CN101843251B - Insecticidal compound containing methoxyfenozide and metaflumizone - Google Patents
Insecticidal compound containing methoxyfenozide and metaflumizone Download PDFInfo
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- CN101843251B CN101843251B CN 201010204261 CN201010204261A CN101843251B CN 101843251 B CN101843251 B CN 101843251B CN 201010204261 CN201010204261 CN 201010204261 CN 201010204261 A CN201010204261 A CN 201010204261A CN 101843251 B CN101843251 B CN 101843251B
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Abstract
The invention relates to an insecticidal compound containing methoxyfenozide and metaflumizone, and the weight ratio of the methoxyfenozide to the metaflumizone is 16:1 to 1:16 and preferred to be 4:1 to 1:8. The insecticidal compound can be prepared into water dispersible granule, wettable powder, suspension and dispersible suspension, has the advantages of reasonable components, good insecticidal effect and low medicine use cost, and the activity and the insecticidal effect thereof are not simply the sum of the activity of all the components; and the insecticidal compound has significant synergy function, can reduce the generation of resistance, is safe to crops and meets the safety requirements of pesticide preparations, and can be used for preventing rice stem borer, leaf roller, cotton bollworm, apple leaf roller, vegetable and beet armyworm, spodoptera litura and plutella xylostella lepidoptera pests.
Description
Technical field
The present invention relates to a kind of insecticides, particularly a kind of Pesticidal combination and application thereof that contains methoxyfenozide and metaflumizone belongs to technical field of compounded pesticide.
Background technology
Methoxyfenozide, english common name: methoxyfenozide, other English names: Intrepid, Runner, chemical name: the N-tert-butyl group-N '-(3-methyl-2-toluyl groups)-3,5-dimethyl benzene formylhydrazine.Methoxyfenozide belongs to the bishydrazide insecticide, it is a kind of insect growth regulator, IGR, moulting hormone for a kind of non-sterol type structure, simulate natural insect moulting hormones---20-HE, activation is also adhered to ecdysone receptor albumen, impel lepidopterous larvae before maturation, to enter the process of casting off a skin ahead of time and can not form healthy new epidermis, thereby cause larva to stop to get food, final death ahead of time.The reaction that lepidopterous larvae is ingested behind the methoxyfenozide is fast.Larva promptly stops to get food after generally ingesting 4～16 hours, poisoning symptom occurs.The methoxyfenozide of Xiao Shouing is the suspending agent of 240 grams per liters in the market, as a kind of bionical steroids insecticide, it has low dose, holds and imitate length, stable, efficient, characteristics such as environment friendly meet requirement and the development trend of people to modern agricultural chemicals, but methoxyfenozide in use exist the use cost height, the risk that resistance increases, and rationally use with dissimilar insecticides, for fully effectively promoting methoxyfenozide, prolong its service life and have important function.
Metaflumizone, english common name: metaflumizone, test code number BAS320I, chemical name: (E+Z)-2-[2-(4-cyano group benzene)-1-(3-trifluoromethylbenzene) ethylidene]-N-(4-trifluomethoxybenzene) hydrazine carbonyl oxamides; Molecular formula: C
24H
16F
6N
4O
2Metaflumizone is a kind of insecticide of brand-new mechanism of action, and by attached on the sodium-ion channel acceptor, it is current to hinder sodium ion, does not have cross resistance with the compound of chrysanthemum ester class or other kinds.This medicine mainly is to get food by insect to enter in its body and stomach toxicity to take place kill off the insect pests, and action of contace poison is less, no systemic action.This medicine all has the better prevention effect for target pest, the larva in each length of time, this medicine enters polypide behind the insect's food-taking, by the sodium-ion channel on the mechanism of action blocking-up insect neuron axon film of uniqueness, make sodium ion can not pass through axolemma, and then suppress nerve impulse and make excessive the loosening of polypide, paralysis is behind the several hrs, insect promptly stops to get food, and is dead in 1～3d.Laboratory research shows, mammal impassivity toxicity, Salmonella reversion test are negative, and the lasting period is short in environment.The metaflumizone of Xiao Shouing is the suspending agent of 240 grams per liters in the market, is mainly used in the caste Lepidoptera and the coleoptera that chew and sting food.Professional insecticide as a kind of new mechanism, metaflumizone in use exists the use cost height, the risk that resistance increases gradually, the defective that lasting period is general, and rationally use with the insecticide of the different mechanisms of action, for fully effectively promoting metaflumizone, prolong its service life and have important function.
At present, the pesticidal preparations that with the methoxyfenozide is effective ingredient is based on 240 grams per liter methoxyfenozide suspending agents, and in actual use, lasting effect is long, but quick-acting is general, the use cost height; Metaflumizone is as a kind of insecticide of brand-new mechanism of action, insecticidal effect is the user all the time and accepts, but use cost height, the risk that resistance increases, the defective that lasting period is general, the inventor is unexpected to find that the use that is mixed of methoxyfenozide and metaflumizone is had significant synergistic effect, can reduce use cost, slow down the generation of pest resistance.
