CN102178896A - Traditional Chinese medicine composition for treating breast hyperplasia and preparation method of composition - Google Patents

Traditional Chinese medicine composition for treating breast hyperplasia and preparation method of composition Download PDF

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CN102178896A
CN102178896A CN2011101085268A CN201110108526A CN102178896A CN 102178896 A CN102178896 A CN 102178896A CN 2011101085268 A CN2011101085268 A CN 2011101085268A CN 201110108526 A CN201110108526 A CN 201110108526A CN 102178896 A CN102178896 A CN 102178896A
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chinese medicine
medicine composition
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traditional chinese
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CN102178896B (en
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时红霞
赵阳媚
朱文岳
赵海洲
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时红霞
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Abstract

The invention discloses a traditional Chinese medicine composition, in particular a traditional Chinese medicine composition for treating breast hyperplasia and a preparation method of the composition. The traditional Chinese medicine composition is characterized by being made from: Bupleurum root, White Peony Root, selfheal, Cyperus rotundus, dried tangerine peel, radix curcumae, radix ranunculi ternati, rhizoma bolbostemmae, Iphigenieae, oysters, kelp, seaweed, Scrophularia, Scutellaria, fried frankincense, fried myrrh, the root of red-rooted salvia, Ligusticum wallichii, safflower and angelica. The traditional Chinese medicine composition is specially used for treating breast hyperplasia, a plurality of medicines are matched properly. With the mutual coordination or resistance of the medicines, the curative effect is enhanced to adapt to the treatment requirement of complex diseases and reduce adverse reaction. The traditional Chinese medicine composition is prominent in curative effect, addresses both symptoms and root causes, safe and reliable and has good treating effect on breast hyperplasia. Used for 240 cases totally, the composition reaches 98% of total effective rate.

