportioning (percent by weight) of Chinese herbal medicine compound extracting thing a+b wherein: the Radix Polygoni Multiflori 5～25%, Semen Juglandis 5～25%, Radix Ginseng 3～15%, Radix Notoginseng 3～15%, Radix Angelicae Sinensis 3～15%, the Fructus Sophorae 3～15%, Herba Ecliptae 5～25%, mountain Zhu's cornel 3-15%, Semen Sesami Nigrum 5～25%, Semen Lini 4～20%, Fructus Ligustri Lucidi 3～15%, Radix Salviae Miltiorrhizae 3～15%, Radix Achyranthis Bidentatae 3～15%, Ramulus Cinnamomi 3～15%, Fructus Zanthoxyli 3～15%, Semen Persicae 3～15%, black ant 3～15% and Radix Antiotrematis dunniani 3～15%.
Above-mentioned 16 kinds of mixed extraction extract a except that Radix Ginseng, Radix Salviae Miltiorrhizae, Chinese herbal medicine Radix Ginseng, Radix Salviae Miltiorrhizae extract extract b, and a+b promptly is a Chinese herbal medicine compound extracting thing.Preparation technology gathers in the step:
The extraction of A, Chinese herbal medicine complex a+b:
(1) above-mentioned 18 kinds of medium-height grass medical herbs are removed Radix Ginseng, Radix Salviae Miltiorrhizae takes by weighing and is ground into ultra powder outward in proportion, adds in the ultrasound wave Chinese herbal medicine extracting machine to extract with ultrasonic extraction, and heating is condensed into fluid extract or extract powder, gets Chinese herbal medicine compound extracting thing a;
(2) Radix Ginseng, Radix Salviae Miltiorrhizae are taken by weighing and are ground into overreinforced in proportion and extract Radix Ginseng soap former times, danshensu, TANSHINONES with supercritical extraction technique, Chinese herbal medicine compound extracting thing b;
B, by proportioning with Chinese herbal medicine compound extracting thing a, Chinese herbal medicine compound extracting thing b, add natural vitamin A, silk peptide, tyrosine, the dirty propylhomoserin of Guang and an amount of adjuvant mix homogeneously, process oral capsule or tablet and adopt the ultrasonic emulsification technology to process external silicone oil or hair conditioner.
Active substance Chinese herbal medicine compound extracting thing a+b can extract by conventional " decoction and alcohol sedimentation technique ", " liquor-saturated water lift sink method " extractive technique, can also use supercritical, the extraction of ultrasonic extraction technology.
Chinese patent CN200510019389.5, a kind of activating element for preventing baldness, this activin are by raw material weight percentage ratio: finasteride 5～10%, Radix Polygoni Multiflori 20～30%, Cacumen Platycladi 30～40%, vitamin B6 1～5% and Bulbus Allii 20～40%.
Method for preparing: the 300ml decocting is put into a certain amount of Radix Polygoni Multiflori, Cacumen Platycladi in (1); Pour into behind the Wen Liang in the 450ml plastic bottle; (2) insert in another bottle after a certain amount of Bulbus Allii is squeezed the juice, after (3) are crushed into powder a certain amount of finasteride and vitamin B6, pour in the bottle in (2) and fully stir with Bulbus Allii juice; (4) material in (3) bottle is poured in the plastic bottle in (1), added water and stir and get final product.
Chinese patent CN200510020229.2, rapid-acting hair promoting liquid.This hair growth liquor component and weight portion: 150～300 parts of Radix Polygoni Multiflori, 30～50 parts of Camphoras, 30～50 parts of Cortex Cinnamomi, 100～150 parts of Fructus Chebulaes, 150～180 parts in Radix Rehmanniae Preparata, 80～120 parts in Radix Glycyrrhizae and Oleum sesami 2500～3000.Manufacture method is: the weight portion proportioning of pressing material medicine; Earlier Radix Polygoni Multiflori, Camphora, GONGGUI, Fructus Chebulae, Radix Rehmanniae Preparata and Radix Glycyrrhizae are pulverized mixing; Insert then in the container that adds Oleum sesami in advance, left standstill immersion at least 5 days after restir is even, obtain the hair growth liquor product through filter pressing at last.
Chinese patent CN201010104214.5, a kind of blackening and nourishing hair slob of processing by various plants and preparation method thereof.Its component and weight portion: 10～30 parts of 10～30 parts of Radix Polygoni Multiflori, 10～30 parts of Galla Chinensiss, 515 parts of mulberry seeds, 5～15 parts of Radix Rehmanniae, 10～30 parts in black careless lotus and Fructus Mumes.
