CN102245758A - 增强造血干细胞植入过程的材料和方法 - Google Patents
增强造血干细胞植入过程的材料和方法 Download PDFInfo
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- CN102245758A CN102245758A CN2009801495225A CN200980149522A CN102245758A CN 102245758 A CN102245758 A CN 102245758A CN 2009801495225 A CN2009801495225 A CN 2009801495225A CN 200980149522 A CN200980149522 A CN 200980149522A CN 102245758 A CN102245758 A CN 102245758A
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Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710777354.0A CN107630001A (zh) | 2008-11-06 | 2009-11-06 | 增强造血干细胞植入过程的材料和方法 |
| CN201810232658.3A CN108379292A (zh) | 2008-11-06 | 2009-11-06 | 增强造血干细胞植入过程的材料和方法 |
| CN201710777353.6A CN107523587A (zh) | 2008-11-06 | 2009-11-06 | 增强造血干细胞植入过程的材料和方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11201808P | 2008-11-06 | 2008-11-06 | |
| US61/112,018 | 2008-11-06 | ||
| PCT/US2009/063654 WO2010054271A1 (en) | 2008-11-06 | 2009-11-06 | Materials and methds to enhance hematopoietic stem cells engraftment procedures |
Related Child Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710777354.0A Division CN107630001A (zh) | 2008-11-06 | 2009-11-06 | 增强造血干细胞植入过程的材料和方法 |
| CN201810232658.3A Division CN108379292A (zh) | 2008-11-06 | 2009-11-06 | 增强造血干细胞植入过程的材料和方法 |
| CN201710777353.6A Division CN107523587A (zh) | 2008-11-06 | 2009-11-06 | 增强造血干细胞植入过程的材料和方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102245758A true CN102245758A (zh) | 2011-11-16 |
Family
ID=42153284
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009801495225A Pending CN102245758A (zh) | 2008-11-06 | 2009-11-06 | 增强造血干细胞植入过程的材料和方法 |
| CN201710777354.0A Pending CN107630001A (zh) | 2008-11-06 | 2009-11-06 | 增强造血干细胞植入过程的材料和方法 |
| CN201710777353.6A Pending CN107523587A (zh) | 2008-11-06 | 2009-11-06 | 增强造血干细胞植入过程的材料和方法 |
| CN201810232658.3A Pending CN108379292A (zh) | 2008-11-06 | 2009-11-06 | 增强造血干细胞植入过程的材料和方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710777354.0A Pending CN107630001A (zh) | 2008-11-06 | 2009-11-06 | 增强造血干细胞植入过程的材料和方法 |
| CN201710777353.6A Pending CN107523587A (zh) | 2008-11-06 | 2009-11-06 | 增强造血干细胞植入过程的材料和方法 |
| CN201810232658.3A Pending CN108379292A (zh) | 2008-11-06 | 2009-11-06 | 增强造血干细胞植入过程的材料和方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (5) | US9107909B2 (https=) |
| EP (3) | EP3031907B1 (https=) |
| JP (5) | JP5846915B2 (https=) |
| CN (4) | CN102245758A (https=) |
| AU (4) | AU2009313290B2 (https=) |
| CA (3) | CA2742876C (https=) |
| ES (1) | ES2845641T3 (https=) |
| PT (1) | PT3031907T (https=) |
| WO (1) | WO2010054271A1 (https=) |
| ZA (1) | ZA201804932B (https=) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104066837A (zh) * | 2011-12-02 | 2014-09-24 | 菲特治疗公司 | 增强的干细胞组合物 |
| CN108220246A (zh) * | 2011-09-30 | 2018-06-29 | 蓝鸟生物公司 | 用于改善病毒转导的化合物 |
| CN114040967A (zh) * | 2018-10-31 | 2022-02-11 | 能源环境与技术研究中心(Ciemat) | 造血干细胞移植后恢复及促进恢复的改进 |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101441843B1 (ko) | 2005-10-18 | 2014-09-17 | 내셔날 쥬이쉬 헬스 | 조건부 불멸화 장기 줄기 세포 및 상기 세포의 제조 및 사용 방법 |
