CN102225102B - 一种用于治疗风湿性关节炎的药酒 - Google Patents
一种用于治疗风湿性关节炎的药酒 Download PDFInfo
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Abstract
本发明提供了一种治疗风湿性关节炎的药酒，它主要是将防己、威灵仙、全蝎、乌梢蛇、黄芪、当归、地鳖虫、甘草等中草药除杂、清洗后，放入40-60度白酒中浸泡10-20天后过滤而成。该药酒治疗风湿性关节炎快速有效，不易复发，配方简单，成本低廉，容易生产，适合大部分风湿性关节炎病患者的需要。
Description
技术领域
本发明涉及中药技术领域，具体涉及一种治疗风湿性关节炎的中草药药酒。
背景技术
风湿性关节炎(rheumatoid arthritis)是一种常见的急性或慢性结缔组织炎症。可反复发作并累及心脏。临床一以关节和肌肉游走性酸楚、重著、疼痛为特征。属变态反应性疾病。是风湿热的主要表现之一，多以急性发热及关节疼痛起病。风湿热起病急，且多见于青少年。风湿性关节炎可侵犯心脏，引起风湿性心脏病，并有发热、皮下结节和皮疹等表现。风湿性关节炎有两个特点：一是关节红、肿、热、痛明显，不能活动，发病部位常常是膝、髋、踝等下肢大关节，其次是肩、肘、腕关节，手足的小关节少见；二是疼痛游走不定，一段时间是这个关节发作，一段时间是那个关节不适，但疼痛持续时间不长，几天就可消退。血化验血沉加快，抗滴度升高，类风湿因子阴性。治愈后很少复发，关节不留畸形，有的病人可遗留心脏病变。
中医认为发病原因和发病过程大体有：外感六淫之邪，风寒湿邪闭阻经络和关节，不通则痛，故而引起关节肿胀疼痛。营气卫血失调，营卫不和，邪气乘虚而入，致风湿病发作。脏腑阴阳内伤，阴阳不平衡，出现偏盛偏衰，受到邪气侵入，发生风湿病的热与寒的症状表现。痰浊疲血内生：病邪由表入里，由轻而重，导致脏腑功能失调，而脏腑功能失调的结果就产生痰浊与癖血，这些就是风湿病情缠绵而难治的根本原因。对于风湿性关节炎治疗，一般分为西药解痛、外用药舒筋活络止痛。如用水杨酸制剂和非类固醇制剂以缓解疼痛，消除炎症，控制风湿活动。用狗皮膏药祛风散寒除湿，舒筋活络止痛。此外还有追风膏等。由于“治标不治本”，且停药后易复发，故对风湿性关节炎的治疗一般认为没有特效药。
患病率高，复发率高是风湿性关节炎疾病的主要特点，同时反映出风湿性关节炎疾病治疗药物市场的需求巨大。中成药已经在风湿性关节炎疾病用药市场占有重要地位，因为中成药副作用小，疗效确切，适用于长期用药，适应了风湿性关节炎疾病容易复发的特点，临床应用非常广泛。
发明内容
发明目的：为了解决上述问题，本发明的目的在于提供一种可治疗风湿性关节炎病的药酒。
技术方案：本发明的目的是通过如下的方案实现的：
一种用于治疗风湿性关节炎的药酒，它所含的活性成分由下列重量份原料配比制备而成：防己6-12份、威灵仙4-8份、全蝎3-5份、乌梢蛇8-16份、黄芪25-35份、当归8-16份、地鳖虫4-8份和甘草3-7份，将上述药材除杂、清洗后，放入500-1500份40-60度白酒中浸泡10-20天，滤去药渣即得药酒。
一种用于治疗风湿性关节炎的药酒，它所含的活性成分由下列重量份原料配比制备而成：防己9份、威灵仙6份、全蝎4份、乌梢蛇12份、黄芪30份、当归12份、地鳖虫6份和甘草5份，将上述药材除杂、清洗后，放入1000份50度白酒中浸泡15天，滤去药渣即得药酒。
本发明中木防己为防己科木防己属植物木防己Coculus trilobus(Thunb.)DC.的根。春秋采挖，洗净，切片，晒干。性苦、辛，寒。具有祛风止痛，利尿消肿，解毒，降血压功能。用于风湿关节痛，肋间神经痛，急性肾炎，尿路感染，高血压病，风湿性心脏病，水肿；外用治毒蛇咬伤。
威灵仙为双子叶植物毛茛科Ranunculaceae威灵仙Clematis chinensis Osbeck的干燥根及根茎。辛咸，温。能祛风除湿，通络止痛，消痰水，散癖积。主治痛风顽痹、风湿痹痛，肢体麻木，腰膝冷痛，筋脉拘挛，屈伸不利，脚气，疟疾，症瘕积聚，破伤风，扁桃体炎，诸骨鲠咽。
全蝎为钳蝎科动物东亚钳蝎Buthus martensii Karsch的干燥体。春末至秋初捕捉，除去泥沙，置沸水或沸盐水中，煮至全身僵硬，捞出，置通风处，阴干。性辛，平，归肝经。能息风镇痉，攻毒散结，通络止痛。用于小儿惊风，抽搐痉挛，中风口歪，半身不遂，破伤风，风湿顽痹，偏正头痛，疮疡，瘰疬。
