CN101953959A - Chinese medicament for treating diabetic gastroparalysis - Google Patents

Abstract

The invention discloses a Chinese medicament for treating diabetic gastroparalysis, which belongs to the field of Chinese medicaments for treating diabetes mellitus and aims to achieve good effect and quick response. The Chinese medicament is prepared from the raw materials of lightyellow sophora roots, glossy ganoderma, pseudo-ginseng, Chinese angelica, official magnolia bark, pinellia tuber, radish seeds and the like. The Chinese medicament has the effects of supporting right, banking the root up, boosting qi, nourishing the blood, quickening the blood, transforming stasis, clearing heat and drying dampness, dispersing glomus and transforming accumulations, and has the advantages of remarkable effects, remarkable potency and relatively quicker response.

Description

A kind of traditional Chinese medicine for treating diabetic gastroparesis

technical field

The invention belongs to the field of traditional Chinese medicine for treating diabetes.

Background technique

Diabetes complicated with stomach lesions, mainly diabetic gastroparesis (gastroparesis), is a kind of abnormal gastric motility, weakened or disappeared gastric motility, which makes gastric emptying obstructed. About 20% to 30% of diabetic patients have this disease, which is a large group of diseases. The current traditional Chinese medicine aimed at treating diabetic gastroparesis has two deficiencies: one is that the effect is not obvious enough, and the other is that the effect is relatively slow, so that a large number of diabetic gastroparesis sufferers suffer from long-term postprandial pain due to lack of effective drug treatment. Fullness, nausea and vomiting, pain, anorexia, and indigestion seriously affect the quality of life, and the patient is not satisfied with it.

In view of the problems raised above, the present invention provides a traditional Chinese medicine for treating diabetic gastroparesis, which can solve the problems that the effect of traditional Chinese medicines in the past is not obvious enough, and the effect is relatively slow. Exactly, the advantage of quicker effect.

Contents of the invention

The present invention is achieved through the following technical solutions:

1, a kind of Chinese medicine for the treatment of diabetic gastroparesis, adopts Chinese medicine raw material to prepare, and formula is (by weight):

Sophora 5——15 parts Ganoderma lucidum 6—18 parts Sanqi 3—9 parts

Angelica 6—18 parts Magnolia officinalis 5—15 parts Pinellia 5—15 parts

radish seeds 5-15 parts

This traditional Chinese medicine for treating diabetic gastroparesis is made by the following method:

(1) According to the above weight ratio, extract Ganoderma lucidum polysaccharides from Ganoderma lucidum with water extraction and alcohol precipitation method, the process is as follows: crush Ganoderma lucidum into granules, pass through a 40-mesh sieve → leaching with 1:20 hot water (95°C) → leaching Extract the liquid under reduced pressure, concentrate → mix with 3 times the volume of 95% ethanol, let stand for 10-12 hours, centrifuge → add 75% ethanol, precipitate polysaccharide → dry to obtain fine powder of Ganoderma lucidum polysaccharide extract;

(2) According to the above weight ratio, Sophora flavescens, Angelica sinensis, Magnolia officinalis officinalis, Pinellia radiata, Laifuzi are extracted through a conventional water extraction process to make extract extract fine powder;

(3) According to the above weight ratio, grind Radix Notoginseng into a fine powder, mix with the fine powder of the above two kinds of extracts (1) and (2), stir evenly, and make traditional Chinese medicine granules, capsules, and tablets.

The present invention is elaborately developed according to the folk traditional formula and the theory of traditional Chinese medicine of strengthening the body and strengthening the body, promoting blood circulation and removing blood stasis. Our research suggests that diabetic gastroparesis is caused by damage to the nerves that control gastric motility. The reason is that the immunity of diabetic patients is generally low, the deficiency is serious, and the fire is internally generated for a long time, the dryness and heat damage the yin, the blood is viscous, and the flow is not smooth, resulting in insufficient blood supply to the stomach, nervous dystrophy, weakened gastric motility, and significantly weakened peristalsis. Treatment should focus on "strengthening the body", nourishing qi and nourishing blood, promoting blood circulation and removing blood stasis, eliminating swelling and accumulation. Ganoderma lucidum, angelica, Sanqi Fuzheng Peiben in this prescription can nourish qi and blood, promote blood circulation and remove blood stasis, enhance the body's immunity, "clear" the immunity, make the blood clean, reduce the viscosity, be full of fluidity, and improve immunity The "repair" effect of flavescens makes the damaged gastric nerves and gastric tissues restore their original peristalsis and digestive functions, which is the key to the treatment of the disease; Magnolia bark lowers qi to eliminate swelling, pinellia dispels phlegm and dissipates stagnation, and the combined use of the two medicines promotes Qi stagnation and harmonizes stomach to dispel stagnation; supplemented with radish seed to relieve food and dissipate qi and dissipate phlegm to relieve abdominal fullness. All the medicines are compatible and complement each other. They play the role of strengthening the body, nourishing qi and nourishing blood, promoting blood circulation and removing blood stasis, clearing away heat and dampness, eliminating swelling and accumulation. It has good effect and quick effect. advantage.

