CN101849822A - Implantable wireless intracranial pressure automatic monitoring method - Google Patents
Implantable wireless intracranial pressure automatic monitoring method Download PDFInfo
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- CN101849822A CN101849822A CN200910081300A CN200910081300A CN101849822A CN 101849822 A CN101849822 A CN 101849822A CN 200910081300 A CN200910081300 A CN 200910081300A CN 200910081300 A CN200910081300 A CN 200910081300A CN 101849822 A CN101849822 A CN 101849822A
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- 238000007917 intracranial administration Methods 0.000 title claims abstract description 70
- 238000012544 monitoring process Methods 0.000 title claims abstract description 37
- 238000000034 method Methods 0.000 title claims abstract description 32
- 238000012545 processing Methods 0.000 claims abstract description 11
- 238000005259 measurement Methods 0.000 claims description 19
- 238000006243 chemical reaction Methods 0.000 claims description 9
- 238000002513 implantation Methods 0.000 claims description 8
- 238000013500 data storage Methods 0.000 claims description 7
- 238000001914 filtration Methods 0.000 claims description 6
- 238000004458 analytical method Methods 0.000 claims description 4
- 230000005540 biological transmission Effects 0.000 claims description 4
- 238000004891 communication Methods 0.000 claims description 4
- 230000003750 conditioning effect Effects 0.000 claims description 4
- 230000008447 perception Effects 0.000 claims description 3
- 208000015181 infectious disease Diseases 0.000 abstract description 5
- 239000007943 implant Substances 0.000 description 5
- 208000027418 Wounds and injury Diseases 0.000 description 4
- 238000007914 intraventricular administration Methods 0.000 description 4
- 230000000087 stabilizing effect Effects 0.000 description 4
- 230000003321 amplification Effects 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000003199 nucleic acid amplification method Methods 0.000 description 3
- 210000004556 brain Anatomy 0.000 description 2
- 230000002490 cerebral effect Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 210000001951 dura mater Anatomy 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 208000014644 Brain disease Diseases 0.000 description 1
- 206010019196 Head injury Diseases 0.000 description 1
- 206010060860 Neurological symptom Diseases 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 208000030886 Traumatic Brain injury Diseases 0.000 description 1
- 238000009530 blood pressure measurement Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 238000002324 minimally invasive surgery Methods 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 210000004761 scalp Anatomy 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
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Abstract
The invention relates to an implantable wireless intracranial pressure automatic monitoring method. In the monitoring method, a monitoring system which is formed by an internal part and an external part completely independently of each other is used. When in use, the two parts are communicated with each other through radio frequency so as to fulfill the aim of monitoring intracranial pressure automatically. The method comprises the following steps that: (1) the external part provides energy for the internal part through radio electromagnetic waves; (2) the internal part receives the energy and starts to operate; (3) the external part sends a command to the internal part through electromagnetic waves; (4) after receiving the command, the internal part acquires intracranial pressure data, encodes the intracranial pressure data and transmits the encoded intracranial pressure data to the external part; and (5) the external part receives the data, decodes and acquires the intracranial pressure data after processing. The automatic monitoring method of the invention has the characteristics of more convenience, rapidness, accuracy, safety, reliability and effectiveness, less infection and high applicability.
Description
Technical field
The present invention relates to a kind of intracranial pressure measuring system method, particularly a kind of implantation type wireless intracranial pressure automatic monitoring method.
Background technology
It is a kind of reflection of intracranial disease or intracranial Secondary cases pathological changes that ICP (intracra-nial pressure (ICP) (intracranial pressure)) increases, and increases and takes therapy measure as can not in time finding ICP, then may cause serious consequence, even threat to life.In clinical position, simple dependence observation neurological symptom or CT, MRI imaging data judge whether ICP increases, be difficult to the practical level of explanation ICP, so adopt the ICP monitoring that continues as " early alert system ", help early discovery and increase and intracranial disease, and improve curative effect with timely processing IC P.According to the objective data of ICP, can guiding clinical treatment, predict prognosis, this is the important measures that improve the cure rate of Heavy craniocerebral injury and other associated patient and reduce mortality rate.
The dynamic monitoring of ICP, very important for the disease of brain patient, the method for the present monitoring of ICP clinically can be divided into wound and noinvasive two big classes.But the non-invasive measurement method exists characteristics such as measuring accuracy is poor, method is loaded down with trivial details and is not widely used in clinical.Therefore, the at present domestic and international comparatively popular clinically method that is wound.Monitoring intracranial pressure technology and equipment thereof so far also and imperfection, exist monitoring result inadequately accurately, problem such as infection easily.
