CN102247446B - Composite whitening and spot correcting lotion and manufacturing method thereof - Google Patents

Composite whitening and spot correcting lotion and manufacturing method thereof Download PDF

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CN102247446B
CN102247446B CN 201110233407 CN201110233407A CN102247446B CN 102247446 B CN102247446 B CN 102247446B CN 201110233407 CN201110233407 CN 201110233407 CN 201110233407 A CN201110233407 A CN 201110233407A CN 102247446 B CN102247446 B CN 102247446B
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parts
alcohol
ko
composite
whitening
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CN 201110233407
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CN102247446A (en )
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刘畅
孙永
孟祥艳
张凯
李丰
罗艳萍
胡兴国
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广州环亚化妆品科技有限公司
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Abstract

The invention specifically discloses a composite whitening and spot correcting lotion, and a manufacturing method thereof. The spot correcting lotion is manufactured from raw materials of, by weight: 2.5 to 25 parts of traditional Chinese medicine active site extracts, 0.5 to 5 parts of arbutin, 0.05 to 0.2 parts of sodium hyaluronate, 5 to 10 parts of soybean fermentation extract, 1 to 10 parts of 1,3-butylene glycol, 1 to 10 parts of propylene glycol, 0.2 to 0.8 parts of tween-80, 0.1 to 0.4 parts of methyl-p-hydroxybenzoate, 0.1 to 0.4 parts of propylparaben, 0.5 to 5 parts pf ethanol, and33.2 to 89.05 of deionized water. The traditional Chinese medicine active site extracts comprise raw materials of, by weight: 5 to 15 parts of ginseng, 5 to 20 parts of mongolian milkvetch root, 5 to25 parts of white peony root, 5 to 30 parts of licorice, and 5 to 35 parts of cottonrose hibiscus flower. According to the composite whitening and spot correcting lotion provided by the invention, a plurality of traditional Chinese medicine active components are added to whitening and spot correcting active substances, such that the activity of tyrosinase can be effectively inhibited, oxygen-derived free radicals can be removed with high efficiency, and melanin can be prevented from appearing. With the composite whitening and spot correcting lotion, various freckles and chloasma can be comprehensively and rapidly corrected. Also, the lotion brings no toxin or harm.

Description

复合美白淡斑液及制作方法 Whitening liquid composite and manufacturing method

技术领域 FIELD

[0001] 本发明涉及一种复合美白淡斑液,具体涉及一种复合美白淡斑液及其制作方法。 [0001] The present invention relates to a composite liquid whitening, whitening particularly relates to a composite liquid and its manufacturing method. 背景技术 Background technique

[0002] 雀斑、黄褐斑是大量黑色素在人体沉积分布不均匀的且难以治愈的一种常见皮肤现象,严重影响了患者的心理健康。 [0002] freckles, melasma is a large amount of melanin in the body is deposited unevenly distributed and difficult to cure a common skin phenomenon, seriously affecting the patient's mental health.

[0003] 黄褐斑对女性的危害最广,主要成因是女性内分泌失调,精神压力大,各种疾病(肝肾功能不全,妇科病、糖尿病)等以及体内缺少维生素及外用化学药物刺激引起。 [0003] chloasma harm to women's widest, is the main cause of female endocrine disorders, mental stress, various diseases (liver and kidney dysfunction, gynecological disease, diabetes), etc., and the body lacks vitamins and topical chemicals stimulation.

[0004] 雀斑是一种发生在面部的皮肤损害,呈斑点状,或芝麻状褐色或浅褐色的小斑点。 [0004] freckles skin damage occurs in a face, in spots, brown or hazel like sesame or small spots. 最好发的部位是双颊部和鼻梁部,也可泛发至整个面部甚至颈部,是影响面部美观的最为常见的原因之一。 The best part of it is fat cheeks and nose bridge section can also be generalized to the entire face and even the neck, it is one of the most common causes of facial aesthetic impact.

[0005] 造成雀斑、黄褐斑的外部因素主要是:紫外线过度照射、长期使用劣质和含有激素类化妆品等。 [0005] caused freckles, melasma external factors are: excessive ultraviolet radiation, long-term use and low-grade cosmetics containing hormones. 解决上述色斑的问题的主要方法是:清除皮层及体内游离氧自由基,抑制酪氨酸酶活性,调节人体内分泌和物质代谢。 The main solution to the problem described above is stain: cortex and remove free oxygen radicals in vivo, inhibit tyrosinase activity, metabolism and endocrine regulation.

[0006]目前市场上美白祛斑的产品很多,其所含的美白祛斑成分主要:熊果苷,汞化合物,氢醌,维生素C、维生素A及其衍生物,曲酸,壬二酸、维A酸、曲酸等。 [0006] Currently on the market many skin lightening products, whitening ingredients contained in the main: arbutin, mercury compounds, hydroquinone, vitamin C, vitamin A and its derivatives, kojic acid, azelaic acid, vitamin A acid, kojic acid and so on. 这些产品存在以下问题:(1)只能对某些色斑有效,如熊果苷只能对黄褐斑有效,对雀斑无效。 The presence of these products the following questions: (1) can only be effective for some stains, such as arbutin only effective melasma, freckles invalid. (2)对皮肤存在刺激和损害,如含汞及氢醌类化妆品更容易引起全身性中毒。 (2) the presence of irritation and damage to the skin, such as cosmetics, mercury and hydroquinones more likely to cause systemic toxicity.

