CN102249855A - Process for preparing erythritol - Google Patents
Process for preparing erythritol Download PDFInfo
- Publication number
- CN102249855A CN102249855A CN2011101484022A CN201110148402A CN102249855A CN 102249855 A CN102249855 A CN 102249855A CN 2011101484022 A CN2011101484022 A CN 2011101484022A CN 201110148402 A CN201110148402 A CN 201110148402A CN 102249855 A CN102249855 A CN 102249855A
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- Prior art keywords
- erythritol
- crystallization
- obtains
- liquid
- reduced
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 title claims abstract description 29
- 239000004386 Erythritol Substances 0.000 title claims abstract description 29
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 title claims abstract description 29
- 229940009714 erythritol Drugs 0.000 title claims abstract description 29
- 235000019414 erythritol Nutrition 0.000 title claims abstract description 29
- 238000004519 manufacturing process Methods 0.000 title abstract description 16
- 238000002425 crystallisation Methods 0.000 claims abstract description 25
- 230000008025 crystallization Effects 0.000 claims abstract description 25
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract description 23
- 238000001704 evaporation Methods 0.000 claims abstract description 10
- 239000000126 substance Substances 0.000 claims abstract description 10
- 238000000034 method Methods 0.000 claims abstract description 9
- 238000005516 engineering process Methods 0.000 claims abstract description 8
- 238000004042 decolorization Methods 0.000 claims abstract description 7
- 238000000855 fermentation Methods 0.000 claims abstract description 7
- 230000004151 fermentation Effects 0.000 claims abstract description 7
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 4
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 4
- 239000007788 liquid Substances 0.000 claims description 28
- 238000000926 separation method Methods 0.000 claims description 11
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 9
- 230000008020 evaporation Effects 0.000 claims description 9
- 150000003384 small molecules Chemical class 0.000 claims description 9
- 238000000746 purification Methods 0.000 claims description 8
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 claims description 6
- 238000004061 bleaching Methods 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 6
- 239000003456 ion exchange resin Substances 0.000 claims description 6
- 229920003303 ion-exchange polymer Polymers 0.000 claims description 6
- 238000005342 ion exchange Methods 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 4
- 239000000919 ceramic Substances 0.000 claims description 4
- 239000008103 glucose Substances 0.000 claims description 4
- 239000012528 membrane Substances 0.000 claims description 4
- 239000002994 raw material Substances 0.000 claims description 4
- 150000005846 sugar alcohols Chemical class 0.000 claims description 4
- 238000002834 transmittance Methods 0.000 claims description 4
- 230000001105 regulatory effect Effects 0.000 claims description 3
- 229910052799 carbon Inorganic materials 0.000 abstract description 3
- 239000012535 impurity Substances 0.000 abstract description 3
- 239000010413 mother solution Substances 0.000 abstract description 3
- 230000005611 electricity Effects 0.000 abstract description 2
- 239000003957 anion exchange resin Substances 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 238000007670 refining Methods 0.000 description 4
- 239000013078 crystal Substances 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- -1 albumen Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000013505 freshwater Substances 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 235000014666 liquid concentrate Nutrition 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
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- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
The invention discloses a process for preparing erythritol, and belongs to the technical field of functional sugar production. In the process, an active carbon decolorization technology is used, and fermentation liquor is refined and purified by active carbon special for removing proteins and micromolecular substances and cation-anion exchange resin. The process comprises the following steps of: (1) preparing dialysate; (2) decoloring; (3) removing odor; (4) purifying; (5) evaporating; (6) crystallizing; and (7) crystallizing, separating and drying to obtain the crystalline erythritol. By the process, the production period is shortened, and the working efficiency is improved; the consumption of steam and electricity in the production is reduced, and the production cost is reduced; and the fermentation liquor is refined, purified, concentrated and crystallized, impurities in the feed liquor are reduced, the crystallization yield and product quality are improved, the quality and reusability of the separated mother solution can be improved, and the production cost is reduced.
