CN102215608B - Nano heating agent used for tumor millimeter wave thermotherapy and preparation method thereof - Google Patents
Nano heating agent used for tumor millimeter wave thermotherapy and preparation method thereof Download PDFInfo
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- CN102215608B CN102215608B CN 201010148833 CN201010148833A CN102215608B CN 102215608 B CN102215608 B CN 102215608B CN 201010148833 CN201010148833 CN 201010148833 CN 201010148833 A CN201010148833 A CN 201010148833A CN 102215608 B CN102215608 B CN 102215608B
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- tumour
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Abstract
The invention relates to the technical field of biological and medical nano preparations and in particular relates to a nano heating agent used for a tumor millimeter wave thermotherapy and a preparation method thereof. The nano heating agent is composed of the following materials in percentage by weight: 25%-35% of alcohol, 10%-20% of glycerine, 10%-16% of stannic chloride, 10%-20% of silver chloride, 5%-10% of ferric oxide, 8.5%-10% of antimony chloride, 6%-10% of indium chloride and 5%-8% of boracic acid; and the materials are subjected to a series of processes, namely liquid medicine preparation, high-temperature spraying and filming and an aging test, so as to prepare the heating agent. The nano heating agent product provided by the invention can radiate heat after being powered on and can produce a millimeter wave to radiate a tumor area, thus having the advantages of tumor recurrence restraining, improved human immunity and obvious therapeutic effect.
Description
Technical field:
The present invention relates to biological and medical science nanometer formulation technical field, refer in particular to nanometer heater that a kind of tumour millimeter wave thermotherapy uses and preparation method thereof.
Background technology:
Current main method for oncotherapy has operation, radiotherapy, chemotherapy, biological therapy etc.Operative treatment is one of the most frequently used method of tumour for the treatment of at present, with the focus of mode tumor resection of operation, itself is difficult to bear wherein misery with regard to weak patient, can't guarantee to no longer include in the body focus fully; Next is radiation treatment, is that the effect that suppresses and treat is arranged to tumour, but the human body viscera physiological function is had very major injury, causes people's alopecia, symptoms such as apocleisis; Being exactly pyromagnetic resonance therapy in addition, the symptom for the treatment of tumour is distinguished disconnected very accurate, equipment is required the precision height, mainly is at the early stage patient of tumour etc.The whole bag of tricks has its indication and bad reaction, does not have fixing treatment pattern to follow to each concrete tumour person.Only adaptation of methods disease and the pluses and minuses of sure treatment are absorbed all the useful ideas and are correctly judged status of patient, the treatment procedure of science, and drug therapy and external physiotherapy could improve patient's quality of life to greatest extent, prolong life.Therefore, the high-tech product of developing a kind of comprehensive physiotherapy is applied in the oncotherapy, is the difficult problem that will solve in the medicine technology field urgent need.
Summary of the invention:
The invention provides nanometer heating film that a kind of tumour millimeter wave thermotherapy uses and preparation method thereof, have efficient solution and suppress tumor regrowth, improve body immunity, the tangible advantage of result for the treatment of.
In order to achieve the above object, realize by following proposal:
The nanometer heating film that a kind of tumour millimeter wave thermotherapy is used, formed by following raw materials by weight percent:
Alcohol 25%～35%
Glycerol 10%～20%
Stannic chloride 10%～16%
Silver chlorate 10%～20%
Iron oxide 5%～10%
Antimony chloride 8.5%～15%
Inidum chloride 6%～10%
Boric acid 5%～8%
Wherein, described alcohol is that purity is 99% alcohol.
Preferably, the nanometer that a kind of tumour millimeter wave thermotherapy is used is sent out film, is made up of following raw materials by weight percent:
Alcohol 30%～34%
Glycerol 10%～15%
Stannic chloride 10%～13%
Silver chlorate 10%～15%
Iron oxide 5%～8%
Antimony chloride 9%～10%
Inidum chloride 8%～10%
Boric acid 5%～8%.
