CN102258812B - 一种相变可控栓塞材料及其制备方法 - Google Patents
一种相变可控栓塞材料及其制备方法 Download PDFInfo
- Publication number
- CN102258812B CN102258812B CN2011101918322A CN201110191832A CN102258812B CN 102258812 B CN102258812 B CN 102258812B CN 2011101918322 A CN2011101918322 A CN 2011101918322A CN 201110191832 A CN201110191832 A CN 201110191832A CN 102258812 B CN102258812 B CN 102258812B
- Authority
- CN
- China
- Prior art keywords
- embolic material
- phase
- change
- iodized oil
- controllable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000463 material Substances 0.000 title claims abstract description 99
- 230000003073 embolic effect Effects 0.000 title claims abstract description 69
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 208000005189 Embolism Diseases 0.000 claims abstract description 38
- 239000007788 liquid Substances 0.000 claims abstract description 29
- 229920000642 polymer Polymers 0.000 claims abstract description 23
- NTHXOOBQLCIOLC-UHFFFAOYSA-N iohexol Chemical compound OCC(O)CN(C(=O)C)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I NTHXOOBQLCIOLC-UHFFFAOYSA-N 0.000 claims abstract description 16
- 229960001025 iohexol Drugs 0.000 claims abstract description 16
- 239000006193 liquid solution Substances 0.000 claims abstract description 8
- 238000003756 stirring Methods 0.000 claims description 16
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 10
- 239000003153 chemical reaction reagent Substances 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 5
- JGSARLDLIJGVTE-UHFFFAOYSA-N 3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid Chemical compound O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-UHFFFAOYSA-N 0.000 claims description 4
- 239000000839 emulsion Substances 0.000 claims description 4
- 239000000178 monomer Substances 0.000 claims description 4
- 239000011435 rock Substances 0.000 claims description 4
- 230000001954 sterilising effect Effects 0.000 claims description 4
- 241000233803 Nypa Species 0.000 claims description 2
- 235000005305 Nypa fruticans Nutrition 0.000 claims description 2
- 239000007864 aqueous solution Substances 0.000 claims description 2
- 238000007334 copolymerization reaction Methods 0.000 claims description 2
- QNILTEGFHQSKFF-UHFFFAOYSA-N n-propan-2-ylprop-2-enamide Chemical compound CC(C)NC(=O)C=C QNILTEGFHQSKFF-UHFFFAOYSA-N 0.000 claims description 2
- WDFKEEALECCKTJ-UHFFFAOYSA-N n-propylprop-2-enamide Chemical compound CCCNC(=O)C=C WDFKEEALECCKTJ-UHFFFAOYSA-N 0.000 claims description 2
- 238000006116 polymerization reaction Methods 0.000 claims description 2
- 230000001105 regulatory effect Effects 0.000 claims description 2
- 230000007704 transition Effects 0.000 claims description 2
- 238000003384 imaging method Methods 0.000 abstract description 4
- 239000007787 solid Substances 0.000 abstract description 4
- 230000036760 body temperature Effects 0.000 abstract description 3
- 239000003814 drug Substances 0.000 abstract description 2
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
- 210000003734 kidney Anatomy 0.000 description 20
- 208000001435 Thromboembolism Diseases 0.000 description 15
- 206010061216 Infarction Diseases 0.000 description 13
- 230000007574 infarction Effects 0.000 description 13
- 241001465754 Metazoa Species 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 8
- 206010028851 Necrosis Diseases 0.000 description 7