Summary of the invention
In order to overcome the shortcoming of above-mentioned prior art, the present invention proposes a kind of new monitoring intracranial pressure method, this method by on the hardware fully independently in the body part and outer body form.Described outer body provides energy and sends instruction by part in the wireless electromagnetic wave direction body, part is obtained the intracranial pressure data by pressure transducer in the body, and these intracranial pressure data are sent to outer body by radio magnetic wave, reach the purpose of automatic monitoring ICP.
In order to achieve the above object, a kind of implantation type wireless intracranial pressure automatic monitoring method provided by the invention may further comprise the steps:
(1) outer body provides energy by part in the wireless electromagnetic wave direction body.
(2) body receives energy inner the branch, brings into operation.
(3) outer body sends instruction by electromagnetic wave to body inner the branch.
(4) after body inside is switched to instruction, obtain the intracranial pressure absolute value, encoded after, send to outer body by radio magnetic wave.
(5) outer body receives data, and decoding, obtains the intracranial pressure data after treatment.
Described step (5) comprises following substep:
(51) first pressure transducer of outer body measures current atmospheric value (in the practical application, can adopt the difference of measuring relative 1 normal atmosphere), and sends into first single-chip microcomputer by the first instrument amplifier circuit and the first reference voltage chip circuit.
(52) aerial coil by radio circuit chip and outer body receives the inner data of dividing transmission of body, and sends into first single-chip microcomputer by the radio circuit chip.
(53) first single-chip microcomputers carry out following processing with the data and the current atmospheric value that receive: intracranial pressure=intracranial pressure absolute value-current atmospheric value (intracranial pressure=body inner sensor reading-external sensor reading), finally obtain the intracranial pressure data.(in the practical application, the intracranial pressure absolute value also can adopt the difference of measuring relative 1 normal atmosphere.)
So-called clinically intracranial pressure, be meant intracranial pressure absolute value and current atmospheric difference, that is: the value that the body inner sensor is measured deducts value that external sensor measurement obtains (with the intracranial pressure absolute value, deduct current atmospheric value), be clinical needed intracranial pressure.
Wherein, part is pressed automatic, the continuous monitoring intracranial pressure in setting-up time interval in the outer body control volume.
Described step (4) comprises following substep:
(41) second pressure transducer of part is measured and is obtained intracranial pressure absolute value signal (in the practical application, can adopt the difference of measuring relative 1 normal atmosphere) in the body;
(42) the second instrument amplifier circuit and the second reference voltage chip circuit of part carry out processing such as filtering, amplification in the body to this signal, and send in the second singlechip;
(43) second singlechip will carry out A/D conversion and coding through the intracranial pressure absolute value signal (in the practical application, can to the difference of its relative 1 normal atmosphere) after the conditioning; This intracranial pressure absolute value (in the practical application, can to the difference of its relative 1 normal atmosphere) data send to outer body by the load-modulate circuit at last.
Described outer body also comprises data storage and serial ports, electrical level transferring chip circuit; Data storage can be preserved the measurement data in the certain hour; Serial ports is sent to other equipment with measurement data; Described electrical level transferring chip circuit is used to realize the level conversion of single-chip microcomputer and serial ports RS232.
Outer body can show, write down measurement result in real time; The measurement result data also can be transferred to that other equipment show by serial ports RS232, analysis and record.
Intracranial pressure detection method of the present invention has following advantage:
(1) convenient, fast
Use other (wound is arranged) when method is monitored, must just can carry out, but also need special technical staff to operate in operating room.Also have, measure once, must puncture once, but also get the concern wound situation of not stopping, cumbersome.
And use this method, and only need to do the most at the beginning a minor operation, " system in the body " is implanted to intracranial, just can monitor patient's ICP afterwards quickly and easily.Monitoring afterwards can be carried out anywhere or anytime, is not subjected to time and spatial restriction, such as can stay at home at any time or the ward in monitor, nor need special technical staff to operate, only need by several buttons, system can move automatically, voluntarily monitoring.
(2) accurate
According to one's analysis, when the monitoring of ICP was carried out in Intraventricular, ratio of precision was higher, and this system can be implanted to Intraventricular with pick off and monitor according to actual needs.Also have, along with improving constantly of sensor technology, can find reliable and stable pick off, it is not subject to the intracranial Effect of Environmental, and its piezoelectricity conversion accuracy can be guaranteed preferably like this.And aspect the transmission and processing of the signal of telecommunication, all can reach higher precision.
