CN101856221A - Detection system for determining damage degree and damage positions of spinal cord - Google Patents
Detection system for determining damage degree and damage positions of spinal cord Download PDFInfo
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- CN101856221A CN101856221A CN201010179856A CN201010179856A CN101856221A CN 101856221 A CN101856221 A CN 101856221A CN 201010179856 A CN201010179856 A CN 201010179856A CN 201010179856 A CN201010179856 A CN 201010179856A CN 101856221 A CN101856221 A CN 101856221A
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- cord injury
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Abstract
The invention relates to a detection system for determining damage degree and damage positions of spinal cord, comprising a laser, a filter, an electroencephalogram signal collecting device, a signal analyzing device and a display device, wherein a laser beam produced by the laser is irradiated on a human body through the filter; the electroencephalogram signal collecting device is used for collecting electroencephalogram signals of the human body; the signal analyzing system adopts a real time signal processing algorithm to process the electroencephalogram signals and output a detection result; and the display device is used for displaying waveforms and detection results at different stimulated positions. The detection system for determining the damage degree and the damage position of the spinal cord just selectively simulates C fiber, the recorded signals are just laser evoked potentials related to C fiber simulation, thus, the signals recorded by the detection system for determining the damage degree and the damage position of the spinal cord are clearer, components are simpler, and the judgment of the damage degree and the damage positions of the spinal cord is corresponding more accurate.
Description
Technical field
The present invention relates to the detection system of a kind of definite spinal cord injury degree and damage location.
Background technology
The impaired spinal nerves that is meant of spinal cord causes damage because of some reason, thereby can influence the body movement function in various degree, and the extent of damage is decided by the position and the order of severity of neurologic defict.Survey the extent of damage of spinal cord and the impaired crucial effects that plays of spinal nerves that damaged part causes for the treatment a variety of causes.It is the detection method of measuring the conduction function of somatosensory system (based on funiculus posterior medullae spinalis) that somatosensory evoked potential is measured (SEP).
Tradition SEP is that the sensation of mixed nerve is propped up around the employing electric-impulse stimulation, and utilize neuroelectricity physiology instrument simultaneously at near-end peripheral nerve, spinal cord surface or territory, scalp cortical sensory area record bioelectric waveform, main observation index is incubation period and wave amplitude, and then judges the spinal cord injury degree.
Electricity irritation has activated the mechanoreceptor (Mechanoreceptor) relevant with seismaesthesia with the skin sense of touch, simultaneously also activate nociceptor (Nociceptive Receptor), caused the cortex signal of telecommunication that records to comprise the signal of mixed nerve fiber conduction, the mechanical stimulus signal of A beta conduction, first pain signal of A δ fiber conduction and second pain signal of C fiber conduction etc.The conducted signal of multiple composition can make that SEP record variability is bigger, and signal to noise ratio is lower, and the signal that records is not easy to analyze, thereby result's accuracy is exerted an influence.
Summary of the invention
In view of this, be necessary at the inaccurate problem of the signal that SEP write down, provide a cover to determine the detection system of spinal cord injury degree and damage location.
The detection system of a kind of definite spinal cord injury degree and damage location comprises laser instrument, filter, eeg signal acquisition device, Signal Analysis System, display device; The laser beam that described laser instrument produces shines on the human body by filter; Described eeg signal acquisition device is used to gather the EEG signals of human body; Described Signal Analysis System adopts the real time signal processing algorithm that EEG signals is handled, and the output testing result; Described display device is used to show the waveform and the testing result at different stimulated position.
Preferably, described laser instrument is a carbon dioxide laser.
Preferably, the wavelength of described laser beam is 10.6 μ m, and diameter is 2mm, and the persistent period is 20ms, and laser intensity is 2-4 watt or 5-7 watt.
Preferably, described filter is the flake aluminum with microwell array.
Preferably, the thickness of described flake aluminum is 0.1mm, and the diameter of described micropore is 0.4mm, and the distance between the adjacent micropore is 1mm.
Preferably, described eeg signal acquisition device comprises acquisition module and signal pre-processing module, and described acquisition module is gathered EEG signals by electrode, described pretreatment module be used for to EEG signals amplify, filtering, sampling and analog-to-digital conversion process.
Preferably, described Signal Analysis System employing real time signal processing algorithm is handled EEG signals and is comprised: EEG signals is carried out pretreatment; Amplitude signal is carried out feature extraction; Eigenvalue and reference value are compared; Obtain time and amplitude that peak value occurs.
Preferably, described testing result comprises the degree of injury and the damage location information of each stimulation location.
The detection system of above-mentioned definite spinal cord injury degree and damage location makes the laser beam irradiation of laser instrument generation on the specific part of human body by filter, can accomplish only optionally to stimulate the C fiber, mechanoreceptor and nociceptor have been avoided stimulating simultaneously, the signal that is recorded only is that the C fiber stimulates relevant laser induced current potential, therefore, the signal that detection system write down of above-mentioned definite spinal cord injury degree and damage location is more clear, composition is simpler, and is also accurately and reliably corresponding to the judgement of spinal cord injury degree and damage location.
