Summary of the invention
The inventor studies assiduously under the incomplete situation of prior art, use Chinese traditional treatment otomycosis externa expelling wind and removing dampness, detoxifying and relieving itching, softening blood vessel dilating promotes downright bad nervous cell regenerating, the treatment otomycosis externa is had unique curative effect, for the patient has removed misery, and have no side effect.
A kind of compound spirit that otomycosis externa infects for the treatment of of the present invention is to be made by the raw material of following weight portion:
Cortex Dictamni 1.5-5.5 part, Cortex tripterygii hypoglauci radicis 1.5-5.5 part, Herba Ajugae 1.0-3.5 part, Spina Gleditsiae 1.0-3.5 part,
Radix Angelicae Dahuricae 2.5-5.0 part, Radix Platycodonis 2.5-5.0 part, Flos Carthami 1.0-3.5 part, Rhizoma Chuanxiong 1.0-3.5 part,
Indigo Naturalis 1.5-5.5 part, Flos Chrysanthemi Indici 2.5-5.0 part, Herba Taraxaci 2.5-5.0 part, Borax 1.5-5.5 part,
100 parts of Borneolum Syntheticum 1.5-5.5 parts, Oleum menthae 1.5-5.5 part, ethanol.
Preparation method:
1) according to formula proportion Cortex Dictamni, Cortex tripterygii hypoglauci radicis, Herba Ajugae, Spina Gleditsiae, the Radix Angelicae Dahuricae, Radix Platycodonis, Flos Carthami, Rhizoma Chuanxiong, Flos Chrysanthemi Indici, Herba Taraxaci, Indigo Naturalis 11 flavor raw materials are put into marmite and added the triplication distilled water immersion 1 hour, be heated to and changed slow fire boiling 1.5 hours after boiling, the filtered while hot waste, filtrate for later use;
2) press formula proportion with stirring and dissolving in the filtrate of Borneolum Syntheticum, Borax 2 flavor raw materials adding step 1), add dehydrated alcohol again,
Add Oleum menthae at last and stir, use ultrasound wave homogenize 10-30 minute then under 0-10 ℃ of temperature, packing is finished product.
Usage and dosage: every day 3~4 times, each 25mg, 7 days/course of treatment; Dip in medical cotton stick and to get hydrogen peroxide or normal saline is cleaned external auditory meatus, dip in cotton swab then and get tincture wiping external auditory meatus of the present invention,, make medicinal liquid can fully arrive focus with cotton swab applying light external auditory meatus.
A kind of compound spirit that otomycosis externa infects for the treatment of of the present invention is to be made by the raw material of following weight portion:
Cortex Dictamni 2.0-5.0 part, Cortex tripterygii hypoglauci radicis 2.0-5.0 part, Herba Ajugae 1.5-2.5 part, Spina Gleditsiae 1.5-2.5 part,
Radix Angelicae Dahuricae 3.0-4.5 part, Radix Platycodonis 3.0-4.5 part, Flos Carthami 1.5-2.5 part, Rhizoma Chuanxiong 1.5-2.5 part,
Indigo Naturalis 2.0-5.0 part, Flos Chrysanthemi Indici 3.0-4.5 part, Herba Taraxaci 3.0-4.5 part, Borax 2.0-5.0 part,
100 parts of Borneolum Syntheticum 2.0-5.0 parts, Oleum menthae 2.0-5.0 part, ethanol.
A kind of compound spirit that otomycosis externa infects for the treatment of of the present invention is to be made by the raw material of following weight portion:
3.5 parts of Cortex Dictamni, 3.5 parts of Cortex tripterygii hypoglauci radiciss, 3.0 parts of Herba Ajugaes, 3.0 parts of Spina Gleditsiaes, 4.0 parts of the Radixs Angelicae Dahuricae,
4.0 parts of Radix Platycodoniss, 3.5 parts on Flos Carthami, 3.5 parts of Rhizoma Chuanxiongs, 3.5 parts of Indigo Naturaliss, 4.0 parts of Flos Chrysanthemi Indicis,
4.0 parts of Herba Taraxacis, 3.5 parts of Boraxs, 3.5 parts of Borneolum Syntheticums, 3.5 parts of Oleum menthae, 100 parts of ethanol.
The raw material pharmacology and the property of medicine involved in the present invention:
Cortex Dictamni: bitter cold, go into spleen, the stomach warp.Function: heat-clearing and toxic substances removing, expelling wind and removing dampness.Be used for diseases such as damp and hot sore, rubella, scabies, skin scratch, arthralgia chiefly caused by damp pathogen, jaundice.
