CN102198185A - Medicament for rapidly treating chronic pharyngolaryngitis - Google Patents

Abstract

The invention discloses a medicament for rapidly treating chronic pharyngolaryngitis. The medicament provided by the invention is produced by decocting and extracting raw materials of Chinese olive, hemp seed, perilla, root of kudzu vine, haw, Peach Seed, licorice, cordate houttuynia, purslane, boat-fruited sterculia and Poria cocos according to a certain weight ratio. The medicament, which can be prepared in any commonly-used oral dosage forms, has functions of relieving inflammation and detoxification, disinhibiting the throat and relieving pains, eliminating stasis and activating blood, alleviating asthma and removing depression, and reducing phlegm and detumescence, treats both manifestation and root cause of diseases such as chronic pharyngolaryngitis and the like, and has reliable curative effect, rapid effectiveness without toxic side-effect.

Description

A drug for rapid treatment of chronic pharyngitis

technical field

The invention relates to a medicine for rapidly treating chronic pharyngitis, in particular to a pharyngitis medicine which is made from herbal traditional Chinese medicines, all of which are used for both medicine and food, has higher safety, and has the effect of treating both symptoms and root causes. .

Background technique

Chronic pharyngolaryngitis is a very common disease. The disease recurs and persists for a long time, and often causes many troubles to the patient's work, communication, and life. In recent years, due to the increasing abuse of antibiotics, many patients have developed drug resistance, which has increased the number of attacks and delayed the course of some patients.

Chronic pharyngitis is a chronic disease with high clinical incidence and relatively difficult treatment. Due to foreign body sensation in the pharynx, itching and slight pain, dryness and hotness, sticky secretions attached to the back wall of the pharynx are difficult to remove, often affecting daily life; especially at night, it is difficult to remove when you want to remove it, which can cause irritating cough, Or nausea, vomiting, affecting normal rest; diffuse hyperemia of pharyngeal mucosa, with a small amount of viscous secretions, or thickened mucosa, diffuse hyperemia, or thickened palatal arch and edge of soft palate, and many granular protrusions on the posterior pharyngeal wall Lymphatic follicles in the lymphatic follicles of the patient are very prone to foreign body sensation, which can't be swallowed and swallowed, and it is related to emotions; it is often accompanied by dizziness, upset and irritability, chest tightness and swelling, palpitation and asthma, night sweats and dreams, hoarse voice, and low pitch. Itching in the throat, dry mouth and discomfort, polyps and small nodules hyperplasia may be cancerous. For these symptoms, the single use of western medicine is not ideal, so it is also a disease that plagues patients for a long time and affects the quality of life of patients.

For the treatment of chronic pharyngitis, antibiotics have a good palliative effect, and are effective in controlling the aggravation of symptoms. However, the etiology of chronic pharyngitis is often multifaceted, including complex pathogenic factors and low autoimmune function. Factors, and even obvious mental factors, so it is difficult to control relapse with antibiotics, often passively waiting for the body's own disease resistance to improve and reduce its relapse rate. In terms of Chinese medicine treatment, although it has great advantages, it is often difficult for patients to accept it due to the troublesome decoction of Chinese medicine decoctions, poor taste, and inconvenience in taking; There is no prescription for controlling recurrence.

How to quickly control the onset symptoms of chronic pharyngitis, and effectively enhance the patient's immune function and prevent recurrence of the disease is a thorny problem in the treatment of chronic pharyngitis, and it is also the goal of the inventor's many years of research on traditional Chinese medicine.

It is the purpose of the present inventors to invent a drug that has reliable curative effect without toxic and side effects, can quickly control the onset symptoms and can gradually control the recurrence effect. Looking at the Chinese and Western medicine market, this kind of medicine is still blank.

Contents of the invention

The object of the present invention is to provide a novel drug for treating chronic pharyngitis, which can be quickly cured, treats both symptoms and root causes, can reduce or even control recurrence, and provides a new, safe and efficient therapeutic drug variety for clinical use.