Description of drawings
Fig. 1 is a sketch map of determining the detection system of spinal cord injury degree and damage location.
The sketch map that Fig. 2 puts for filtering light.
Fig. 3 is the eeg signal acquisition schematic representation of apparatus.
Fig. 4 is the workflow diagram of Signal Analysis System.
Fig. 5 is the incubation period of Ultra-late LEP of record different parts and the experimental data figure of amplitude.
The specific embodiment
Fig. 1 is a sketch map of determining the detection system of spinal cord injury degree and damage location.The detection system of determining spinal cord injury degree and damage location comprises laser instrument, filter, eeg signal acquisition device, Signal Analysis System, display device.
Laser instrument is the low-power carbon dioxide laser, and the wavelength of the laser beam of generation is 10.6 μ m, and diameter is 2mm, and the persistent period is 20ms.
Fig. 2 is the sketch map of filter.Filter 201 is for having the flake aluminum of microwell array, and microwell array is positioned at the middle part of flake aluminum.The diameter of micropore 202 is 0.4mm, and the distance between the adjacent micropore 202 is 1mm.
In addition, filter also can be the flake aluminum that has only a micropore.
Fig. 3 is the eeg signal acquisition schematic representation of apparatus.The eeg signal acquisition device comprises acquisition module and signal pre-processing module.Acquisition module is gathered EEG signals by electrode.Pretreatment module be used for to EEG signals amplify, filtering, sampling and analog-to-digital conversion process.
Fig. 4 is the workflow diagram of Signal Analysis System.Signal Analysis System adopts the real time signal processing algorithm that the EEG signals at different stimulated position is handled.Processing procedure comprises: EEG signals is carried out pretreatment, amplitude signal is carried out feature extraction, eigenvalue and reference value are compared, obtain time and amplitude that peak value occurs, the output testing result.Testing result comprises the degree of injury and the damage location information of each stimulation location.
Display device is used to show the waveform and the testing result at different stimulated position.
The using method of the detection system of above-mentioned definite spinal cord injury degree and damage location is as follows:
Flake aluminum is placed on the skin surface of subjects's spinal crest of Rauber top, opens laser instrument, the laser that microwell array will allow laser instrument to produce shines on the skin through 1 to 4 micropore.Laser intensity is respectively 2-4 watt and 5-7 watt.For fear of adaptability, when irradiation, select the 3-10 break time of second.The position of each impulse stimulation is the center with the spinous process, little moving in the scope of horizontal 2cm * 1cm.The density of C fiber sensory nerve ending in skin is than A δ fiber height, and activated threshold value is lower, therefore can realize optionally only stimulating no myelin C fiber by regulating laser intensity (being preferably the low-power carbon dioxide laser beam).The electrode of eeg signal acquisition device is placed on C2, C3 and C4 position (according to international 10/20 standard), is reference electrode with the ear-lobe, record subjects's EEG signals.Computer stimulates the peak value incubation period of relevant laser induced current potential and the degree of injury that peak amplitude is determined spinal cord according to the C fiber.
According to the spinal column collection of illustrative plates, different parts is shone successively, the C fiber that can obtain different parts stimulates relevant laser induced current potential, stimulates the peak value incubation period and the peak amplitude of relevant laser induced current potential can determine the spinal cord injury position by the C fiber of analyzing different parts.
Select 11 normal male volunteers of health to test, their the range of age was from 27 years old to 43 years old, and height is from 165cm to 180cm.According to the spinal column collection of illustrative plates, the skin of the spinous process top of the different parts of spinal column is stimulated, and write down the Ultra-late LEP incubation period and the amplitude at each position, as the reference value of clinical diagnosis, patient's spinal cord injury degree is diagnosed.Selecting C7, T4, T8 and these four positions of T12 is the reference position, stimulates the skin of this spinal crest of Rauber top, four positions respectively, and writes down the Ultra-late LEP incubation period and the amplitude (see figure 5) at each position.Can see from experimental result, can both record Ultra-late LEP clearly,, can obtain 4 average latency and standard deviations (seeing the following form) thereof that the position is different by weighted average calculation at these 4 different parts.
| Time delay (ms) | Mean+/-standard error | Scope |
| ?Ultra-late?LEPs?P1(C7)?P1(T4)?P1(T8)?P1(T12) | ???458.2±40.2??516.7±45.3??579.0±61.2??629.0±56.5 | ???395-539??455-602??474-701??546-725 |
Utilize resulting data as the reference index, the result that patient's test is obtained analyzes, thereby judges patient's spinal cord extent of damage.Simultaneously,, different parts is stimulated successively, can obtain the Ultra-late LEP incubation period and the amplitude of different parts, thereby detect the impaired position of spinal cord according to the spinal column collection of illustrative plates.