Method for preparing: 1, take by weighing Radix Polygoni Multiflori, Galla Chinensis, mulberry seed, Radix Rehmanniae, Mo Caolian, the Fructus Mume of said proportioning, mix, extract, spray drying is produced medicated powder, and is subsequent use; 2, the water of medication powder amount 70～80% and 1～2% carbomer mix, and dissolving adds the azone of medicated powder amount 1～2% again, slob; 3, vitamin B6, the vitamin C with cystine, taurine and the medicated powder amount 0.5-1% of above-mentioned medicated powder and medicated powder amount 1～2% joins in the above-mentioned slob, stirs, and places 5～10 hours, gets final product.
Chinese patent CN201010511028.3, a kind of compositions of hair-blackening tonic.Its composition total weight is: Herba Saussureae Involueratae 5～40%, Paederus densipennis Bernh. 5～40%, Semen Hoveniae (Fructus Hoveniae) 5～40% and Chinese liquor 50～80%.Said compositions preservation under room temperature is for oral administration after 3 months, every day twice, and each 50g, one after each meal if be coated with juice in hair simultaneously, keeps not having one's hair wash in 4 hours, dries naturally until hair, and effect is better.Said juice is the mixed squeezed fluids of weight ratio such as Aloe and white sugar.After can also being coated with juice outside Rhizoma Zingiberis Recens is blended into juice with Fructus Capsici, spread upon on the scalp uniformly.
Chinese patent CN 200810167825.7, hair growing hair follicle injection liquid.Technical scheme: raw materials used component and parts by weight are: 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of Radix Aconitis, 30～50 parts on Flos Carthami, 50～60 parts of Fructus Psoraleaes, 100～200 parts of Radix Polygoni Multiflori, 100～200 parts of mulberry seeds, 50～100 parts of Radix Angelicae Sinensis, 50～80 parts of Rhizoma Chuanxiongs, 50～60 parts in Semen Persicae, 60～70 parts of Camphoras, 80～100 parts of Cortex Cinnamomi, 60～90 parts of Fructus Chebulaes, 100～150 parts in Radix Rehmanniae Preparata, 100～150 parts in Radix Glycyrrhizae and 200～300 parts of 15 kinds of Chinese medicines of Cacumen Platycladi, and formulated through pulverizing, immersion and filter pressing.Directly act on the injection of hair follicle, promote natural on-off cycles of hair growth.
The inventor is according to Chinese medicine " liver is the mother of kidney; hair is the sign of blood condition " kidney storing essence; Liver hemopoietic, essence and blood sharing the same origin transforms each other, the theory that both are indispensable; The hair of verifying the people is inseparable with the health status and the relation between the blood of skin, the pitch-black soft and moist nutrition that depends on essence and blood of hair.Normal person's QI and blood when young is full, the dense and pitch-black light of the skin tender smooth hair of children; If overtired, diet is bad, do not have enough sleep, stress is crossed and caused Liver and kidney two empty insufficiency of vital energy and bloods mostly easily, the blood circulation of whole body is weak, makes us Light-headedness, and xerosis cutis is withered and yellow, causes the hair quality variation of hair, occur easily early white with come off.The inventor a kind ofly has no side effect, shows a double hair follicle of controlling and transform an agent through for a long time groping in a large number to sum up to prepare.
Summary of the invention
The objective of the invention is to adopt according to Chinese medicine the scheme of inner disease outer treat, provide a kind of and have no side effect, show double controlling, the hair follicle of better efficacy is transformed agent; Another object of the present invention provides the method for preparing that this hair follicle is transformed agent.
Of the present invention being achieved in that
A kind of hair follicle is transformed agent, is made up of Chinese medicine extract A and synergist B; Described Chinese medicine extract A material component and parts by weight: 2～8 parts of 10～20 parts of Fructus Ligustri Lucidi, 10～20 parts of Herba Ecliptaes, 10～20 parts of Herba Taxillis, 8～15 parts of the Radixs Polygoni Multiflori, 5～15 parts of Fructus Rubies, 8～15 parts of Herba Portulacaes, 8～15 parts of Herba Dianthis, 3～10 parts of Radix Angelicae Sinensis and Herba Menthaes; Described synergist B comprises in lysine, vitamin B5, vitamin B6, vitamin B12 and the essence 4～6 parts in the mixture of proportioning arbitrarily.
The described essence of described synergist B is the commercially available essence that contains trace element, collagen protein, serum.
Hair follicle is transformed the Chinese medicine extract A component and the parts by weight of agent: 5 parts of 15 parts of Fructus Ligustri Lucidi, 15 parts of Herba Ecliptaes, 15 parts of Herba Taxillis, 10 parts of the Radixs Polygoni Multiflori, 10 parts of Fructus Rubies, 10 parts of Herba Portulacaes, 10 parts of Herba Dianthis, 5 parts of Radix Angelicae Sinensis and Herba Menthaes; Synergist B5 part.
