CN102026661B - Nutrient composition capable of adjusting energy amount, water amount and salt equivalent - Google Patents
Nutrient composition capable of adjusting energy amount, water amount and salt equivalent Download PDFInfo
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- CN102026661B CN102026661B CN200980117020.4A CN200980117020A CN102026661B CN 102026661 B CN102026661 B CN 102026661B CN 200980117020 A CN200980117020 A CN 200980117020A CN 102026661 B CN102026661 B CN 102026661B
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- alimentation composition
- alimentation
- composition
- energy
- sal
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
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Abstract
Provided is a method capable of omitting an operation of adding water, sodium chloride or the like to a nutrient composition and resolving the problem of contamination upon preparation by developing a method capable of simply and rapidly preparing a nutrient composition having most appropriate energy amount, water amount, sodium amount, etc. according to the conditions of various people. A nutrient composition with a most appropriate formulation can be simply and rapidly prepared by combining two or more nutrient compositions which contain a nutrient element serving as an energy source, water and sodium, wherein the contents of the respective components are different although they contain substantially the same components, to freely design the formulation such as the energy amount, water amount, sodium amount, etc. of the nutrient composition after combining the same.
Description
Technical field
The present invention relates to a kind of can adjust energy, water content and Sal conversion amount, for the alimentation composition of enteral nutrition method.
Background technology
Trophotherapy is for to low patient, infant, the old people of digestion organ dysfunction and need care-giver, in its food intake inadequate or can not feeding situation under to its supply nutrition.Wherein, enteral nutrition therapy is as than through intravenous feeding safety and trophotherapy and being widely used cheaply.This is because central vein nutrition method without digestive tract, therefore there will be the digestive organs complication such as metabolic complication, gastrointestinal mucosal atrophy such as abnormal carbohydrate metabolism and the problem such as the infection that causes because of medical catheter.Therefore, can bring into play function if established gradually in recent years digestive appartus official, not adopt central vein nutrition method, and select the principle of enteral nutrition method.
As mentioned above, enteral nutrition method is as safety and trophotherapy cheaply, be widely used in many patients, infant, old people and need care-giver etc., as food or pharmaceuticals, the various mobility alimentation compositions for enteral nutrition method (hereinafter referred to as " liquid food ") are being sold on the market.And, also proposed to allocate the liquid food of various nutritional labelings.Exemplify patent documentation formulation example, representative that discloses liquid food below.
Patent documentation 1: TOHKEMY 2002-142720 communique
Patent documentation 2: TOHKEMY 2004-051494 communique
Patent documentation 3: TOHKEMY 2004-075664 communique
At this, the liquid food that the existing commercially available liquid food for enteral nutrition method or above-mentioned patent documentation are recorded, it is mainly the angle design proportioning from the concentration of energy or various nutritional labelings, therefore need according to picked-up people's state, regulate energy, the water content of each meal and sodium content is converted into Sal conversion amount of sodium chloride (Sal) etc., conventionally need to be take the energy of commercially available liquid food as benchmark, calculate the content of water and sodium etc., by not enough part add in liquid food, adjust after administration again.
Now, particularly in the welfare institutions such as the medical institutions such as hospital, child-care facility and nursing facility, the people of picked-up liquid food has patient, infant, old people and needs care-giver etc. multiple, and energy, water content and Sal conversion amount that everyone needs are not identical.And, even between same class people, for example, to suffer between the patient of disease of the same race, energy, water content and Sal conversion amount that everyone needs are not identical yet.
But, the existing commercially available liquid food for enteral nutrition method, its present situation is by the patient who suffers from certain disease, infant, old people, needs care-giver etc. to be classified as separately a class, and the liquid food that is mixed with the concentration of standard energy and nutritional labeling is sold.
Therefore, need to be according to the state of the different people such as patient, in commercially available liquid food, add water and sodium chloride etc. adjustment, therefore must have the interpolation operation of adding the water and the sodium chloride etc. that meet everyone requirement, make the operation in clinical scene etc. become extremely loaded down with trivial details.
For example, generally in clinical scene etc., the interpolation of moisture is by directly adding the method that cold water mixes or add method that liquid food and cold water mix etc. to carry out in other containers different from liquid food container in liquid food container; In addition, the interpolation of sodium chloride is by dissolving in cold water after sodium chloride, and this solution is added to the method for mixing in liquid food or solution syringe is carried out to the method through pipe nutritive canal administration etc.And the people who is engaged in nursing and nurse work carries out aforesaid operations one day three times, even and for example also need every meal all to carry out for the liquid food of the same prescription of same person, have operator repeat same operation, the low-down present situation of efficiency.
And, the existing commercially available liquid food for enteral nutrition method, from the concentration angle design proportioning of energy or each nutritional labeling, water content and Sal conversion amount contain mantissa as mentioned above, are therefore difficult to calculate, and also may occur mistake in computation.
And in general, liquid food administration need to be carried out a few hours continuously, because the interpolation of above-mentioned water and sodium chloride operates the liquid food breaking a seal once, may there is the pollution that caused by microorganism etc., produce the problem of health aspect.
