CN101991743A - Traditional Chinese medicine for treating diabetic heart disease - Google Patents

Traditional Chinese medicine for treating diabetic heart disease Download PDF

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CN101991743A
CN101991743A CN2010105429674A CN201010542967A CN101991743A CN 101991743 A CN101991743 A CN 101991743A CN 2010105429674 A CN2010105429674 A CN 2010105429674A CN 201010542967 A CN201010542967 A CN 201010542967A CN 101991743 A CN101991743 A CN 101991743A
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刘新壮
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Lvyuan Qiuzheng Technology Development Co Ltd
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Abstract

The invention discloses a traditional Chinese medicine for treating diabetic heart disease, belonging to the field of traditional Chinese medicines for treating diabetes and aiming at achieving favorable effect and quick response. The traditional Chinese medicine is prepared from nutgrass galingale rhizome, Chinese angelica, panaxnotoginseng, cynanchum atratum, glossy ganoderma, the root of red-rooted salvia and other raw materials and has the functions of centralizing and cultivating the body, invigorating qi and nourishing blood, replenishing the vital essence and removing heat and activating blood circulation to dissipate blood stasis as well as the advantages of remarkable effect, definite medicine effect and quicker response.

Description

一种治疗糖尿病性心脏病的中药 A kind of traditional Chinese medicine for treating diabetic heart disease

技术领域technical field

本发明属于治疗糖尿病的中药领域。The invention belongs to the field of traditional Chinese medicine for treating diabetes.

背景技术Background technique

糖尿病性心脏病(简称糖心痛)是指糖尿病患者并发的心脏病(糖尿病性冠心病、心肌病及心动过速等),是在糖、脂肪等代谢紊乱的基础上所发生的心脏大血管病变和神经病变所致。为糖尿病最常见的并发症,也是糖尿病患者主要的致死原因。据统计,糖尿病患者70%死于糖尿病性心脏病。目前的旨在治疗糖尿病性心脏病的中药方面,存在两个方面的不足:一是效果不够明显,二是见效比较迟缓。以致于许多糖尿病性心脏病患者由于得不到有效药物的治疗,长期忍受胸闷胸痛、心悸烦躁的折磨,面临心肌梗死的危险,患者及其家属对此不满意。Diabetic heart disease (abbreviated as sugar heart pain) refers to the heart disease (diabetic coronary heart disease, cardiomyopathy, tachycardia, etc.) complicated by diabetes patients, and is a disease of the heart and large vessels that occurs on the basis of metabolic disorders such as sugar and fat. and neuropathy. It is the most common complication of diabetes and the leading cause of death in diabetic patients. According to statistics, 70% of diabetic patients died of diabetic heart disease. There are two deficiencies in the current traditional Chinese medicine aimed at treating diabetic heart disease: the one is that the effect is not obvious enough, and the other is that the effect is relatively slow. As a result, many diabetic heart disease patients suffer from chest tightness, chest pain, palpitation and irritability for a long time due to lack of effective drug treatment, and face the danger of myocardial infarction. Patients and their families are not satisfied with this.

针对以上提出的问题,本发明提供一种治疗糖尿病性心脏病的中药,它能解决以往此类中药效果不够明显,见效比较迟缓的问题,效果好、见效快,具有效果显著,药效确切,见效较快的优点。In view of the problems raised above, the present invention provides a traditional Chinese medicine for the treatment of diabetic heart disease, which can solve the problem that the effect of such traditional Chinese medicines is not obvious enough in the past, and the effect is relatively slow. The advantage of quicker results.

发明内容Contents of the invention

本发明是通过以下技术方案来实现的:The present invention is achieved through the following technical solutions:

1、一种治疗糖尿病性心脏病的中药,采用中药原料制备,配方为(按重量比):1, a kind of Chinese medicine for the treatment of diabetic heart disease, adopts Chinese medicine raw material to prepare, and formula is (by weight):

香附5-15份 当归6-18份 三七3-9份Cyperus 5-15 parts Angelica 6-18 parts Panax notoginseng 3-9 parts

白薇5-15份 灵芝6-18份 丹参6-18份5-15 parts of Baiwei, 6-18 parts of Ganoderma lucidum, 6-18 parts of Danshen

这种治疗糖尿病性心脏病的中药是由下列方法制成的:This traditional Chinese medicine for treating diabetic heart disease is made by the following methods:

