CN101843913A - Preparation method and application of ray radiopasteurization discoloration indicator card - Google Patents
Preparation method and application of ray radiopasteurization discoloration indicator card Download PDFInfo
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- CN101843913A CN101843913A CN201010156504A CN201010156504A CN101843913A CN 101843913 A CN101843913 A CN 101843913A CN 201010156504 A CN201010156504 A CN 201010156504A CN 201010156504 A CN201010156504 A CN 201010156504A CN 101843913 A CN101843913 A CN 101843913A
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Abstract
The invention relates to a preparation method and application of a ray radiopasteurization discoloration indicator card. The preparation method comprises the following steps: taking 5-18 parts of 10, 12-diyne pentacosanoicacid, 4-64 parts of a photoinitiator and 5-30 parts of an adhesive as raw materials, adding the raw materials to 1000 parts of an organic solvent, and then fully dissolving the obtained mixture into a radiation discoloration solution at the temperature of 40-62 DEG C;; coating the radiation discoloration solution on a polyethylene terephthalate plastic film to show pink; cutting the coated plastics into an indication card, pasting an anti-ultraviolet film on the surface; and finally pasting a double-sided adhesive tape on external package of a medical substance to be sterilized and disinfected. For the indication card of the invention, the response range of dosage is 5kGy-50kGy; in the process of radiation discoloration indication, pink is changed into dark blue; and the indication card has the advantages of simple preparation, high sensitivity, stable performance, wide application prospect in the field of radiopasteurization, being capable of truly reflecting the process of radiopasteurization and the like.
Description
Technical field
The present invention relates to a kind of preparation method and application of ray radiopasteurization discoloration indicator card, belong to the application of Radiation Chemistry of Polymer and nuclear technology.
Background technology
In modern medicine, the radiosterilization sterilization is to use gamma ray to penetrate the interior goods of irradiation container, acts on microorganism, ribonucleic acid, protein and the enzyme of direct or indirect destroy microorganisms, thus kill microorganisms plays the effect of sterilization.
The advantage of radiosterilization sterilization:
Energy savings.
Sterilization thoroughly, and is pollution-free.Because gamma-rays has very strong penetration power, can kill various bacterial micro-organisms (comprising virus) under the doses condition, therefore, radiation sterilization is a kind of very effective sterilizing methods.
The radiation sterilization sterilization is a kind of " cold sterilization " method, can sterilize at normal temperatures.Be particularly suitable for some thermo-sensitive materials such as plastic, nylon, chemical fibre product, biological product etc.
Can pack the back sterilization.As long as the not saturating bacterium of used packaging material, the medical supplies after the sterilization can long preservation.
Sterilization speed is fast, and is easy and simple to handle, can work continuously, and helps realizing suitability for industrialized production.
In the radiation sterilization disinfecting process, the sterilization process indication is absolutely necessary, and the operating procedure process of present most of producers is to stick radiation sterilization sterilization Warning Mark after the radiosterilization sterilization process is finished.This radiosterilization sterilization process that does not have real online reflection medical and hygiene article subject to sterilization has very big potential safety hazard.Therefore, on the medical supplies for the treatment of the radiosterilization sterilization, stick the radiation sterilization indicating card, allow indicating card and medical supplies pass through radiation sterilization sterilization process process together, so just really reflected that whether medical supplies have passed through the radiosterilization sterilization process, have stopped human error.
Ray radiopasteurization discoloration indicator card (Radiochromic film is called for short RCF) is to utilize chemical compound solid phase radiation polymerization effect to come a kind of organic solid thin film of measuring radiation dosage, and its extent of polymerization has the characteristics of linear response to absorbed dose.It can be widely used in the radiative process indication of radiation source.
