CN101941980A - 哌拉西林酸的改良的结晶提纯析出方法 - Google Patents
哌拉西林酸的改良的结晶提纯析出方法 Download PDFInfo
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- CN101941980A CN101941980A CN201010273253.8A CN201010273253A CN101941980A CN 101941980 A CN101941980 A CN 101941980A CN 201010273253 A CN201010273253 A CN 201010273253A CN 101941980 A CN101941980 A CN 101941980A
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- CN
- China
- Prior art keywords
- piperacillin
- ethyl acetate
- acetone
- cooled
- monohydrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229960002292 piperacillin Drugs 0.000 title claims abstract description 28
- 238000002425 crystallisation Methods 0.000 title claims abstract description 22
- 230000008025 crystallization Effects 0.000 title claims abstract description 22
- 239000002253 acid Substances 0.000 title claims abstract description 21
- IVBHGBMCVLDMKU-GXNBUGAJSA-N piperacillin Chemical compound O=C1C(=O)N(CC)CCN1C(=O)N[C@H](C=1C=CC=CC=1)C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 IVBHGBMCVLDMKU-GXNBUGAJSA-N 0.000 title claims abstract 12
- 238000000034 method Methods 0.000 title abstract description 8
- 230000001376 precipitating effect Effects 0.000 title abstract 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims abstract description 84
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims abstract description 44
- 239000007864 aqueous solution Substances 0.000 claims abstract description 11
- 239000012043 crude product Substances 0.000 claims abstract description 11
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims abstract description 8
- 239000013078 crystal Substances 0.000 claims abstract description 7
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims abstract description 4
- 235000017557 sodium bicarbonate Nutrition 0.000 claims abstract description 4
- 238000010438 heat treatment Methods 0.000 claims abstract description 3
- 239000011259 mixed solution Substances 0.000 claims description 13
- 238000000746 purification Methods 0.000 claims description 8
- 238000002156 mixing Methods 0.000 claims description 5
- 238000000926 separation method Methods 0.000 claims description 4
- 239000000706 filtrate Substances 0.000 claims description 3
- 238000001914 filtration Methods 0.000 abstract description 5
- 150000003952 β-lactams Chemical class 0.000 abstract description 2
- 238000001816 cooling Methods 0.000 abstract 4
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- NBXPLBPWMYNZTC-IDYPWDAWSA-N (2s,5r,6r)-6-[[(2r)-2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;hydrate Chemical compound O.O=C1C(=O)N(CC)CCN1C(=O)N[C@H](C=1C=CC=CC=1)C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 NBXPLBPWMYNZTC-IDYPWDAWSA-N 0.000 description 25
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 12
- 239000012535 impurity Substances 0.000 description 12
- 238000003756 stirring Methods 0.000 description 8
- 150000004682 monohydrates Chemical class 0.000 description 7
- 238000007670 refining Methods 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 238000004128 high performance liquid chromatography Methods 0.000 description 5
- WCMIIGXFCMNQDS-IDYPWDAWSA-M piperacillin sodium Chemical compound [Na+].O=C1C(=O)N(CC)CCN1C(=O)N[C@H](C=1C=CC=CC=1)C(=O)N[C@@H]1C(=O)N2[C@@H](C([O-])=O)C(C)(C)S[C@@H]21 WCMIIGXFCMNQDS-IDYPWDAWSA-M 0.000 description 4
- 229960005264 piperacillin sodium Drugs 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 3
- 239000008213 purified water Substances 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 2
- 230000000845 anti-microbial effect Effects 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- NDIURPSCHWTXDC-UHFFFAOYSA-N 2-(4,5-dimethoxy-2-nitrophenyl)acetohydrazide Chemical compound COC1=CC(CC(=O)NN)=C([N+]([O-])=O)C=C1OC NDIURPSCHWTXDC-UHFFFAOYSA-N 0.000 description 1
- 241001112741 Bacillaceae Species 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 206010061695 Biliary tract infection Diseases 0.000 description 1
- 241000588921 Enterobacteriaceae Species 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 206010058674 Pelvic Infection Diseases 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 206010062255 Soft tissue infection Diseases 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 125000003368 amide group Chemical group 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 208000003167 cholangitis Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- RBKMMJSQKNKNEV-RITPCOANSA-N penicillanic acid Chemical compound OC(=O)[C@H]1C(C)(C)S[C@@H]2CC(=O)N21 RBKMMJSQKNKNEV-RITPCOANSA-N 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 239000013557 residual solvent Substances 0.000 description 1
- 230000000452 restraining effect Effects 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 206010040872 skin infection Diseases 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- FKENQMMABCRJMK-RITPCOANSA-N sulbactam Chemical compound O=S1(=O)C(C)(C)[C@H](C(O)=O)N2C(=O)C[C@H]21 FKENQMMABCRJMK-RITPCOANSA-N 0.000 description 1