Cortex tripterygii hypoglauci radicis: bitterness, temperature, severe toxicity.Reunion of fractured tendons and bones, eliminating blood stasis and smoothing collaterals.Control fracture, rheumatalgia, traumatic injury.
Herba Ajugae: acrid in the mouth, bitterness are cold, return Liver Channel, but liver heat removing and eyesight improving, dispersing swelling and dissipating binds, suppressing the hyperactive liver sun.
Spina Gleditsiae: suffering, temperature, nontoxic.
Blood circulation promoting medicine, the medicine that dispels the wind is used for: swollen ulcer drug, scrofula, skin ulcer rash stubborn dermatitis, puerperal hypogalactia, placenta retention, leprosy.
The Radix Angelicae Dahuricae: nature and flavor suffering, temperature are gone into lung, spleen, stomach warp; Effect: control headache, supraorbital bone pain, toothache, cold-damp stomachache, skin pruritus, scabies.
Radix Platycodonis: nature and flavor are flat, hide bitter.Function cures mainly: lung qi dispersing, sore-throat relieving eliminates the phlegm, evacuation of pus.Be used for cough with copious phlegm, uncomfortable in chest not smooth, laryngopharynx swelling and pain, bronchitis, lung abscess, pleuritis.
Flos Carthami: warm in nature, acrid in the mouth.Invigorate blood circulation latus rectum, eliminating stasis to stop pain.Be used for that amenorrhea, dysmenorrhea, lochia are not all right, lump in the abdomen mass in the abdomen, traumatic injury, be suitable for various varicosis, peripheral neuritis, blood circulation, lower limb numbness or congestion such as livid purple.
Rhizoma Chuanxiong: suffering, temperature.Return liver, gallbladder, pericardium channel.Effect: activating QI to alleviate the depression, the method wind-dryness is wet, promoting blood circulation and stopping pain.Control air-cooled headache and revolve dizzyly, the hypochondriac pain abdomen is painful, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation piece pain, ulcer sores.Be used for menoxenia, amenorrhea dysmenorrhea, abdominal mass stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.Blood-activating and qi-promoting, wind-expelling pain-stopping. be used for menoxenia, amenorrhea dysmenorrhea, abdominal mass stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.
Indigo Naturalis: salty, cold.Return Liver Channel.Function cures mainly: heat-clearing and toxic substances removing, removing heat from blood, arresting convulsion.Be used for maculae caused by violent heat pathogen, heat in blood is told nosebleed, chest pain hemoptysis, aphtha, mumps, sore throat, pediatric epilepsy scared.
Flos Chrysanthemi Indici: be valued for wild, beautiful natural; Its cold nature, bitter in the mouth and suffering; Function: effect with heat-clearing and toxic substances removing.
Herba Taraxaci: sweet, little hardship, cold.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.Cure mainly: upper respiratory tract infection, eye conjunctivitis, mumps, acute mastitis swells and ache, gastritis, dysentery, hepatitis, gallbladder is assisted inflammation, acute appendicitis, urinary system infection, pelvic inflammatory disease, carbuncle furuncle furuncle, pharyngitis is controlled acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, urinary tract infection.
Borax: sweet, salty, cold.Attach to the lung and stomach meridians.The external heat-clearing and toxic substances removing, detumescence, anticorrosion; Removing heat from the lung and dissipating phlegm for oral administration.Be used for acute tonsillitis, pharyngolaryngitis, laryngopharynx swelling and pain, aphtha of the mouth and tongue, stomatitis, gingivitis, otitis media, conjunctival congestion and swelling pain.
Borneolum Syntheticum: acrid in the mouth, hardship are slightly cold.GUIXIN, spleen, the lung hydrocarbon.Effect: the refreshment of having one's ideas straightened out, clearing away heat to alleviate pain.
The specific embodiment:
Embodiment 1, prescription:
Cortex Dictamni 1.5g, Cortex tripterygii hypoglauci radicis 1.5g, Herba Ajugae 1.0g, Spina Gleditsiae 1.0g,
Radix Angelicae Dahuricae 2.5g, Radix Platycodonis 2.5g, Flos Carthami 1.0g, Rhizoma Chuanxiong 1.0g,
Indigo Naturalis 1.5g, Flos Chrysanthemi Indici 2.5g, Herba Taraxaci 2.5g, Borax 1.5g,
Borneolum Syntheticum 1.5g, Oleum menthae 1.5g, ethanol 100g.