Description
Technical field
The invention belongs to technical field of functional sugar production, be specifically related to a kind of refining, crystallization processes of erythritol fermented liquid.
Background technology
Erythritol is that a kind of sugariness is 60 ~ 80% the polynary sugar of empty calory four carbon of sucrose.Because erythritol has low energy value, high dosis tolerata, has no side effect, diabetics's edible and the non-advantageous characteristic such as carious tooth that causes, and is used in recent years in the functional foodstuffs such as low sugar, health care.At present, the industrial production process of erythritol is mainly microbe fermentation method, its production method is to be raw material with glucose, ooze yeast by height and obtain the erythritol fermented liquid through fermentation, fermented liquid removes by filter yeast through ceramic membrane or plate filter, obtain the erythritol coarse crystal through evaporation concentration, crystallization again,, obtain the finished product erythritol through activated carbon decolorizing, the refining purification of ion exchange resin, evaporation, crystallization, separation then with the coarse crystal fresh water dissolution.Present this production method will just can obtain the finished product erythritol through twice crystallization, and the production cycle is long, steam consumption is big; And the erythritol fermented liquid concentrates without refining purification direct evaporation after removing yeast, crystallization, and crystallization yield is low, and the crystalline mother solution color is dark, viscosity is big, can not utilize once more, causes whole yield low, is no more than 75%.
Summary of the invention
The present invention aims to provide a kind of erythritol preparation technology, and to solve the prior art for preparing complex process, the production cycle is long, steam consumption is big, the low crystalline mother solution color of yield is dark, viscosity is big, problem such as can not utilize once more.
The technical solution adopted for the present invention to solve the technical problems is to use the activated carbon decolorizing technology, deproteinated, the special-purpose activated charcoal regulating YIN and YANG ion exchange resin that takes off small-molecule substance are made with extra care purification to fermented liquid, can remove the impurity such as pigment, albumen, colloid and yin, yang ion of erythritol fermented liquid, make moss sugar alcohol fermented liquid just to obtain the finished product erythritol by primary crystallization.Its processing step is as follows:
1, dialyzate preparation: with glucose is raw material, oozes the fermented liquid that yeast fermentation obtains through height, removes yeast through ceramic membrane filter, obtains dialyzate;
2, decolouring: dialyzate adds common sugar alcohol by 0.1% ~ 1%(w/v) and decolours with gac under 40 ℃ ~ 75 ℃, bleaching time 20min ~ 80min, and filtering separation obtains destainer one time;
3, taste removal: a destainer is under 40 ℃ ~ 75 ℃, carry out removing of small-molecule substances such as protein, color prerequisite by the special-purpose activated charcoal that 0.02% ~ 0.1%(w/v) adds deproteinated, takes off small-molecule substance, bleaching time 20min ~ 80min, filtering separation obtains secondary decolourization liquid;
4, purify: secondary decolourization liquid carries out ion-exchange according to the technical process of the moon-sun-the moon, further the erythritol feed liquid is made with extra care purification, requires feed liquid transmittance 〉=99.8% through ion-exchange, specific conductivity≤10 μ s/cm;
5, the evaporation: with erythritol feed liquid evaporation concentration to refractive power concentration 55% ~ 75%;
6, crystallization: the gradient cooling crystallization is adopted in the erythritol crystallization, and starting temperature is 65 ℃ ~ 75 ℃, and cooling rate is 0.5 ℃ ~ 10 ℃/hr;
7, separate oven dry: the crystallization massecuite obtains the crystallization erythritol through whizzer separation, oven dry.
The yin, yang ion exchange resin of indication can be used all ion exchange resin in above-mentioned 4.
The invention has the beneficial effects as follows: shortened the production cycle, helped increasing work efficiency; The consumption of steam, electricity helps reducing production costs in less the production; Fermented liquid is purified again at condensing crystal through refining, has reduced the impurity in the feed liquid, helps improving crystallization yield, more help improving the quality of products, can improve the mother liquor quality after the separation in addition, improve its recycling property, have very great help reducing production costs.
