CN101995479A - 用于液体样品处理的处理单元和方法 - Google Patents

用于液体样品处理的处理单元和方法 Download PDF

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Publication number
CN101995479A
CN101995479A CN2010102492233A CN201010249223A CN101995479A CN 101995479 A CN101995479 A CN 101995479A CN 2010102492233 A CN2010102492233 A CN 2010102492233A CN 201010249223 A CN201010249223 A CN 201010249223A CN 101995479 A CN101995479 A CN 101995479A
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CN
China
Prior art keywords
sample
reagent
channel
valve
processing unit
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Pending
Application number
CN2010102492233A
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English (en)
Chinese (zh)
Inventor
J-P·博利格
M·格劳泽尔
O·古特曼
M·海因里希
R·D·耶吉
E·乌斯特布鲁克
E·萨罗菲姆
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication of CN101995479A publication Critical patent/CN101995479A/zh
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1065—Multiple transfer devices
    • G01N35/1072—Multiple transfer devices with provision for selective pipetting of individual channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0621—Control of the sequence of chambers filled or emptied
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0663—Whole sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/14—Means for pressure control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B01L2400/049—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics vacuum
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0622—Valves, specific forms thereof distribution valves, valves having multiple inlets and/or outlets, e.g. metering valves, multi-way valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099—Characterised by type of test elements
    • G01N2035/00158—Elements containing microarrays, i.e. "biochip"
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
CN2010102492233A 2009-08-07 2010-08-06 用于液体样品处理的处理单元和方法 Pending CN101995479A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09167521.5 2009-08-07
EP09167521A EP2311563A1 (en) 2009-08-07 2009-08-07 Processing units and methods for the processing of liquid samples

Publications (1)

Publication Number Publication Date
CN101995479A true CN101995479A (zh) 2011-03-30

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN2010102492233A Pending CN101995479A (zh) 2009-08-07 2010-08-06 用于液体样品处理的处理单元和方法

Country Status (4)

Country Link
US (1) US8778696B2 (https=)
EP (1) EP2311563A1 (https=)
JP (1) JP5323014B2 (https=)
CN (1) CN101995479A (https=)

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CN103217401A (zh) * 2011-12-27 2013-07-24 霍尼韦尔国际公司 可弃置流体分析盒
CN105651767A (zh) * 2015-12-29 2016-06-08 厦门大学 一种使用3d打印模具制备的即吸即测液体检测装置
CN110891795A (zh) * 2017-02-27 2020-03-17 沃克索8股份有限公司 包括混合喷嘴的3d打印装置
CN111569967A (zh) * 2020-06-24 2020-08-25 深圳市国赛生物技术有限公司 微流控芯片
CN111830266A (zh) * 2020-08-06 2020-10-27 江苏信安佳医疗科技有限公司 一种试剂自动分配装置
CN113390693A (zh) * 2021-07-15 2021-09-14 北京凤栖桐科技有限公司 一种快速食品检测系统及其食品检测方法
CN113711049A (zh) * 2019-05-10 2021-11-26 深圳迈瑞生物医疗电子股份有限公司 样本检测装置和样本检测装置的运行方法
CN116328860A (zh) * 2014-06-05 2023-06-27 伊鲁米那股份有限公司 用于样品制备或样品分析中的至少一个的包括旋转阀的系统和方法
US11701813B2 (en) 2017-02-27 2023-07-18 Kornit Digital Technologies Ltd. Methods for three-dimensionally printing and associated multi-input print heads and systems
US11904614B2 (en) 2017-02-27 2024-02-20 Kornit Digital Technologies Ltd. Multi-input print heads for three-dimensionally printing and associated systems and methods

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EP3151015A1 (en) * 2010-11-15 2017-04-05 F. Hoffmann-La Roche AG Instrument and method for the automated thermal treatment of liquid samples
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US9632102B2 (en) 2011-09-25 2017-04-25 Theranos, Inc. Systems and methods for multi-purpose analysis
US9810704B2 (en) 2013-02-18 2017-11-07 Theranos, Inc. Systems and methods for multi-analysis
EP2758510A4 (en) * 2011-09-25 2015-05-06 Theranos Inc SYSTEMS AND METHOD FOR MULTILAYER ANALYSIS
US10012664B2 (en) 2011-09-25 2018-07-03 Theranos Ip Company, Llc Systems and methods for fluid and component handling
GB201414247D0 (en) * 2014-08-12 2014-09-24 Cambsolv Ltd Modular microfluidic device
GB2546233A (en) * 2015-08-19 2017-07-19 Cambsolv Ltd Modular microfluidic device for analytical bioassay
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CN109073664B (zh) 2016-04-22 2022-12-06 贝克顿·迪金森公司 自动诊断分析仪及其操作方法
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US11857023B2 (en) 2017-02-27 2024-01-02 Kornit Digital Technologies Ltd. Digital molding and associated articles and methods
CN110106072B (zh) * 2019-04-25 2022-05-13 珠海迪尔生物工程股份有限公司 一种微生物样品测试卡加样装置及加样方法
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Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103217401B (zh) * 2011-12-27 2017-04-19 霍尼韦尔国际公司 可弃置流体分析盒
CN103217401A (zh) * 2011-12-27 2013-07-24 霍尼韦尔国际公司 可弃置流体分析盒
CN116328860A (zh) * 2014-06-05 2023-06-27 伊鲁米那股份有限公司 用于样品制备或样品分析中的至少一个的包括旋转阀的系统和方法
CN105651767A (zh) * 2015-12-29 2016-06-08 厦门大学 一种使用3d打印模具制备的即吸即测液体检测装置
WO2017113545A1 (zh) * 2015-12-29 2017-07-06 厦门大学 一种即吸即测液体检测装置
CN105651767B (zh) * 2015-12-29 2018-06-05 厦门大学 一种使用3d打印模具制备的即吸即测液体检测装置
US11497275B2 (en) 2017-02-27 2022-11-15 Kornit Digital Technologies Ltd. 3D printed articles of footwear with particles
CN110891795A (zh) * 2017-02-27 2020-03-17 沃克索8股份有限公司 包括混合喷嘴的3d打印装置
US11904614B2 (en) 2017-02-27 2024-02-20 Kornit Digital Technologies Ltd. Multi-input print heads for three-dimensionally printing and associated systems and methods
US11701813B2 (en) 2017-02-27 2023-07-18 Kornit Digital Technologies Ltd. Methods for three-dimensionally printing and associated multi-input print heads and systems
CN113711049A (zh) * 2019-05-10 2021-11-26 深圳迈瑞生物医疗电子股份有限公司 样本检测装置和样本检测装置的运行方法
CN111569967A (zh) * 2020-06-24 2020-08-25 深圳市国赛生物技术有限公司 微流控芯片
CN111830266A (zh) * 2020-08-06 2020-10-27 江苏信安佳医疗科技有限公司 一种试剂自动分配装置
CN113390693A (zh) * 2021-07-15 2021-09-14 北京凤栖桐科技有限公司 一种快速食品检测系统及其食品检测方法

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Publication number Publication date
EP2311563A1 (en) 2011-04-20
US20110189785A1 (en) 2011-08-04
US8778696B2 (en) 2014-07-15
JP5323014B2 (ja) 2013-10-23
JP2011039051A (ja) 2011-02-24

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