乌梢蛇为脊索动物门游蛇科动物乌梢蛇Zaocys dhumnades(Cantor)除去内脏的干燥体。性甘，平。归肝经。能祛风，通络，止痉。用于风湿顽痹，麻木拘挛，中风口眼歪斜，半身不遂，抽搐痉挛，破伤风，麻风疥癣，瘰疬恶疮。
黄芪为豆科植物蒙古黄芪Astragalus membranaceus(Fisch.)Bge.var.mongho-licus(Bge.)Hsiao的干燥根。性甘，温。归肺、脾经。能补气固表，利尿托毒，排脓，敛疮生肌。用于气虚乏力，食少便溏，中气下陷，久泻脱肛，便血崩漏，表虚自汗，气虚水肿，痈疽难溃，久溃不敛，血虚痿黄，内热消渴；慢性肾炎蛋白尿，糖尿病。
当归为伞形科植物当归Angelica sinensis(Oliv.)Diels的干燥根。秋末采挖，除去须根及泥沙，待水分稍蒸发后，捆成小把，上棚，用烟火慢慢熏干。性温，昧甘、辛。归肝、心、脾经。能补血活血，调经止痛，润肠通便。用于血虚萎黄、眩晕心悸、月经不调、经闭痛经、虚寒腹痛、肠燥便秘、风湿痹痛、跌扑损伤、痈疽疮疡。
地鳖虫为鳖蠊科昆虫地鳖Eupolyphagasinensis Walker的雌虫干燥体。捕捉后，置沸水中烫死，晒干或烘干。性咸，寒；归肝经。能破瘀血，续筋骨。用于筋骨折伤，瘀血经闭，症瘕痞块。
甘草为双子叶植物豆科Leguminosae甘草Glycyrrhiza uralensis Fisch.的根及根茎。补脾益气，清热解毒，祛痰止咳，缓急止痛，调和诸药。用于脾胃虚弱，倦怠乏力，心悸气短，咳嗽痰多，脘腹、四肢挛急疼痛，痈肿疮毒，缓解药物毒性、烈性。
有益效果：
1、从中医理论看，本方中木防己祛风止痛，威灵仙祛风除湿，通络止痛，两者为君药，全蝎息风镇痉，攻毒散结，通络止痛，乌梢蛇祛风，通络，止痉，两者为臣药，助君药通络之功，黄芪补气固表，当归补血活血，调经止痛，两者为佐药，提高君臣药祛风通络的作用，地鳖虫破瘀血，续筋骨，甘草调和诸药，两者为使药。诸药相合，共奏祛风止痛作用，用于治疗风湿性关节炎疾病。
2、本发明处方设计合理，配伍严谨，经长期的临床验证，疗效确切。
3、本发明组成为中药材，无毒副作用，价格便宜。
具体实施方式
以下通过实施例形式，对本发明的上述内容再作进一步的详细说明，但不应将此理解为本发明上述主题的范围仅限于以下的实例，凡基于本发明上述内容所实现的技术均属于本发明的范围。
1、结合具体实施方式，对本发明进一步说明如下：
按下表中所列重量配比称取本发明所需原料，单位：份
| 防己 | 威灵仙 | 全蝎 | 乌梢蛇 | 黄芪 | 当归 | 地鳖虫 | 甘草 | 白酒(度) | |
| 1 | 6 | 8 | 3 | 16 | 25 | 16 | 4 | 7 | 500(40) |
| 2 | 9 | 6 | 4 | 12 | 30 | 12 | 6 | 5 | 1000(50) |
| 3 | 12 | 4 | 5 | 8 | 35 | 8 | 8 | 3 | 1500(60) |
2.制备实施例
以上表中原料配比为例，包括以下步骤：
实施例1：防己6份、威灵仙8份、全蝎3份、乌梢蛇16份、黄芪25份、当归16份、地鳖虫4份和甘草7份，将上述药材除杂、清洗后，放入500份40度白酒中浸泡15天，滤去药渣即得药酒。
实施例2：防己9份、威灵仙6份、全蝎4份、乌梢蛇12份、黄芪30份、当归12份、地鳖虫6份和甘草5份，将上述药材除杂、清洗后，放入1000份50度白酒中浸泡15天，滤去药渣即得药酒。
实施例3：防己12份、威灵仙4份、全蝎5份、乌梢蛇8份、黄芪35份、当归8份、地鳖虫8份和甘草3份，将上述药材除杂、清洗后，放入1500份60度白酒中浸泡15天，滤去药渣即得药酒。
3.临床观察资料
样品制备：取防己9份、威灵仙6份、全蝎4份、乌梢蛇12份、黄芪30份、当归12份、地鳖虫6份和甘草5份，将上述药材除杂、清洗后，放入1000份50度白酒中浸泡15天，滤去药渣即得药酒。