Description

A kind of Chinese medicine composition for the treatment of cyclomastopathy and preparation method thereof
(1) technical field
The present invention relates to a kind of Chinese medicine composition, particularly a kind of Chinese medicine composition for the treatment of cyclomastopathy and preparation method thereof.
(2) background technology
Cyclomastopathy is a kind of proliferative disease of mammary gland tissue, and motherland medical science belongs to " nodules of the breast " category, is characterized in periodically pain of lump in breast, increase the weight of through before swelling and ache, through after alleviate, be equivalent to the cyclomastopathy of doctor trained in Western medicine.Its etiology and pathogenesis complexity, many owing to depressed rage impairing the liver, depression of liver-QI, stagnation of QI expectorant coagulates, and pents up in breast, and newborn network meridian and vessels obstruction is obstructed, stagnation of QI and blood may bring about pain; Or Chong and Ren channel disorder, stagnation of QI-blood accumulates in breast, and causes breast caking and pain, menoxenia etc.Primary disease is sent out in young women well, and age of onset is many in 30-50 year, and sickness rate accounts for 75% of cystic hyperplasia of breast.Present Therapeutic Method has a variety of, but effect is all undesirable, and Western medicine side effect for oral administration merely is big, and grow, cost an arm and a leg the course of treatment; Simple Chinese patent medicine DeGrain for oral administration, and relapse rate height; And operative treatment has a big risk, and wound is big, and patient is difficult to accept.
(3) summary of the invention
The present invention is in order to remedy the deficiencies in the prior art, and Chinese medicine composition of a kind of evident in efficacy, safe and reliable treatment cyclomastopathy and preparation method thereof is provided.
The present invention is achieved through the following technical solutions:
A kind of Chinese medicine composition for the treatment of cyclomastopathy, its special character is: the component by following parts by weight is made:
Radix Bupleuri 12-20 part, Radix Paeoniae Alba 15-20 part, Spica Prunellae 15-20 part, Rhizoma Cyperi 10-15 part
Pericarpium Citri Reticulatae 10-15 part, Radix Curcumae 10-15 part, Radix Ranunculi Ternati 12-15 part, Rhizoma Bolbostematis 12-15 part
Pseudobulbus Cremastrae Seu Pleiones 10-15 part, Concha Ostreae 10-15 part, Thallus Laminariae (Thallus Eckloniae) 10-15 part, Sargassum 10-15 part
Radix Scrophulariae 12-15 part, Radix Scutellariae 10-15 part, Olibanum (parched) 10-15 part, Myrrha (parched) 10-15 part
Radix Salviae Miltiorrhizae 10-15 part, Rhizoma Chuanxiong 15-20 part, Flos Carthami 10-15 part, Radix Angelicae Sinensis 15-20 part.
The present invention treats the preparation method of the Chinese medicine composition of cyclomastopathy, comprises the steps:
Take by weighing each crude drug Radix Bupleuri, the Radix Paeoniae Alba, Spica Prunellae, Rhizoma Cyperi, Pericarpium Citri Reticulatae, Radix Curcumae, Radix Ranunculi Ternati, Rhizoma Bolbostematis, Pseudobulbus Cremastrae Seu Pleiones, Concha Ostreae, Thallus Laminariae (Thallus Eckloniae), Sargassum, Radix Scrophulariae, Radix Scutellariae, Olibanum (parched), Myrrha (parched), Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Flos Carthami, the Radix Angelicae Sinensis decontamination of described parts by weight, add then in the traditional Chinese medicine extracting machine and to decoct promptly.
Therapeutic Method: oral, every day 2 times sooner or later, general 3 menstrual cycle are cured.
Chinese medicine composition of the present invention is specifically designed to the treatment cyclomastopathy, multiple medicine is suitably cooperated, utilize its mutual collaborative or resistant function, improve curative effect,, reduce untoward reaction to adapt to the treatment requirement of the complicated state of an illness, evident in efficacy, treating both the principal and secondary aspects of a disease, safe and reliable, cyclomastopathy there is better therapeutic effect.Treat 240 examples altogether, total effective rate reaches 98%.
(4) specific embodiment
Embodiment 1:
The Chinese medicine composition of treatment cyclomastopathy, make by the component of following weight:
Radix Bupleuri 16 grams, the Radix Paeoniae Alba 18 grams, Spica Prunellae 18 grams, Rhizoma Cyperi 13 grams, Pericarpium Citri Reticulatae 13 grams, Radix Curcumae 13 grams, Radix Ranunculi Ternati 14 grams, Rhizoma Bolbostematis 14 grams, Pseudobulbus Cremastrae Seu Pleiones 13 grams, Concha Ostreae 13 grams, Thallus Laminariae (Thallus Eckloniae) 13 grams, Sargassum 13 grams, Radix Scrophulariae 14 grams, Radix Scutellariae 13 grams, Olibanum (parched) 13 grams, Myrrha (parched) 13 grams, Radix Salviae Miltiorrhizae 13 grams, Rhizoma Chuanxiong 18 grams, Flos Carthami 13 grams, Radix Angelicae Sinensis 18 grams.
The preparation method of the Chinese medicine composition of this treatment cyclomastopathy, adopt following steps:
Take by weighing Radix Bupleuri, the Radix Paeoniae Alba, Spica Prunellae, Rhizoma Cyperi, Pericarpium Citri Reticulatae, Radix Curcumae, Radix Ranunculi Ternati, Rhizoma Bolbostematis, Pseudobulbus Cremastrae Seu Pleiones, Concha Ostreae, Thallus Laminariae (Thallus Eckloniae), Sargassum, Radix Scrophulariae, Radix Scutellariae, Olibanum (parched), Myrrha (parched), Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Flos Carthami, the Radix Angelicae Sinensis decontamination of above-mentioned weight, add then in the traditional Chinese medicine extracting machine and to decoct promptly.
Using of traditional Chinese medicine extracting machine is prior art, no longer describes in detail.
Therapeutic Method: oral, every day 2 times sooner or later, general 3 menstrual cycle are cured.
Embodiment 2:
The Chinese medicine composition of this treatment cyclomastopathy, make by the component of following weight:
Radix Bupleuri 12 grams, the Radix Paeoniae Alba 15 grams, Spica Prunellae 15 grams, Rhizoma Cyperi 10 grams, Pericarpium Citri Reticulatae 10 grams, Radix Curcumae 10 grams, Radix Ranunculi Ternati 12 grams, Rhizoma Bolbostematis 12 grams, Pseudobulbus Cremastrae Seu Pleiones 10 grams, Concha Ostreae 10 grams, Thallus Laminariae (Thallus Eckloniae) 10 grams, Sargassum 10 grams, Radix Scrophulariae 12 grams, Radix Scutellariae 10 grams, Olibanum (parched) 10 grams, Myrrha (parched) 10 grams, Radix Salviae Miltiorrhizae 10 grams, Rhizoma Chuanxiong 15 grams, Flos Carthami 10 grams, Radix Angelicae Sinensis 15 grams.