Embodiment
The preferred embodiments of the invention are to use the activated carbon decolorizing technology, and deproteinated, the special-purpose activated charcoal regulating YIN and YANG ion exchange resin that takes off small-molecule substance are made with extra care purification to fermented liquid, and concrete processing step is as follows:
1, with glucose is raw material, oozes the fermented liquid that yeast fermentation obtains, remove yeast, obtain dialyzate, dialyzate refractive power 16% through ceramic membrane filter through height;
2, the decolouring: dialyzate is under 62 ℃, by 0.5%(w/v) adding common sugar alcohol decolour with gac, bleaching time 45min, filtering separation obtains destainer, destainer transmittance 79.8% one time;
3, taste removal: a destainer is under 55 ℃, by 0.05%(w/v) add deproteinated, the special-purpose activated charcoal that takes off small-molecule substance carries out removing of small-molecule substances such as protein, color prerequisite, bleaching time 40min, filtering separation obtains secondary decolourization liquid;
4, purify: ion-exchange is carried out in the technical process of secondary decolourization liquid is according to D301---001*7---D301, further the erythritol feed liquid make with extra care purification, exchanges liquid transmittance 100%, specific conductivity 5 μ s/cm;
5, the evaporation: with erythritol feed liquid evaporation concentration to refractive power concentration 63%;
6, crystallization: the gradient cooling crystallization is adopted in the erythritol crystallization, and starting temperature is 68 ℃, and cooling rate is 8 ℃/hr;
7, separate oven dry: the crystallization massecuite obtains the crystallization erythritol through whizzer separation, oven dry.Crystallization yield 86.7%.
Claims (1)
1. an erythritol preparation technology is characterized in that using the activated carbon decolorizing technology, and deproteinated, the special-purpose activated charcoal regulating YIN and YANG ion exchange resin that takes off small-molecule substance are made with extra care purification to fermented liquid, and its processing step is as follows:
(1) dialyzate preparation: with glucose is raw material, oozes the fermented liquid that yeast fermentation obtains through height, removes yeast through ceramic membrane filter, obtains dialyzate;
(2) decolouring: dialyzate adds common sugar alcohol by 0.1% ~ 1%(w/v) and decolours with gac under 40 ℃ ~ 75 ℃, bleaching time 20min ~ 80min, and filtering separation obtains destainer one time;
(3) taste removal: a destainer is under 40 ℃ ~ 75 ℃, carry out removing of small-molecule substances such as protein, color prerequisite by the special-purpose activated charcoal that 0.02% ~ 0.1%(w/v) adds deproteinated, takes off small-molecule substance, bleaching time 20min ~ 80min, filtering separation obtains secondary decolourization liquid;
(4) purify: secondary decolourization liquid is according to the moon---sun---, and ion-exchange is carried out in cloudy technical process, further the erythritol feed liquid is made with extra care purification, requires feed liquid transmittance 〉=99.8% through ion-exchange, specific conductivity≤10 μ s/cm;
(5) evaporation: with erythritol feed liquid evaporation concentration to refractive power concentration 55% ~ 75%;
(6) crystallization: the gradient cooling crystallization is adopted in the erythritol crystallization, and starting temperature is 65 ℃ ~ 75 ℃, and cooling rate is 0.5 ℃ ~ 10 ℃/hr;
(7) separate oven dry: the crystallization massecuite obtains the crystallization erythritol through whizzer separation, oven dry.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011101484022A CN102249855B (en) | 2011-06-03 | 2011-06-03 | Process for preparing erythritol |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011101484022A CN102249855B (en) | 2011-06-03 | 2011-06-03 | Process for preparing erythritol |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102249855A true CN102249855A (en) | 2011-11-23 |