| EP2285832B1 (en) | 2008-05-16 | 2020-08-26 | Taiga Biotechnologies, Inc. | Antibodies and processes for preparing the same |
| EP2318435B1 (en) | 2008-08-28 | 2015-12-23 | Taiga Biotechnologies, Inc. | Modulators of myc, methods of using the same, and methods of identifying agents that modulate myc |
| PT3031907T (pt) | 2008-11-06 | 2021-01-28 | Univ Indiana Res & Tech Corp | Materiais e métodos para melhorar procedimentos de enxerto de células estaminais hematopoiéticas |
| US10813917B2 (en) | 2009-12-11 | 2020-10-27 | Medregen, Llc | Treatment methods utilizing stem cell mobilizers and immunosuppressive agents |
| EP2603227B1 (en) * | 2010-08-12 | 2017-10-04 | Fate Therapeutics, Inc. | Improved hematopoietic stem and progenitor cell therapy |
| EA033717B1 (ru) * | 2011-01-13 | 2019-11-19 | Scipharm Sarl | Способ ex vivo предварительной обработки гемопоэтических стволовых клеток и фармацевтическая композиция для улучшения приживления гемопоэтических стволовых клеток |
| US10111907B2 (en) * | 2011-12-02 | 2018-10-30 | Fate Therapeutics, Inc. | Methods of treating ischemia |
| WO2013130499A1 (en) * | 2012-02-29 | 2013-09-06 | University Of Virginia Patent Foundation | Compositions and methods for cxcr4 signaling and umbilical cord blood stem cell engraftment |
| WO2014015318A1 (en) * | 2012-07-19 | 2014-01-23 | Bluebird Bio, Inc. | Soluble compounds for improved gene therapy methods |
| JP6285930B2 (ja) * | 2012-07-20 | 2018-02-28 | タイガ バイオテクノロジーズ,インク. | 造血コンパートメントの再構築及び自家再構築の増進 |
| US20150216903A1 (en) * | 2012-08-10 | 2015-08-06 | Bluebird Bio, Inc. | Compounds for improved viral transduction |
| JP2016516672A (ja) | 2013-02-28 | 2016-06-09 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 幹細胞を動員するための方法および組成物 |
| US10272115B2 (en) | 2013-03-11 | 2019-04-30 | Taiga Biotechnologies, Inc. | Production and use of red blood cells |
| US9943545B2 (en) | 2013-03-15 | 2018-04-17 | Fate Therapeutics, Inc. | Stem cell culture media and methods of enhancing cell survival |
| US10851412B2 (en) | 2013-03-15 | 2020-12-01 | Fate Therapeutics, Inc. | Cell potency assay for therapeutic potential |
| DK3030232T3 (da) | 2013-04-29 | 2022-10-10 | Medregen Llc | Sårheling via autolog stamecellemobilisering |
| KR101489861B1 (ko) * | 2013-05-07 | 2015-02-05 | 경북대학교 산학협력단 | Amd3100을 포함하는 골질환 예방 또는 치료용 조성물 |
| US20180112180A1 (en) | 2015-01-26 | 2018-04-26 | Fate Therapeutics, Inc. | Cells with increased immuno-regulatory properties and methods for their use and manufacture |
| CN104774806B (zh) * | 2015-04-09 | 2019-02-15 | 广州赛莱拉干细胞科技股份有限公司 | 一种胎盘造血干细胞的制备方法 |
| RU2018106515A (ru) | 2015-07-21 | 2019-08-21 | Зе Чилдрен'С Медикал Сентер Корпорейшн | Pd-l1-экспрессирующие гемопоэтические стволовые клетки и применения |
| WO2017139576A1 (en) | 2016-02-12 | 2017-08-17 | Bluebird Bio, Inc. | Vcn enhancer compositions and methods of using the same |