Hair follicle is transformed the method for preparing of agent; Chinese medicine extract A comprises that employing alcohol extraction+water extracting method lixiviate prepares the Chinese medicine clear paste, earlier each Chinese medicine is carried out coarse pulverization, adds the solvent soaking 1～2 time of 3～6 times of Chinese medicine weight portions; 25～60 ℃ of control temperature; Each 1～5 hour time, filter, remove slag to such an extent that extracting solution is subsequent use; The aqueous solvent that medicinal residues add 2～6 times of Chinese medicine weight portions decocts 1 time, 60～95 ℃ of control temperature, and 1～3 hour time, filter and remove residue gets extracting solution, and merge extractive liquid, is condensed into relative density and is 1.05～1.20 clear paste, obtains Chinese medicine extract A product.
Hair follicle is transformed the method for preparing of agent, and the preparation of synergist B is earlier the potentiation solid medicine to be pulverized, and adds in the potentiation liquid drug again and grinds evenly, obtains synergist B product.
Described alcohol extraction+water extracting method can be adopted independent pure extracting method.
Described solvent comprises that water and commonly used organic solvent ethanol are or/and propanol, n-butyl alcohol or liquor with high degree.
Hair follicle of the present invention is transformed agent, and use is medicament to be coated with put on the skin on patient's scalp.Dispenser is to coat synergist B at scalp earlier, sooner or later coats with rice wine modulation Chinese medicine extract A, and whenever uses synergist B separately once at a distance from three days in second day.
Below be that a kind of hair follicle of the present invention is transformed the pharmacological property that former medicine is adopted in agent:
(1) Fructus Ligustri Lucidi (ructus Ligustri Lucidi), another name: Fructus Ligustri Lucidi reality, Fructus Ilicis Purpureae, quick-fried lattice flea, white beeswax tree and Mus Chinese catalpa.Fructus Ligustri Lucidi is returned liver and kidney channel; Cure mainly: Light-headedness; Soreness of the waist and knees; Seminal emission; Tinnitus; Early whitening of beard and hair, osteopyrexia and fever; Poor vision.
(2) Herba Ecliptae (Herba Ecliptae Eclipta prostrala L.), another name: Nanjing grass, Alternanthera sessilis (L.) DC., Herba Ecliptae and yerbadetajo seed.Herba Ecliptae has removing heat from blood, hemostasis, the kidney invigorating and tonifying YIN effect.Cure mainly: haematemesis, hemoptysis, epistaxis, hematuria, have blood in stool, dysentery, knife injury are hemorrhage, early whitening of beard and hair, diphtheria, stranguria with turbid discharge, leukorrhagia, pudendum pruritus due to damp pathogen and mouse nevus.
(3) Herba Taxilli (axillus sutchuenensis (Lecomte) Danser), Herba Taxilli, its bitter but sweet flavor, its gas is gentle, and is cold not hot.Have invigorating the liver and kidney, bone and muscle strengthening, remove rheumatism, blood vessel dilating, resisting myocardial ischemia and arrhythmia, the meridian dredging, beneficial blood and antiabortive effect.Also have effects such as antiplatelet aggregation, raise immunity.Cure mainly: soreness of waist and knee joint, muscles and bones flaccidity are weak, hemiplegia, beriberi, anemofrigid-damp arthralgia, vaginal bleeding during pregnancy metrorrhagia and lack of lactation after delivery." Bencao Jingshu " cloud: lumbago and children's's stiffback, times of insufficiency of blood all, the tooth person also, sends out the person after the bone, and also, beneficial blood is then sent out China after the blood, and kidney qi foot then tooth is hard and to send out eyebrow long.
(4) Radix Polygoni Multiflori (P.multiflorum), another name: the Radix Polygoni Multiflori, CHISHOU crow, Herba Stellariae Saxatilis, red holding back and Chen Zhibai.Effect: the liver and the kidney tonifying, controlling nocturnal emission with astringent drugs reducing urination, nourish blood, dispel the wind and make eye bright.Radix Polygoni Multiflori is warm in nature, can nourish hair, impels hair melanin to generate, and gives the nutrition of healthy hair deep layer, makes the tough not frangible of healthy hair, and nourishing hair makes hair pitch-black shinny, and it is atherosis to extenuate human body artery." Kaibao Bencao " cloud: " improving healthy complexion is obeyed long muscles and bones for a long time for replenishing QI and blood, black moustache temples, beneficial marrow, and it is not old to prolong life.”
(5) Fructus Rubi (Rubus idaeus), another name: Fructus Rubi corchorifolii Immaturus, cover the basin certain kind of berries, black Fischer and little pallet.Return liver and kidney channel; Effect is divided astringent therapy and the kidney invigorating.Cure mainly: impotence and premature ejaculation, emission and spermatorrhea, cold womb is infertile, leukorrhagia is rare clearly, frequent micturition incontinence of urine, blurred vision dark and early whitening of beard and hair." Bencao Jingshu " cloud: Fructus Rubi, its main QI invigorating person says beneficial vital essence also.Kidney storing essence, kidney improving inspiration by invigorating kidney-QI, vital essence is sufficient, and then body is sent out not in vain not also from light.
