CN102271683A - 恶性血液病的治疗 - Google Patents
恶性血液病的治疗 Download PDFInfo
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- CN102271683A CN102271683A CN2009801540979A CN200980154097A CN102271683A CN 102271683 A CN102271683 A CN 102271683A CN 2009801540979 A CN2009801540979 A CN 2009801540979A CN 200980154097 A CN200980154097 A CN 200980154097A CN 102271683 A CN102271683 A CN 102271683A
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Abstract
Description
试验 | 试验结果 |
外观 | 稍稍灰白色粉末 |
1H-NMR | 与参比一致的光谱 |
HPLC分析 | 98.1%(无水、无溶剂) |
手性纯度(HPLC) | 98.2%ee |
试验 | 试验结果 |
炽灼残渣 | 0.11% |
红外光谱(FTIR) | 与参比一致的光谱 |
13C-NMR | 与参比一致的光谱 |
粒度分析 | 中间粒径:11.3μm |
水(卡氏水分测定仪) | 0.56% |
组 | 方案 | 化合物I | 安慰剂 |
1(n=8) | SD | 17mg(n=6) | 安慰剂(n=2) |
2(n=8) | SD | 50mg(n=6) | 安慰剂(n=2) |
3(n=8) | SD | 125mg(n=6) | 安慰剂(n=2) |
4(n=8) | SD | 250mg(n=6) | 安慰剂(n=2) |
5(n=8) | SD | 400mg(n=6) | 安慰剂(n=2) |
6(n=8) | MD | 50mg BID×7d(n=6) | 安慰剂BID×7d(n=2) |
7(n=8) | MD | 100mg BID×7d(n=6) | 安慰剂BID×7d(n=2) |
8(n=8) | MD | 200mg BID×7d(n=6) | 安慰剂BID×7d(n=2) |
I)细胞遗传异常 | |
13q14.3 | 58% |
11q22.3 | 33% |
17p13.1 | 20% |
三体性12 | 12% |
II)治疗历史 | |
氟达拉滨难治的 | 29% |
未知的 | 54% |
II)IgVH状态 | |
突变的 | 33% |
未突变的 | 33% |
未知的 | 33% |
Claims (41)
Priority Applications (1)
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CN201410246030.0A CN104042618B (zh) | 2008-11-13 | 2009-11-13 | 恶性血液病的治疗 |
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US11443408P | 2008-11-13 | 2008-11-13 | |
US61/114,434 | 2008-11-13 | ||
US14284509P | 2009-01-06 | 2009-01-06 | |
US61/142,845 | 2009-01-06 | ||
US15505709P | 2009-02-24 | 2009-02-24 | |
US61/155,057 | 2009-02-24 | ||
US18076809P | 2009-05-22 | 2009-05-22 | |
US61/180,768 | 2009-05-22 | ||
US23127809P | 2009-08-04 | 2009-08-04 | |
US61/231,278 | 2009-08-04 | ||
US24519609P | 2009-09-23 | 2009-09-23 | |
US61/245,196 | 2009-09-23 | ||
PCT/US2009/064471 WO2010057048A1 (en) | 2008-11-13 | 2009-11-13 | Therapies for hematologic malignancies |
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CN102271683A true CN102271683A (zh) | 2011-12-07 |
CN102271683B CN102271683B (zh) | 2014-07-09 |
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CN200980154097.9A Expired - Fee Related CN102271683B (zh) | 2008-11-13 | 2009-11-13 | 恶性血液病的治疗 |
CN201410246030.0A Expired - Fee Related CN104042618B (zh) | 2008-11-13 | 2009-11-13 | 恶性血液病的治疗 |
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CN201410246030.0A Expired - Fee Related CN104042618B (zh) | 2008-11-13 | 2009-11-13 | 恶性血液病的治疗 |
Country Status (13)
Country | Link |
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US (5) | US20100202963A1 (zh) |
EP (2) | EP3427739A1 (zh) |
JP (3) | JP5794919B2 (zh) |
KR (3) | KR101664511B1 (zh) |
CN (2) | CN102271683B (zh) |
AU (6) | AU2009313878B2 (zh) |
CA (3) | CA2743642C (zh) |
ES (1) | ES2674719T3 (zh) |
IL (1) | IL212851A0 (zh) |
NZ (3) | NZ631024A (zh) |
PT (1) | PT2355828T (zh) |
SG (2) | SG195655A1 (zh) |
WO (1) | WO2010057048A1 (zh) |
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