Therefore, in this case, being engaged in people's the routine work of nursing and nurse work, there is potentially the heavy problem of work load of the water content and the Sal conversion amount etc. that are used for adjusting commercially available liquid food.And the probability that liquid food pollutes also becomes large problem.
Summary of the invention
The inventor is conceived to above-mentioned unexpected, uncared-for problem so far, its object is, can prepare easy and rapidly by exploitation method state, that there is the liquid food of optimum energy, water content and Sal conversion amount etc. that is suitable for the different people such as patient, thereby provide a kind of can omission in liquid food to add the operation of water and sodium chloride etc., and can eliminate the method for the pollution problem while preparation.
According to the present invention, prepare in advance two or more alimentation compositions, for subsequent use, described alimentation composition contains as the nutrient of energy source, water and sodium, composition is each other substantially identical, but is selected from as more than one component content difference in nutrient, water and the sodium of energy source; According to the prescription that meets different people state, two or more described alimentation compositions is combined, thereby can be simultaneously easy and adjust rapidly energy, water content and the Sal conversion amount of the alimentation composition after combination, and further study, result has completed the present invention.
, the present invention relates to a kind of alimentation composition containing as nutrient, water and the sodium of energy source, described alimentation composition is by combining with other more than one alimentation composition, thereby can adjust energy, water content and Sal conversion amount after combination, described alimentation composition contains the identical composition of all alimentation compositions cardinal principles being combined with this, but and between more than one in this alimentation composition being combined, it is selected from as more than one the component content difference in the nutrient of energy source, water and sodium.
Further, described alimentation composition of the present invention, the integral multiple that the integral multiple that its energy is 5kcal, the integral multiple that water content is 5ml, Sal conversion amount are 0.25g.
And, described alimentation composition of the present invention, its energy is that 100～600kcal, water content are that 100～800ml, Sal conversion amount are 0.25g～4.5g.
And, described alimentation composition of the present invention, its energy, water content and Sal conversion amount are respectively done for oneself: 300kcal, 300ml and 1.0g; 300kcal, 400ml and 1.5g; 300kcal, 500ml and 2.0g; 400kcal, 400ml and 1.5g; 400kcal, 500ml and 2.0g; Or be 400kcal, 600ml and 2.5g.
Further, described alimentation composition of the present invention, its nutrient as energy source is selected from more than one in lipid, protein, carbohydrate and their hydrolyzate.
And described alimentation composition of the present invention, as the composition of adjusting content, also contains vitamin and/or the mineral except sodium.
And, existing alimentation composition design is mixed with respect to the energy of water content and exceedes 1.0kcal/ml, the water content that bed old man that this and physical activity level are low etc. is required and the balance of energy are variant, the inventor is conceived to this situation, has developed applicable bed old man's etc. alimentation composition physical activity level, that have optimum water content and the energy balance simultaneously.
Therefore, the present invention's described alimentation composition that also to provide with respect to the energy of the water content of alimentation composition be 0.5～1.0kcal/ml.
And the design of existing alimentation composition is mixed with respect to the Sal conversion amount of energy and is less than 0.25g/100kcal, the energy that the bed old man that this and physical activity level are low etc. are required and the balance of Sal conversion amount are variant.The inventor is conceived to this situation, has developed applicable bed old man's etc. alimentation composition physical activity level, that have optimum energy and Sal conversion amount balance simultaneously.
Therefore, the present invention's described alimentation composition that also to provide with respect to the Sal conversion amount of energy be 0.25～1.0g/100kcal.
The inventor is by putting into hermetic container by described alimentation composition, can be to patient's administration under minimally contacts with the external world, further reduce the contaminated probability of alimentation composition, the inventor is conceived to this point, has completed the invention that packs the alimentation composition in container into joining in hermetic container simultaneously.
Therefore, the present invention also provides and packs described alimentation composition into the alimentation composition in container that packs in hermetic container.
And the present invention also provides to contain described in two or more and packs suit alimentation composition, that pack the alimentation composition in container into (kit) in container into.
Further, the present invention also provides by two or more described alimentation compositions or the alimentation composition that packs in container are combined, thereby adjusts the method for energy, water content and the Sal conversion amount of the alimentation composition after combination.
According to the present invention, two or more alimentation compositions is combined, described alimentation composition contains the nutrient as energy source, water and sodium, contain each other substantially identical composition, but be selected from the nutrient as energy source, the component content difference of more than one in water and sodium, thereby proportioning can freely be designed adjust simultaneously the energy of the alimentation composition after combination, water content and Sal conversion amount etc., therefore can omit the prescription that basis meets the state of different people, calculate the requirement of one day required water and sodium etc., add the operation in alimentation composition to and become laborsaving.And then can significantly reduce the probability that produces pollution while preparing alimentation composition.
The specific embodiment
In the present invention, so-called alimentation composition refers to the alimentation composition for enteral nutrition method, and it is food or medicine.
Here, enteral nutrition method comprise carry out from oral cavity the oral uptake method of nutrient and with catheter drug delivery through pipe alimentation, be typically through pipe alimentation.Further, comprise per os method, per nasal method and through fistula method through pipe alimentation.