发明内容 SUMMARY

[0007] 为了解决现有美白祛斑产品存在的问题,本发明目的在于提供一种疗效全面、安全的复合美白淡斑液及其制作方法。 [0007] In order to solve the problem of the conventional whitening products, object of the present invention to provide an effective and comprehensive security solution Whitening composite and manufacturing method thereof.

[0008] 为实现上述发明目的,本发明所采用技术方案如下: [0008] In order to achieve the above object, the technical solution employed in the present invention is as follows:

[0009] 一种复合淡斑液,其原料重量份数为: [0009] A composite Blemish liquid raw material by weight is:

[0010] 中药活性部位提取物2. 5-25、熊果苷0. 5-5、透明质酸钠0. 05-0. 2、大豆发酵提取液5-10、1,3- 丁二醇1-10、丙二醇1-10、吐温-80 0. 2-0. 8、尼泊金甲酯0. 1-0. 4、尼泊金丙酯0. 1-0. 4、乙醇0. 5-5和去离子水33. 2-89. 05 ;其中,所述中药活性部位提取物的原料重量份数为:人参5-15、黄芪5-20、白芍5-25、甘草5_30、芙蓉花5_35。 [0010] 2. Chinese active extracts of 5-25, 5-5 0. arbutin, sodium hyaluronate 0. 05-0. 2, fermented soybean extract 5-10,1,3- butanediol 1-10, 1-10 propylene glycol, Tween-80 0. 2-0. 8, methyl paraben 0. 1-0. 4, propyl paraben 0. 1-0. 4, 0 ethanol. 5-5 and 33. 2-8905 deionized water; wherein the active material by weight of the extracts of Chinese medicine is: 5-15 ginseng, astragalus 5-20, 5-25 peony, licorice 5_30, Hibiscus 5_35.

[0011] 优选的,所述复合淡斑液原料的重量份数为: [0011] Preferably, parts by weight of the composite material is liquid Blemish:

[0012] 中药活性部位提取物20、熊果苷5、透明质酸钠0. I、大豆发酵提取液5、1,3_ 丁二醇5、丙二醇3、吐温-800. 4、尼泊金甲酯0. 2、尼泊金丙酯0. I、乙醇4、去离子水57. 2 ;其中,所述中药活性部位提取物的原料重量份数为:人参5、黄芪10、白芍20、甘草10、芙蓉花10。 [0012] Chinese active extracts of 20, 5 arbutin, sodium hyaluronate 0. I, fermented soybean extract 5 5,1,3_ butylene, 3-propylene glycol, Tween -800. 4, paraben methyl 0.2, propyl paraben 0. I, 4 ethanol, deionized water 57.2; wherein the active material by weight of the extracts of Chinese medicine are: 5 ginseng, astragalus 10, 20 peony , licorice 10, 10 hibiscus flowers.

[0013] 一种复合美白祛斑液的制作方法,包括以下步骤: [0013] A method of making a composite skin lightening solution, comprising the steps of:

[0014] (I)中药活性部位提取物的提取纯化方法为: [0014] (I) the active site medicine extract extract purification method:

[0015] 将人参5-15份、黄芪5-20份、白芍5-25份、甘草5_30份、以及芙蓉花5_35份的中药活性部位提取物原料按照I : 5到I : 10的药物和溶剂比例浸泡于浓度为30%〜85%乙醇中,浸泡时间为24-96小时; [0015] 5-15 parts of ginseng, astragalus parts 5-20, 5-25 peony root, licorice parts 5_30, 5_35 and hibiscus flower parts active site material according herbal extracts I:. 5 to I: Drug and 10 solvent ratio immersed in a concentration of 30% ~ 85% ethanol immersion time is 24-96 hours;

[0016] 然后滤过,将滤液于50°C -80°C减压回收乙醇至无醇味后,加2-5倍量水稀释,再上树脂型号为DlOl或AB-8的大孔树脂柱水洗到无色后,再用20% -80%乙醇洗脱到洗脱液无色,并收集乙醇洗脱液,再于50°C-8(TC减压回收乙醇至药液与药材比为I : 2〜I : 10,制得中药活性部位提取物; [0016] was then filtered, the filtrate under reduced pressure to recover ethanol at 50 ° C -80 ° C to no alcohol odor after 2-5 times the amount of dilution water added, and then the type of resin, or a macroporous resin AB-8 of DlOl after washing the column as a colorless, with 20% -80% ethanol to the eluate was colorless, and the ethanol eluate was collected, and then at 50 ° C-8 (TC recover the ethanol under reduced pressure to liquid ratio of Radix It is I: 2~I: 10, to prepare active site herbal extracts;