The present invention is based on traditional syndrome differentiation and treatment as the criterion, clearing fire and relieving sore throat, expelling pathogenic factors and strengthening the body, regulating qi and reducing phlegm, detoxification and promoting blood circulation. Combined with western medicine, the drugs used have been proved by modern medical pharmacological experiments to be effective and reliable in anti-bacterial, anti-viral, and immune-enhancing functions, as well as their effectiveness and reliability in relieving throat, reducing swelling, and reducing phlegm. Every medicine all hints that there is no toxic side effect.

The present invention is realized by the following technical solutions. A medicine for treating recurrent respiratory tract infection and hypoimmunity in children, characterized in that it is made of the following raw materials in parts by weight: 10-30 parts of green fruit, 10-25 parts of hemp seed, perilla seed 10-25 parts, 12-30 parts of kudzu root, 10-30 parts of hawthorn, 10-25 parts of peach kernel, 10-22 parts of licorice, 12-30 parts of Houttuynia cordata, 10-20 parts of purslane, 10-30 parts of fat sea part, 10-30 parts of Poria cocos.

The above-mentioned raw material medicine and dosage formula were obtained by the inventor in more than 20 years of clinical trials, and all have remarkable curative effects within the above-mentioned dosage range.

The medicine of the present invention is compatible with green fruit, hemp seed, perilla, kudzu root, hawthorn, peach kernel, licorice, houttuynia cordata, purslane, fat sea, and poria cocos. Symptoms and the effect of preventing recurrence. In the prescription, Qingguo clears heat and promotes body fluid, sore throat and phlegm, invigorates the spleen and detoxifies, and has good antibacterial effect; hemp seed has a flat nature, moistens the intestines and removes dryness, promotes blood circulation and removes blood stasis, nourishes blood and protects body fluid, and exerts a reliable moisturizing effect; fat sea Purging fire and detoxifying, clearing lung qi, relieving throat and resolving phlegm, is an essential medicine for throat infections; the combination of the three can clear the fire of the triple burner, remove upper and lower dryness, and detoxify the throat. Perilla soothes qi, reduces phlegm and depression, and can relieve symptoms of foreign body sensation in chronic pharyngitis; kudzu root benefits yin and promotes body fluid, invigorates spleen and raises yang, and has good antibacterial effect; Certain antibacterial effect; peach kernel promotes blood circulation and removes blood stasis, laxes bowels, relieves phlegm and relieves cough, and has good anti-inflammatory, bactericidal and immunoregulatory effects; the combination of the four can relieve the qi stagnation in the liver and stomach, break the phlegm stagnation in the throat, and smooth the throat Department of blood stasis. Licorice nourishes qi and resolves phlegm, harmonizes various medicines. Houttuynia cordata detoxifies and eliminates carbuncles, relieves cough and fire, has significant anti-pathogenic microorganisms, and enhances the phagocytosis of white blood cells; Expelling dampness and resolving phlegm has a good immune-enhancing effect; the three complement each other to detoxify and eliminate carbuncle, cool blood and purging fire, expelling dampness and resolving phlegm, have the effects of treating both symptoms and root causes, strengthening the body and eliminating pathogenic factors. The combination of all prescriptions is coordinated, and the curative effects complement each other, which fully conforms to the basic principles of TCM syndrome differentiation and treatment.

The medicine of the present invention can be made into an oral dosage form by conventional methods of traditional Chinese medicine preparations. The medicine of the present invention can be ground into powder from raw materials and mixed evenly to form powders, granules, tablets, granules and oral liquids. The raw materials can be decocted and concentrated into decoctions to obtain active ingredients, and then prepared into various oral preparations, but these do not limit the protection scope of the present invention.

The medicine of the present invention can also adopt semi-bionic extraction method (Semi-bionic Extraction method, SBE method), supercritical fluid extraction (Supercritical Fluid Extraction, SFE), microwave extraction (Microwave extraction), enzyme engineering technology (cellulase engineering technology), ultrasonic extraction (TheUltrasonicwithdrawsthetechnique), Methods such as macroabsorption resin (MacroAbsorptionResin) are used to extract active ingredients, but these extraction methods do not limit the protection scope of the present invention.

The preferred preparation method of the medicine of the present invention is as follows:

The present invention preferably adopts the following capsule dosage forms and tablets.