(6) Herba Portulacae (Portulaca oleracea L.), another name: horse Herba Amaranthi tricoloris, five elements' grass, long life dish, five FANGCAO, Semen Benincasae dish, rope made of hemp dish, Dens Equi dish and horse Caulis et Folium Lactucae Sativae.Cold in nature, sweet in the mouth acid; Go into the heart, liver, spleen, large intestine channel.Have heat-clearing and toxic substances removing, diuretic dry, loose blood detumescence, dedusting antibacterial, anti-inflammatory analgetic and hemostasis removing heat from blood effect.Cure mainly dysentery, enteritis, nephritis, puerperal metrorrhagia, have blood in stool and disease such as mastitis.Contain abundant Y-3 fatty acid in the Herba Portulacae; It can suppress the generation of blood in human body in clearing gallbladder sterin and triglyceride acid, helps the synthetic prostaglandin of vascular endothelial cell to increase, and suppresses platelet and forms thromboxane A2; Blood viscosity is descended; Impel vasodilation, can prevent platelet aggregation, coronary vasospasm and thrombosis, thereby play the effect of cleaning and unimpeded blood vessel.Herba Portulacae has stronger inhibitory action to dysentery bacterium, Bacillus typhi and escherichia coli, can be used for the auxiliary treatment of various inflammation, have the title of " natural antibiotics ".
(7) Herba Dianthi (Dianthus superbus), another name: wild wheat, ten kinds of scape flowers, Herba Commelinae Diffusae, huge sentence wheat, Da Lan, mountain Herba Dianthi, Fructus Nandinae Domesticae grass, shorn velvet flower, big chrysanthemum, fringed pink wheat, Flos Carthami Herba Dianthi, wooden dish flower and shears flowers.The property bitter and cold.GUIXIN and small intestine meridian.Has inducing diuresis for treating stranguria syndrome and the removing blood stasis effect of stimulating the menstrual flow.The essentials of Matea Medica cloud: " fall heart-fire, sharp small intestinal is by the bladder pathogenic heat, for controlling the pouring key medicine." be used for pyretic stranguria, stranguria with blood, stranguria caused by urinary stone, urinary obstruction, the puckery pain of pouring drop and menstruation apolipsis.
(8) Radix Angelicae Sinensis (Angelica sinensis), another name: Radix Angelicae Sinensis, cloud are returned, western Radix Angelicae Sinensis and Min Radix Angelicae Sinensis.Warm in nature, hide sweet, hot.Return liver, the heart and spleen channel.Curing mainly enriches blood invigorates blood circulation, menstruction regulating and pain relieving and loosening bowel to relieve constipation.Be used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Have anti-hypoxia, regulate body's immunity, anticancer, improve looks, enrich blood invigorate blood circulation, effect such as antibacterial and arteriosclerosis.
(9) Herba Menthae (Herba Menthae Haplocalycis), another name: wild mint, fragrant, the southern Herba Menthae of breath at night." book on Chinese herbal medicine is newly organized " cloud: Herba Menthae goes into lung and envelope two warps, also can go into liver and gallbladder.Have dispelling wind and heat pathogens, the clear sharp head, sore-throat relieving rash and soothing the liver circulation of qi promoting effect.Cure mainly affection due to external wind and heat, headache, conjunctival congestion, laryngopharynx swelling and pain, dyspepsia flatulence, aphtha, toothache, skin ulcer scabies and urticaria.A small amount of Herba Menthae for oral administration has the effect of stimulating central nervous system; Oleum menthae has stimulation to skin, and can slowly infiltrate through in the skin, causes long hyperemia; The Oleum menthae external can be anaesthetized teleneuron, has refrigerant, antiinflammatory, pain relieving and itching-relieving action.
(10) lysine (lysine) formal name used at school: 2, the 6-diaminocaproic acid.Unique aminoacid that has the side chain primary amino radical in the protein.L-lysine is a kind of basic amino acid in common 20 seed amino acids of constitutive protein matter, is mammiferous essential amino acids and ketogenic amino acid.Lysine is one of essential amino acid; Can promote the cellular oxidation restoring function; Make liver function vigorous, and can neutralize a toxin, promote that hyperplasia, promotion human development, prevention pathogen grow, raise immunity, and the effect that improves the central nervous tissue function is arranged.