[0017] (2)将所述中药活性部位提取物2. 5-25份、熊果苷0. 5_5份、透明质酸钠0. 05-0. 2份、1,3_ 丁二醇1-10份、丙二醇1-10份、以及大豆发酵提取液5-10份加入到20-40份去离子水中,在加料过程中一边加料一边搅拌,且在加料结束之后再搅拌10-20分钟; [0017] (2) The active extracts of said herbal 2. 5-25, arbutin 5_5 0.5 parts, sodium hyaluronate 0. 05-0. 2 parts, 1,3_ glycol 1- 10 parts, 10 parts of propylene glycol, and 5-10 parts of fermented soybean extract is added to 20-40 parts of deionized water while stirring in the feed during the addition, and after the end of the addition and then stirred for 10-20 minutes;

[0018] (3)再加入尼泊金甲酯0. 1-0. 4份、吐温-800. 2_0. 8份、尼泊金丙酯0. 1_0. 4份和乙醇0. 5-5份的混合物,再加入去离子水至总量达到100份,并充分搅拌均匀; [0018] (3) then Jiaru Ni Methylparaben 0. 1-0. 4 parts Tween -800. 2_0. 8 parts, propyl paraben 0. 1-0. 4 parts of ethanol and 0. 5-5 parts of a mixture of deionized water was added to 100 parts of the total amount, and stir uniformly;

[0019] (4)紫外线灭菌40-60分钟,静置6-48小时,上清液即得成品。 [0019] (4) UV sterilized for 40-60 minutes, allowed to stand for 6-48 hours, the supernatant derived products.

[0020] 优选的,所述复合美白淡斑液的制作方法中:在所述步骤(I)之前还包括将所述中药活性部位提取物原料粉碎成粗粉的步骤。 [0020] Preferably, the method for manufacturing a composite liquid whitening of: prior to said step (I) further comprises said herbal extracts of active material into the step of pulverizing coarse powder.

[0021] 优选的,所述复合美白淡斑液的制作方法中:所述步骤(I)中的用于浸泡中药活性部位提取物原料的乙醇浓度为60%,所述中药活性部位提取物原料与乙醇比例为I : 8,所述浸泡时间为48小时。 [0021] Preferably, the method for manufacturing a composite liquid for Whitening: ethanol concentration for the active site of herbal extracts soaking said starting material in step (I) is 60% active extracts of said herbal material ethanol ratio of I: 8, the soaking time is 48 hours.

[0022] 优选的,所述复合美白淡斑液的制作方法中:所述步骤(I)中用于洗脱的乙醇浓度为70%。 [0022] Preferably, the method for manufacturing the composite liquid whitening: the step (I) for the elution ethanol concentration of 70%. 本发明制备的复合美白祛斑液外观为浅黄色澄清透明液体到棕色半透明液体,气味轻微,pH值为5. 0〜7. 0,本发明所得的产品应密封贮存于15〜25°C阴凉干燥避光环境。 Skin lightening compound was prepared according to the present invention, the appearance of a pale yellow clear liquid to a transparent brown translucent liquid, mild odor, pH = 5. 0 to 7. 0, the resulting product of the present invention is to be sealed and stored in a cool 15~25 ° C dry and dark environment.

[0023] 本发明制备的复合美白祛斑液可直接加去离子水稀释成含复合液0. 01-99%的水剂后直接涂抹于色斑部位,也可以按0. 01-20%的添加量加到膏霜、精华液、乳液中。 [0023] The compound was prepared in whitening the present invention can be directly added to the deionized water of 0. 01-99% composite agent applied to the solution containing the stain site directly, may be added in 0. 01-20% of amount to cream, essence, emulsion.

[0024] 本发明制备的复合美白祛斑液是多种中药成分和美白祛斑活性组分的组合。 [0024] The skin lightening compound was prepared according to the invention a variety of Chinese medicines, and a combination of skin lightening active ingredient. 其中,人参提取物能有效阻碍黑色素的生物合成,同时具有很强的抗氧化功能;黄芪提取物有滋养皮肤和抗衰老作用;甘草含有甘草黄酮等成分,具有很强的抑制酪氨酸酶活性作用,有效防止黑色素的生成和过度沉积,同时还可以有效地分解、还原在皮肤中形成的黑色素;白芍、芙蓉花具有极强的抑制酪氨酸酶的活性,能有效抑制黑色素的生成,淡化已经形成的黑色素;熊果苷有较强的抑制酪氨酸酶活性的功能,是现代化妆品中安全性较高的美白剂;透明质酸具有较强的皮肤水分及修复功能。 Wherein the ginseng extract can effectively hinder melanin biosynthesis, also has a strong antioxidant; Astragalus extract nourish the skin and anti-aging effects; licoflavone containing licorice and other ingredients, has a strong inhibiting tyrosinase activity effect, and to effectively prevent excessive deposition of melanin, but also can effectively decompose, reducing the formation of melanin in the skin; peony, hibiscus flower with a strong tyrosinase inhibitory activity, could effectively inhibit the formation of melanin, melanin already formed; arbutin strong function of inhibiting the enzymatic activity of tyrosine, modern high security cosmetic whitening agent; hyaluronic acid has a strong moisture and skin repair. 大豆发酵提取液富含大豆异黄酮、氨基酸等成分,具有很好的抑制酪氨酸酶活性和保湿功能。 Fermented soybean extract component enriched soy isoflavones, amino acids, having good inhibition of tyrosinase activity and moisturizing functions.