- 229960005256 sulbactam Drugs 0.000 description 1
- 229960000373 tazobactam sodium Drugs 0.000 description 1
- 210000001635 urinary tract Anatomy 0.000 description 1
- 208000019206 urinary tract infection Diseases 0.000 description 1
- 230000003462 zymogenic effect Effects 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Description
Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN2010102732538A CN101941980B (zh) | 2010-09-06 | 2010-09-06 | 哌拉西林酸的结晶提纯析出方法 |
Applications Claiming Priority (1)
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CN2010102732538A CN101941980B (zh) | 2010-09-06 | 2010-09-06 | 哌拉西林酸的结晶提纯析出方法 |
Publications (2)
Publication Number | Publication Date |
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CN101941980A true CN101941980A (zh) | 2011-01-12 |
CN101941980B CN101941980B (zh) | 2012-02-08 |
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CN2010102732538A Active CN101941980B (zh) | 2010-09-06 | 2010-09-06 | 哌拉西林酸的结晶提纯析出方法 |
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102807572A (zh) * | 2011-05-30 | 2012-12-05 | 秦引林 | 一种哌拉西林钠的精制方法 |
CN102977119A (zh) * | 2012-12-14 | 2013-03-20 | 江西富祥药业股份有限公司 | 一种用溶媒法制备哌拉西林钠的工艺 |
CN103087079A (zh) * | 2013-02-21 | 2013-05-08 | 齐鲁天和惠世制药有限公司 | 一种哌拉西林的结晶方法 |
CN109734724A (zh) * | 2019-01-30 | 2019-05-10 | 齐鲁天和惠世(乐陵)制药有限公司 | 一种哌拉西林酸的结晶方法 |
CN113072565A (zh) * | 2021-03-17 | 2021-07-06 | 内蒙古常盛制药有限公司 | 一种哌拉西林的结晶方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DD295162A5 (de) * | 1990-06-15 | 1991-10-24 | Arzneimittelwerk Dresden Gmbh I. V.,De | Verfahren zur herstellung von d-alpha-(4-ethyl-2,3-dioxo-piperazin-1-carbonylamino)-benzylpenicillin |
ES2321153A1 (es) * | 2007-10-11 | 2009-06-02 | Astur Pharma S.A. | Intermedio para la sintesis de piperacilina. |
-
2010
- 2010-09-06 CN CN2010102732538A patent/CN101941980B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DD295162A5 (de) * | 1990-06-15 | 1991-10-24 | Arzneimittelwerk Dresden Gmbh I. V.,De | Verfahren zur herstellung von d-alpha-(4-ethyl-2,3-dioxo-piperazin-1-carbonylamino)-benzylpenicillin |
ES2321153A1 (es) * | 2007-10-11 | 2009-06-02 | Astur Pharma S.A. | Intermedio para la sintesis de piperacilina. |
Non-Patent Citations (1)
Title |
---|
《STN检索记录》 20110616 赵贞贞 2010102732538 , 1 * |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102807572A (zh) * | 2011-05-30 | 2012-12-05 | 秦引林 | 一种哌拉西林钠的精制方法 |
CN102977119A (zh) * | 2012-12-14 | 2013-03-20 | 江西富祥药业股份有限公司 | 一种用溶媒法制备哌拉西林钠的工艺 |
CN103087079A (zh) * | 2013-02-21 | 2013-05-08 | 齐鲁天和惠世制药有限公司 | 一种哌拉西林的结晶方法 |
CN103087079B (zh) * | 2013-02-21 | 2014-12-10 | 齐鲁天和惠世制药有限公司 | 一种哌拉西林的结晶方法 |
CN109734724A (zh) * | 2019-01-30 | 2019-05-10 | 齐鲁天和惠世(乐陵)制药有限公司 | 一种哌拉西林酸的结晶方法 |
CN109734724B (zh) * | 2019-01-30 | 2021-06-29 | 山东安舜制药有限公司 | 一种哌拉西林酸的结晶方法 |
CN113072565A (zh) * | 2021-03-17 | 2021-07-06 | 内蒙古常盛制药有限公司 | 一种哌拉西林的结晶方法 |
CN113072565B (zh) * | 2021-03-17 | 2023-08-29 | 内蒙古常盛制药有限公司 | 一种哌拉西林的结晶方法 |
Also Published As
Publication number | Publication date |
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CN101941980B (zh) | 2012-02-08 |
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Owner name: JIANGXI FUSHINE PHARMACEUTICAL CO., LTD. Free format text: FORMER NAME: JINGDEZHEN FUXIANG PHARMACEUTICAL CO., LTD. |
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Address after: 333000 Jiangxi Province, Jingdezhen City Changjiang district fish Li Industrial Zone No. two (206 National Highway) Patentee after: JINGDEZHEN FUXIANG PHARMACEUTICAL Co.,Ltd. Address before: 333000 Jiangxi Province, Jingdezhen City Changjiang district fish Li Industrial Zone No. two (206 National Highway) Patentee before: JINGDEZHEN FUXIANG PHARMACEUTICAL Co.,Ltd. |
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Denomination of invention: Crystallization purification and precipitation method of piperacillin acid Effective date of registration: 20220826 Granted publication date: 20120208 Pledgee: Jingdezhen branch of Bank of Communications Co.,Ltd. Pledgor: JINGDEZHEN FUXIANG PHARMACEUTICAL Co.,Ltd. Registration number: Y2022980013691 |
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Date of cancellation: 20230906 Granted publication date: 20120208 Pledgee: Jingdezhen branch of Bank of Communications Co.,Ltd. Pledgor: JINGDEZHEN FUXIANG PHARMACEUTICAL Co.,Ltd. Registration number: Y2022980013691 |
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Denomination of invention: Crystallization purification and precipitation method of piperacillin acid Effective date of registration: 20231205 Granted publication date: 20120208 Pledgee: Jingdezhen branch of Bank of Communications Co.,Ltd. Pledgor: JINGDEZHEN FUXIANG PHARMACEUTICAL Co.,Ltd. Registration number: Y2023980069713 |
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