本发明人对120例病例(试验组70例、对照组50例)临床观察，其中，男60例，女60例，年龄最小38岁，最大72岁，病程最长18年，最短者半年，平均7年。病例选择根据症状和医院检查确诊为风湿性关节炎的患者。其中，试验组70例，包括男40例、女30例，年龄最小35岁，最大72岁，病程最长19年，最短者半年，平均7.2年。对照组50例，包括男30例、女20例，年龄最小38岁，最大69岁，病程最长17.8年，最短者半年，平均6.7年。两组病例的病程、症状轻重程度等，综合平均后无显著性差异，各组之间有可比性。
试验组采用本发明之药物制得的药酒进行治疗，治疗时，用药方法为：每日服用3次，早、中、晚各一次，一次20mL，服药期间禁食生冷腥食物，连服2个月。对照组给国产布洛芬0.4g口服，每日三次，连服2个月。
两组病例均于用药后第1周、第2周、第1个月、第2个月观察主要症状和体征。
疗效的判断标准，采用Huskisson提出的百分计分法，即直观模拟疼痛标度尺(VAPS)，即用100毫米直线，一端为无痛，另一端为最疼。病人定期十该日的同一时间在线上标出疼痛的程度。结合临床实际，疗效分基本治愈、显效、有效和无效。疗效具体标准如下：
基本治愈：疼痛症状消失，VAPS小于20；
显效：疼痛症状明显减轻，VAPS在20-50间；
有效：疼痛症状减轻，VAPS在21-50间；
无效：疼痛症状减轻小明显，VAPS在80以上。
疗效情况一览表
| 组别 | 基本治愈 | 显效 | 有效 | 无效 | 总有效率 |
| 试验组 | 54 | 8 | 4 | 4 | 94.3％ |
| 对照组 | 16 | 20 | 2 | 12 | 76.0％ |
从上表可以看出，试验组的总有效率为94.3，对照组的总有效率为76.0％。试验组的有效率与对照组相比有明显效果。试验组的治愈率为77.1％，对照组的治愈率为32.0％。试验组的治愈率与对照组相比有显著性效果。
试验组中的治愈病例，半年、1年后分别作回访，均无复发。综上所述，木发明之药物的治疗效果明显优于对照组。
4.典型病例
病例1：张某，女40岁。来诊时腰肩及右腿疼痛麻木发凉7年余，尤以有骼关节、髋关节痛甚，遇冷加剧，晨起时疼痛加重，肢体活动不灵活，活动量逐渐减轻。化验：血沉42mm/h，X线显示无骨质改变，麻木感减轻，服用按本发明实施例2所述方法制备的药酒，两个月后症状完全消失，关节活动自如，血沉18mm/h，随访至今未复发。
病例2：王某，男58岁。全身关节疼痛反复发作已8年，肢体沉重，晨起僵硬，关节屈伸不利，遇冷加重。化验：血沉50mm/h，类风湿因子阴性。临床诊断：风湿性关节炎，证属寒温痹病，服用按本发明实施例2所述方法制备的药酒，30天后，关节疼痛减轻，连续坚持用药3个多月后，关节疼痛、晨起僵硬诸症消失，功能恢复，化验指标均正常。
病例3：金某，男48岁。患类风湿关节炎10年，四肢关节肿痛，指趾变形，颈部活动受限，十分痛苦。经市医院检查，血沉80mm/h，类风湿因子阳性(+)，长期服用激索，镇痛片等药，行走功能障碍、肌肉萎缩、痛苦不堪，服用按本发明实施例3所述方法制备的药酒，治疗两个月，病人症状明显减轻，又治疗两个月，血沉、类风湿因子恢复正常，全身关节疼痛好转，腰能直起来，病人临床治愈，随访两年未见复发。
Claims (3)
1.一种用于治疗风湿性关节炎的药酒，其特征在于，它所含的活性成分由下列重量份原料配比制备而成：防己6-12份、威灵仙4-8份、全蝎3-5份、乌梢蛇8-16份、黄芪25-35份、当归8-16份、地鳖虫4-8份和甘草3-7份，将上述药材除杂、清洗后，放入500-1500份40-60度白酒中浸泡10-20天，滤去药渣即得药酒。
2.一种用于治疗风湿性关节炎的药酒，其特征在于，它所含的活性成分由下列重量份原料配比制备而成：防己9份、威灵仙6份、全蝎4份、乌梢蛇12份、黄芪30份、当归12份、地鳖虫6份和甘草5份，将上述药材除杂、清洗后，放入1000份50度白酒中浸泡15天，滤去药渣即得药酒。
3.根据权利要求1或2所述用于治疗风湿性关节炎的药酒，其特征在于，所述防己为木防己。
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| Title |
|---|
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| 王国朗.动物药治疗类风湿性关节炎浅谈.《湖南中医杂志》.2000,第16卷(第04期),第50页. * |
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