[0025] 本发明的复合美白被祛斑液应用中西医结合的理论,在美白祛斑活性物中添加了多种中药活性成分,通过中药活性成分与其它美白祛斑活性物相互协同的作用,能有效的抑制酪氨酸酶的活性,高效清除氧自由基,防止黑色素的产生,分解淡化已经形成的黑色素,同时能够调节人体的内分泌系统,修复由于激素等化学成分对皮肤造成的损伤,从而达到全面快速、标本兼治的效果。 [0025] Theoretical composite of the present invention is incorporated whitening freckle application liquid medicine, skin lightening actives added in a variety of reactive component, of reactive component through the other skin lightening actives mutual synergistic effect, can effectively inhibit the activity of tyrosinase, efficient scavenging oxygen free radicals and prevent the production of melanin, melanin dilute the already formed, while being able to regulate the body's endocrine system, repair the damage due to the chemical composition of the skin caused by hormones, reducing the overall flash tackling the problem of the effect. 本发明的复合美白祛斑液不含对人体有毒有害物质,是一种安全有效的产品。 Composite whitening liquid of the invention does not contain harmful substances toxic to humans, it is a safe and effective product.

[0026] 因此,本发明的复合美白被祛斑液在美白祛斑活性物中添加了多种中药活性成分,能有效的抑制酪氨酸酶的活性,高效清除氧自由基,防止黑色素的产生,不仅可以全面快速淡化各种雀斑和黄褐斑,而且无毒无害。 [0026] Accordingly, the present invention is the composite whitening cream was added to the whitening active in a variety of reactive component, can effectively inhibit the activity of tyrosinase, efficient scavenging oxygen free radicals and prevent the production of melanin, only you can quickly fade comprehensive variety of freckles and melasma, and non-toxic.

具体实施方式 detailed description

[0027] 下面将结合具体实施方法来详细说明本发明,在本发明的示意性实施及说明用来解释本发明,但并不作为对本发明的限定。 [0027] The following specific embodiments in conjunction with the method of the present invention is described in detail, in the exemplary embodiment of the present invention and described for explaining the present invention but are not intended to limit the present invention.

[0028] 实施例I : [0028] Example I:

[0029] 本实施例公开了一种复合美白淡斑液的配方及其制作方法,其原料配方中的原料份数为: [0029] This Example discloses a method for manufacturing a composite formulation and whitening liquid feedstock fraction which is a raw material formulation:

[0030] 中药活性部位提取物2. 5、熊果苷0. 5、透明质酸钠0. 05、大豆发酵提取液5、1,3-丁二醇I、丙二醇I、吐温-80 0. 2、尼泊金甲酯0. I、尼泊金丙酯0. I、乙醇0.5和去离子水89. 05 ;其中,所述中药活性部位提取物的原料重量份数为:人参5、黄芪5、白芍5、甘草5、芙蓉花5。 [0030] Chinese active extracts of 2.5, 0.5 arbutin, sodium hyaluronate 0.05, fermented soybean extract 5,1,3- butanediol I, propylene glycol, I, Tween -800 2, methyl paraben 0. I, propylparaben 0. I, and deionized water 0.5 ethanol 89.05; wherein said herbal extract active site of the raw material composition by weight: 5 ginseng, Astragalus 5, 5 white peony root, licorice 5, 5 hibiscus flowers. 本实施例的复合美白祛斑液制作方法是这样实现的: The method of skin lightening compound was prepared according to the present embodiment is implemented as follows:

[0031] (I)中药活性部位提取物的提取纯化方法为:将重量份数为:人参5、黄芪5、白芍5、甘草5、芙蓉花5的原料混合粉碎成粗粉,按照药粉与溶剂I : 5的比例浸泡于浓度为30%乙醇中,浸泡时间为24小时; [0031] (I) active sites TCM extraction and purification method of extraction was as follows: parts by weight is: 5 ginseng, astragalus 5, 5 peony, licorice 5, 5 hibiscus flower mixed raw material pulverized into a coarse powder, the powder according to the solvent I: Comparative Example 5 was soaked in 30% ethanol concentration, immersion time of 24 hours;

[0032] 然后滤过,将滤液于50°C减压回收乙醇至无醇味后,加2倍量水稀释,再上树脂型号为DlOl的大孔树脂柱水洗到无色后,再用20%乙醇洗脱到洗脱液无色,并收集乙醇洗脱液,再于50°C减压回收乙醇至药液与药材比为I : 2〜I : 10,制得中药活性部位提取物; [0032] was then filtered, the filtrate under reduced pressure to recover ethanol at 50 ° C and after no alcohol taste, plus 2 times the amount of dilution water, and then on the type of resin after DlOl macroporous resin column with water until colorless, and then 20 % ethanol to the eluent a colorless, ethanol and the eluate was collected, and then at 50 ° C under reduced pressure to recover the ethanol and medicinal liquid ratio I: 2~I: 10, to obtain active extracts of traditional Chinese medicine;