More excellent, the nanometer heating film that a kind of tumour millimeter wave thermotherapy is used, formed by following raw materials by weight percent:
Alcohol 33%
Glycerol 10%
Stannic chloride 12%
Silver chlorate 15%
Iron oxide 6%
Antimony chloride 10%
Inidum chloride 8%
Boric acid 6%.
The preparation method of the nanometer heating film that a kind of tumour millimeter wave thermotherapy is used may further comprise the steps:
A, elder generation are poured on alcohol in the container, slowly add stannic chloride again, mix with glass bar and to make stannic chloride dissolving, again silver chlorate, iron oxide, antimony chloride, inidum chloride, boric acid are joined in the solution and stirs, add glycerol after the dissolving again and stir at last, made the liquid medicine that contains the various heavy medicament;
B, high temperature resistant flat panel substrates is put in high temperature furnace or the continuous tunnel furnace toasts, when making substrate surface temperature reach 600C °～800C °, press from both sides out with tool, the liquid medicine for preparing is taken advantage of in the low-pressure spray gun container, flat panel substrates is sprayed equably, be put into smooth place cooling then;
C, cooled tabular nanometer heating film is carried out burn-in test, connect with the mains and carry out the test of pulse interruption with exceeding 10% of normal voltage, be adjusted to the normal rating voltage detecting after 30 minutes, if power stability is qualified, namely obtain product nanometer heating film of the present invention.
During use, ready-made nanometer heating film is installed on the support of safe insulation of ready-made corresponding size, connect anticreep safety switch, again being equipped with below the doss that the nanometer sheet support is installed in the patient, the nanometer heating film energising back heating of installing, the generation millimeter wave is radiated tumor locus and gets final product through bedstead, the mattress of patient's doss.
Advantage of the present invention be no matter the patient be tumour in early days or late period, the nanometer heating film can both suppress diffusion and the growth of tumour cell, strengthens patient's immunity, the patient is as long as cooperate doctor's drug therapy, need not operate on the purpose that also can reach rehabilitation.
Embodiment:
The following examples can make those skilled in the art more fully understand the present invention, but do not limit the present invention in any way.
Embodiment 1:
The first step: (all component amounts to 100 parts with 33 parts of alcohol earlier, every part 100 gram, be poured in the molten device down together), slowly add 12 parts of stannic chlorides again, mix with glass bar and to make stannic chloride dissolving, again 15 parts of silver chlorates, 6 parts of iron oxide, 10 parts of antimony chlorides, 8 parts of inidum chlorides, 6 parts of boric acid are joined in the solution simultaneously and stir, add 10 parts of glycerol after the dissolving again and stir at last, made the liquid medicine that contains the various heavy medicament;
Second goes on foot: high temperature resistant flat panel substrates is put in high temperature furnace or the continuous tunnel furnace toasts, when making substrate surface temperature reach 700C °, press from both sides out with tool, the liquid medicine for preparing is taken advantage of in the low-pressure spray gun container, flat panel substrates is sprayed equably, be put into smooth place cooling then;
The 3rd step: cooled tabular nanometer heating film is carried out burn-in test, connect with the mains and carry out the test of pulse interruption with exceeding 10% of normal voltage, be adjusted to the normal rating voltage detecting after 30 minutes, if power stability is qualified, namely obtain product nanometer heating film of the present invention.
Embodiment 2:
The first step: (all component amounts to 100 parts with 34 parts of alcohol earlier, every part 100 gram, be poured in the molten device down together), slowly add 10 parts of stannic chlorides again, mix with glass bar and to make stannic chloride dissolving, again 12 parts of silver chlorates, 7 parts of iron oxide, 9 parts of antimony chlorides, 10 parts of inidum chlorides, 5 parts of boric acid are joined in the solution simultaneously and stir, add 13 parts of glycerol after the dissolving again and stir at last, made the liquid medicine that contains the various heavy medicament;
Second goes on foot: high temperature resistant flat panel substrates is put in high temperature furnace or the continuous tunnel furnace toasts, when making substrate surface temperature reach 750C °, press from both sides out with tool, the liquid medicine for preparing is taken advantage of in the low-pressure spray gun container, base material is sprayed equably, be put into smooth place cooling then;
The 3rd step: cooled tabular nanometer heating film is carried out burn-in test, connect with the mains and carry out the test of pulse interruption with exceeding 10% of normal voltage, be adjusted to the normal rating voltage detecting after 30 minutes, if power stability is qualified, namely obtain product nanometer heating film of the present invention.