(3) safety, reliable effective, the few infection
When using other (wound is arranged) method monitoring patients' ICP, the capital makes some position and the extraneous communications and liaison of patient's head, like this, not only cause intracranial infection easily, but also be subjected to the influence of non-intracranial factor easily, cause moving of pick off such as restless, or can cause the distortion of connecting line or fracture, cause inaccurate even other major accidents of measurement or the like.
And this method, will be in the body part be buried in intracranial, adopt wireless mode with the communication in the external world, so just not only can reduce infection, can also reduce the pick off that causes because of other factors unfavorable factor that is shifted or the like.Because implant surgery belongs to Wicresoft, and is also smaller to the influence that health causes.
(4) suitability height
This method can be implanted to corresponding position with pick off as required, as: places such as (or outer) in Intraventricular, the brain essence, under the arachnoidea or under the cerebral dura mater.Since not with extraneous communications and liaison, the applicable long-time monitoring that continues.Details can be decided according to practical situation.
Description of drawings
Fig. 1 is an implantation type wireless intracranial pressure automatic monitoring method frame diagram of the present invention;
Fig. 2 is an implantation type wireless intracranial pressure automatic monitoring method outer body structure chart of the present invention;
Fig. 3 is part-structure figure in the implantation type wireless intracranial pressure automatic monitoring method body of the present invention;
Fig. 4 is that implantation type wireless intracranial pressure automatic monitoring method of the present invention uses flow chart.
The specific embodiment
The intracranial pressure detection method that present embodiment provides, by on the hardware fully independently in the body part and outer body form, as shown in Figure 1.The outer body of this method can partly be pressed automatic, the continuous monitoring intracranial pressure in setting-up time interval in the control volume.Outer body can show, write down measurement result in real time; The measurement result data also can be transferred to that other equipment show by output interface, analysis and record.
As shown in Figure 2, outer body comprises: power supply, voltage stabilizing chip (MAX8881) circuit, single-chip microcomputer PIC, radio circuit chip (MLX90121) circuit, aerial coil, show and the control interface, data storage, serial ports RS232, electrical level transferring chip (MAX3226) circuit, pressure transducer, instrument amplifier (MAX4194) circuit, reference voltage chip (MAX6120) circuit; Power supply and voltage stabilizing chip (MAX8881) circuit are the total system power supply, the difference of described pressure transducer, instrument amplifier (MAX4194) circuit and relative 1 normal atmosphere of the current atmospheric value of reference voltage chip (MAX6120) circuit measuring, intracranial pressure date processing after being used for, single-chip microcomputer PIC control also sends the electromagnetic wave of 13.56MHz by radio frequency chip, and part transmits energy and control instruction in body; During measuring, outer body receives the inner measurement data that sends of dividing of body, and this data signal is sent into single-chip microcomputer PIC, after decoding is handled, obtains the intracranial pressure data, shows by display, is stored in the memorizer, also can be by serial ports RS232 output.Described electrical level transferring chip (MAX3226) circuit is used to realize the level conversion of single-chip microcomputer PIC and serial ports RS232.
As shown in Figure 3, body comprises inner the branch: aerial coil, current rectifying and wave filtering circuit, voltage stabilizing chip (MAX8881) circuit, load-modulate circuit (AN7002L type mos pipe and corresponding resistor electric capacity), single-chip microcomputer PIC, pressure transducer EPI-41, instrument amplifier (MAX4194) circuit, reference voltage chip (MAX6120) circuit; After the aerial coil of part in the body receives radio magnetic wave, by the processing of current rectifying and wave filtering circuit and voltage stabilizing chip (MAX8881) circuit, for each circuit unit of part in the body provides required voltage; Pressure transducer EPI-41 perception intracranial pressure signal, described instrument amplifier (MAX4194) circuit and reference voltage chip (MAX6120) circuit carry out processing such as filtering, amplification to this signal, and send among the single-chip microcomputer PIC; Described single-chip microcomputer PIC will carry out A/D conversion and coding through the intracranial pressure signal after the conditioning; This intracranial pressure measurement data sends to outer body by the load-modulate mode at last.