Embodiment 3:
The Chinese medicine composition of this treatment cyclomastopathy, make by the component of following weight:
Radix Bupleuri 20 grams, the Radix Paeoniae Alba 20 grams, Spica Prunellae 20 grams, Rhizoma Cyperi 15 grams, Pericarpium Citri Reticulatae 15 grams, Radix Curcumae 15 grams, Radix Ranunculi Ternati 15 grams, Rhizoma Bolbostematis 15 grams, Pseudobulbus Cremastrae Seu Pleiones 15 grams, Concha Ostreae 15 grams, Thallus Laminariae (Thallus Eckloniae) 15 grams, Sargassum 15 grams, Radix Scrophulariae 15 grams, Radix Scutellariae 15 grams, Olibanum (parched) 15 grams, Myrrha (parched) 15 grams, Radix Salviae Miltiorrhizae 15 grams, Rhizoma Chuanxiong 20 grams, Flos Carthami 15 grams, Radix Angelicae Sinensis 20 grams.
Embodiment 4: clinical observation
(1) physical data
The inventor carries out clinical observation treatment to 480 routine cyclomastopathy patients, 480 examples are the women, be divided into treatment group and matched group at random: 240 examples are organized in treatment, minimum 20 years old of age, maximum 50 years old, 35 years old mean age, the married's 220 examples, unmarried's 20 examples, a wherein one-sided patient 195 examples, bilateral is sent out patient's 45 examples.The course of disease is the shortest to be 3 months, and the longest is 8 years.Matched group 240 examples, minimum 19 years old of age, maximum 5l year, 35 years old mean age, a wherein one-sided patient 190 examples, bilateral is sent out patient's 50 examples.The course of disease is the shortest to be 3 first quarter moons, and the longest is 9 years.
Diagnostic criteria: with reference to the diagnostic criteria of nodules of the breast in " Surgery of Chinese Medicine ", and adopt breast molybdenum target X line to take the photograph sheet, the infrared ray breast scanning, lump puncture smear etc. is made auxiliary diagnosis, gets rid of other breast benign tumor and malignant tumor.
Include standard in: meet above-mentioned diagnosis, the age is the 19-51 women in year.
Exclusion standard: trimester of pregnancy, women breast-feeding their children, hepatic and renal function are unusual or with serious primary disease, mammitis and mammary gland fibroma etc.
(2) Therapeutic Method: oral, every day 2 times sooner or later, general 3 menstrual cycle are cured.
Matched group: 4-6 sheet of oral RUZENGNING PIAN (Shenzhen Sanshun Pharmaceutical Co., Ltd.), 3 times on the one, 3 menstrual cycle are a course of treatment.
(3) efficacy assessment standard
" healing ": lump in breast disappears, and pain also disappears, and aluminum target X line is taken the photograph sheet, and the infrared ray breast scanning does not have the mammary gland hypertrophy.
" produce effects ": mastalgia alleviates or disappears, and molybdenum target X line is taken the photograph sheet, and infrared ray breast scanning lump in breast dwindles more than 1/2 before the treatment.
" effectively ": mastalgia disappears, but lump in breast does not obviously dwindle.
Engineering noise: lump in breast size and pain is the preceding no change of treatment.
(4) therapeutic effect:
Chinese medicine composition of the present invention: clinical cure 187 examples account for 78%; Produce effects 26 examples account for 11%; Effective 22 examples account for 9%; Invalid 5 examples, total effective rate 98%, case treatment time is the shortest to be 3 menstrual cycle, the longest about 1 year, follows up a case by regular visits to the shortest 6 menstrual cycle, does not have recurrence in the longest 3 years.Treatment finishes the back every patient is carried out liver, kidney function test, and every index is all normal, has no side effect.
Matched group: clinical cure 168 examples account for 70%; Produce effects 24 examples account for 10%; Effective 19 examples account for 8%; Invalid 29 examples, total effective rate 88%.
Model case:
1 Wang, the woman, 34 years old, in December in 2004 first visit on the 13rd, two mammary swellings pains appearred in the patient before 6 years, whenever before menstruation obviously, through the back alleviation, irritability is vexed, and angry postemphasis was persistence and increases the weight of in nearly 2 months, through after slow, companion's dry mouth with bitter taste, insomnia, receive can, stool is normal, menstruation is irregular, amount can, the time clot is arranged, color is dark.Have a medical check-up: two newborn profiles are normal, can reach a plurality of lumps that do not wait in two breasts, and quality is tough, and tenderness is obvious, activity can, axillary gland (-).Light red tongue, tongue is white, deep-thready pulse.Western medicine diagnose: cyclomastopathy.Tcm diagnosis: nodules of the breast disease.Dialectical genus stagnation of QI due to depression of the liver, blood stasis expectorant coagulates, and controls suitable dispersing the stagnated live-QI to relieve the stagnation of QI, dissipating phlegm and resolving masses; get behind the embodiment of the invention 1 made drug decocting oral; every day 2 times sooner or later, all rear udder attachment pain reliefs of taking medicine, take again one week the back pain relief obvious; continue to take 3 menstrual cycle and alleviate; two swelling of the breast pieces and pain all disappeared, and surplus all diseases are all taken a turn for the better, with not recurrence in anti-1 year with disease.
2 Huangs, the woman, 42 years old, the left breast distending pain, whenever before menstruation obviously, alleviate through the back, get behind the embodiment of the invention 1 made drug decocting orally, every day 2 times sooner or later, all rear udder attachment pain reliefs of taking medicine continue to take 3 menstrual cycle healings.
3 Zhangs, the woman, 50 years old, two mammary swellings pain, whenever before menstruation obviously, alleviate through the back, get behind the embodiment of the invention 1 made drug decocting oral, every day 2 times sooner or later, take medicine two week the back pain obviously alleviate, continue to take 3 menstrual cycle and cure, recur so far.