The Related product of external though (U.S., Japan) existing radiating color changing aspect [Zhou Yingjuan etc. the characteristic of radiation developer amount film and in the application of radiological medicine. international oncology's magazine, 2007,34 (1): 28.31], its technology is in confidential state.The domestic research report that only has in this respect seldom of China: the Li Huazhi of China Atomic Energy Science Research Institute, it is base material, hexahydroxy ethyl paramagenta cyanide (} with nylon that people such as Xiao Zhenhong have developed: IPR.CN) for the thin indicator of the radiating color changing of dyestuff [Li Huazhi etc. the research 1 of batch thin indicator of system radiating color changing, its dose response range of linearity is 1.0 * 10
2Gy～1.5 * 10
5Gy; Xu Xuechun, people such as Lin Libin are carrier with the high polymer, with organic dyestuff and additive is the color indicator system, prepared a kind of radiating color changing film [Xu Xuechun etc. the research of a kind of bifurcation x ray irradiation x of novel radiating color changing film. light laser and particle beam, 2005,17 (2): 291 1 .294], its dose response range of linearity is 10kGy～90kGy.In radiating medical, scientific experiments, often want the lower ray radiopasteurization discoloration indicator card of using dosage response range, the domestic relevant report of also not making the radiating color changing card at present at present.
Summary of the invention
The objective of the invention is to provide at the deficiencies in the prior art a kind of preparation method of ray radiopasteurization discoloration indicator card, this ray radiopasteurization discoloration indicator card dose response scope is 5kGy～50kGy.This ray radiopasteurization discoloration indicator card also has simple, highly sensitive, the stable performance of preparation, cheap characteristics, is with a wide range of applications in radiosterilization sterilization field.
The present invention is realized that by following technical measures wherein said raw material umber is mass fraction except that specified otherwise.
The preparation method of ray radiopasteurization discoloration indicator card may further comprise the steps: a kind of preparation method of ray radiopasteurization discoloration indicator card is characterized in that step is as follows:
1) preparation of radiating color changing solution: the raw material umber is mass fraction:
10,5～30 parts of 5～18 parts of 12-diine hyenic acids, 4～64 parts of light triggers, adhesive make it to be dissolved into fully radiating color changing solution for 40～62 ℃ in temperature;
2) coating of radiating color changing solution
Mode by intaglio printing is coated in radiating color changing solution on the polyethylene terephthalate plastic foil pinkiness;
3) making of ray radiopasteurization discoloration indicator card
The plastics that coating is good are cut into the indication card, and the anti-ultraviolet film of one deck is pasted on the surface; Be attached in the outer package of the article that need sterilization with double faced adhesive tape during use.
Described light trigger is any in 1 monohydroxy-cyclohexyl benzophenone, alpha-hydroxyalkyl benzophenone, the α alpha, alpha-dimethyl oxygen base-α phenyl 1-Phenylethanone..
Described adhesive is any in polyvinyl alcohol, polyvinyl butyral resin, polyvinyl formal, Polyethylene Glycol or the pure molten nylon.
Described organic solvent is any in dehydrated alcohol, anhydrous propanol, anhydrous butanols or the anhydrous acetic acid.
The application of ray radiopasteurization discoloration indicator card of the present invention, the red indication of the molding powder card that coating is good is attached to double faced adhesive tape in the outer package of the article that need sterilization; Be blue through x radiation x.
Can be applied to the sterilization of radiating medical sterilization system on line.
Indicating card of the present invention, anti-ultraviolet film be the ultraviolet isolating rate greater than 95% and visible light transmissivity be higher than 70% thin film, can be applied to shelves film before the automobile.
Performance test:
1. the ray radiopasteurization discoloration indicator card of made of the present invention, the dose response scope is 5kGy～50kGy.
2. the result shows radiation dose in 5kgy～50kgy scope, and radiating color changing discoloration indication process is that pink becomes navy blue.
The present invention has following advantage:
1. the radiating color changing film of made of the present invention, the dose response range of linearity is 5KGy～50KGy, is with a wide range of applications in radiation sterilization sterilization field.
2. the radiating color changing card of manufacturing of the present invention is a pink, becomes navy blue behind the irradiation, and color contrast is obvious before and after the radiation, is convenient to perusal.
3. price helps promoting the use of far below external like product.
4. it is simple, highly sensitive that the present invention has preparation, and stable performance can truly reflect characteristics such as radiosterilization sterilization process.