Outer body also comprises data storage and serial ports RS232, electrical level transferring chip (MAX3226) circuit; Data storage can be preserved the measurement data in the certain hour; RS232 can be sent to measurement data other equipment.Described electrical level transferring chip (MAX3226) circuit is used to realize the level conversion of single-chip microcomputer PIC and serial ports RS232.
During use, comprise following two parts:
1, implants " part in the body "
At first to do a minor operation, implant " part in the body ", perhaps when doing other operation, finish in passing.As the case may be, piezoelectric transducer can be placed Intraventricular, brain essence, arachnoidea down or under the cerebral dura mater (or outer), partial circuit module in the connected body is planted under the scalp layer.This belongs to Minimally Invasive Surgery, and is little to physical effects.
2, measure ICP
During measurement, the aerial coil opposite position that needs elder generation that external aerial coil is placed on and implants, only need open the on and off switch and the start button of outer body then, all can receive the measuring-signal of ex vivo implant anywhere or anytime, thereby automatically continuously, repeat to monitor patient's ICP, up to the power supply of closing outer body.
Measurement result shows in real time that on the display screen of outer body measurement data is automatic record in the memorizer of outer body, and measurement data also can be sent to other equipment by data output interface.
As shown in Figure 4, concrete steps are as follows:
(1) outer body provides energy by part in the wireless electromagnetic wave direction body.
(2) body receives energy inner the branch, brings into operation.
(3) outer body sends instruction by electromagnetic wave to body inner the branch.
(4) after body inside is switched to instruction, obtain the difference of relative 1 normal atmosphere of intracranial pressure absolute value, encoded after, send to outer body by radio magnetic wave, comprise following substep:
(41) difference of relative 1 normal atmosphere of the second pressure transducer perception intracranial pressure absolute value signal of part in the body;
(42) the second instrument amplifier circuit and the second reference voltage chip circuit of part carry out processing such as filtering, amplification in the body to this signal, and send in the second singlechip;
(43) second singlechip will carry out A/D conversion and coding through the intracranial pressure absolute value signal after the conditioning; The difference data of relative 1 normal atmosphere of this intracranial pressure absolute value sends to outer body by the load-modulate circuit at last.
(5) outer body receives data, and decoding, obtains the intracranial pressure data after treatment, comprises following substep:
(51) first pressure transducer of outer body is measured the difference of relative 1 normal atmosphere of current atmospheric value, and sends into first single-chip microcomputer by the first instrument amplifier circuit and the first reference voltage chip circuit.
(52) radio circuit chip and the aerial coil by outer body receives the inner data of dividing transmission of body, and sends into first single-chip microcomputer by the radio circuit chip.
(53) first single-chip microcomputers carry out following processing with the data and the current atmospheric value that receive:
Intracranial pressure=intracranial pressure absolute value-current atmospheric value is finally obtained the intracranial pressure data.
Claims (6)
1. implantation type wireless intracranial pressure automatic monitoring method, the monitoring system that described monitoring method is used by on the hardware fully independently in the body part and outer body form, during use, two parts pass through radio-frequency communication, reach the purpose of automatic monitoring intracranial pressure, this method may further comprise the steps:
(1) outer body provides energy by part in the wireless electromagnetic wave direction body;
(2) body receives energy inner the branch, brings into operation;
(3) outer body sends instruction by electromagnetic wave to body inner the branch;
(4) after body inside is switched to instruction, obtain the intracranial pressure absolute value, encoded after, send to outer body by radio magnetic wave;
(5) outer body receives data, and decoding, obtains the intracranial pressure data after treatment.
2. monitoring method according to claim 1 is characterized in that, described step (5) comprises following substep:
(51) first pressure transducer of outer body measures the difference of relative 1 normal atmosphere of current atmospheric value, and sends into first single-chip microcomputer by the first instrument amplifier circuit and the first reference voltage chip circuit;
(52) aerial coil by radio circuit chip and outer body receives the inner data of dividing transmission of body, and sends into first single-chip microcomputer by the radio circuit chip;
(53) first single-chip microcomputers deduct the difference of relative 1 normal atmosphere of current atmospheric value with the difference of relative 1 normal atmosphere of intracranial pressure absolute value that receives, finally obtain the intracranial pressure data.
3. monitoring method according to claim 1 and 2 is characterized in that, part is pressed automatic, the continuous monitoring intracranial pressure in setting-up time interval in the described outer body control volume.