(11) vitamin (Vitamin) B5 has the function of making antibody, is safeguarding that hair, skin and blood also playing the part of important role aspect healthy.Effect: make and the renewal bodily tissue; Help wound healing; Make antibody, the opposing infectious disease; Prevent fatigue, help resistance to compression; Relax multiple antibiotic side effect and toxin; The premenstrual syndrome of releiving; Relax the symptom of feeling sick.Can participate in the multiple metabolic process of hair to the destruction and removing free radical of free radical resisting in hair follicle; Be a kind of very important vessel expander and anticoagulant, can strengthen the blood flow of scalp blood capillary, increase the resistance of blood vessel, keep the normal permeability of blood capillary cold; Can see through scalp and be absorbed, promote the cell growth, delay the atrophy and the degeneration of hair, skin, quicken the rehabilitation of multiple damage; Its chemical constitution is similar to estrogen, can facedown secrete the prosperous alopecia that causes by androgen.Can import in the thin meninges of hairs, hair cell will increase with multiple, and hair can be released to skin surface from hair follicle, regenerated hairs, and poliosis, alopecia and wind syndrome of head are controlled in the hair care hair growth promoting, and nourishing kidney is nourished blood, crow palpus hair color, life lengthening, bone and muscle strengthening, strong QI and blood.
(12) vitamin (Vitamin) B6 is actually the compositions by pyridoxol, 2-methyl-3-hydroxy-4-formyl-5-hydroxymethylpyridine., several kinds of materials of pyridoxamine, and confidential relation and mutual effect are arranged each other; Effect: can suitably digest, absorb protein and fat, help the tryptophan transfer in the essential amino acid to be changed to nicotinic acid; Prevent the disease of various nerves, skin, alleviate vomiting, promote the synthetic of nucleic acid; Prevent the aging of histoorgan; Reducing because of taking diseases such as xerostomia that resist melancholy agent causes and dysuria, slow down the neuritic symptoms of various brothers such as muscle spasm at night, cramp paralysis, is natural diuretic.
(13) vitamin (Vitamin) B12 is mainly derived from animal food, and liver is best source, and kidney, lean meat, fish also are good sources.Effect: promote erythrocytic formation and regeneration, prevent anemia, promote childhood development; Appetite stimulator, physical strength reinforcing is kept neural normal function; Fat, carbohydrate, protein are suitably in the body to be utilized; Eliminate dysphoria, impel attention to concentrate, promote memory and equilibrium sense.
(14) essence contains trace element, collagen protein, serum, is the superfine product in the skin care item, and composition is exquisite, and effect is powerful, and effect is remarkable.That its effect has is anti-aging, crease-resistant, preserve moisture, whiten and remove speckle etc.
Advantage of the present invention and good effect:
Medicament composing prescription of the present invention is scientific and reasonable, has that enriching yin and nourishing kidney, hair color make eye bright, a function of disease preventing and treating and slow down aging, improves function, nourishing the liver and kidney, and the black hair that nourishes blood activates tryrosinase rapidly, makes poliosis black by leucismus gradually.The scheme of employing inner disease outer treat is through " clear, benefit, beneficial, foster thoroughly." targeting location directly execute and control." pass through " with the transdermal penetration ability of menthol through the structural change medicine of change horny layer lipid; " clearly " suppresses the generation of blood in human body in clearing gallbladder sterin and triglyceride acid with the Y-3 fatty acid of Herba Portulacae; Help the synthetic prostaglandin of vascular endothelial cell to increase; Suppress platelet and form thromboxane A2, blood viscosity is descended, impel vasodilation; Can prevent platelet aggregation, coronary vasospasm and thrombosis, thereby play the effect of cleaning and unimpeded blood vessel; Herba Portulacae has stronger inhibitory action to dysentery bacterium, Bacillus typhi and escherichia coli, can be used for the auxiliary treatment of various inflammation, have the title of " natural antibiotics "; Lysine, vitamin B6, B12 can participate in the multiple metabolic process of hair to the destruction and the removing free radical of free radical resisting in hair follicle; Be a kind of very important vessel expander and anticoagulant, can strengthen the blood flow of scalp blood capillary, increase the resistance of blood vessel, keep the normal permeability of blood capillary cold; Can see through scalp and be absorbed, promote the cell growth, delay the atrophy and the degeneration of hair, skin, quicken the rehabilitation of multiple damage; Its chemical constitution is similar to estrogen, can facedown secrete the prosperous alopecia that causes by androgen; " benefit " with the Fructus Rubi settling five organs, beneficial color is supported vital essence, and long hair is controlled early whitening of beard and hair; " benefit " with Herba Taxilli benefit blood and blood vessel dilating, the function of microcirculation improvement, and antiplatelet aggregation, raise immunity, beneficial blood is then sent out China, and kidney qi foot then tooth is hard and to send out eyebrow long; " support " with Herba Dianthi and support kidney qi, contrary by the bladder heresy, hair.