(1)按上述重量比,将灵芝用水提醇沉法提取灵芝多糖,工艺流程如下:将灵芝破碎成颗粒状,过40目筛→用1∶20的热水(95℃)浸提→浸提液减压、浓缩→用3倍体积的95%乙醇混合、静置10-12小时、离心→加75%的乙醇,沉淀多糖→烘干得灵芝多糖提取物细粉;(1) According to the above weight ratio, extract Ganoderma lucidum polysaccharides from Ganoderma lucidum with water extraction and alcohol precipitation method, the process is as follows: crush Ganoderma lucidum into granules, pass through a 40-mesh sieve → leaching with 1:20 hot water (95°C) → leaching Extract the liquid under reduced pressure, concentrate → mix with 3 times the volume of 95% ethanol, let stand for 10-12 hours, centrifuge → add 75% ethanol, precipitate polysaccharide → dry to obtain fine powder of Ganoderma lucidum polysaccharide extract;

(2)按上述重量比,将香附、当归、白薇、丹参经常规水提取工艺提取,制成提取物浸膏细粉;(2) according to the above-mentioned weight ratio, Cyperus cyperi, Angelica sinensis, Baiwei, and Salvia miltiorrhiza are extracted through a conventional water extraction process to make extract extract fine powder;

(3)按上述重量比,将三七研成细粉,与上述(1)、(2)两种提取物细粉混合,搅拌均匀,制成中药颗粒剂、胶囊剂、片剂。(3) According to the above weight ratio, grind Radix Notoginseng into a fine powder, mix with the fine powder of the above two kinds of extracts (1) and (2), stir evenly, and make traditional Chinese medicine granules, capsules, and tablets.

本发明根据民间传统配方,根据中医扶正培本、活血化瘀的理论,精心研制而成。我们研究认为,糖尿病患者普遍免疫力低下,该病多由糖尿病日久,燥热伤阴耗气,气阴两虚,心脉瘀阻所致。在致病的诸多因素中,免疫力低下是问题的核心和关键。故本发明以增强免疫力为重点,益气养血,养阴清热,活血化瘀,取得良好疗效。目前,我国市场上有多种治疗心脏病、冠心病的西药和中药——硝酸甘油、速效救心丸的优势是当胸痛胸闷突然发生时救急,让患者免于心肌梗死;硝酸异山梨脂片、丹参滴丸的优势是在8~12小时的时间里,控制胸痛胸闷轻度发生或不要发生;而本发明中药的优势是从根本上改善心肌供血,让胸痛胸闷不是在12小时之内而是在较长的时间里逐步减少、减轻、直至不发生。可以说,本发明与上述四种出类拔萃的中西药相比,前者侧重治“标”,本药侧重治“本”,是各有各的优势,各有各的用途。由此,本病患者多了一种更好的优化治疗方案——“1+1+1”,即用硝酸甘油(速效救心丸)“救急”;用硝酸异山梨脂片(丹参滴丸)控制12小时不发作;用本发明减少胸痛胸闷发生。这就是本发明的价值。本方之中灵芝、当归扶正培本,益气养血,养心安神,增强机体免疫力,免疫力的“清除”作用,使血液清洁,不再黏稠,而是富有流动性,这是改善心肌供血的基础;丹参、三七养血活血,化瘀止痛,灵芝、当归与丹参、三七合用,气旺血足,生新血而去瘀血,免疫力的“修复”作用,软化冠脉血管,减少瘀阻,使心肌供血充盈;辅以香附疏肝理气,通脉止痛;白薇清热,利尿,养心阴,滋任脉。诸药配伍,相得益彰,共奏扶正培本,益气养血,养阴清热,活血化瘀之功。纵观全方,既有培元固本之功,又无耗气伤阴之痹,寓补于通,确是养心通脉之良方。效果好,见效快,具有效果显著,药效确切,见效较快的优点。The present invention is elaborately developed according to the folk traditional formula and the theory of traditional Chinese medicine of strengthening the body and strengthening the body, promoting blood circulation and removing blood stasis. According to our research, diabetic patients generally have low immunity, and the disease is mostly caused by prolonged diabetes, dryness and heat damage yin and consumes qi, deficiency of both qi and yin, and stasis of heart vessels. Among the many factors causing the disease, low immunity is the core and key of the problem. Therefore, the present invention focuses on enhancing immunity, replenishing qi and nourishing blood, nourishing yin and clearing heat, promoting blood circulation and removing blood stasis, and obtains good curative effect. At present, there are a variety of Western medicines and traditional Chinese medicines for the treatment of heart disease and coronary heart disease on the market in our country - nitroglycerin and quick-acting Jiuxin pills. The advantage of Danshen Dropping Pills is that it can control the mild or no occurrence of chest pain and distress within 8 to 12 hours; and the advantage of the traditional Chinese medicine of the present invention is to fundamentally improve the blood supply to the myocardium, so that the chest pain and distress are not caused within 12 hours but Over a long period of time, gradually reduce, alleviate, until it does not occur. It can be said that the present invention is compared with the above four outstanding Chinese and Western medicines. The former focuses on treating the "symptoms", while this medicine focuses on treating the "basic". Each has its own advantages and uses. As a result, patients with this disease have a better optimized treatment plan - "1+1+1", that is, use nitroglycerin (Suxiao Jiuxin Pills) for "emergency"; Control 12 hours without attack; use the present invention to reduce the occurrence of chest pain and oppression. Here it is the value of the present invention. Ganoderma lucidum and Angelica Fuzheng Peiben in this prescription can nourish qi and blood, nourish the heart and calm the nerves, enhance the body's immunity, and the "clearing" effect of immunity makes the blood clean, no longer viscous, but full of fluidity, which is an improvement The basis of myocardial blood supply; Danshen and Panax notoginseng nourish blood and activate blood, remove blood stasis and relieve pain, Ganoderma lucidum, Angelica, Danshen and Sanqi are used in combination to stimulate blood flow, generate new blood and remove blood stasis, "repair" immunity, soften crown Blood vessels, reduce blood stasis, make myocardial blood supply full; Supplemented with Rhizoma Cyperi to soothe the liver and regulate Qi, dredge the meridian and relieve pain; The compatibility of all medicines brings out the best in each other, and they play the functions of strengthening the body and strengthening the body, nourishing qi and nourishing blood, nourishing yin and clearing away heat, promoting blood circulation and removing blood stasis. Looking at the whole prescription, it not only has the merit of cultivating the Yuan and strengthening the foundation, but also does not have the numbness of consuming Qi and hurting Yin. The utility model has the advantages of good effect, quick effect, remarkable effect, definite drug effect and quick effect.