| WO2017139561A1 (en) | 2016-02-12 | 2017-08-17 | Bluebird Bio, Inc. | Vcn enhancer compositions and methods of using the same |
| JP2019507596A (ja) * | 2016-02-26 | 2019-03-22 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 生着性の高い造血幹細胞 |
| US20200224165A1 (en) * | 2016-07-22 | 2020-07-16 | Senlin Li | Methods and compositions for rejuvenation |
| KR20190092472A (ko) | 2016-12-02 | 2019-08-07 | 타이가 바이오테크놀로지스, 인코포레이티드 | 나노입자 제제 |
| JP7175277B2 (ja) * | 2017-01-27 | 2022-11-18 | チルドレンズ ホスピタル メディカル センター | 造血幹細胞の生着活性を向上させる方法 |
| US10149898B2 (en) | 2017-08-03 | 2018-12-11 | Taiga Biotechnologies, Inc. | Methods and compositions for the treatment of melanoma |
| US11213546B2 (en) | 2017-09-07 | 2022-01-04 | Emory University | Methods to mobilize tissue resident cells for adoptive t cell therapy |
| WO2019060708A1 (en) | 2017-09-22 | 2019-03-28 | The Children's Medical Center Corporation | TREATMENT OF TYPE 1 DIABETES AND AUTOIMMUNE DISEASES OR DISORDERS |
| FR3074189A1 (fr) * | 2017-11-30 | 2019-05-31 | Assistance Publique - Hopitaux De Paris | Methode de generation de greffons de cellules souches hematopoietiques |
| CN108404112B (zh) * | 2018-04-01 | 2020-05-12 | 北京诺赛启研再生医学研究院有限公司 | 提高造血干细胞归巢及植入率的方法及其试剂 |
| WO2020210231A1 (en) | 2019-04-08 | 2020-10-15 | Taiga Biotechnologies, Inc. | Compositions and methods for the cry opreservation of immune cells |
| EP3969041A4 (en) | 2019-05-14 | 2023-05-10 | Taiga Biotechnologies, Inc. | COMPOSITIONS AND METHODS FOR TREATMENT OF T-CELL DEPLETION |
| EP4129911A4 (en) | 2020-03-31 | 2023-10-04 | Denka Company Limited | Alumina powder, resin composition, and heat dissipation component |
| CN116509834B (zh) * | 2023-01-20 | 2025-05-13 | 东北师范大学 | 化合物在制备造血干/祖细胞增殖和损伤修复药物中的应用 |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030215452A1 (en) * | 2002-02-04 | 2003-11-20 | Millennium Pharmaceuticals, Inc. | Methods and compositions for treating hematological disorders using 131, 148, 199, 12303, 13906, 15513, 17822, 302, 5677, 194, 14393, 28059, 7366, 12212, 1981, 261, 12416, 270, 1410, 137, 1871, 13051, 1847, 1849, 15402, 340, 10217, 837, 1761, 8990 or 13249 molecules |
| US20050163760A1 (en) * | 2001-12-06 | 2005-07-28 | Nathalie Cartier-Lacave | Use of cd34+ hematopoietic progenitor cells for the treatment of cns disorders |
| US20070087988A1 (en) * | 2005-09-30 | 2007-04-19 | New York University | Hematopoietic progenitor kinase 1 for modulation of an immune response |
| WO2008073748A1 (en) * | 2006-12-08 | 2008-06-19 | University Of Rochester | Expansion of hematopoietic stem cells |
| US20080207584A1 (en) * | 2004-06-23 | 2008-08-28 | Ono Pharmaceutical Co., Ltd. | Compound Having S1P Receptor Binding Potency and Use Thereof |
| US20080261922A1 (en) * | 2005-10-14 | 2008-10-23 | Carley David W | Pharmacological Treatments for Sleep Disorders (Apnoe) With Prostanoid Receptor Antagonists |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5399493A (en) * | 1989-06-15 | 1995-03-21 | The Regents Of The University Of Michigan | Methods and compositions for the optimization of human hematopoietic progenitor cell cultures |