The character of alimentation composition of the present invention is liquid, fluid, gel or pasty state, is typically liquid or fluid.And, also alimentation composition can be concentrated or dry make Powdered or solid etc., add in use water etc. to become the use form of liquid or fluid etc.
In addition, the classification of alimentation composition has composition nutrient, digestion state liquid food or digestion state nutrient, partly digests state liquid food or partly digest state nutrient or natural dense liquid food etc., is typically digestion state liquid food or digestion state nutrient or partly digests state liquid food or partly digest state nutrient.
In the present invention, so-called combination refers to and will between the monomer of alimentation composition of the present invention and monomer, combine, and by a part for the alimentation composition being mixed into by combination of monomers, a part for the alimentation composition becoming with monomer and/or by monomer hybrid combining combines.
Adjust the alimentation composition of energy, water content and Sal conversion amount by combining two or more alimentation compositions of the present invention, the monomer of each alimentation composition of combination can be carried out to administration as a meal, in addition, also, after the monomer of two or more alimentation compositions can being mixed with each other, all or part of of this mixed alimentation composition carried out to administration as a meal.
In the present invention, other more than one the alimentation composition that what is called is combined, containing each other identical composition substantially refers to, between the two or more alimentation composition being combined, contain mutually the same composition, or contain and mutually the same adjust the composition of content, also contain other compositions that differ from one another by combination.
The alimentation composition angle that can adapt with multiple prescription from combination considers, more than one the quantity of alimentation composition of other that are combined, for example, be 1～5; From the viewpoint of the operation burden of easy calculating and preparation, be preferably 1～4, more preferably 1～3.
The energy of the alimentation composition from combination can adapt with multiple prescription, and the easily angle consideration of calculating of energy, alimentation composition of the present invention, and its energy is preferably 5kcal, 10kcal, 25kcal, the integral multiple of 50kcal or 100kcal; Consider more preferably 25kcal, the integral multiple of 50kcal or 100kcal from the angle that reduces kind number; Be particularly preferably the integral multiple of 50kcal or 100kcal.
The water content of the alimentation composition from combination can adapt with multiple prescription equally, and the easily angle consideration of calculating of water content, alimentation composition of the present invention, and its water content is preferably the integral multiple of 5ml, 10ml, 25ml, 50ml or 100ml; Consider that from the angle that reduces kind number the more preferably integral multiple of 25ml, 50ml or 100ml is particularly preferably the integral multiple of 50ml or 100ml.
Alimentation composition of the present invention, so-called Sal conversion amount refers to the numerical value that sodium content contained in alimentation composition is converted into the amount of sodium chloride (Sal).
The Sal conversion amount of the alimentation composition from combination can adapt with multiple prescription equally, and the easily angle consideration of calculating of Sal conversion amount, alimentation composition of the present invention, and its Sal conversion amount is preferably the integral multiple of 0.25g, 0.5g, 1.0g or 2.5g; Consider that from the angle that reduces kind number the more preferably integral multiple of 0.25g, 0.5g or 1.0g is particularly preferably the integral multiple of 0.5g or 1.0g.
Energy, water content and the Sal conversion amount of the alimentation composition from combination can adapt, easily calculate and reduce the angle of kind number and consider with multiple prescription, alimentation composition of the present invention, the proportioning of its energy, water content and Sal conversion amount, being preferably energy, water content and Sal conversion amount is respectively the scope of 100kcal～600kcal, 100ml～800ml and 0.25g～4.5g; The more preferably scope of 200kcal～500kcal, 200ml～700ml and 0.5g～3.5g; Particularly preferably be the scope of 300kcal～400kcal, 300ml～600ml and 0.5g～2.5g.
The energy of the alimentation composition from combination equally, water content and Sal conversion amount can adapt with multiple prescription, easily calculate and reduce the angle consideration of kind number, alimentation composition of the present invention, concrete energy, the proportioning example of water content and Sal conversion amount, can exemplify out energy, water content and Sal conversion amount are respectively 300kcal, 300ml and 0.5g, 300kcal, 300ml and 1.0g, 300kcal, 400ml and 1.0g, 300kcal, 400ml and 1.5g, 300kcal, 500ml and 1.5g, 300kcal, 500ml and 2.0g, 400kcal, 400ml and 1.0g, 400kcal, 400ml and 1.5g, 400kcal, 500ml and 1.5g, 400kcal, 500ml and 2.0g, 400kcal, 600ml and 2.0g, or 400kcal, the alimentation composition of 600ml and 2.5g etc., preferably, energy value, water content and Sal conversion amount be can list and 300kcal, 300ml and 1.0g are respectively, 300kcal, 400ml and 1.5g, 300kcal, 500ml and 2.0g, 400kcal, 400ml and 1.5g, 400kcal, 500ml and 2.0g, or the alimentation composition of 400kcal, 600ml and 2.5g etc.