具体实施方式Detailed ways

通过以下实施方式对本发明做具体说明:The present invention is specifically described by the following embodiments:

1、取以下配方(重量按克为单位):1. Take the following formula (weight is in grams):

香附50克 当归60克 三七30克Cyperus 50g Angelica 60g Panax notoginseng 30g

白薇50克 灵芝60克 丹参60克Baiwei 50g Ganoderma lucidum 60g Salvia 60g

按规定重量,用水提醇沉法将灵芝进行提取;用常规水提取工艺将香附、当归、白薇、丹参提取,共制成提取物细粉56克,将三七研成细粉,与上述提取物细粉混合,搅拌均匀,制成细小颗粒,装入0号胶囊,制成中药胶囊307粒,每粒胶囊内含中药细粉及提取物0.28克。Extract Ganoderma lucidum by water extraction and alcohol precipitation method according to the specified weight; extract Rhizoma Cyperi, Angelica, Bai Wei, and Salvia miltiorrhiza by conventional water extraction process, and make a total of 56 grams of extract fine powder, grind Panax notoginseng into fine powder, and mix with The above-mentioned extract fine powders are mixed, stirred evenly, made into fine granules, packed into No. 0 capsules, and made into 307 Chinese medicine capsules, each capsule containing 0.28 grams of Chinese medicine fine powder and extract.

2、取以下配方(重量按克为单位):2. Take the following formula (weight is in grams):

香附100克 当归120克 三七60克Cyperus 100g Angelica 120g Panax notoginseng 60g

白薇100克 灵芝120克 丹参120克Baiwei 100g Ganoderma lucidum 120g Salvia 120g

按上述同样的方法,制成中药胶囊614粒,每粒胶囊内含中药细粉及提取物0.28克。By above-mentioned same method, make 614 Chinese medicine capsules, every capsule contains Chinese medicine fine powder and extract 0.28 gram.

3、取以下配方(重量按克为单位):3. Take the following formula (the weight is in grams):

香附150克 当归180克 三七90克Cyperus 150g Angelica 180g Panax notoginseng 90g

白薇150克 灵芝180克 丹参180克Baiwei 150g Ganoderma lucidum 180g Salvia 180g

按上述同样的方法,制成中药胶囊921粒,每粒胶囊内含中药细粉及提取物0.28克。By above-mentioned same method, make 921 Chinese medicine capsules, every capsule contains Chinese medicine fine powder and extract 0.28 gram.

4、取以下配方(按重量比):4. Take the following formula (by weight):

香附6份 当归7份 三七3份Cyperus 6 parts Angelica 7 parts Panax notoginseng 3 parts

白薇6份 灵芝7份 丹参7份6 parts of Baiwei, 7 parts of Ganoderma lucidum, 7 parts of Danshen

按上述同样的方法,制成中药胶囊,每粒胶囊内含中药细粉及提取物0.28克。By the above-mentioned same method, Chinese medicine capsules are made, and each capsule contains 0.28 grams of Chinese medicine fine powder and extract.