Preparation method:
1) according to formula proportion Cortex Dictamni, Cortex tripterygii hypoglauci radicis, Herba Ajugae, Spina Gleditsiae, the Radix Angelicae Dahuricae, Radix Platycodonis, Flos Carthami, Rhizoma Chuanxiong, Flos Chrysanthemi Indici, Herba Taraxaci, Indigo Naturalis 11 flavor raw materials are put into marmite and added the triplication distilled water immersion 1 hour, be heated to and changed slow fire boiling 1.5 hours after boiling, the filtered while hot waste, filtrate for later use;
2) press formula proportion with stirring and dissolving in the filtrate of Borneolum Syntheticum, Borax 2 flavor raw materials adding step 1), add dehydrated alcohol again, add Oleum menthae at last and stir, use ultrasound wave homogenize 10-30 minute then under 0-10 ℃ of temperature, packing is finished product.
Usage and dosage: every day 3~4 times, each 25mg, 7 days/course of treatment; Dip in medical cotton stick and to get hydrogen peroxide or normal saline is cleaned external auditory meatus, dip in cotton swab then and get tincture wiping external auditory meatus of the present invention,, make medicinal liquid can fully arrive focus with cotton swab applying light external auditory meatus.
Embodiment 2, prescription:
Cortex Dictamni 2.0g, Cortex tripterygii hypoglauci radicis 2.0g, Spina Gleditsiae 1.5g, Radix Angelicae Dahuricae 3.0g, Radix Platycodonis 3.0g, Oleum menthae 2.0g,
Flos Carthami 1.5g, Rhizoma Chuanxiong 1.5g, Indigo Naturalis 2.0g, Flos Chrysanthemi Indici 3.0g, Herba Taraxaci 3.0g, Borax 2.0g,
Borneolum Syntheticum 2.0g, Herba Ajugae 1.5g, ethanol 100g.
Preparation method, usage and dosage are identical with embodiment 1.
Embodiment 3, prescription:
Cortex Dictamni 3.5g, Cortex tripterygii hypoglauci radicis 3.5g, Spina Gleditsiae 3.0g, Radix Angelicae Dahuricae 4.0g, Radix Platycodonis 4.0g, Flos Carthami 3.5g,
Indigo Naturalis 3.5g, Flos Chrysanthemi Indici 4.0g, Herba Taraxaci 4.0g, Borax 3.5g, Borneolum Syntheticum 3.5g, Oleum menthae 3.5g,
Rhizoma Chuanxiong 3.5g, Herba Ajugae 3.0g, ethanol 100g.
Preparation method, usage and dosage are identical with embodiment 1.
Embodiment 4, prescription:
Cortex Dictamni 5.0g, Cortex tripterygii hypoglauci radicis 5.0g, Spina Gleditsiae 2.5g, Radix Angelicae Dahuricae 4.5g, Radix Platycodonis 4.5g, Flos Carthami 1.5-2.5g,
Rhizoma Chuanxiong 2.5g, Indigo Naturalis 5.0g, Flos Chrysanthemi Indici 4.5g, Herba Taraxaci 4.5g, Borax 5.0g, Borneolum Syntheticum 5.0g,
Oleum menthae 5.0g, Herba Ajugae 2.5g, ethanol 100g.
Preparation method, usage and dosage are identical with embodiment 1.
Embodiment 5, prescription:
Cortex Dictamni 5.5g, Cortex tripterygii hypoglauci radicis 5.5g, Spina Gleditsiae 3.5g, Radix Angelicae Dahuricae 5.0g, Radix Platycodonis 5.0g, Flos Carthami 3.5g,
Rhizoma Chuanxiong 3.5g, Indigo Naturalis 5.5g, Flos Chrysanthemi Indici 5.0g, Herba Taraxaci 5.0g, Borax 5.5g, Borneolum Syntheticum 5.5g,
Oleum menthae 5.5g, Herba Ajugae 3.5g, ethanol 100g.
Preparation method, usage and dosage are identical with embodiment 1.
The observation of curative effect of treatment otomycosis externa
We obtain good result in 2009-2010 treatment otomycosis externa 300 examples, now are summarized as follows.
The typical clinical case is selected:
MethodsThe cases enrolled 60 examples, MethodsThe cases enrolled are my outpatient of section.Wherein male 32 examples, women 28 examples are the oldest 60 years old, minimum 12 years old, the shortest 2 weeks of medical history, the longest 9 years.
Efficacy assessment standard:
Cure: sings and symptoms disappears, and mycology is checked negative;
Produce effects: sings and symptoms is clearly better, and mycology is checked negative;
Take a turn for the better: sings and symptoms partly takes a turn for the better, and mycology is checked negative or positive;
Invalid: sings and symptoms no change or increase the weight of, mycology is checked positive
60 exception auditory meatus mycosis cases are carried out retrospective analysis, all patients all after the mycology inspection is diagnosed as otomycosis externa, topical application tincture of the present invention, the time of following up a case by regular visits to was 12 weeks.The total effective rate in 12 weeks is 98.8% as a result, and cure rate is 86%, and obvious effective rate is 8.1%, and improvement rate is 4.7%, invalid 1.2%.