In actual clinical scene etc., the prescription of enteral nutrition method is of a great variety, the scope of energy, water content and the Sal conversion amount of prescription is not necessarily clear and definite, but under normal circumstances energy in the scope of 600～2000kcal, water content in the scope of 600～2000ml, Sal conversion amount the scope at 3～12g, therefore, by the two or more alimentation compositions that are mixed with are as mentioned above combined, thereby can adapt with desired most of prescription in actual clinical scene etc.
In the present invention, can list as the nutrient of energy source, water, sodium, vitamin, mineral and dietary fiber etc. except sodium as adjusting the composition of content, typically have nutrient, water and sodium as energy source.Can list lipid, protein, carbohydrate and their hydrolyzate etc. as the nutrient of energy source.To describe these compositions below in detail.
Consider the physical activity level that gives patient of alimentation composition of the present invention etc., alimentation composition of the present invention, its energy is preferably 0.5～1.0kcal/ml with respect to the water content of alimentation composition, and more preferably 0.5～0.9kcal/ml, is particularly preferably 0.5～0.8kcal/ml.Wait physical activity level low owing to being suitable for the bed old man of enteral nutrition method, therefore need to reduce the energy with respect to the water content of alimentation composition, if in the scope of 0.5～1.0kcal/ml, can prevent the problems such as the urinary tract infection that causes because of the not enough dewatering state causing of moisture picked-up or because of hypourocrinia.
Consider and give the necessary heats such as the patient of alimentation composition of the present invention, alimentation composition of the present invention, its Sal conversion amount is preferably 0.25～1.0g/100kcal with respect to the energy of alimentation composition, more preferably 0.35～1.0g/100kcal, is particularly preferably 0.45～1.0g/100kcal.Owing to being suitable for, the required heat of the bed old man etc. of enteral nutrition method is few, therefore needs to improve the Sal conversion amount with respect to energy, if in the scope of 0.25～1.0g/100kcal, can prevent the problems such as the hyponatremia that caused by urine concentrating power.
In the present invention, so-called hermetic container refers to for using alimentation composition and the extraneous airtight container (closed pack) cutting off as content, as the form of container, the container and the tank etc. that for example typically have capsule (pack), wet heat sterilization bag (retort pouch), Soft Roll (soft bag), sizing, be preferably the container of capsule, wet heat sterilization bag, Soft Roll, sizing etc.As the material of container, typically there are paper, plastics, glass and metal etc., be preferably paper, plastics and metal etc.
And it is above for flowing out and/or thin oral area for mixing that container can have 1 or 2, this thin oral area can have be before use sealing shape, while using can with give the direct-connected mechanism such as the pipe of alimentation composition or the thin oral area of other nutrient combination containers.
The container that alimentation composition of the present invention is housed is made to above-mentioned hermetic container, thereby can be in the situation that not breaking a seal or only breaking a seal minimal thin oral area, carry out to patient give alimentation composition, to adding that the compositions such as other proteins,vitamins,mineralses and alimentation composition are mixed with each other in alimentation composition etc., can suppress to make its Min. and extraneous contact preventing is polluted.
In the present invention, the suit of so-called alimentation composition refers to and contains two or more alimentation composition in container, the suits for the alimentation composition of enteral nutrition method of packing into of the present invention, except the two or more alimentation compositions that pack in container, can also comprise for the flexible pipe through pipe alimentation, cock, syringe and connect the adapter etc. of use.
In order can be definitely to adapt with the required major part prescription such as clinical scene, be contained in two or more in suit and pack the alimentation composition in container into, can be that the alimentation composition packing in container of two or more specific proportionings is combined, as a series that packs the alimentation composition in container into; Can also contain the series that this packs the alimentation composition in container into of overlapping more.
And the angle that the alimentation composition in container can adapt from different prescriptions etc. that packs into from combination considers, the kind number that packs the alimentation composition in container into containing in suit, for example, have 1～18 kind; Count angle consideration from easy calculating and minimizing kind, be preferably 1～12 kind, more preferably 1～6 kind.
As a serial object lesson that packs the alimentation composition in container into, for example have the proportioning of energy, water content and Sal conversion amount to be respectively (A) 300kcal, 300ml and 1.0g, (B) 300kcal, 400ml and 1.5g and (C) 300kcal, 500ml and 2.0g 3 kinds pack alimentation composition in container into as a series; By (D) 400kcal, 400ml and 1.5g, (E) 400kcal, 500ml and 2.0g and (F) 400kcal, 600ml and 2.5g 3 kinds pack alimentation composition in container into as a series; To be somebody's turn to do (A)～(F) 6 kinds pack alimentation composition in container into as a series; Will (A ') 300kcal, 300ml and 0.5g, (B ') 300kcal, 400ml and 1.0g, and (C ') 300kcal, 500ml and 1.5g 3 kinds pack alimentation composition in container into as a series; Will (D ') 400kcal, 400ml and 1.0g, (E ') 400kcal, 500ml and 1.5g and (F ') 400kcal, 600ml and 2.0g 3 kinds pack alimentation composition in container into as a series; To be somebody's turn to do (A ')～(F ') 6 kinds pack alimentation composition in container into as a series; And 12 kinds of will be somebody's turn to do (A)～(F) and should (A ')～(F ') pack in container alimentation composition into as a series etc.