The detection system of above-mentioned definite spinal cord injury degree and damage location makes the laser beam irradiation of laser instrument generation on the specific part of human body by filter, can accomplish only optionally to stimulate the C fiber, mechanoreceptor and nociceptor have been avoided stimulating simultaneously, the signal that is recorded only is that the C fiber stimulates relevant laser induced current potential, therefore, the signal that detection system write down of above-mentioned definite spinal cord injury degree and damage location is more clear, composition is simpler, and is also accurately and reliably corresponding to the judgement of spinal cord injury degree and damage location.
The above embodiment has only expressed several embodiment of the present invention, and it describes comparatively concrete and detailed, but can not therefore be interpreted as the restriction to claim of the present invention.Should be pointed out that for the person of ordinary skill of the art without departing from the inventive concept of the premise, can also make some distortion and improvement, these all belong to protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Claims (8)
1. the detection system of definite spinal cord injury degree and damage location is characterized in that: comprise laser instrument, filter, eeg signal acquisition device, Signal Analysis System, display device; The laser beam that described laser instrument produces shines on the human body by filter; Described eeg signal acquisition device is used to gather the EEG signals of human body; Described Signal Analysis System adopts the real time signal processing algorithm that EEG signals is handled, and the output testing result; Described display device is used to show the waveform and the testing result at different stimulated position.
2. the detection system of definite spinal cord injury degree as claimed in claim 1 and damage location, it is characterized in that: described laser instrument is a carbon dioxide laser.
3. the detection system of definite spinal cord injury degree as claimed in claim 2 and damage location is characterized in that: the wavelength of described laser beam is 10.6 μ m, and diameter is 2mm, and the persistent period is 20ms, and laser intensity is 2-4 watt or 5-7 watt.
4. the detection system of definite spinal cord injury degree as claimed in claim 1 and damage location is characterized in that: described filter is the flake aluminum with microwell array.
5. the detection system of definite spinal cord injury degree as claimed in claim 4 and damage location, it is characterized in that: the thickness of described flake aluminum is 0.1mm, and the diameter of described micropore is 0.4mm, and the distance between the adjacent micropore is 1mm.
6. the detection system of definite spinal cord injury degree as claimed in claim 1 and damage location, it is characterized in that: described eeg signal acquisition device comprises acquisition module and signal pre-processing module, described acquisition module is gathered EEG signals by electrode, described pretreatment module be used for to EEG signals amplify, filtering, sampling and analog-to-digital conversion process.
7. the detection system of definite spinal cord injury degree as claimed in claim 1 and damage location is characterized in that: described Signal Analysis System employing real time signal processing algorithm is handled EEG signals and is comprised: EEG signals is carried out pretreatment; Amplitude signal is carried out feature extraction; Eigenvalue and reference value are compared; Obtain time and amplitude that peak value occurs.
8. the detection system of definite spinal cord injury degree as claimed in claim 1 and damage location is characterized in that: described testing result comprises the degree of injury and the damage location information of each stimulation location.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102512757A (en) * | 2011-12-12 | 2012-06-27 | 中国科学院电工研究所 | Method and device for injury potential compensation after spinal cord injury |
| CN103638604A (en) * | 2012-12-31 | 2014-03-19 | 深圳先进技术研究院 | Walking assisting system |
| CN106618566A (en) * | 2015-11-03 | 2017-05-10 | 中国科学院遗传与发育生物学研究所 | Method for positioning chronic-spinal-cord-injury scar tissue |
| CN112426126A (en) * | 2020-09-29 | 2021-03-02 | 广西美澳妇产医院有限公司 | Spinal cord injury assessment body surface projection positioning system |
-
2010
- 2010-05-12 CN CN201010179856A patent/CN101856221A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102512757A (en) * | 2011-12-12 | 2012-06-27 | 中国科学院电工研究所 | Method and device for injury potential compensation after spinal cord injury |
| CN102512757B (en) * | 2011-12-12 | 2014-07-23 | 中国科学院电工研究所 | Method and device for injury potential compensation after spinal cord injury |
| CN103638604A (en) * | 2012-12-31 | 2014-03-19 | 深圳先进技术研究院 | Walking assisting system |
| CN103638604B (en) * | 2012-12-31 | 2016-05-04 | 深圳先进技术研究院 | A kind of walk help system |
| CN106618566A (en) * | 2015-11-03 | 2017-05-10 | 中国科学院遗传与发育生物学研究所 | Method for positioning chronic-spinal-cord-injury scar tissue |
| CN112426126A (en) * | 2020-09-29 | 2021-03-02 | 广西美澳妇产医院有限公司 | Spinal cord injury assessment body surface projection positioning system |
| CN112426126B (en) * | 2020-09-29 | 2023-02-24 | 广西美澳妇产医院有限公司 | Spinal cord injury assessment body surface projection positioning system |
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Open date: 20101013 |