[0033] (2)将上述中药活性部位提取物2. 5份、熊果苷0. 5份、透明质酸钠0. 05份、1,3- 丁二醇I份、丙二醇I份、以及大豆发酵提取液5份加入到20份去离子水中,在加料过程中一边加料一边搅拌,且在加料结束之后再搅拌10分钟; [0033] (2) the active site of the medicine was 2.5 parts of extract, arbutin 0.5 parts, 0.05 parts of sodium hyaluronate, I parts 1,3-butanediol, propylene glycol, parts I, and fermented soybean extract was added 5 parts to 20 parts of deionized water while stirring in the feed during the addition, after the end of the addition and stirred for a further 10 min;

[0034] (3)再加入尼泊金甲酯0. I份、吐温-800. 2份、尼泊金丙酯0. I份和乙醇0. 5份的混合物,再加入69. 05份去离子水,使得总量达到100份,并充分搅拌均匀; [0034] (3) then Jiaru Ni Methylparaben 0. I parts of Tween -800. 2 parts, propyl paraben 0. I parts of ethanol and 0.5 parts of a mixture, further added 69.05 parts of deionized water, such that the total amount to 100 parts, and stir uniformly;

[0035] (4)紫外线灭菌40分钟,静置6小时,上清液即得成品。 [0035] (4) UV sterilization for 40 minutes and allowed to stand for 6 hours, the supernatant derived products.

[0036] 实施例2 : [0036] Example 2:

[0037] 本实施例原料的重量份数为: Parts by weight [0037] The present embodiment as raw materials:

[0038] 中药活性部位提取物5、熊果苷5、透明质酸钠0. I、大豆发酵提取液5、1,3_ 丁二醇5、丙二醇3、吐温-800. 4、尼泊金甲酯0. 2、尼泊金丙酯0. I、乙醇4、去离子水72. 2 ;其中,所述中药活性部位提取物的原料重量份数为:人参5、黄芪10、白芍20、甘草10、芙蓉花10。 [0038] Chinese active extracts of 5, 5 arbutin, sodium hyaluronate 0. I, fermented soybean extract 5 5,1,3_ butylene, 3-propylene glycol, Tween -800. 4, paraben methyl 0.2, propyl paraben 0. I, 4 ethanol, deionized water 72.2; wherein the active material by weight of the extracts of Chinese medicine are: 5 ginseng, astragalus 10, 20 peony , licorice 10, 10 hibiscus flowers. 本发明实施例所述发明的制作方法与实施例I基本相同,不同之处除了原料的重量份数外,还包括: Example embodiments of the invention, the production method of the present invention is substantially the same as in Example I, except the starting material in addition to parts by weight, further comprising:

[0039] 所述步骤(I)中用于浸泡药粉的乙醇浓度为60%,所述中药活性部位提取物原料与乙醇比例为I : 8,所述浸泡时间为48小时,所述用于洗脱的乙醇浓度为70%。 [0039] The step (I) for dipping the ethanol concentration was 60% powder, extracts of said herbal active material to ethanol ratio of I: 8, the soaking time is 48 hours, for washing the ethanol concentration was 70% de.

[0040] 实施例3 [0040] Example 3

[0041] 本实施例原料的重量份数为: Parts by weight [0041] The present embodiment as raw materials:

[0042] 中药活性部位8、熊果苷2、透明质酸钠0. I、1,3-丁二醇5、丙二醇3、大豆发酵提取液10、尼泊金甲酯0.2、尼泊金丙酯0.2、吐温-80 0.4、乙醇2、去离子水69. I。 [0042] Chinese active site 8, 2 arbutin, sodium hyaluronate 0. I, 1,3- butylene glycol 5, 3-propanediol, fermented soybean extract 10, 0.2 methyl paraben, propyl paraben ester 0.2, 0.4 Tween-80, 2 ethanol, deionized water 69. I. 其中,所述的中药提取物原料重量份数为:人参10、黄芪10、白芍20、甘草20、芙蓉花20。 Wherein said herbal extracts parts by weight of the raw material: 10 ginseng, astragalus 10, peony 20, licorice 20, 20 hibiscus flower.

[0043] 本发明实施例所述发明的制作方法与实施例I基本相同,不同的除了原料的重量份数外,仅是浸泡药粉的乙醇浓度为55%,浸泡时间为48小时。 Example of the manufacturing method of the embodiment of the invention [0043] The present invention is substantially the same as in Example I, except that in addition to the parts by weight of the raw material, the ethanol concentration is only 55% of powder dipping, soaking for 48 hours. 纯化时大孔树脂型号为AB-8,洗脱大孔树脂柱的乙醇浓度为70%。 When the model was purified macroporous resin AB-8, ethanol concentration macroporous resin column eluting with 70%.