Described sodium, lipid, protein, carbohydrate, vitamin and the mineral etc. that in alimentation composition of the present invention, use, as long as normally used material in food, beverage and medicine field, be not particularly limited, but preferably use the raw material as food and medicine and the additive approved by MHLW.For example, and the use amount of each nutrient, can determine according to " Japanese's diet picked-up standard (version in 2005) " of MHLW's regulation.The object lesson of the nutrient using in alimentation composition of the present invention is as follows.
As the sodium source of alimentation composition of the present invention, for example there are sodium acetate, sodium chloride, sodium citrate, sodium hydroxide, sodium carbonate, sodium bicarbonate, sodium dihydrogen phosphate, sodium hydrogen phosphate, Polymeric sodium metaphosphate., tetrasodium pyrophosphate and sodium tripolyphosphate etc., are preferably sodium chloride and sodium citrate etc.And, can use more than one above-mentioned sodium source.
In addition, for the water of alimentation composition of the present invention, for example, there is pure water, purify waste water and deionized water etc.
As the lipid using, for example, there are soybean oil, Petiolus Trachycarpi oil, fractional distillation Petiolus Trachycarpi oil and Fructus Canarii albi wet goods vegetative grease in alimentation composition of the present invention; The animal raw fats such as butter oil, Adeps Sus domestica and fish oil; And the free fatty such as oleic acid, linolenic acid and gamma-Linolenic acid etc., be preferably soybean oil and Petiolus Trachycarpi wet goods.And, can use more than one above-mentioned lipid.The use amount of lipid is preferably 0～4% scope, and more preferably 2.2～3.3% scope is considered from the angle of the Japanese mean intake of health, is preferably 0～30% scope of the whole energy of alimentation composition, more preferably 20～25% scope.
As the protein using, for example, there are the vegetable proteins such as soybean protein in alimentation composition of the present invention; The animal proteins such as casein and lactalbumin etc., are preferably soybean protein, casein and whey protein etc.And, can use the hydrolyzate of these protein etc., can also use more than one above-mentioned protein and hydrolyzate etc. thereof.The use amount of protein is preferably 2～10% scope, more preferably 3～6.5% scope, consider from the angle of the Japanese mean intake of health, be preferably 12～40% scope of the whole energy of alimentation composition, more preferably 16～25% scope.
As the carbohydrate using in alimentation composition of the present invention, for example there are dextrin, sucrose, lactose and oligosaccharide etc., be preferably dextrin, sucrose and isomaltulose etc.In addition, the hydrolyzate of these carbohydrates etc. can also be used, more than one above-mentioned carbohydrate and hydrolyzate etc. can also be used.The use amount of carbohydrate is preferably 5～20% scope, more preferably 10～15% scope, consider from the angle of the Japanese mean intake of health, be preferably 20～80% scope of the whole energy of alimentation composition, more preferably 40～60% scope.
As the vitamin using in alimentation composition of the present invention, for example, there are vitamin A, vitamin D, vitamin E, vitamin B
1, vitamin B
2, nicotinic acid, vitamin B
6, folic acid, vitamin B
12, pantothenic acid and vitamin C etc., be preferably vitamin B
1, vitamin B
2, nicotinic acid, vitamin B
6, folic acid, vitamin B
12, pantothenic acid and vitamin C etc.And, can use more than one said vitamin.
As the mineral except sodium using in alimentation composition of the present invention, for example there are calcium, ferrum, phosphorus, magnesium, potassium, copper and zinc etc., be preferably calcium, phosphorus, magnesium, potassium etc.And, can use more than one above-mentioned mineral.
And alimentation composition of the present invention can also contain dietary fiber, as water soluble dietary fiber, for example, there are indigestible dextrins and reduction indigestible dextrins etc.In addition, as Water insoluble dietary fiber, for example, there is cellulose etc.And then alimentation composition of the present invention can also contain various spice, sweeting agent and other additives etc.
From local flavor aspect and physical property aspect consider, the pH value of alimentation composition of the present invention is preferably the scope of pH3～11, more preferably 4～10 scope, more preferably 5～9 scope, can be in fact 7.And in order to regulate pH value, can contain the pH adjusting agents such as citric acid.
And, consider from the angle of the digestive organs such as diarrhoea, the stomachache symptom that prevents from being caused by hyperosmosis, the osmotic pressure of alimentation composition of the present invention is preferably the scope of 200～800mOsm/L (this mole rubs), the more preferably scope of 300～750mOsm/L.
Further, when alimentation composition of the present invention is liquid or fluid, consider from the angle for through pipe alimentation, its viscosity is preferably the scope of 3～40mPas, the more preferably scope of 5～20mPas while at room temperature mensuration.
Alimentation composition of the present invention can be prepared by means commonly known in the art.For example have: take each composition, and be added to the water after abundant mixing, make its emulsifying, after heat sterilization, sterilely pack this alimentation composition into method (for example,, by the method for UHT sterilization and aseptic packaging method use) in container in advance; Maybe this alimentation composition is packed into after container, carry out the method (for example, autoclaving) of heat sterilization etc. together with container.