4. monitoring method according to claim 1 is characterized in that, described step (4) comprises following substep:
(41) difference of relative 1 normal atmosphere of the second pressure transducer perception intracranial pressure absolute value signal of part in the body;
(42) the second instrument amplifier circuit and the second reference voltage chip circuit of part carry out filtering, processing and amplifying to this signal in the body, and send in the second singlechip;
(43) second singlechip will carry out A/D conversion and coding through the intracranial pressure absolute value signal after the conditioning; The difference data of relative 1 normal atmosphere of this intracranial pressure absolute value sends to outer body by the load-modulate circuit at last.
5. monitoring method according to claim 1 is characterized in that, described outer body also comprises data storage and serial ports, electrical level transferring chip circuit; Data storage can be preserved the measurement data in the certain hour; Serial ports is sent to other equipment with measurement data; Described electrical level transferring chip circuit is used to realize the level conversion of single-chip microcomputer and serial ports.
6. monitoring method according to claim 1 is characterized in that, described outer body can show, write down measurement result in real time; The measurement result data also can be transferred to that other equipment show by serial ports, analysis and record.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2009100813006A CN101849822B (en) | 2009-04-01 | 2009-04-01 | Implanted wireless intracranial pressure signal automatic monitoring method |
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| CN2009100813006A CN101849822B (en) | 2009-04-01 | 2009-04-01 | Implanted wireless intracranial pressure signal automatic monitoring method |
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| CN101849822A true CN101849822A (en) | 2010-10-06 |
| CN101849822B CN101849822B (en) | 2012-05-23 |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104352232A (en) * | 2014-12-05 | 2015-02-18 | 苏州景昱医疗器械有限公司 | Intracranial pressure monitoring system |
| CN104665805A (en) * | 2015-03-11 | 2015-06-03 | 杭州创辉医疗电子设备有限公司 | Implantable wireless intracranial pressure automatic monitoring system and method |
| CN104814730A (en) * | 2015-05-07 | 2015-08-05 | 上海新微技术研发中心有限公司 | Disease monitoring and diagnosis system |
| CN104825150A (en) * | 2015-05-07 | 2015-08-12 | 复旦大学附属华山医院 | Intracranial disease monitoring and treating device |
| CN104983413A (en) * | 2015-07-03 | 2015-10-21 | 林昌军 | Human tissue pressure monitoring sensor |
| CN106691429A (en) * | 2016-04-06 | 2017-05-24 | 成都拓蓝医疗技术有限公司 | Invasive intracranial wireless detecting device and using and detecting method thereof |
| TWI845433B (en) * | 2022-11-17 | 2024-06-11 | 美商道思倍司股份有限公司 | Human body pressure sensing system |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4186749A (en) * | 1977-05-12 | 1980-02-05 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Induction powered biological radiosonde |
| US6248080B1 (en) * | 1997-09-03 | 2001-06-19 | Medtronic, Inc. | Intracranial monitoring and therapy delivery control device, system and method |
| CN101744620B (en) * | 2008-12-03 | 2011-09-21 | 北京锐致聪科技有限公司 | Implantable wireless intracranial pressure automatic monitoring system |
| CN201333032Y (en) * | 2008-12-05 | 2009-10-28 | 北京奥麦特科技有限公司 | Implanted wireless automatic intracranial pressure monitoring system |
-
2009
- 2009-04-01 CN CN2009100813006A patent/CN101849822B/en not_active Expired - Fee Related
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104352232A (en) * | 2014-12-05 | 2015-02-18 | 苏州景昱医疗器械有限公司 | Intracranial pressure monitoring system |
| CN104665805A (en) * | 2015-03-11 | 2015-06-03 | 杭州创辉医疗电子设备有限公司 | Implantable wireless intracranial pressure automatic monitoring system and method |
| CN104814730A (en) * | 2015-05-07 | 2015-08-05 | 上海新微技术研发中心有限公司 | Disease monitoring and diagnosis system |
| CN104825150A (en) * | 2015-05-07 | 2015-08-12 | 复旦大学附属华山医院 | Intracranial disease monitoring and treating device |
| CN104983413A (en) * | 2015-07-03 | 2015-10-21 | 林昌军 | Human tissue pressure monitoring sensor |
| CN106691429A (en) * | 2016-04-06 | 2017-05-24 | 成都拓蓝医疗技术有限公司 | Invasive intracranial wireless detecting device and using and detecting method thereof |
| TWI845433B (en) * | 2022-11-17 | 2024-06-11 | 美商道思倍司股份有限公司 | Human body pressure sensing system |
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