Embodiment 3:
The first step: (all component amounts to 100 parts with 35 parts of alcohol earlier, every part 100 gram, be poured in the molten device down together), slowly add 15 parts of stannic chlorides again, mix with glass bar and to make stannic chloride dissolving, again 10 parts of silver chlorates, 5 parts of iron oxide, 9 parts of antimony chlorides, 6 parts of inidum chlorides, 5 parts of boric acid are joined in the solution simultaneously and stir, add 15 parts of glycerol after the dissolving again and stir at last, made the liquid medicine that contains the various heavy medicament;
Second goes on foot: high temperature resistant flat panel substrates is put in high temperature furnace or the continuous tunnel furnace toasts, when making substrate surface temperature reach 700C °, press from both sides out with tool, the liquid medicine for preparing is taken advantage of in the low-pressure spray gun container, base material is sprayed equably, be put into smooth place cooling then;
The 3rd step: cooled tabular nanometer heating film is carried out burn-in test, connect with the mains and carry out the test of pulse interruption with exceeding 10% of normal voltage, be adjusted to the normal rating voltage detecting after 30 minutes, if power stability is qualified, namely obtain product nanometer heating film of the present invention.
The nanometer heating film that embodiment 1-3 produces, during use, ready-made nanometer heating film is installed on the support of safe insulation of ready-made corresponding size, connect anticreep safety switch, again being equipped with below the doss that the nanometer sheet support is installed in the patient, the nanometer heating film energising back heating of installing, the generation millimeter wave is radiated tumor locus and gets final product through bedstead, the mattress of patient's doss.
In order to verify technique effect of the present invention, below be embodiment 1-3 in the technical indicator of clinical practice:
| Embodiment | 1 | 2 | 3 |
| Nanometer heating film surface particles average grain diameter | 51 nanometers | 52 nanometers | 50 nanometers |
| Nanometer heating film thickness | 256 nanometers | 256 nanometers | 256 nanometers |
| Application site | Thigh soft tissue top layer tumour | Early stage tumor of breast | Liver's tumour |
| Access times | 15 days, and cooperate traditional Chinese medical science drug therapy | 25 days, and cooperate traditional Chinese medical science drug therapy | 30 days, and cooperate traditional Chinese medical science drug therapy |
| Result for the treatment of | Dense swollen disappearing, walking freely | Swelling disappears | Patient's liver pain rises to feel and eliminates, in the rehabilitation |
Above content is preferred embodiment of the present invention only, and for those of ordinary skill in the art, according to thought of the present invention, the part that all can change in specific embodiments and applications, this description should not be construed as limitation of the present invention.
Claims (1)
1. nanometer heating film that tumour millimeter wave thermotherapy is used is characterized in that: be made up of following raw materials by weight percent:
Alcohol 25% ~ 35%
Glycerol 10% ~ 20%
Stannic chloride 10% ~ 16%
Silver chlorate 10% ~ 20%
Iron oxide 5% ~ 10%
Antimony chloride 8.5% ~ 15%
Inidum chloride 6% ~ 10%
Boric acid 5% ~ 8%
Wherein, described alcohol is that purity is 99% alcohol.
2, the nanometer heating film used of a kind of tumour millimeter wave thermotherapy according to claim 1 is characterized in that: be made up of following raw materials by weight percent:
Alcohol 30% ~ 34%
Glycerol 10% ~ 15%
Stannic chloride 10% ~ 13%
Silver chlorate 10% ~ 15%
Iron oxide 5% ~ 8%
Antimony chloride 9% ~ 10%
Inidum chloride 8% ~ 10%
Boric acid 5% ~ 8%.