The preparation method of described medicine is carried out as follows:

(1) Take raw materials in proportion, and set aside;

(2) decoct the 11 herbs of green fruit, hemp seed, perilla, kudzu root, hawthorn, peach kernel, licorice, houttuynia cordata, purslane, fat sea and Poria cocos in the weight ratio for 5 times, and then combine 5 secondary decoction;

(3) concentrating the decoction obtained in step (2) into an extract;

(4) drying the extract to obtain a dry extract;

(5) pulverize the dry extract into powder;

(6) Keep at 110°C for 10 minutes, then drop to 105°C for 5 minutes, then cool down to 100°C, keep for 5 minutes, and cool to room temperature;

(7) Pack into capsules.

It is advisable that the amount of water added each time in the step (2) is not over the medicine noodles, and it is decocted for 30 minutes each time.

The medicated powder obtained in the step (5) is mixed with commonly used adjuvants for tablets, and compressed into tablets.

Medicine of the present invention shows through clinical application result, has following advantage:

1. The present invention selects natural edible plant medicines as raw materials, and each component conforms to the provisions of the Drug Law and the principles of traditional Chinese medicine prescriptions, highlighting the basic characteristics of the combination of TCM syndrome differentiation and two-medicine disease differentiation, and the combination of etiological treatment and symptomatic treatment;

2. The medicine of the present invention does not need to be decocted, has a good taste, is convenient to take, and is non-toxic and harmless before and after the prescription of each medicine, and no side effects are found when taken in normal doses;

3. The medicine of the present invention not only has a good effect on chronic pharyngitis, chronic tonsillitis, chronic oral ulcer, etc., but also has a good health care effect of preventing "getting angry", and has a wide range of applications;

4. The medicines of the present invention are all selected from the varieties that can be used for both medicine and food as stipulated by the Ministry of Health, with higher safety, and can be taken for a long time to treat chronic pharyngitis, chronic tonsillitis, etc.;

5. The medicine of the present invention has good compatibility, and has a certain therapeutic effect on symptoms such as constipation, cough, and hoarseness in patients who are prone to "get angry";

6. The composition of the present invention is novel, which not only conforms to the principle of syndrome differentiation in traditional Chinese medicine, but also takes into account the pharmacological effects of drugs. It clears away fire but not too cold and cools down, and focuses on strengthening immunity for anti-inflammatory. Comprehensive effects such as lowering qi and relieving depression, resolving phlegm and reducing bloat;

7. The medicine of the present invention treats both symptoms and root causes, has quick effect and high cure rate.

Detailed ways

Below in conjunction with embodiment and clinical application statistics further illustrate the effect of medicine of the present invention.

Embodiment 1: capsule preparation

Green fruit 15kg, hemp seed 15kg, perilla 18kg, kudzu root 22kg, hawthorn 18kg, peach kernel 18kg, licorice 15kg, houttuynia cordata 26kg, purslane 20kg, fat sea 22kg, poria cocos 25kg, add water and decoct 5 times, adding water each time It is advisable to have no medicinal noodles, decoct for 30 minutes each time, and combine the decoction 5 times; extract the decoction with conventional alcohol and concentrate it into an extract; And perform conventional high-temperature disinfection; put the fine powder into capsules, 0.45g of each powder.

Embodiment 2: Granule preparation

Green fruit 15kg, hemp seed 15kg, perilla 18kg, kudzu root 22kg, hawthorn 18kg, peach kernel 18kg, licorice 15kg, houttuynia cordata 26kg, purslane 20kg, fat sea 22kg, poria cocos 25kg, made by the method described in Example 1 Medicinal powder, supplemented with commonly used auxiliary materials for granules to make granules, 2g per bag of granules.

Drug clinical observation of the present invention

1. General conditions and test methods

In order to confirm the clinical curative effect of the medicine of the present invention, at the beginning of November 2007 to the end of October 2008, the treatment group selected 57 cases of chronic pharyngitis, including 26 males and 31 females; aged 21-57 years, with an average of 35.8 years old. The control group consisted of 55 cases, including 22 males and 23 females; aged 22-59 years, with an average of 34.6 years. The two groups were statistically comparable, and the difference was not significant (P>0.05).