[0044] 实施例4 : [0044] Example 4:

[0045] 本实施例原料的重量份数为: [0046] 中药活性部位提取物25、熊果苷5、透明质酸钠0.2、大豆发酵提取液10、1,3-丁二醇10、丙二醇10、吐温-80 0. 8、尼泊金甲酯0. 4、尼泊金丙酯0. 4、乙醇5和去离子水33. 2 ;其中,所述中药活性部位提取物的原料重量份数为:人参15、黄芪20、白芍25、甘草30、芙蓉花35。 Parts by weight [0045] The starting material for the present embodiment: [0046] Chinese active extracts of 25, 5 arbutin, sodium hyaluronate 0.2, fermented soybean extract 10 10,1,3- butanediol, propylene glycol 10, Tween-80 0.8, 0.4 methyl paraben, propyl paraben 0.4, 5 ethanol and deionized water 33.2; wherein the active site of the Chinese medicine extract raw weight of the composition copies to: 15 ginseng, astragalus 20, peony 25, licorice 30, 35 hibiscus flowers. 本实施例的复合美白祛斑液制作方法是这样实现的: The method of skin lightening compound was prepared according to the present embodiment is implemented as follows:

[0047] 将人参15份、黄芪20份、白芍25份、甘草30份、以及芙蓉花35份的中药活性部位提取物原料按照I : 10的药物和溶剂比例浸泡于浓度为85%乙醇中,浸泡时间为96小时; [0047] 15 parts of Ginseng, Radix Astragali 20 parts, 25 parts of white peony root, licorice 30 parts, and 35 parts of hibiscus flower extracts of Chinese medicine active material according to I: drug and solvent ratio is immersed in 10% ethanol concentration of 85 soak time of 96 hours;

[0048] 然后滤过,将滤液于80°C减压回收乙醇至无醇味后,加5倍量水稀释,再上树脂型号为DlOl的大孔树脂柱水洗到无色后,再用80%乙醇洗脱到洗脱液无色,并收集乙醇洗脱液,再于80°C减压回收乙醇至药液与药材比为I : 5,制得中药活性部位提取物; [0048] was then filtered, the filtrate under reduced pressure to recover ethanol at 80 ° C to no alcohol odor after adding 5 times the amount of dilution water, and then the resin model DlOl macroporous resin column with water until the colorless, then 80 % ethanol to the eluent a colorless, ethanol and the eluate was collected, and then at 80 ° C under reduced pressure to recover the ethanol and medicinal liquid ratio I: 5, to obtain active extracts of traditional Chinese medicine;

[0049] (2)将所述中药活性部位提取物25份、熊果苷5份、透明质酸钠0. 2份、1,3_ 丁二醇10份、丙二醇10份、以及大豆发酵提取液10份加入到20份去离子水中,在加料过程中一边加料一边搅拌,且在加料结束之后再搅拌20分钟; [0049] (2) The active extracts of said herbal 25 parts, 5 parts of arbutin, 0.2 parts of sodium hyaluronate, 1,3_-butanediol 10 parts, 10 parts of propylene glycol, and fermented soy extract was added to 20 parts of 10 parts of deionized water while stirring in the feed during the addition, and after the end of the addition and then stirred for 20 min;

[0050] (3)再加入尼泊金甲酯0. 4份、吐温-80 0. 8份、尼泊金丙酯0. 4份和乙醇5份的混合物,再加入去离子水至总量达到100份,并充分搅拌均匀; [0050] (3) then Jiaru Ni Methylparaben 0.4 parts, 0.8 parts Tween-80, propylparaben and 0.4 parts Ethanol 5 parts of a mixture of deionized water was further added to a total an amount of 100 parts, and stir uniformly;

[0051] (4)紫外线灭菌60分钟,静置48小时,上清液即得成品。 [0051] (4) UV sterilization 60 minutes, allowed to stand for 48 hours, the supernatant derived products.

[0052] 本发明中尼泊金甲酯和尼泊金丙酯均为防腐剂,两者复配具有很好的预防微生物生长;乙醇和吐温-80为增溶剂。 [0052] In the present invention, methyl paraben and propyl paraben preservatives are both complex has good preventing microbial growth; of ethanol and Tween-80 as solubilizing agent. 其中,提取时的乙醇浓度最佳为60%,该浓度乙醇可以最大限度的提取配方中中药的各类活性成分,包括水溶性和醇溶性的有效成分。 Wherein, when extracting the optimum ethanol concentration was 60%, the maximum concentration of ethanol can extract all types of active ingredients in the formulation of medicine, include water-soluble and alcohol-soluble active ingredient. 经过实验研究比较,各中药材粉碎成粗粉添加乙醇比例为I : 8,浸泡时间为72小时,有效成分提取较完全,而且杂质较少,洗脱大孔树脂乙醇浓度为70%,提取液经过大孔树脂纯化后,除去了淀粉、果胶等杂质,提高了活性物含量,使产品更加稳定,效果最佳,比较适合用于皮肤。 After comparative experimental study, each of the herbal medicine ethanol was added to a coarse powder ratio I: 8, soaking time of 72 hours, more complete extract active ingredients, and less impurities, eluting macroporous resin concentration of ethanol is 70% Extract after purification macroporous resin, removal of starch, pectin and other impurities to improve the active content, make the product more stable, the best, better suited for skin.