Summary of the invention
The object of the present invention is to provide a kind of component reasonable, significantly synergy, good disinsection effect, drug cost is low, the Pesticidal combination that contains methoxyfenozide and metaflumizone that is difficult for developing immunity to drugs.
Another object of the present invention is to provide the application of the Pesticidal combination that contains methoxyfenozide and metaflumizone.
In order to overcome the defective of existing unitary agent, technical scheme of the present invention is to solve like this:
Contain the Pesticidal combination of methoxyfenozide and metaflumizone, comprising:
A) the first active component methoxyfenozide;
B) the second active component metaflumizone;
The weight ratio of first active component and second active component is 16: 1～1: 16, is preferably 4: 1～1: 8.
The cumulant of first active component and second active component (weight add and) is 5%～90% of described composition total weight, be preferably 10%～50%, the size of active component cumulant is also closely related with formulation, is no more than 50% as the active component cumulant of suspending agent.
But it is water dispersible granules, wetting powder, suspending agent dispersed oil suspending agent that the present invention contains the preparation formulation that the Pesticidal combination of methoxyfenozide and metaflumizone can prepare according to known method.
For water dispersible granules, those skilled in the art are familiar with the use corresponding adjuvants and finish the present invention very much.In dispersant such as polycarboxylate, lignosulfonates, alkylnaphthalene sulfonate, alkylphenol polyoxyethylene, the EO/PO block polyether one or more; In wetting agent such as alkyl sulfate, alkylsulfonate, naphthalene sulfonate, sodium lignin sulfonate, fatty alcohol-polyoxyethylene ether, the alkylphenol polyoxyethylene one or more; In disintegrant such as ammonium sulfate, sodium sulphate, sodium chloride, ammonium chloride, urea, sucrose, glucose, carboxymethyl cellulose, soluble starch, the polyvinylpyrrolidone one or more; In binding agent such as polyvinyl alcohol, soluble starch, dextrin, xanthans, carboxymethyl (ethyl) cellulose family one or more; Filler such as diatomite, kaolin, white carbon, precipitated calcium carbonate, talcum powder, attapulgite, potter's clay one or more.
To wetting powder, spendable auxiliary agent has: in dispersant such as polycarboxylate, lignosulfonates, the alkylnaphthalene sulfonate one or more; In wetting agent such as alkyl sulfate, alkylsulfonate, the naphthalene sulfonate one or more; Filler such as ammonium sulfate, urea, sucrose, glucose, diatomite, kaolin, white carbon, precipitated calcium carbonate, talcum powder, attapulgite, potter's clay one or more.
To suspending agent, spendable auxiliary agent has: among dispersant such as polycarboxylate, lignosulfonates, alkylnaphthalene sulfonate, the TERSPERSE 2425 (U.S. Huntsman Corporation produces, the alkyl naphthalene sulfonic acid salt) one or more; Alkyl phenol formaldehyde resin polyoxyethylene ether), farming breast 2201, this dish-60# (common name: sorbitan monostearate), emulsifier T-60 (common name: the sorbitan monostearate APEO), agricultural newborn 1601# (common name: phenethyl phenol polyoxyethylene poly-oxygen propylene aether), among the TERSPERSE 4894 (U.S. Huntsman Corporation product) one or more emulsifier such as Nongru-700 # (common name:; Among wetting agent such as alkylphenol-polyethenoxy base ether formaldehyde condensation products sulphate, alkylphenol-polyethenoxy base ether phosphate, phenethyl phenol polyethenoxy base ether phosphate, alkyl sulfate, alkylsulfonate, naphthalene sulfonate, the TERSPERSE 2500 (U.S. Huntsman Corporation product) one or more; In thickener such as xanthans, polyvinyl alcohol, bentonite, the aluminium-magnesium silicate one or more; In preservative such as formaldehyde, benzoic acid, the Sodium Benzoate one or more; Defoamer such as organic silicon defoamer; In antifreezing agent such as ethylene glycol, propane diols, glycerine, urea, the inorganic salts (as sodium chloride) one or more.