The specific embodiment
Embodiment 1
The 20g polyvinyl butyral resin is dissolved in the 1000ml dehydrated alcohol, add 20g 10,12. diine hyenic acid (10,12 1 pentacosadiynoic acid) and 80g 1 monohydroxy-cyclohexyl benzophenone (trade name Irgacure1841), in 40 ℃ of heated and stirred dissolvings of temperature, be made into the coating solution that is used for the radiating color changing film;
Mode by intaglio printing is coated in radiating color changing solution on polyethylene terephthalate (PET) plastic foil makes radiation discoloration indication point, notes lucifuge in operating process.
The radiation discoloration indication point that coating is good cuts into the square indicating card that length and width are three centimeters sizes, and the anti-ultraviolet film of one deck is pasted on the surface, is attached in the outer package of disinfectant article subject to sterilization with double faced adhesive tape during use.
Embodiment 2
The molten nylon of 22g alcohol is dissolved in the 1000ml anhydrous acetic acid, add 18g 10 then, 12-diine hyenic acid (10,12 1 pentacosadiynoic acid) and 48g alpha-hydroxyalkyl benzophenone (trade name Darocur2959), in 50 ℃ of stirring and dissolving of temperature, be made into the coating solution that is used for the radiating color changing film.
Mode by intaglio printing is coated in radiating color changing solution on polyethylene terephthalate (PET) plastic foil makes radiation discoloration indication point, notes lucifuge in operating process.
The radiation discoloration indication point that coating is good cuts into the square indicating card that length and width are three centimeters sizes, and the anti-ultraviolet film of one deck is pasted on the surface, is attached in the outer package of disinfectant article subject to sterilization with double faced adhesive tape during use.
Embodiment 3
The 40g Polyethylene Glycol is dissolved in the anhydrous butanols of 1000ml, add 22g 10,12 1 diine hyenic acids (10,12.pentacosadiynoic acid) with 112g α alpha, alpha-dimethyl oxygen base-α phenyl 1-Phenylethanone. (trade name Irgacure6511), in 62 ℃ of stirring and dissolving of temperature, be made into the coating solution that is used for the radiating color changing film.
Mode by intaglio printing is coated in radiating color changing solution on polyethylene terephthalate (PET) plastic foil makes radiation discoloration indication point, notes lucifuge in operating process.
Coated radiation discoloration indication point is cut into the square indicating card that length and width are three centimeters sizes, and the anti-ultraviolet film of one deck is pasted on the surface, is attached in the outer package of disinfectant article subject to sterilization with double faced adhesive tape during use.
Embodiment 4
Step is same as the previously described embodiments, and different is: organic solvent is 1000 parts a anhydrous acetic acid, 10, and 5 parts of 12-diine hyenic acids, 1 monohydroxy-4 parts of cyclohexyl benzophenones, 5 parts of Polyethylene Glycol.
Embodiment 5
Step is same as the previously described embodiments, and different is: organic solvent is 1000 parts an anhydrous butanols, 10, and 18 parts of 12-diine hyenic acids, 1 monohydroxy-64 parts of cyclohexyl benzophenones, 30 parts of polyvinyl alcohol.
Embodiment 6
Step is same as the previously described embodiments, and different is: organic solvent is 1000 parts an anhydrous propanol, 10, and 10 parts of 12-diine hyenic acids, 30 parts of alpha-hydroxyalkyl benzophenones, 20 parts of polyvinyl butyral resins.
Embodiment 7
Step is same as the previously described embodiments, and different is: organic solvent is 1000 parts a dehydrated alcohol, 10, and 15 parts of 12-diine hyenic acids, α alpha, alpha-dimethyl oxygen base-24 parts of α phenyl 1-Phenylethanone .s, 18 parts of polyvinyl formals.
In actual use radiation discoloration indication sticker in medical article outer package subject to sterilization, accept the irradiation of gamma ray with medical article subject to sterilization, the indicating card color progressively becomes navy blue by pink in the irradiation process, indicates that medical article subject to sterilization has passed through the sterilization of gamma ray.Can be applied to the sterilization of radiating medical sterilization system on line.