Claims (2)

1. Chinese medicine composition for the treatment of cyclomastopathy, it is characterized in that: the component by following parts by weight is made:
Radix Bupleuri 12-20 part, Radix Paeoniae Alba 15-20 part, Spica Prunellae 15-20 part, Rhizoma Cyperi 10-15 part
Pericarpium Citri Reticulatae 10-15 part, Radix Curcumae 10-15 part, Radix Ranunculi Ternati 12-15 part, Rhizoma Bolbostematis 12-15 part
Pseudobulbus Cremastrae Seu Pleiones 10-15 part, Concha Ostreae 10-15 part, Thallus Laminariae (Thallus Eckloniae) 10-15 part, Sargassum 10-15 part
Radix Scrophulariae 12-15 part, Radix Scutellariae 10-15 part, Olibanum (parched) 10-15 part, Myrrha (parched) 10-15 part
Radix Salviae Miltiorrhizae 10-15 part, Rhizoma Chuanxiong 15-20 part, Flos Carthami 10-15 part, Radix Angelicae Sinensis 15-20 part.
2. the preparation method of the Chinese medicine composition of treatment cyclomastopathy according to claim 1 is characterized in that: comprise the steps:
Take by weighing each crude drug Radix Bupleuri, the Radix Paeoniae Alba, Spica Prunellae, Rhizoma Cyperi, Pericarpium Citri Reticulatae, Radix Curcumae, Radix Ranunculi Ternati, Rhizoma Bolbostematis, Pseudobulbus Cremastrae Seu Pleiones, Concha Ostreae, Thallus Laminariae (Thallus Eckloniae), Sargassum, Radix Scrophulariae, Radix Scutellariae, Olibanum (parched), Myrrha (parched), Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Flos Carthami, the Radix Angelicae Sinensis decontamination of described parts by weight, add then in the traditional Chinese medicine extracting machine and to decoct promptly.
CN201110108526A 2011-04-28 2011-04-28 Traditional Chinese medicine composition for treating breast hyperplasia and preparation method of composition Expired - Fee Related CN102178896B (en)