Model case:
Case 1: king xx, 29 years old, when swimming before 9 years, ear was intake accidentally, occurred the external ear Dodge subsequently and itched incomparably, after remove local hospital admission, hospital intends examining and is " otomycosis externa ", gives tincture treatment of the present invention, treated 10 days, symptom is controlled fully, so far not recurrence.
Case 2: open XX, the man, 46 years old because of left pain and bulge of the ear, tinnitus, auditory dysesthesia, itches unbearably after three days in the external ear Dodge, and to having cured institute's inspection: auris dextra is normal, left side ear external auditory canal opening erosion, have sticking purulent secretion to overflow in the external auditory meatus, clean up the later stage, the doctor uses tincture of the present invention, subjective symptoms alleviates after three days, and audition is normal.Use after 10 days, symptom all disappears.Check to hospital again after later six months, external auditory meatus, tympanum is all normal.
Case 3: Liu xx, very to itch sometimes in left itching in the ear February, night is heavy, outbreak repeatedly, no tinnitus and auditory dysesthesia.Once dripped ear with ear-drop oil voluntarily, just effectively, outbreak can not be effected a radical cure repeatedly.Looking into ear sees: the visible mould tongue of yellow-white in the external auditory meatus of left side, be the crust shape with the contact skin place, and remove surperficial dry crusts, visible contrafluxion, tympanum is normal.Press tragus and traction lug profile has mild pain.Left side ear peripheral lymph node does not touch enlargement.2 10% sodium hydroxide solutions dissolving back smears, visible mycelia and circular or oval spore under the mirror will be added after the crust taking-up in the external auditory meatus.Through outside after ear's medication symptom eliminate, after recurrence again.
Case 4: neat xx, in ear is itched, with night for very.The inspection auditory meatus of regarding sb. as an outsider has yellow fine hair shape tongue film, and secretions or crust are tubular sometimes, sees after removing that the affected part is slightly congested moist.When merging bacterial infection, otalgia is arranged, suppurate.Be diagnosed as: otomycosis externa, 2 weeks recovery from illness after tincture treatment of the present invention, not recurrence so far.
Case 5: open xx, the in ear sense is very itched, with night for very.Inspection sees that drum covers, the Powdered tongue film of the equal adularescent of external auditory meatus, and secretions is tubular sometimes, sees after removing that the affected part is slightly congested moist.When merging bacterial infection, otalgia can be arranged, suppurate.Be diagnosed as: otomycosis externa, 2 weeks recovery from illness after tincture treatment of the present invention, not recurrence so far.
Case 6: Wei XX, the man itched unbearably because of left pain and bulge of the ear, tinnitus, external ear Dodge in 20 years old, to having cured institute's inspection: left ear is normal, the erosion of auris dextra external auditory canal opening has sticking purulent secretion to overflow in the external auditory meatus, clean up the later stage, the doctor uses tincture of the present invention, and subjective symptoms alleviates after three days, and audition is normal.After using for two weeks, symptom all disappears.Check to hospital again afterwards, external auditory meatus, tympanum is all normal.
Case 7: the Meng xx, external auditory meatus is because of inflammation, constitutes crust and blocks external auditory meatus and cause shallow table exuviation and mycelium, even when being overlying on the tympanum surface, tinnitus, auditory dysesthesia can take place.2 weeks recovery from illness after tincture treatment of the present invention, not recurrence so far.
Case 8: Jiang xx, there is the black membranoid substance in the external auditory meatus deep, and performance has yellow powder,, observe at magnifier or microscopically, tympanum is covered by Mycoderma sometimes, 2 weeks recovery from illness after tincture treatment of the present invention, not recurrence so far.
Case 9: Cao xx, behind the taking-up auditory meatus crust, the ear channel skin of regarding sb. as an outsider often has hyperemia, erosion and thin secretions, tympanum Chang Mingxian hyperemia.The doctor uses tincture of the present invention, and subjective symptoms alleviates after three days, and audition is normal.After using for two weeks, symptom all disappears.Check to hospital again afterwards, external auditory meatus, tympanum is all normal.
Case 10: permitted xx, external auditory meatus membranoid substance plate coating checking can be found mycelium and spore, and the ear channel skin of regarding sb. as an outsider often has hyperemia, erosion and thin secretions, tympanum Chang Mingxian hyperemia.The doctor uses tincture of the present invention, and subjective symptoms alleviates after three days, and audition is normal.After using for two weeks, symptom all disappears.Check to hospital again afterwards, external auditory meatus, tympanum is all normal.