Below, according to embodiment, the present invention is described in detail, but the present invention has more than and be limited to these embodiment, in the scope that does not depart from the technology of the present invention design, can make a variety of changes.
Embodiment
[embodiment 1]
Be 300kcal by energy, water content and Sal conversion amount are respectively: A type is 300ml and 1.0g; Type B is 400ml and 1.5g; C type is that 500ml and 2.0g design the each raw material of proportioning.After each composition is joined mixing in the pure water of approximately 60 ℃, mixed liquor is put into homixerizer (Homomixer), under about 5000rpm, carry out thick emulsifying in 10 minutes.Then, be heated to 90 ℃ and leave standstill after 5 minutes, carry out smart emulsifying (20kgf/cm with high-pressure emulsification machine
2).The emulsion obtaining is cooled to approximately 20 ℃, adds after vitamin, mineral and spice, carry out standardize solution, obtain the mobility alimentation composition of A～C type.Proportioning example using the proportioning example of the alimentation composition of the A～C type being mutually combined into as embodiment 1, as shown in table 1 below.
The proportioning example of table 1 embodiment 1
| Title | A type | Type B | C type |
| Energy value [kcal] | 300 | 300 | 300 |
| Water content [ml] | 300 | 400 | 500 |
| Sal conversion amount [g] | 1.0 | 1.5 | 2.0 |
| Sodium [mg] | 394 | 591 | 788 |
| Proportion | 1.064 | 1.051 | 1.042 |
[0076]
| Lipid [g] | 8.4 | 8.4 | 8.4 |
| Protein [g] | 12.0 | 12.0 | 12.0 |
| Carbohydrate [g] | 46.5 | 46.5 | 46.5 |
| Capacity [ml] | 347 | 447 | 547 |
| Unit energy [kcal/ml] | 0.86 | 0.67 | 0.55 |
And, the raw material composition example using the raw material composition example of the above-mentioned A～C type alimentation composition being mutually combined into as embodiment 1, as shown in table 2 below.
The raw material composition example of table 2 embodiment 1
[embodiment 2]
Be 400kcal by energy, water content and Sal conversion amount are respectively: D type is 400ml and 1.5g; E type is 500ml and 2.0g; F type is that 600ml and 2.5g design the each raw material of proportioning, uses the method preparation identical with described A～C type, obtains the mobility alimentation composition of D～F type.By the proportioning example of the alimentation composition of the D～F type being mutually combined into, as the proportioning example of embodiment 2, as shown in table 3 below.
The proportioning example of table 3 embodiment 2
| Title | D type | E type | F type |
| Energy value [kcal] | 400 | 400 | 400 |
| Water content [ml] | 400 | 500 | 600 |
| Sal conversion amount [g] | 1.5 | 2.0 | 2.5 |
| Sodium [mg] | 591 | 788 | 985 |
| Proportion | 1.065 | 1.054 | 1.047 |
| Lipid [g] | 11.2 | 11.2 | 11.2 |
| Protein [g] | 16.0 | 16.0 | 16.0 |
| Carbohydrate [g] | 62.0 | 62.0 | 62.0 |
| Capacity [ml] | 462 | 562 | 662 |
| Unit energy [kcal/ml] | 0.87 | 0.71 | 0.60 |
And, the raw material composition example using the raw material composition example of the above-mentioned D～F type alimentation composition being mutually combined into as embodiment 2, as shown in table 4 below.
The raw material composition example of table 4 embodiment 2
As an example confirming quality, above-mentioned F type alimentation composition is packed into after the sealed plastic container having for the interface of enteral nutrition method, wet heat sterilization (be preheated to 80 ℃, 121 ℃ sterilization 9 points and 30 seconds), is mixed with the alimentation composition packing in container.The physical property of this alimentation composition is as shown in table 5 below.And the product specification (reference value) in table is the conventional desired product specification of mobility alimentation composition for enteral nutrition method.
The physical property of table 5 alimentation composition
| Title | Product specification (reference value) | F type packs in hermetic container |
| Proportion | 1.046±0.003 | 1.047 |
| pH | - | 6.7 |
| Viscosity [mPas] (25 ℃) | Approximately 5 | 5.0 |
| Particle diameter [μ m] | Below 0.8 | 0.159 |
| Local flavor | Well | Well |
| Outward appearance | Well | Well |
| Mobility | Well | Well |
The each physical property that packs the alimentation composition in container into of above-mentioned F type meets product specification, preserves variations such as also not occurring significant tackify, formation precipitation and fat separation even long-term.
By the alimentation composition of two or more described A～F types is combined, thereby can the most suitably adjust energy, water content and the Sal conversion amount of the alimentation composition after combination, tackle rapidly and neatly desired at clinical scene, to be applicable to the multiple nutrients compositions of patient's etc. disease prescription.The medication that will use existing product (unit energy: 1kcal/ml) alimentation composition as a comparative example 1～6, the medication that two or more described A～F type alimentation compositions is combined is as embodiment 3～8.Comparative result is as shown in table 6 below.