| JPH08205860A (ja) * | 1994-01-21 | 1996-08-13 | Usa Government | 造血細胞の膨大化および移植方法 |
| US5928638A (en) * | 1996-06-17 | 1999-07-27 | Systemix, Inc. | Methods for gene transfer |
| EP1438075A4 (en) * | 2001-10-02 | 2006-04-19 | Inst Clayton De La Rech | METHOD AND COMPOSITIONS ASSOCIATED WITH LENTIVIRAL VECTORS WITH LIMITED EXPRESSION AND ITS APPLICATIONS |
| AU2004227205B2 (en) | 2003-04-08 | 2010-06-10 | Yeda Research And Development Co. Ltd | Stem cells having increased sensitivity to a chemoattractant and methods of generating and using same |
| IL158868A0 (en) | 2003-11-13 | 2004-05-12 | Yeda Res & Dev | Methods of generating and using stem cells enriched with immature primitive progenitor |
| US20080021078A1 (en) | 2006-07-18 | 2008-01-24 | Horizon Therapeutics, Inc. | Methods and medicaments for administration of ibuprofen |
| JP2007099724A (ja) | 2005-10-06 | 2007-04-19 | Shizuoka Prefecture | スルファチドを標的とした抗ウイルス剤 |
| EP3424507A1 (en) | 2006-03-24 | 2019-01-09 | Children's Medical Center Corporation | Method to modulate hematopoietic stem cell growth |
| EP2049129B1 (en) | 2006-06-22 | 2013-06-12 | Yeda Research And Development Co., Ltd. | Catecholamine receptor modulation |
| EP2679221B1 (en) | 2006-10-20 | 2020-09-23 | Children's Medical Center Corporation | Method to enhance tissue regeneration |
| US8598328B2 (en) | 2006-12-13 | 2013-12-03 | National University Corporation Nagoya University | Tol1 factor transposase and DNA introduction system using the same |
| PT3031907T (pt) | 2008-11-06 | 2021-01-28 | Univ Indiana Res & Tech Corp | Materiais e métodos para melhorar procedimentos de enxerto de células estaminais hematopoiéticas |
| EP2408444A4 (en) | 2009-03-19 | 2012-09-26 | Fate Therapeutics Inc | COMPOSITIONS WITH CYCLIC AMP AMPLIFIERS AND / OR EP LIGANDS, AND METHOD FOR THEIR PRODUCTION AND USE |
| PT2760994T (pt) | 2011-09-30 | 2017-08-24 | Bluebird Bio Inc | Compostos para melhor transdução viral |
-
2009
- 2009-11-06 PT PT161535265T patent/PT3031907T/pt unknown
- 2009-11-06 EP EP16153526.5A patent/EP3031907B1/en not_active Revoked
- 2009-11-06 JP JP2011534934A patent/JP5846915B2/ja not_active Expired - Fee Related
- 2009-11-06 CA CA2742876A patent/CA2742876C/en active Active
- 2009-11-06 EP EP20195600.0A patent/EP3824884A1/en not_active Withdrawn
- 2009-11-06 CN CN2009801495225A patent/CN102245758A/zh active Pending
- 2009-11-06 US US13/128,074 patent/US9107909B2/en active Active
- 2009-11-06 CA CA3012803A patent/CA3012803C/en active Active
- 2009-11-06 CN CN201710777354.0A patent/CN107630001A/zh active Pending
- 2009-11-06 CN CN201710777353.6A patent/CN107523587A/zh active Pending
- 2009-11-06 EP EP09825528.4A patent/EP2362733B1/en not_active Not-in-force
- 2009-11-06 CA CA3203374A patent/CA3203374A1/en active Pending
- 2009-11-06 AU AU2009313290A patent/AU2009313290B2/en not_active Ceased
- 2009-11-06 ES ES16153526T patent/ES2845641T3/es active Active