Through above-mentioned kinds of traditional Chinese medicines combined effect, the secretion of balancing head haze wax fat strengthens trichotrophy; With the hair care is basic, recovers the hair follicle vigor effectively, promotes the dense growth of hair; Can not only resist the androgen that causes alopecia; And can improve the scalp nutrition supply, stimulate natural on-off cycles of hair growth, newborn hair quality amount is obviously improved, effectively solve problems such as alopecia, withered and yellow and poliosis.
This product is natural product, and is safe and reliable to the people, no side effects.The medicine source is extensive, low price, and preparation is simple, and curative effect is fast, and it is extensive, easy to use, safe and reliable to be suitable for disease, is well suited for industrial-scale production.
Description of drawings
Fig. 1 is a process flow diagram of the present invention.
The specific embodiment
Below in conjunction with accompanying drawing and embodiment the present invention is further specified.
(1) preparation embodiment
Embodiment 1 (adapting to general crowd)
Chinese medicine component and parts by weight: 5 parts of 15 parts of Fructus Ligustri Lucidi, 15 parts of Herba Ecliptaes, 15 parts of Herba Taxillis, 10 parts of the Radixs Polygoni Multiflori, 10 parts of Fructus Rubies, 10 parts of Herba Portulacaes, 10 parts of Herba Dianthis, 5 parts of Radix Angelicae Sinensis and Herba Menthaes; 5 parts of synergist B.
Method for preparing: earlier each Chinese medicine is carried out coarse pulverization, add each 50% solvent soaking of ethanol and n-butyl alcohol 2 times of 6 times of Chinese medicine weight portions, 25～35 ℃ of control temperature, each 5 hours time, filtration is removed slag to such an extent that extracting solution is subsequent use; The aqueous solvent that medicinal residues add 3 times of Chinese medicine weight portions decocts 1 time, 55 ℃ of control temperature, and 2 hours time, filter and remove residue gets extracting solution, and merge extractive liquid, is condensed into relative density and is 1.15 clear paste, obtains Chinese medicine extract A product.
Embodiment 2 (adapting to the cold inclined to one side thin body crowd in the end)
Chinese medicine component and parts by weight: 6 parts of 12 parts of Fructus Ligustri Lucidi, 10 parts of Herba Ecliptaes, 10 parts of Herba Taxillis, 15 parts of the Radixs Polygoni Multiflori, 15 parts of Fructus Rubies, 8 parts of Herba Portulacaes, 5 parts of Herba Dianthis, 15 parts of Radix Angelicae Sinensis and Herba Menthaes; 4 parts of synergist B.
Method for preparing: earlier each Chinese medicine is carried out coarse pulverization, the alcohol solvent that adds 4.5 times of Chinese medicine weight portion concentration 50% soaks 1 time, 60 ℃ of control temperature, and 3 hours time, filter, remove slag to such an extent that extracting solution is subsequent use; The aqueous solvent that medicinal residues add 5 times of Chinese medicine weight portions decocts 1 time, 90 ℃ of control temperature, and 1 hour time, filter and remove residue gets extracting solution, and merge extractive liquid, is condensed into relative density and is 1.20 clear paste, obtains Chinese medicine extract A product.
Embodiment 3 (adapting to the fat partially crowd in the hot end)
Chinese medicine component and parts by weight: 5 parts of 20 parts of Fructus Ligustri Lucidi, 20 parts of Herba Ecliptaes, 10 parts of Herba Taxillis, 5 parts of the Radixs Polygoni Multiflori, 5 parts of Fructus Rubies, 15 parts of Herba Portulacaes, 10 parts of Herba Dianthis, 5 parts of Radix Angelicae Sinensis and Herba Menthaes; Synergist B5 part.
Method for preparing: earlier each Chinese medicine is carried out coarse pulverization, the alcohol solvent that adds 4 times of Chinese medicine weight portions 65% soaks 2 times, 45 ℃ of control temperature, and each 2 hours time, filter, remove slag to such an extent that extracting solution is subsequent use; The aqueous solvent that medicinal residues add 2 times of Chinese medicine weight portions decocts 1 time, 85 ℃ of control temperature, and 1.5 hours time, filter and remove residue gets extracting solution, and it is 1.25 clear paste that merge extractive liquid,, vacuum concentration become relative density, obtains Chinese medicine extract A product.
Embodiment 4 (adapting to the empty crowd of body of the cold end)
Chinese medicine component and parts by weight: 5 parts of 10 parts of Fructus Ligustri Lucidi, 10 parts of Herba Ecliptaes, 10 parts of Herba Taxillis, 10 parts of the Radixs Polygoni Multiflori, 20 parts of Fructus Rubies, 5 parts of Herba Portulacaes, 5 parts of Herba Dianthis, 20 parts of Radix Angelicae Sinensis and Herba Menthaes; Synergist B4 part.