| CN102249855B CN102249855B (en) | 2013-11-20 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011101484022A Active CN102249855B (en) | 2011-06-03 | 2011-06-03 | Process for preparing erythritol |
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| Country | Link |
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| CN (1) | CN102249855B (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102826958A (en) * | 2012-09-26 | 2012-12-19 | 山东福田药业有限公司 | Treatment method of erythritol mother liquor |
| CN102826959A (en) * | 2012-09-26 | 2012-12-19 | 山东福田药业有限公司 | Method for extracting erythritol from erythritol mother liquor |
| CN102839202A (en) * | 2012-09-26 | 2012-12-26 | 山东福田药业有限公司 | Method for processing erythritol fermentation liquor |
| CN103373901A (en) * | 2013-07-05 | 2013-10-30 | 上海交通大学 | Method for extracting erythritol from erythritol mother liquor and special barm strain for erythritol |
| CN103524303A (en) * | 2013-10-28 | 2014-01-22 | 武汉科技大学 | Method of auxiliary judging seed crystal adding time in erythritol crystallizing process based on specific gravity |
| CN104086365A (en) * | 2014-06-30 | 2014-10-08 | 山东省食品发酵工业研究设计院 | Method for preparing mixed sugar alcohol product by reutilizing erythritol production mother solution |
| CN106748657A (en) * | 2016-11-30 | 2017-05-31 | 山东福田药业有限公司 | A kind of processing method of fermented erythritol liquor |
| WO2023124396A1 (en) * | 2021-12-29 | 2023-07-06 | 浙江华康药业股份有限公司 | Refinement system for xylitol fermented liquid, and method therefor |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4906569A (en) * | 1988-02-02 | 1990-03-06 | Mitsubishi Kasei Corporation | Process for isolating and recovering erthritol from culture medium containing the same |
| CN101085720A (en) * | 2007-06-15 | 2007-12-12 | 淄博中舜生物技术有限公司 | Purification method for erythritol fermentation liquor |
-
2011
- 2011-06-03 CN CN2011101484022A patent/CN102249855B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4906569A (en) * | 1988-02-02 | 1990-03-06 | Mitsubishi Kasei Corporation | Process for isolating and recovering erthritol from culture medium containing the same |
| CN101085720A (en) * | 2007-06-15 | 2007-12-12 | 淄博中舜生物技术有限公司 | Purification method for erythritol fermentation liquor |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102826958A (en) * | 2012-09-26 | 2012-12-19 | 山东福田药业有限公司 | Treatment method of erythritol mother liquor |
| CN102826959A (en) * | 2012-09-26 | 2012-12-19 | 山东福田药业有限公司 | Method for extracting erythritol from erythritol mother liquor |
| CN102839202A (en) * | 2012-09-26 | 2012-12-26 | 山东福田药业有限公司 | Method for processing erythritol fermentation liquor |
| CN102826958B (en) * | 2012-09-26 | 2014-07-30 | 山东福田药业有限公司 | Treatment method of erythritol mother liquor |
| CN103373901A (en) * | 2013-07-05 | 2013-10-30 | 上海交通大学 | Method for extracting erythritol from erythritol mother liquor and special barm strain for erythritol |
| CN103524303A (en) * | 2013-10-28 | 2014-01-22 | 武汉科技大学 | Method of auxiliary judging seed crystal adding time in erythritol crystallizing process based on specific gravity |
| CN104086365A (en) * | 2014-06-30 | 2014-10-08 | 山东省食品发酵工业研究设计院 | Method for preparing mixed sugar alcohol product by reutilizing erythritol production mother solution |
| CN104086365B (en) * | 2014-06-30 | 2016-05-18 | 山东省食品发酵工业研究设计院 | A kind of method of being prepared by antierythrite production mother liquor recycling to mixing sugar alcohol product |
| CN106748657A (en) * | 2016-11-30 | 2017-05-31 | 山东福田药业有限公司 | A kind of processing method of fermented erythritol liquor |
| WO2023124396A1 (en) * | 2021-12-29 | 2023-07-06 | 浙江华康药业股份有限公司 | Refinement system for xylitol fermented liquid, and method therefor |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102249855B (en) | 2013-11-20 |
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Effective date of registration: 20231114 Granted publication date: 20131120 |