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Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102406899A (en) * 2011-11-29 2012-04-11 宋爱民 Chinese medicine preparation for treating hyperplasia of mammary glands
CN102579774A (en) * 2012-03-13 2012-07-18 李永泉 Traditional Chinese medicine composition for treating tuberculosis of cervical lymph nodes
CN102716420A (en) * 2012-06-19 2012-10-10 吴金虎 Medicament for treating cyclomastopathy and hyperprolactinemia and preparation method of medicament
CN102716296A (en) * 2012-06-24 2012-10-10 李延玲 Breast nodule pill
CN102755596A (en) * 2012-07-18 2012-10-31 杨洁 Traditional Chinese medicine for treating phlegm-dampness hyperplasia of mammary glands and preparation method thereof
CN103417909A (en) * 2013-07-08 2013-12-04 鲁奎 Chinese medicine for treating mammary gland hyperplasia
CN105250686A (en) * 2015-10-20 2016-01-20 黄培龙 Traditional Chinese medicine composition for treating hyperplasia of mammary glands
CN106390011A (en) * 2016-09-14 2017-02-15 李广臣 Mammary node stasis-removing capsule
CN106924671A (en) * 2017-04-07 2017-07-07 买莹莹 A kind of newborn addiction dispersing paste and preparation method thereof
CN109276684A (en) * 2017-07-19 2019-01-29 邓泽潭 A kind of oral traditional Chinese medicine composition for treating the proliferation of mammary gland

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1418683A (en) * 2002-11-29 2003-05-21 张慧芳 Medicine composition for treating mammary gland proliferation, and its prepn. method

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1418683A (en) * 2002-11-29 2003-05-21 张慧芳 Medicine composition for treating mammary gland proliferation, and its prepn. method

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
《陕西中医》 20091105 杨芳等 消乳散结胶囊治疗乳腺增生症48例疗效及钼靶分析 1452-1453 1-8 第30卷, 第11期 *

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102406899A (en) * 2011-11-29 2012-04-11 宋爱民 Chinese medicine preparation for treating hyperplasia of mammary glands
CN102579774A (en) * 2012-03-13 2012-07-18 李永泉 Traditional Chinese medicine composition for treating tuberculosis of cervical lymph nodes
CN102716420A (en) * 2012-06-19 2012-10-10 吴金虎 Medicament for treating cyclomastopathy and hyperprolactinemia and preparation method of medicament
CN102716296A (en) * 2012-06-24 2012-10-10 李延玲 Breast nodule pill
CN102755596A (en) * 2012-07-18 2012-10-31 杨洁 Traditional Chinese medicine for treating phlegm-dampness hyperplasia of mammary glands and preparation method thereof
CN102755596B (en) * 2012-07-18 2013-10-09 杨洁 Traditional Chinese medicine for treating phlegm-dampness hyperplasia of mammary glands and preparation method thereof
CN103417909B (en) * 2013-07-08 2015-06-10 鲁奎 Chinese medicine for treating mammary gland hyperplasia
CN103417909A (en) * 2013-07-08 2013-12-04 鲁奎 Chinese medicine for treating mammary gland hyperplasia
CN105250686A (en) * 2015-10-20 2016-01-20 黄培龙 Traditional Chinese medicine composition for treating hyperplasia of mammary glands
CN106390011A (en) * 2016-09-14 2017-02-15 李广臣 Mammary node stasis-removing capsule
CN106924671A (en) * 2017-04-07 2017-07-07 买莹莹 A kind of newborn addiction dispersing paste and preparation method thereof
CN106924671B (en) * 2017-04-07 2020-04-10 买莹莹 Mammary nodule eliminating ointment and preparation method thereof
CN109276684A (en) * 2017-07-19 2019-01-29 邓泽潭 A kind of oral traditional Chinese medicine composition for treating the proliferation of mammary gland

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