As can be seen from the above Table 6, in the medication of comparative example 1～6, for according to the dosage of each meal of the alimentation composition of patient's prescription, need the interpolation of adding water and sodium chloride for one day 3 times to operate to adjust water content and Sal conversion amount.And it can also be seen that, in actual clinical scene, in general consider operation burden, by energy with 100kcal, water content with 100ml, Sal conversion amount take 0.5 or 1g manage as unit, and the water content of existing product and Sal conversion amount contain mantissa, therefore, between the demand of patient's prescription and dosage, can produce error.
Can find out on the other hand, in the medication of embodiment 3～8, by two or more described A～F type alimentation compositions being combined, can easy and promptly make the alimentation composition that meets patient's prescription completely.
Below, the alimentation composition of described A～F type is combined, adjust one of example of the administration model of energy, water content and Sal conversion amount, as shown in table 7 below.
As can be seen from the above Table 7, by the dispensing model that 6 kinds of alimentation compositions of described A～F type are combined, can make energy adjust in 800～1800ml, the great scope of Sal conversion amount at 3.0～7.5g in 800kcal～1200kcal, water content.
Patient's in actual clinical scene etc. prescription is varied, the scope of energy, water content and the Sal conversion amount of prescription is not necessarily clear and definite, but generally, energy in the scope of 600～2000kcal, water content in the scope of 600～2000ml, Sal conversion amount the scope at 3～12g, therefore by the alimentation composition of two or more described A～F type preparations is combined, can meet the requirement of the on-the-spot required major part prescription of actual clinical.
According to the present invention, prepare in advance two or more alimentation compositions, for subsequent use, described alimentation composition contains as the nutrient of energy source, water and sodium, and composition is each other substantially identical, but the content difference of this composition; By two or more above-mentioned alimentation compositions is combined, thereby can freely design proportioning and adjust the energy of the alimentation composition after combination, water content and Sal conversion amount etc. simultaneously, therefore can omit according to patient's etc. prescription, calculate the requirement of one day required water and sodium etc. and be added into the operation of alimentation composition and become laborsaving, and can significantly reduce preparation alimentation composition time, produce the probability of polluting, be therefore specially adapted to the welfare institutions such as the medical institutions such as hospital, child-care facility and nursing facility etc.
Claims (12)
1. an alimentation composition, it contains and is selected from lipid, protein, the nutrient of more than one in carbohydrate and their hydrolyzate, water and sodium, wherein, energy is 200～500kcal and the integral multiple for 5kcal, water content is 200～700ml and the integral multiple for 50ml, Sal conversion amount is 0.5～3.5g and the integral multiple for 0.5g, described alimentation composition is by combining with other more than one alimentation composition, thereby adjust the energy after combination, water content and Sal conversion amount, identical composition between all alimentation compositions that described alimentation composition contains and this is combined, but and between more than one in this alimentation composition being combined, its choosing is freely selected from lipid, protein, the nutrient of more than one in carbohydrate and their hydrolyzate, the content difference of the composition of more than one in water and sodium.
2. alimentation composition as described in claim 1, its energy, water content and Sal conversion amount are respectively: 300kcal, 300ml and 1.0g; 300kcal, 400ml and 1.5g; 300kcal, 500ml and 2.0g; 400kcal, 400ml and 1.5g; 400kcal, 500ml and 2.0g; Or 400kcal, 600ml and 2.5g.
3. alimentation composition as claimed in claim 1, as the mineral of adjusting the composition of content and also comprising vitamin and/or be selected from calcium, ferrum, phosphorus, magnesium, potassium, copper and zinc more than one.
4. alimentation composition as claimed in claim 1, its energy is 0.5～1.0kcal/ml with respect to the water content of alimentation composition.
5. alimentation composition as claimed in claim 1, its Sal conversion amount is 0.25～1.0g/100kcal with respect to the energy of alimentation composition.
6. pack the alimentation composition in container into, it is that alimentation composition claimed in claim 1 is packed in hermetic container.
7. alimentation composition as claimed in claim 6, it is for through pipe alimentation, hermetic container is Packed one or more the thin oral area of tool before use, this thin oral area have give in use alimentation composition pipe or can with the direct-connected mechanism of thin oral area of other nutrient combination containers.
8. alimentation composition as claimed in claim 7, hermetic container is the container of Soft Roll or sizing.
9. alimentation composition as claimed in claim 7, hermetic container is tank.
10. pack a suit for the alimentation composition in container into, it contains the two or more alimentation compositions packing in container claimed in claim 6.
11. by two or more alimentation compositions claimed in claim 1 is combined, thereby adjust the method for energy, water content and the Sal conversion amount of the alimentation composition after combination.