Method for preparing: earlier each Chinese medicine is carried out coarse pulverization, the liquor with high degree that adds 3 times of Chinese medicine weight portions soaks 1 time, 40 ℃ of control temperature, and 5 hours time, filter, remove slag to such an extent that extracting solution is subsequent use; The liquor with high degree that medicinal residues add 3 times of Chinese medicine weight portions soaks 1 time again, 55 ℃ of temperature of control, and 3 hours time, filter and remove residue gets extracting solution, and merge extractive liquid, is condensed into relative density and is 1.20 clear paste, obtains Chinese medicine extract A product.
Embodiment 5 (adapting to the strong crowd of body of the hot end)
Chinese medicine component and parts by weight: 5 parts of 15 parts of Fructus Ligustri Lucidi, 20 parts of Herba Ecliptaes, 5 parts of Herba Taxillis, 5 parts of the Radixs Polygoni Multiflori, 5 parts of Fructus Rubies, 20 parts of Herba Portulacaes, 15 parts of Herba Dianthis, 5 parts of Radix Angelicae Sinensis and Herba Menthaes; Synergist B6 part.
Method for preparing: earlier each Chinese medicine is carried out coarse pulverization, the aqueous solvent that adds 6 times of Chinese medicine weight portions decocts 1 time, 60 ℃ of control temperature, and 5 hours time, filter, remove slag to such an extent that extracting solution is subsequent use; The aqueous solvent that medicinal residues add 3 times of Chinese medicine weight portions decocts 1 time again, 75 ℃ of temperature of control, and 3 hours time, filter and remove residue gets extracting solution, and merge extractive liquid, is condensed into relative density and is 1.15 clear paste, obtains Chinese medicine extract A product.
Embodiment 6 (synergist B)
Synergist B component and parts by weight: 3 parts of 2 parts of lysines, 0.5 part of vitamin B5,1 part of vitamin B6,1.5 parts of vitamin B1ies and essences.
Method for preparing: earlier potentiation solid vitamin B5, vitamin B6 and vitamin B12 medicine are ground, add in the essence medicine with lysine again and grind evenly, obtain synergist B product.
(2) embodiment on probation
Case 1 on probation
Zhao XX, the man, 59, in year, civilian post because of pondering over too much, causes premature gray hair (to belong to one type of old poliosis) all over the face.Also belong to regularly and normal because of its work and rest and diet in addition, use the basic prescription that adapts to general crowd according to this situation, dispenser is that elder generation coats synergist B at scalp, and second day morning and evening coated Chinese medicine extract A, whenever used synergist B separately once at a distance from three days.Use ten days rear section hair follicles to begin to change, use most of hair follicle generation fundamental change after two months, grow achromachia, use after three months achromachia to change black, uses whole hair follicle generation fundamental changes after four months, grew hair color in eight months.
Case 2 on probation
Song X, the woman, 26, year, the performer, because of excessively vegetarian diet fat-reducing, and competitive pressure causes a small amount of alopecia (belonging to one type of alopecia areata) greatly, cold partially body constitution.This patient uses the prescription that adapts to the cold inclined to one side thin body crowd in the end, and dispenser is to coat synergist B at scalp earlier, sooner or later coats Chinese medicine extract A, and whenever uses synergist B separately once at a distance from three days in second day.Use week rear section hair follicle to begin to change, use most of hair follicle generation fundamental change after month, grow than fine, soft fur and send out, use to go out than coarse wool to send out after two months, re-use three months after whole hair follicle generation fundamental changes, grow normal hair color.
Case 3 on probation
Yellow XX, the man, 45, the year, the proprietor of an establishment in response to reward and drinking and smoking a lot, causes getting a bit thin on top (belonging to one type of seborrheic alopecia).Thereby the food because of the long-term edible high nutrition of high fat forms fat partially body constitution simultaneously.This patient uses the prescription that adapts to the fat partially crowd in the hot end, and dispenser is to coat synergist B at scalp earlier, sooner or later coats Chinese medicine extract A, and whenever uses synergist B separately once at a distance from three days in second day.Use two weeks rear section hair follicle begins to change, and uses most of hair follicle generation fundamental change after two months, grows fine, soft fur and sends out, and uses all hair follicle generation fundamental changes after ten months, grows normal hair color.
Case 4 on probation
Open XX, the woman, 32, the year, puerperal alopecia (belonging to one type of body alopecia of the cold end).This agent of dispenser is to coat synergist B at scalp earlier, sooner or later coats Chinese medicine extract A, and whenever uses synergist B separately once at a distance from three days in second day.Use 12 days rear section hair follicles to begin to change, use most of hair follicle generation fundamental change after month, grow than fine, soft fur and send out, use to grow than coarse wool behind two first quarter moons and send out, re-use three months after all hair follicle generation fundamental changes, grow normal hair color.