5、取以下配方(按重量比):5. Take the following formula (by weight):

香附12份 当归16份 三七7份Cyperus 12 parts Angelica 16 parts Panax notoginseng 7 parts

白薇12份 灵芝16份 丹参16份12 parts of Baiwei, 16 parts of Ganoderma lucidum, 16 parts of Salvia miltiorrhiza

按上述同样的方法,制成中药胶囊,每粒胶囊内含中药细粉及提取物0.28克。By the above-mentioned same method, Chinese medicine capsules are made, and each capsule contains 0.28 grams of Chinese medicine fine powder and extract.

临床资料:clinical information:

本发明以中医糖尿病性心脏病为例,经7例临床观察。选择中医诊断糖尿病性冠心病为标准:糖尿病患者在劳动、情绪激动、饱餐或受寒后时有心区不适症状——心悸烦躁、肢软乏力、胸痛胸闷、呼吸困难,休息或服用硝酸甘油后缓解。如上症状,即可确诊。在确诊观察的对象中,男性3例,女性4例,无其它严重疾病,年龄为47岁-81岁,平均年龄63.7岁。The present invention takes TCM diabetic heart disease as an example, through clinical observation of 7 cases. Choose TCM diagnosis of diabetic coronary heart disease as the standard: Diabetic patients have heart discomfort symptoms after labor, emotional agitation, full meal or exposure to cold - palpitations, irritability, limb weakness, chest pain and tightness, dyspnea, which are relieved after rest or taking nitroglycerin . The above symptoms can be diagnosed. Among the confirmed observation subjects, there were 3 males and 4 females, without other serious diseases, aged from 47 to 81 years old, with an average age of 63.7 years.

疗效判定:Judgment of curative effect:

1、显效:糖尿病患者在劳动、情绪激动、饱餐或受寒后等同样条件下心区不适症状明显缓解——心悸烦躁减轻,心动过速消失,脉搏60~90次/分钟;肢软乏力缓解,身上有劲;胸痛胸闷明显改善,发作次数减少,程度减轻;呼吸顺畅,心区舒适;心电图可见心肌供血改善。1. Significantly effective: Diabetic patients have obvious relief of heart discomfort symptoms under the same conditions such as labor, emotional agitation, full meal or exposure to cold - palpitations and irritability are relieved, tachycardia disappears, pulse is 60-90 beats/min; limb weakness is relieved, There is strength in the body; chest pain and tightness are significantly improved, the number of attacks is reduced, and the degree is alleviated; the breathing is smooth and the heart area is comfortable; the electrocardiogram shows that the blood supply to the myocardium is improved.

2、有效:心悸烦躁、胸痛胸闷、呼吸困难等心区不适有所缓解。2. Effective: heart palpitations, irritability, chest pain, chest tightness, dyspnea and other discomfort in the heart area are relieved.

3、无效:病症无变化。3. Ineffective: no change in symptoms.

临床实验时,除糖尿病患者必须的降糖药照常服用(药不变、量不变)外,停服其它药物和保健营养品。服用本发明中药胶囊,观察6个月,为一个疗程。服用方法:每日2次,每次3粒胶囊,每粒胶囊内含中药细粉及提取物0.28克,饭后温开水送服,1个月后症状即有缓解,服用6个月后,症状明显改善。临床实验的7人中,显效3人,有效3人,无效1人,总有效率85.7%。During clinical trials, except for the necessary hypoglycemic drugs for diabetic patients to take as usual (drugs and doses unchanged), other drugs and health nutrition products were stopped. Take Chinese medicine capsule of the present invention, observe 6 months, be a course of treatment. Dosing method: 2 times a day, 3 capsules each time, each capsule contains 0.28 grams of fine powder and extract of traditional Chinese medicine, take it with warm water after meals, the symptoms will be relieved after 1 month, and after 6 months of taking, Symptoms improved significantly. Among the 7 people in the clinical trial, 3 people were markedly effective, 3 people were effective, and 1 person was ineffective, and the total effective rate was 85.7%.

Claims (1)

1. Chinese medicine for the treatment of diabetic cardiopathy, it is characterized in that: it is to make with the component of following weight ratio: Rhizoma Cyperi 5-15 part, Radix Angelicae Sinensis 6-18 part, Radix Notoginseng 3-9 part, Radix Cynanchi Atrati 5-15 part, Ganoderma 6-18 part, Radix Salviae Miltiorrhizae 6-18 part.
CN2010105429674A 2010-11-11 2010-11-11 Traditional Chinese medicine for treating diabetic heart disease Pending CN101991743A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102389493A (en) * 2011-07-23 2012-03-28 北京绿源求证科技发展有限责任公司 Traditional Chinese medicine for treating diabetic heart disease

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102389493A (en) * 2011-07-23 2012-03-28 北京绿源求证科技发展有限责任公司 Traditional Chinese medicine for treating diabetic heart disease

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Application publication date: 20110330