12. 1 kinds by by the alimentation composition for enteral nutrition method by combining with other more than one alimentation composition, thereby adjust the method for energy, water content and Sal conversion amount after combination, the described alimentation composition for enteral nutrition method contains more than one nutrient, water and three kinds of compositions of sodium that are selected from lipid, protein, carbohydrate and their hydrolyzate, it is characterized in that, controlled alimentation composition contains the composition identical with other all alimentation compositions that are combined; Be selected from more than one the composition in described three kinds of compositions, compared with this composition in the alimentation composition of more than one that are combined with described, its content difference; And the energy of controlled alimentation composition and other all alimentation compositions of being combined be 200～500kcal and for integral multiple, the water content of 5kcal be 200～700ml and for integral multiple and the Sal conversion amount of 50ml be 0.5～3.5g and the integral multiple for 0.5g.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008128521 | 2008-05-15 | ||
| JP2008-128521 | 2008-05-15 | ||
| PCT/JP2009/002107 WO2009139167A1 (en) | 2008-05-15 | 2009-05-14 | Nutrient composition capable of adjusting energy amount, water amount and salt equivalent |
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| CN102026661A CN102026661A (en) | 2011-04-20 |
| CN102026661B true CN102026661B (en) | 2014-06-04 |
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| CN200980117020.4A Active CN102026661B (en) | 2008-05-15 | 2009-05-14 | Nutrient composition capable of adjusting energy amount, water amount and salt equivalent |
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| Country | Link |
|---|---|
| JP (2) | JP5160569B2 (en) |
| KR (1) | KR20110008331A (en) |
| CN (1) | CN102026661B (en) |
| HK (1) | HK1155672A1 (en) |
| WO (1) | WO2009139167A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107106598A (en) * | 2014-12-26 | 2017-08-29 | 株式会社明治 | Replenisher comprising food fiber |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102026661B (en) * | 2008-05-15 | 2014-06-04 | 株式会社明治 | Nutrient composition capable of adjusting energy amount, water amount and salt equivalent |
| JP2009284848A (en) * | 2008-05-30 | 2009-12-10 | Q P Corp | Liquid food richly containing sodium |
| US8840950B2 (en) | 2010-05-26 | 2014-09-23 | Jacqueline M. Hibbert | Compositions of nutrition supplementation for nutritional deficiencies and method of use therefore |
| JP6449648B2 (en) * | 2012-06-28 | 2019-01-09 | 株式会社明治 | Nutritional composition |
| JP6084092B2 (en) * | 2013-03-28 | 2017-02-22 | テルモ株式会社 | Thorough nutritional composition |
| JP6306943B2 (en) * | 2014-05-30 | 2018-04-04 | 株式会社明治 | Container for nutritional composition |
| JP2018110893A (en) * | 2018-03-09 | 2018-07-19 | 株式会社明治 | Container for nutrition composition |
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| JPH07116049B2 (en) * | 1991-06-05 | 1995-12-13 | 株式会社ツムラ | Easy-to-use Kampo formulation |
| US5223285A (en) * | 1992-03-31 | 1993-06-29 | Abbott Laboratories | Nutritional product for pulmonary patients |
| JPH06343417A (en) * | 1993-06-07 | 1994-12-20 | Chiyoujiyuen Kk | Salted seasoning |
| JPH08127534A (en) * | 1994-10-31 | 1996-05-21 | Tsutako Nishishiro | Sodium ion scavenger |
| JPH1021197A (en) * | 1996-07-01 | 1998-01-23 | Mitsuo Yamashita | Diet design method |
| JP2001309767A (en) * | 2000-04-28 | 2001-11-06 | Ezaki Glico Co Ltd | Packaged food |
| JP3713421B2 (en) * | 2000-07-13 | 2005-11-09 | 株式会社タニタ | Intake salt meter |
| JP4521168B2 (en) * | 2002-08-15 | 2010-08-11 | テルモ株式会社 | Vitamin B1-containing nutritional composition for suppressing blood sugar level elevation |
| JP4989240B2 (en) * | 2007-01-24 | 2012-08-01 | パナソニック株式会社 | Meal management support system |
| JP5418956B2 (en) * | 2007-10-22 | 2014-02-19 | 味の素株式会社 | Total nutritional composition |
| CN102026661B (en) * | 2008-05-15 | 2014-06-04 | 株式会社明治 | Nutrient composition capable of adjusting energy amount, water amount and salt equivalent |
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2009
- 2009-05-14 CN CN200980117020.4A patent/CN102026661B/en active Active
- 2009-05-14 JP JP2009550844A patent/JP5160569B2/en active Active
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- 2009-05-14 WO PCT/JP2009/002107 patent/WO2009139167A1/en active Application Filing
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1346057A (en) * | 2000-07-13 | 2002-04-24 | 株式会社百利达 | Salt content extracting instrument |
| CN101027074A (en) * | 2004-09-22 | 2007-08-29 | 味之素株式会社 | Total enteral nutritious composition |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107106598A (en) * | 2014-12-26 | 2017-08-29 | 株式会社明治 | Replenisher comprising food fiber |
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| JP5404558B2 (en) | 2014-02-05 |
| KR20110008331A (en) | 2011-01-26 |
| JPWO2009139167A1 (en) | 2011-09-15 |
| WO2009139167A1 (en) | 2009-11-19 |
| HK1155672A1 (en) | 2012-05-25 |
| JP5160569B2 (en) | 2013-03-13 |
| JP2010275318A (en) | 2010-12-09 |
| CN102026661A (en) | 2011-04-20 |
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