[0053] 体外抑制酪氨酸酶试验 [0053] In vitro tyrosinase inhibition test

[0054] 实验方法 [0054] Experimental Method

[0055] 实验材料 [0055] Experimental Materials

[0056] L-酪氨酸溶液(0. 5mg/mL),酪氨酸酶(100U/ml),复合美白淡斑液。 [0056] L- tyrosine solution (0. 5mg / mL), tyrosinase (100U / ml), the composite Whitening liquid.

[0057] 2、仪器: [0057] 2, the instrument:

[0058] IOml试管,水浴锅,振荡器,紫外分光度计。 [0058] IOml tube, water bath, an oscillator, an ultraviolet photometer points.

[0059] 3、试验方法: [0059] 3, Test Method:

[0060] ①将实施例4所得复合美白淡斑液加去离子水稀释成0. 1%,0. 2%,0. 4%,0.6%,0.8%,1%的溶液,按文献方法测定稀释液的抑制酪氨酸酶活性。 [0060] ① The compound obtained in Example 4 Whitening was diluted with deionized water to 0.1%, 0.2%, 0.4%, 0.6%, 0.8%, 1% solution, measured by literature methods inhibit tyrosinase activity diluent. 该文献是:任清、于晓艳等在2008年03期的《香料香精化妆品》中发表的《微生物酵素美白抗衰老功效研究》; This document is: either clear, in Xiaoyan and other "microbial enzyme whitening anti-aging efficacy studies" published in 2008, 03 of the "Fragrance Flavor and Cosmetic" in;

[0061] 4、实验结果 [0061] 4, the experimental results

[0062] 美白淡斑液抑制酪氨酸酶测定结果 [0062] Whitening was tyrosinase inhibition assay results

[0063] [0063]

Figure CN102247446BD00071

[0064] 以上对本发明实施例所提供的技术方案进行了详细介绍,本文中应用了具体个例对本发明实施例的原理以及实施方式进行了阐述,以上实施例的说明只适用于帮助理解本发明实施例的原理;同时,对于本领域的一般技术人员,依据本发明实施例,在具体实施方式以及应用范围上均会有改变之处,综上所述,本说明书内容不应理解为对本发明的限制。 Described in detail describes the technical solution provided in [0064] the above embodiment of the present invention herein apply the principle of specific examples of embodiments of the present invention and embodiments are set forth in the above embodiments apply only to aid in understanding the present invention the principles of the embodiment; the same time, those of ordinary skill in the art, according to embodiments of the present invention, may make modifications at specific embodiments and application scope, Therefore, the specification shall not be construed as the present invention limits.

Claims (6)