- 230000017074 necrotic cell death Effects 0.000 description 7
- 239000000126 substance Substances 0.000 description 5
- 230000002146 bilateral effect Effects 0.000 description 4
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000010102 embolization Effects 0.000 description 3
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000034994 death Effects 0.000 description 2
- 230000001788 irregular Effects 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 230000007170 pathology Effects 0.000 description 2
- 239000000829 suppository Substances 0.000 description 2
- 206010003178 Arterial thrombosis Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010038470 Renal infarct Diseases 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000002697 interventional radiology Methods 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 208000002741 leukoplakia Diseases 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000216 vascular lesion Toxicity 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
Abstract
Description
实施例 | 5ml液体中碘化油含量 | 推注时间(s) |
实施例1 | 0.3ml | 25-38 |
实施例2 | 0.7ml | 40-57 |
实施例3 | 1ml | 55-60 |
实施例4 | 2ml | 73-100 |
实施例5 | 3ml | 98-134 |
动物编号 | 梗死表现 | 梗死灶比例 |
A1 | 凝固性梗死 | >90% |
A2 | 凝固性梗死 | >70% |
A3 | 坏死伴大部分液化性改变 | >90% |
A4 | 坏死伴大部分液化性改变 | 80% |
A5 | 梗死位于肾脏下极,伴部分液化性改变 | 40% |
A6 | 坏死伴大部分液化性改变 | 100% |
A7 | 梗死位于肾脏下极,部分液化性改变 | 35% |
A8 | 凝固性梗死 | 70% |
A9 | 坏死伴大部分液化性改变 | 90% |
A10 | 凝固性梗死 | 90% |
Claims (12)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2011101918322A CN102258812B (zh) | 2011-07-08 | 2011-07-08 | 一种相变可控栓塞材料及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2011101918322A CN102258812B (zh) | 2011-07-08 | 2011-07-08 | 一种相变可控栓塞材料及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102258812A CN102258812A (zh) | 2011-11-30 |
CN102258812B true CN102258812B (zh) | 2013-11-27 |
Family
ID=45005773
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2011101918322A Active CN102258812B (zh) | 2011-07-08 | 2011-07-08 | 一种相变可控栓塞材料及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN102258812B (zh) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112876604A (zh) * | 2021-01-21 | 2021-06-01 | 杨杨 | 流动性好的温度敏感型聚合物、栓塞材料及其制备方法 |
CN112870428B (zh) * | 2021-01-21 | 2022-05-27 | 北京冠合医疗科技有限公司 | 一种显影清晰的栓塞材料及其制备方法 |
CN112812223A (zh) * | 2021-01-21 | 2021-05-18 | 杨杨 | 一种载药型温度敏感型聚合物、栓塞材料及其制备方法 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1569909A (zh) * | 2004-05-11 | 2005-01-26 | 山东省医疗器械研究所 | 温度敏感型聚合物、温度敏感型液体栓塞材料及其制备方法 |
WO2009081169A2 (en) * | 2007-12-21 | 2009-07-02 | Iopharma Technologies Ab | Biodegradable contrast agents |
CN101618022A (zh) * | 2009-07-29 | 2010-01-06 | 中国人民解放军第三军医大学第二附属医院 | 一种改进的动脉栓塞剂的制备方法 |
CN101972493A (zh) * | 2010-10-15 | 2011-02-16 | 中国人民解放军第二军医大学 | 可显影碘化油-5-氟尿嘧啶聚乳酸微球制剂及其制备方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7459142B2 (en) * | 2002-06-06 | 2008-12-02 | Micro Therapeutics, Inc. | High viscosity embolizing compositions comprising prepolymers |
-
2011
- 2011-07-08 CN CN2011101918322A patent/CN102258812B/zh active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1569909A (zh) * | 2004-05-11 | 2005-01-26 | 山东省医疗器械研究所 | 温度敏感型聚合物、温度敏感型液体栓塞材料及其制备方法 |
WO2009081169A2 (en) * | 2007-12-21 | 2009-07-02 | Iopharma Technologies Ab | Biodegradable contrast agents |