Indicating card of the present invention, anti-ultraviolet film be the ultraviolet isolating rate greater than 95% and visible light transmissivity be higher than 70% thin film, can be applied to shelves film before the automobile.
Claims (7)
1. the preparation method of a ray radiopasteurization discoloration indicator card is characterized in that step is as follows:
1) preparation of radiating color changing solution: the raw material umber is mass fraction:
With 10,5～18 parts of 12-diine hyenic acids, 4～64 parts of light triggers, 5～30 parts of adhesive add in 1000 parts of the organic solvents, make it to be dissolved into fully radiating color changing solution for 40～62 ℃ in temperature;
2) coating of radiating color changing solution
Mode by intaglio printing is coated in radiating color changing solution on the polyethylene terephthalate plastic foil pinkiness;
3) making of ray radiopasteurization discoloration indicator card
The plastics that coating is good are cut into the indication card, and the anti-ultraviolet film of one deck is pasted on the surface; Be attached in the outer package of the article that need sterilization with double faced adhesive tape during use.
2. preparation method as claimed in claim 1 is characterized in that light trigger is any in 1 monohydroxy-cyclohexyl benzophenone, alpha-hydroxyalkyl benzophenone, the α alpha, alpha-dimethyl oxygen base-α phenyl 1-Phenylethanone..
3. preparation method as claimed in claim is characterized in that adhesive is any in polyvinyl alcohol, polyvinyl butyral resin, polyvinyl formal, Polyethylene Glycol or the pure molten nylon.
4. preparation method as claimed in claim is characterized in that organic solvent is any in dehydrated alcohol, anhydrous propanol, anhydrous butanols or the anhydrous acetic acid.
5. the application of ray radiopasteurization discoloration indicator card is characterized in that the red indication of the molding powder card that coating is good, is attached to double faced adhesive tape in the outer package of the article that need sterilization; Be blue through x radiation x.
6. application as claimed in claim 5 is characterized in that being used for the sterilization of radiating medical sterilization system on line.
7. application as claimed in claim 5, it is characterized in that the anti-ultraviolet film be the ultraviolet isolating rate greater than 95% and visible light transmissivity be higher than 70% thin film, be applied to shelves film before the automobile.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010156504A CN101843913A (en) | 2010-04-27 | 2010-04-27 | Preparation method and application of ray radiopasteurization discoloration indicator card |
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|---|---|---|---|
| CN201010156504A CN101843913A (en) | 2010-04-27 | 2010-04-27 | Preparation method and application of ray radiopasteurization discoloration indicator card |
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| CN101843913A true CN101843913A (en) | 2010-09-29 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102360081A (en) * | 2011-08-24 | 2012-02-22 | 周明非 | Irradiation indicating card and methods for preparing and using the same |
| CN103543460A (en) * | 2013-09-30 | 2014-01-29 | 深圳市华科核医疗技术有限公司 | Novel irradiation indication film and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000055599A2 (en) * | 1999-03-16 | 2000-09-21 | Cryovac, Inc. | Dosimetric package and methods of making and characterizing same |
| CN101299069A (en) * | 2008-06-24 | 2008-11-05 | 四川大学 | Method for manufacturing radiation color changing film dosage meter |
-
2010
- 2010-04-27 CN CN201010156504A patent/CN101843913A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000055599A2 (en) * | 1999-03-16 | 2000-09-21 | Cryovac, Inc. | Dosimetric package and methods of making and characterizing same |
| CN101299069A (en) * | 2008-06-24 | 2008-11-05 | 四川大学 | Method for manufacturing radiation color changing film dosage meter |
Non-Patent Citations (1)
| Title |
|---|
| 周颖娟: "辐射显色剂量胶片的特性及其在放射医学的应用", 《国际肿瘤学杂志》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102360081A (en) * | 2011-08-24 | 2012-02-22 | 周明非 | Irradiation indicating card and methods for preparing and using the same |
| CN103543460A (en) * | 2013-09-30 | 2014-01-29 | 深圳市华科核医疗技术有限公司 | Novel irradiation indication film and preparation method thereof |
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Application publication date: 20100929 |