Case 5 on probation
Guo X, the man, 29, year, company's white collar, because of operating pressure is big, the undesired poliosis early existing (belonging to one type of teen-ager leukotrichia) that causes of diet.Thereby form partial heat body constitution because of the long-term edible fried foreign fast food of frying class of frying in shallow oil simultaneously.This patient uses the prescription that adapts to the strong crowd of body of the hot end, and dispenser is to coat synergist B at scalp earlier, sooner or later coats Chinese medicine extract A, and whenever uses synergist B separately once at a distance from two days in second day.Use week rear section hair follicle to begin to change, uses most of hair follicle generation fundamental change after month, grow achromachia, uses after two months achromachia to change and deceive, use whole hair follicle generation fundamental changes after three months, grow hair color.
Claims (4)
1. a hair follicle is transformed agent, it is characterized in that: be made up of Chinese medicine extract A and synergist B; Described Chinese medicine extract A material component and parts by weight: 2～8 parts of 10～20 parts of Fructus Ligustri Lucidi, 10～20 parts of Herba Ecliptaes, 10～20 parts of Herba Taxillis, 8～15 parts of the Radixs Polygoni Multiflori, 5～15 parts of Fructus Rubies, 8～15 parts of Herba Portulacaes, 8～15 parts of Herba Dianthis, 3～10 parts of Radix Angelicae Sinensis and Herba Menthaes; Described synergist B is any 4～6 parts in the mixture of proportioning in lysine, vitamin B5, vitamin B6, vitamin B12 and the essence.
2. hair follicle as claimed in claim 1 is transformed agent, it is characterized in that: Chinese medicine extract A component and parts by weight: 5 parts of 15 parts of Fructus Ligustri Lucidi, 15 parts of Herba Ecliptaes, 15 parts of Herba Taxillis, 10 parts of the Radixs Polygoni Multiflori, 10 parts of Fructus Rubies, 10 parts of Herba Portulacaes, 10 parts of Herba Dianthis, 5 parts of Radix Angelicae Sinensis and Herba Menthaes; 5 parts of synergist B.
3. according to claim 1 or claim 2 hair follicle is transformed agent; It is characterized in that: described Chinese medicine extract A adopts alcohol extraction and/or the lixiviate of water extracting method to prepare the Chinese medicine clear paste, earlier each Chinese medicine is carried out coarse pulverization, adds the solvent soaking 1～2 time of 3～6 times of Chinese medicine weight portions; 25～60 ℃ of control temperature; Each 1～5 hour time, filter, remove slag to such an extent that extracting solution is subsequent use; The aqueous solvent that medicinal residues add 2～6 times of Chinese medicine weight portions decocts 1 time, 60～95 ℃ of control temperature, and 1～3 hour time, filter and remove residue gets extracting solution, and merge extractive liquid, is condensed into relative density and is 1.05～1.20 clear paste, obtains Chinese medicine extract A product.
4. hair follicle as claimed in claim 1 is transformed agent, it is characterized in that: the preparation of described synergist B is earlier the potentiation solid medicine to be pulverized, and adds in the potentiation liquid drug again and grinds evenly, obtains synergist B product.
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| CN116196240B (en) * | 2022-12-30 | 2023-09-15 | 广州市勇辉精细化工有限公司 | Hair-loss-preventing and hair-fixing shampoo containing natural plant components and preparation method thereof |
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Inventor after: Liu Yanyu Inventor after: Dabo Anthony Paul Inventor after: Zhang Yuyuan Inventor before: Liu Yanyu Inventor before: Dai Boan Inventor before: Zhang Yuyuan |
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| COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: LIU YANYU DAI BOAN ZHANG YUYUAN TO: LIU YANYU DABBLE ANTHONY PAUL ZHANG YUYUAN |
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| CP01 | Change in the name or title of a patent holder |
Address after: Qingxiu District, Nanning City, the Guangxi Zhuang Autonomous Region No. 5 530022 Patentee after: Liu Yanyu Patentee after: Dabo Anthony Paul Patentee after: Zhang Yuyuan Address before: Qingxiu District, Nanning City, the Guangxi Zhuang Autonomous Region No. 5 530022 Patentee before: Liu Yanyu Patentee before: Dai Boan Patentee before: Zhang Yuyuan |
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| EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20111214 Assignee: Guangxi Nanning Mei Mei Century Trade Co.,Ltd. Assignor: Liu Yanyu|Zhang Yuyuan|Dabo Anthony Paul Contract record no.: 2015990000428 Denomination of invention: Hair follicle transformation agent and preparation method thereof Granted publication date: 20121205 License type: Exclusive License Record date: 20150610 |
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| LICC | Enforcement, change and cancellation of record of contracts on the licence for exploitation of a patent or utility model | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20121205 Termination date: 20210722 |