Detailed ways

The present invention is specifically described by the following embodiments:

1. Take the following formula (weight is in grams):

Sophora flavescens 50 grams Ganoderma lucidum 60 grams Panax notoginseng 30 grams

Angelica 60g Magnolia officinalis 50g Pinellia 50g

radish seeds 50 grams

Extract Ganoderma lucidum by water extraction and alcohol precipitation method according to the specified weight; extract Sophora flavescens, Angelica sinensis, Magnolia officinalis, Pinellia, and Laifuzi with conventional water extraction process, and make a total of 64 grams of extract fine powder, and grind Panax notoginseng into Fine powder, mixed with the fine powder of the above-mentioned extract, stirred evenly, made into fine particles, packed into No. 0 capsules, and made into 335 Chinese medicine capsules, each capsule containing 0.28 grams of Chinese medicine fine powder and extract.

2. Take the following formula (weight is in grams):

Sophora 90g Ganoderma lucidum 120g Panax notoginseng 60g

Angelica 120g Magnolia officinalis 90g Pinellia 90g

radish seeds 90g

By above-mentioned same method, make 642 Chinese medicine capsules, every capsule contains Chinese medicine fine powder and extract 0.28 gram.

3. Take the following formula (the weight is in grams):

Sophora flavescens 140g Ganoderma lucidum 180g Panax notoginseng 90g

Angelica 180g Magnolia officinalis 140g Pinellia 140g

radish seeds 140g

By the same method as above, 978 Chinese medicine capsules were made, each capsule containing 0.28 grams of Chinese medicine fine powder and extract.

4. Take the following formula (by weight):

6 parts of Sophora flavescens 7 parts of Ganoderma lucidum 3 parts of Panax notoginseng

Angelica 7 parts Magnolia 6 parts Pinellia 6 parts

6 servings of radish

By the above-mentioned same method, Chinese medicine capsules are made, and each capsule contains 0.28 grams of Chinese medicine fine powder and extract.

5. Take the following formula (by weight):

12 parts of Sophora flavescens 16 parts of Ganoderma lucidum 7 parts of Panax notoginseng

Angelica 16 parts Magnolia officinalis 12 parts Pinellia 12 parts

12 radish seeds

By the above-mentioned same method, Chinese medicine capsules are made, and each capsule contains 0.28 grams of Chinese medicine fine powder and extract.

clinical information:

The present invention takes TCM diabetic gastroparesis (gastroparesis) as an example, through clinical observation of 8 cases. Choose TCM diagnosis of diabetic gastroparesis as the standard: Diabetic patients have limb weakness, stomach pain, upper abdominal fullness after meals, indigestion, long gastric emptying time, loss of appetite, and often have symptoms such as nausea, vomiting, heartburn, and acid reflux . The above symptoms can be diagnosed. Among the objects under confirmed observation, there were 4 males and 4 females, without other serious diseases, aged from 42 to 77 years old, with an average age of 60.3 years.

Judgment of curative effect:

1. Significant effect: Physical fitness is enhanced, limbs are strong; symptoms such as stomach pain, upper abdominal fullness, indigestion, and long gastric emptying time are significantly relieved.

2. Effective: Physical fitness is enhanced, stomach pain, upper abdominal fullness, indigestion and other symptoms are relieved.

3. Ineffective: no change in symptoms.

During the clinical trial, except for the hypoglycemic drugs, stop taking other drugs and health nutrition products. Take Chinese medicine capsule of the present invention, observe 3 months and be a course of treatment. Dosing method: 2 times a day, 4 capsules each time, each capsule contains 0.28 grams of fine powder and extract of traditional Chinese medicine, take it with warm water after meals, the symptoms will be relieved after 1 month, and after 3 months of taking, Symptoms improved significantly. Among the 8 clinical trials, 4 people were markedly effective, 3 people were effective, and 1 person was ineffective, with a total effective rate of 87.5%.

Claims (1)

1. Chinese medicine for the treatment of diabetic gastroparalysis, it is characterized in that: it is to make with the component of following weight ratio: Radix Sophorae Flavescentis 5---15 parts, Ganoderma---18 parts, Radix Notoginseng 3---9 parts, Radix Angelicae Sinensis 6---18 parts, Cortex Magnoliae Officinalis 5---15 parts, the Rhizoma Pinelliae 5---15 parts, Semen Raphani 5---15 parts.