3, the nanometer heating film used of a kind of tumour millimeter wave thermotherapy according to claim 1 is characterized in that: be made up of following raw materials by weight percent:
Alcohol 33%
Glycerol 10%
Stannic chloride 12%
Silver chlorate 15%
Iron oxide 6%
Antimony chloride 10%
Inidum chloride 8%
Boric acid 6%.
4, the preparation method of the nanometer heating film used of the described a kind of tumour millimeter wave thermotherapy of claim 1-3 is characterized in that: may further comprise the steps:
A, elder generation are poured on alcohol in the container, slowly add stannic chloride again, mix with glass bar and to make tin dissolving, again silver chlorate, iron oxide, antimony chloride, inidum chloride, boric acid are joined in the solution and stirs, add glycerol after the dissolving again and stir at last, made the liquid medicine that contains the various heavy medicament;
B, high temperature resistant flat panel substrates is put in high temperature furnace or the continuous tunnel furnace toasts, when making substrate surface temperature reach 600C ° ~ 800 C °, press from both sides out with tool, the liquid medicine for preparing is taken advantage of in the low-pressure spray gun container, flat panel substrates is sprayed equably, be put into smooth place cooling then;
C, cooled tabular nanometer heating film is carried out burn-in test, connect with the mains and carry out the test of pulse interruption with exceeding 10% of normal voltage, be adjusted to the normal rating voltage detecting after 30 minutes, if power stability is qualified, namely obtain product nanometer heating film of the present invention.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN 201010148833 CN102215608B (en) | 2010-04-10 | 2010-04-10 | Nano heating agent used for tumor millimeter wave thermotherapy and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN 201010148833 CN102215608B (en) | 2010-04-10 | 2010-04-10 | Nano heating agent used for tumor millimeter wave thermotherapy and preparation method thereof |
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| CN102215608A CN102215608A (en) | 2011-10-12 |
| CN102215608B true CN102215608B (en) | 2013-07-03 |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0040512A1 (en) * | 1980-05-19 | 1981-11-25 | Corning Glass Works | Ceramic suitable for inducing localised heating in the presence of a radio frequency magnetic field, and use thereof |
| CN1640498A (en) * | 2004-01-12 | 2005-07-20 | 中国科学院上海应用物理研究所 | Magnetic nano radioactive medicine and its preparing method |
| CN1712488A (en) * | 2005-07-15 | 2005-12-28 | 东南大学 | Production of nanometer heater for tumor magnetic thermal therapy |
| CN101206944A (en) * | 2007-10-29 | 2008-06-25 | 华东师范大学 | Method of preparing bioavailability water-based magnetofluid |
| CN101477867A (en) * | 2008-10-07 | 2009-07-08 | 同济大学 | Magnetic material having high magnetic heating performance and preparation thereof |
-
2010
- 2010-04-10 CN CN 201010148833 patent/CN102215608B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0040512A1 (en) * | 1980-05-19 | 1981-11-25 | Corning Glass Works | Ceramic suitable for inducing localised heating in the presence of a radio frequency magnetic field, and use thereof |
| CN1640498A (en) * | 2004-01-12 | 2005-07-20 | 中国科学院上海应用物理研究所 | Magnetic nano radioactive medicine and its preparing method |
| CN1712488A (en) * | 2005-07-15 | 2005-12-28 | 东南大学 | Production of nanometer heater for tumor magnetic thermal therapy |
| CN101206944A (en) * | 2007-10-29 | 2008-06-25 | 华东师范大学 | Method of preparing bioavailability water-based magnetofluid |
| CN101477867A (en) * | 2008-10-07 | 2009-07-08 | 同济大学 | Magnetic material having high magnetic heating performance and preparation thereof |
Non-Patent Citations (2)
| Title |
|---|
| 游劲松等.热疗用四氧化三铁磁性纳米粒子的制备及其性质表征.《中国药剂学杂志》.2008,第6卷(第6期),309-315. |
| 热疗用四氧化三铁磁性纳米粒子的制备及其性质表征;游劲松等;《中国药剂学杂志》;20081130;第6卷(第6期);309-315 * |
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