CN101618022A (zh) * | 2009-07-29 | 2010-01-06 | 中国人民解放军第三军医大学第二附属医院 | 一种改进的动脉栓塞剂的制备方法 |
CN101972493A (zh) * | 2010-10-15 | 2011-02-16 | 中国人民解放军第二军医大学 | 可显影碘化油-5-氟尿嘧啶聚乳酸微球制剂及其制备方法 |
Also Published As
Publication number | Publication date |
---|---|
CN102258812A (zh) | 2011-11-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6789329B2 (ja) | 液体塞栓性組成物 | |
US10022469B2 (en) | Microspheres useful for therapeutic vascular embolization | |
CN102585258B (zh) | 一种明胶栓塞微球及其制备方法和应用 | |
CN105462142B (zh) | 一种温敏型互穿网络水凝胶材料及其制备方法和应用 | |
CN102258812B (zh) | 一种相变可控栓塞材料及其制备方法 | |
US11911532B2 (en) | Reverse thermal gels and their use as vascular embolic repair agents | |
CN104208755A (zh) | 一种壳聚糖微球的制备方法 | |
CA2732488C (en) | Microspheres useful for therapeutic vascular embolization | |
CN104208757A (zh) | 一种壳聚糖微球及其制备方法 | |
CN103536972A (zh) | 磁共振成像可检测的液体栓塞组合物及其制备和应用 | |
Sommer et al. | Multimodal visibility (radiography, computed tomography, and magnetic resonance imaging) of microspheres for transarterial embolization tested in porcine kidneys | |
CN104353131B (zh) | 一种羧甲基壳聚糖微球及其制备方法 | |
CN110496243A (zh) | 一种基于液态金属的血管栓塞剂及其制备方法 | |
CN105693920A (zh) | 长期显影原位凝胶化温度敏感型液体栓塞材料的制备方法 | |
Wang et al. | Delivery of liquid metal to the target vessels as vascular embolic agent to starve diseased tissues or tumors to death | |
CN112870428B (zh) | 一种显影清晰的栓塞材料及其制备方法 | |
Lin et al. | Molecular photoacoustic imaging for early diagnosis and treatment monitoring of rheumatoid arthritis in a mouse model | |
CN106511261A (zh) | 一种替代针灸埋植用羊肠线的可注射原位凝胶 | |
CN105106976B (zh) | 一种碘克沙醇注射液及其制备方法 | |
CN104645424B (zh) | 一种复合基质凝胶血管栓塞剂及其制备与应用 | |
Ryba et al. | Utility of indocyanine green in the detection of radiologically silent hemangioblastomas: case report | |
CN108236734A (zh) | 一种可载化疗药吉西他滨的聚乙烯醇栓塞微球合成方法 | |
Lee et al. | Percutaneous sclerotherapy for low-flow vascular malformations in paediatric patients: 6-year experience of a multidisciplinary team. Disclosure | |
CA2900440A1 (en) | Kit for in situ provision of contrast media at user-defined concentrations | |
CN104208756A (zh) | 一种羧甲基壳聚糖微球的制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
DD01 | Delivery of document by public notice |
Addressee: Liu Zhentao Document name: Notification that Application Deemed not to be Proposed |
|
ASS | Succession or assignment of patent right |
Owner name: BEIJING DERUNJUN TECHNOLOGY CO., LTD. Free format text: FORMER OWNER: YANG YANG Effective date: 20141225 |
|
C41 | Transfer of patent application or patent right or utility model | ||
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 100091 HAIDIAN, BEIJING TO: 102600 DAXING, BEIJING |
|
TR01 | Transfer of patent right |
Effective date of registration: 20141225 Address after: 102600 Daxing District biological medicine base, Yongxing Road, 25, Beijing Patentee after: Beijing Derun Jun Technology Co., Ltd. Address before: 100091 Beijing city Haidian District No. 2 Huayuan Road Jinshang home 1-1-704 Patentee before: Yang Yang |
|
CP01 | Change in the name or title of a patent holder |
Address after: 102600 25 Yongxing Road, biological medicine base, Daxing District, Beijing Patentee after: Beijing Guanhe Medical Technology Co.,Ltd. Address before: 102600 25 Yongxing Road, biological medicine base, Daxing District, Beijing Patentee before: Beijing Derun Jun Technology Co.,Ltd. |
|
CP01 | Change in the name or title of a patent holder |