The treatment group took all the medicinal capsules of Example 1, 5 capsules each time, 3 times a day; the control group took Qingrexiaoyanning capsules, 4 capsules each time, 3 times a day. Spicy food was avoided during the medication period of the two groups, and the administration time was 14 days as a course of treatment, and the treatment time was 1-2 courses of treatment.

2. Clinical Observation Standards

The diagnostic criteria of the two groups were in line with the diagnostic criteria of chronic pharyngitis.

Efficacy criteria: all pharyngeal symptoms disappear, and those who have no recurrence in the follow-up one month after drug withdrawal are considered cured; the basic link of main symptoms, foreign body sensation in the pharynx basically disappears, is markedly effective; pharyngeal symptoms are alleviated, foreign body sensation and follicular hyperplasia on the posterior pharyngeal wall are obvious Reduction is effective; no improvement in pharyngeal symptoms is invalid.

3. Analysis of treatment effect

In the observation group, 29 cases were cured, 21 cases were markedly effective, 4 cases were effective, and 3 cases were ineffective, with a total effective rate of 94.7%; in the control group, 8 cases were cured, 15 cases were markedly effective, 16 cases were effective, and 16 cases were ineffective, with a total effective rate of 70.9%. The difference between the two groups was statistically significant (P<0.05).

Claims (7)

1. quick medicine of treatment chronic pharyngolaryngitis is characterized in that it is to be made by following raw medicaments in portion by weight:

Fructus Canarii 10-30 part Fructus Cannabis 10-25 part Fructus Perillae 10-25 part Radix Puerariae 12-30 part

Fructus Crataegi 10-30 part Semen Persicae 10-25 part Radix Glycyrrhizae 10-22 part Herba Houttuyniae 12-30 part

Herba Portulacae 10-20 part Semen Sterculiae Lychnophorae 10-30 part Poria 10-30 part.

2. preparation method for preparing the described medicine of claim 1 is characterized in that it may further comprise the steps:

A) take by weighing each crude drug, standby;

B) Fructus Canarii, Fructus Cannabis, Fructus Perillae, Radix Puerariae, Fructus Crataegi, Semen Persicae, Radix Glycyrrhizae, Herba Houttuyniae, Herba Portulacae, Semen Sterculiae Lychnophorae, the Poria 11 flavor medicine water purification with described weight proportion decoct with water 5 times after washing, add water was not advisable to have powder at every turn, merge 5 times decoction liquor, filter to get filtrate 1;

C) with filtrate with water extraction or alcohol extraction, be condensed into fluid extract, master stream extractum is made in oven dry in drying baker;

D) dry extract is broken into the active ingredient that powder must the invention medicine.

3. preparation method for preparing the described medicine of claim 1 is characterized in that it may further comprise the steps:

A) take by weighing each crude drug, standby;

B) Fructus Canarii, Fructus Cannabis, Fructus Perillae, Radix Puerariae, Fructus Crataegi, Semen Persicae, Radix Glycyrrhizae, Herba Houttuyniae, Herba Portulacae, Semen Sterculiae Lychnophorae, the Poria 11 flavor medicine water purification with described weight proportion decoct with water 5 times after washing, add water was not advisable to have powder at every turn, merge 5 times decoction liquor, filter to get filtrate 1;

C) filtrate is suitably concentrated, handle, directly make the oral liquid of effective ingredient through corrosion-proof and sterilization.

4. preparation method according to claim 2 is characterized in that step 2d) with the effective ingredient of dry extract 110 ℃ incapsulate after the sterilization cooling in 10 minutes down capsule.

5. according to right 3 described process for preparing medicine, it is characterized in that step 3c) effective ingredient of oral liquid invention medicine is mixed with adjuvant commonly used, make oral liquid.

6. preparation method according to claim 2 is characterized in that step 2d) effective ingredient of dry extract and tablet adjuvant commonly used are mixed, tabletting becomes tablet.

7. preparation method according to claim 2 is characterized in that step 2d) effective ingredient of dry extract and granule adjuvant commonly used are mixed, make granule.