  1. 1. 一种复合淡斑液,其特征在于其原料重量份数为: 中药活性部位提取物2. 5-25、熊果苷0. 5-5、透明质酸钠0. 05-0. 2、大豆发酵提取液5-10、1,3- 丁ニ醇1-10、丙ニ醇1-10、吐温-800. 2-0. 8、尼泊金甲酷0. 1-0. 4、尼泊金丙酷0. 1-0. 4、こ醇0. 5-5 和去离子水33. 2-89. 05 ; 其中,所述中药活性部位提取物的原料重量份数为: 人參5-15、黄芪5-20、白芍5-25、甘草5_30、芙蓉花5_35。 A composite Blemish liquid, characterized in that it is a raw material by weight: active extracts of Chinese medicine 2. 5-25, 5-5 0. arbutin, sodium hyaluronate 0. 05-02. , fermented soybean extract 5-10,1,3- butyl alcohol 1-10 ni, ni propan-1-10 alcohol, Tween -800. 2-0. 8, Kap cool paraben 0. 1-0. 4 . paraben, propyl cool 0. 1-04, 5-5 and ko alcohol 0.5 33. 2-8905 deionized water; wherein the active site of herbal extracts as starting materials in parts by weight: ginseng 5-15, astragalus 5-20 5-25 peony, licorice 5_30, 5_35 hibiscus flower.
  2. 2.根据权利要求I所述的复合淡斑液,其特征在于其原料的重量份数为: 中药活性部位提取物20、熊果苷5、透明质酸钠0. I、大豆发酵提取液5、1,3- 丁ニ醇5、丙ニ醇3、吐温-800. 4、尼泊金甲酷0. 2、尼泊金丙酷0. I、こ醇4、去离子水57. 2 ; 其中,所述中药活性部位提取物的原料重量份数为: 人參5、黄芪10、白芍20、甘草10、芙蓉花10。 The composite Blemish liquid I according to claim, characterized in that the weight parts of the starting material is: Herbal extracts of 20 active, 5 arbutin, sodium hyaluronate of 0. The I, fermented soybean extract 5 , 1,3-5-ol ni, ni propan-3-ol, Tween -800. 4, Kap cool paraben 0.2 paraben, propyl cool 0. I, 4 ko alcohol, deionized water 57.2 ; wherein the active material by weight of the extracts of Chinese medicine are: 5 ginseng, astragalus 10, peony 20, licorice 10, 10 hibiscus flower.
  3. 3. 一种复合美白祛斑液的制作方法,其特征在于包括以下步骤: (1)中药活性部位提取物的提取纯化方法为: 将人參5-15份、黄芪5-20份、白芍5-25份、甘草5_30份、以及芙蓉花5_35份的中药活性部位提取物原料按照I : 5到I : 10的药物和溶剂比例浸泡于浓度为30%〜85%こ醇中,浸泡时间为24-96小时; 然后滤过,将滤液于50°C _80°C减压回收こ醇至无醇味后,加2-5倍量水稀释,再上树脂型号为DlOl或AB-8的大孔树脂柱水洗到无色后,再用20% -80%こ醇洗脱到洗脱液无色,并收集こ醇洗脱液,再于50°C-80°C减压回收こ醇至药液与药材比为I : 2〜I : 10,制得中药活性部位提取物; (2)将所述中药活性部位提取物2. 5-25份、熊果苷0. 5-5份、透明质酸钠0. 05-0. 2份、I,3-丁ニ醇1-10份、丙ニ醇1-10份、以及大豆发酵提取液5-10份加入到20-40份去离子水中,在加料过程中一边加料一边搅拌, 3. A method for manufacturing a composite liquid whitening, comprising the steps of: extracting purification method was (1) the active site is extracted as a medicine: 5-15 parts of ginseng, 5-20 parts astragalus, peony 5- 25 parts, parts of liquorice 5_30, 5_35 parts and hibiscus flower extracts of Chinese medicine active material according to I:. 5 to I: drug and soaked in solvent ratio 10 ~ 85% concentration of 30% alcohol ko, a soak time of 24- 96 hours; then filtered, the filtrate under reduced pressure at 50 ° C _80 ° C ko recovered after the alcohol to no alcohol flavor, add 2-5 times the amount of dilution water, and then the resin model DlOl or AB-8 macroporous resin after washing the column as a colorless, with 20% -80% alcohol ko colorless eluate eluted, and the eluate collected ko alcohol, and then at 50 ° C-80 ° C under reduced pressure to recover the alcohol liquid ko Radix ratio of I: 2~I: 10, to prepare an active site medicine extract; (2) the active extracts of Chinese medicine 2. 5-25, 0. 5-5 parts by arbutin, hyaluronic sodium 0. 05-0. 2 parts, I, 3- butyl alcohol 1-10 parts by ni, ni propyl alcohol 10 parts, and the fermented soy extract is added to 5-10 parts 20 to 40 parts of deionized water, in addition while stirring during the addition, 在加料结束之后再搅拌10-20分钟; (3)再加入尼泊金甲酯0. 1-0. 4份、吐温-80 0. 2-0. 8份、尼泊金丙酯0. 1-0. 4份和こ醇0. 5-5份的混合物,再加入去离子水至总量达到100份,并充分搅拌均匀; (4)紫外线灭菌40-60分钟,静置6-48小时,取上清液即得成品。 After the end of the addition and then stirred for 10-20 min; (3) further Jiaru Ni Methylparaben 0. 1-04 parts of Tween-80 0. 2-08 parts, propyl paraben 0. 0. 5-5 parts of a mixture of 1-04 parts of an alcohol and ko, then deionized water was added to 100 parts of the total amount, and stir uniformly; (4) UV sterilized for 40-60 minutes, allowed to stand 6- 48 hours, the supernatant derived products.
  4. 4.如权利要求3复合美白淡斑液的制作方法,其特征在于: 在所述步骤(I)之前还包括将所述中药活性部位提取物原料粉碎成粗粉的步骤。 4. A method of manufacturing a composite 3 Whitening liquid claim, wherein: prior to said step (I) further comprises said herbal extracts of active material into the step of pulverizing coarse powder.
  5. 5.根据权利要求3或4所述的复合美白祛斑液的制作方法,其特征在于: 所述步骤(I)中的用于浸泡中药活性部位提取物原料的こ醇浓度为60%,所述中药活性部位提取物原料与こ醇比例为I : 8,所述浸泡时间为48小时。 The manufacturing method of claim 3 or 4 skin lightening compound according to claim liquid, wherein: said step (I) is used ko extract feedstock alcohol concentration of 60% active site soaking medicine, the Chinese medicine extracts of active material and ko alcohol ratio I: 8, the soaking time is 48 hours.
  6. 6.根据权利要求3或4所述的复合美白祛斑液的制作方法,其特征在于: 所述步骤(I)中用于洗脱的こ醇浓度为70%。 6. A method of manufacturing a composite according to 3 or 4 whitening liquid according to claim, wherein: said step (I) for the elution ko alcohol concentration of 70%.
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