- 2009-11-06 WO PCT/US2009/063654 patent/WO2010054271A1/en not_active Ceased
- 2009-11-06 CN CN201810232658.3A patent/CN108379292A/zh active Pending
-
2014
- 2014-06-27 US US14/318,167 patent/US10213460B2/en active Active
-
2015
- 2015-03-04 US US14/638,676 patent/US9675641B2/en not_active Expired - Fee Related
- 2015-07-03 JP JP2015134076A patent/JP6632822B2/ja not_active Expired - Fee Related
-
2016
- 2016-07-21 AU AU2016206316A patent/AU2016206316C1/en not_active Ceased
-
2017
- 2017-05-11 US US15/592,375 patent/US11241454B2/en not_active Expired - Fee Related
- 2017-10-05 JP JP2017195168A patent/JP2018048156A/ja not_active Withdrawn
-
2018
- 2018-07-23 ZA ZA2018/04932A patent/ZA201804932B/en unknown
- 2018-10-08 AU AU2018241208A patent/AU2018241208B2/en not_active Ceased
-
2019
- 2019-11-29 JP JP2019217044A patent/JP2020063263A/ja not_active Withdrawn
-
2020
- 2020-08-21 AU AU2020220191A patent/AU2020220191B2/en not_active Ceased
-
2021
- 2021-12-14 US US17/550,737 patent/US20220313735A1/en not_active Abandoned
-
2023
- 2023-01-06 JP JP2023001015A patent/JP2023052244A/ja active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050163760A1 (en) * | 2001-12-06 | 2005-07-28 | Nathalie Cartier-Lacave | Use of cd34+ hematopoietic progenitor cells for the treatment of cns disorders |
| US20030215452A1 (en) * | 2002-02-04 | 2003-11-20 | Millennium Pharmaceuticals, Inc. | Methods and compositions for treating hematological disorders using 131, 148, 199, 12303, 13906, 15513, 17822, 302, 5677, 194, 14393, 28059, 7366, 12212, 1981, 261, 12416, 270, 1410, 137, 1871, 13051, 1847, 1849, 15402, 340, 10217, 837, 1761, 8990 or 13249 molecules |
| US20080207584A1 (en) * | 2004-06-23 | 2008-08-28 | Ono Pharmaceutical Co., Ltd. | Compound Having S1P Receptor Binding Potency and Use Thereof |
| US20070087988A1 (en) * | 2005-09-30 | 2007-04-19 | New York University | Hematopoietic progenitor kinase 1 for modulation of an immune response |
| US20080261922A1 (en) * | 2005-10-14 | 2008-10-23 | Carley David W | Pharmacological Treatments for Sleep Disorders (Apnoe) With Prostanoid Receptor Antagonists |
| WO2008073748A1 (en) * | 2006-12-08 | 2008-06-19 | University Of Rochester | Expansion of hematopoietic stem cells |
Non-Patent Citations (1)
| Title |
|---|
| 高立艳等: "G_CSF和GM_CSF动员小鼠造血干_祖细胞过程中对外周血T淋巴细胞亚群的影响", 《徐州医学院学报》 * |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108220246A (zh) * | 2011-09-30 | 2018-06-29 | 蓝鸟生物公司 | 用于改善病毒转导的化合物 |
| CN108220246B (zh) * | 2011-09-30 | 2022-07-12 | 蓝鸟生物公司 | 用于改善病毒转导的化合物 |
| CN104066837A (zh) * | 2011-12-02 | 2014-09-24 | 菲特治疗公司 | 增强的干细胞组合物 |
| CN104066837B (zh) * | 2011-12-02 | 2020-12-08 | 菲特治疗公司 | 增强的干细胞组合物 |
| CN112375734A (zh) * | 2011-12-02 | 2021-02-19 | 菲特治疗公司 | 增强的干细胞组合物 |
| CN112410298A (zh) * | 2011-12-02 | 2021-02-26 | 菲特治疗公司 | 增强的干细胞组合物 |
| CN114040967A (zh) * | 2018-10-31 | 2022-02-11 | 能源环境与技术研究中心(Ciemat) | 造血干细胞移植后恢复及促进恢复的改进 |
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