But to the dispersed oil suspending agent, spendable auxiliary agent has: among dispersant such as polycarboxylate, lignosulfonates, alkylnaphthalene sulfonate (dispersing agent NNO), the TERSPERSE 2425 (U.S. Huntsman Corporation produces, the alkyl naphthalene sulfonic acid salt) one or more; Serial emulsifier (the BY-110 of emulsifier such as BY (castor oil polyoxyethylene ether), BY-125, BY-140), Nongru-700 # (common name: alkyl phenol formaldehyde resin polyoxyethylene ether), farming breast 2201, this dish-60# (common name: sorbitan monostearate), Tween-60 # (common name: the sorbitan monostearate APEO), the newborn 1601# of farming (common name: phenethyl phenol polyoxyethylene poly-oxygen propylene aether), among the TERSPERSE 4894 (U.S. Huntsman Corporation product) one or more; Among wetting agent such as alkylphenol-polyethenoxy base ether formaldehyde condensation products sulphate, alkylphenol polyoxyethylene phosphate, phenethyl phenol polyethenoxy base ether phosphate, alkyl sulfate, alkylsulfonate, naphthalene sulfonate, the TERSPERSE 2500 (U.S. Huntsman Corporation product) one or more; In thickener such as white carbon, polyvinyl alcohol, bentonite, the aluminium-magnesium silicate one or more; In antifreezing agent such as ethylene glycol, propane diols, glycerine, urea, inorganic salts such as the sodium chloride one or more; In stabilizing agent such as epoxidized soybean oil, epoxychloropropane, the triphenyl phosphate one or more; In dispersion medium such as soybean oil, rapeseed oil, corn oil, methyl oleate, diesel oil, machine oil, the mineral oil one or more.
Component of the present invention is reasonable, good disinsection effect, and drug cost is low, and its active and insecticidal effect is not the simple superposition of each composition activity, but significant synergistic effect is arranged, and can slow down the generation of resistance, and is good to crop safety, meets the security requirement of pesticidal preparations.The present invention has the better prevention effect to rice-stem borer, rice leaf roller, cotton cotton bollworm, apple skin worm, vegetables beet armyworm, prodenia litura, plutella maculipennis insect.
Embodiment
In order to prevent and treat rice-stem borer, rice leaf roller, cotton cotton bollworm, apple olethreutid, vegetables beet armyworm, prodenia litura, the diamond-back moth insect in the agricultural production, the inventor has carried out mutual composite synergy research with compositions such as methoxyfenozide, metaflumizones, and concrete grammar is:
1) rice-stem borer formal name used at school (Chilo supperssalis) Lepidoptera, Pyralidae, another name borer; Rice leaf roller (Cnaphalocrocis medialis Guenee), Lepidoptera, Pyralidae, medicament can be represented paddy rice rice leaf roller indoor virulence result rice-stem borer Toxicity Determination result, therefore this test is Toxicity Determination test examination worm with the rice-stem borer, the former medicine that the former medicine of test medicine metaflumizone adopts BASF Aktiengesellschaft to produce, the former medicine that the former medicine of methoxyfenozide adopts The Dow Agrosciences, LLC. to produce, former medicine is mixed with the test medicine that needs by technology department of Shanggezhilu Biosciences Co., Ltd., Shaanxi, test method is soaked the rice seedling feeding method, with reference to " the agricultural industry criteria NY/T1282-2007 of the People's Republic of China (PRC) ".At first single agent and each Mixed Pharmacy are provided with 5 variable concentrations gradients (on preliminary experiment result's basis, the rice-stem borer lethality is set by geometric progression) in 5%～90% scope.The examination worm is the striped rice borer of picking up from the field, select in the laboratory three the length of time uniformity striped rice borer, access is equipped with in the dactylethrae of the rice seedling that chemicals treatment crosses, every pipe 10 cephalont, 3 dactylethraes of every processing repeat 3 times, the dactylethrae that to handle is put into 25 ℃ of constant incubators cultivations then, keep observation ward's relative moisture about 75%, 4d checks dead borer population, calculates lethality.Blank is handled the equivalent clear water.
2) cotton cotton bollworm (Helibthis armigera Hiibner).Former medicine is mixed with the test medicine that needs by technology department of Shanggezhilu Biosciences Co., Ltd., Shaanxi, test method is the malicious blade method of folder, with " the agricultural industry criteria NY/T1154.2-2006 of the People's Republic of China (PRC) " is reference, at first single agent and each Mixed Pharmacy are provided with 5 variable concentrations gradients (on preliminary experiment result's basis, the cotton bollworm lethality is set by geometric progression in 5%～90% scope), the examination worm is the cotton bollworm of picking up from the field, select in the laboratory three the length of time uniformity cotton bollworm, hungry 4～8h, choose 50 larvas, use scales/electronic balance weighing, calculate every average quality.Insert in the tissue culturing plate, every empty 1 cephalont, every processing repeats 4 times, cultivates under normal condition, and 4d checks dead borer population, writes down total borer population and dead borer population.Blank is the processing that equivalent does not contain the corresponding organic solvent of medicament.
3) apple olethreutid (Adoxophyes orana), beet armyworm (Laphygma exiguaHubner), prodenia litura (Spodoptera litra), four Toxicity Determination methods of diamond-back moth (Plutella xylostella) are reference for the malicious blade method of folder with " the agricultural industry criteria NY/T1154.2-2006 of the People's Republic of China (PRC) ".The concrete operations brief introduction is as 2) the cotton cotton bollworm.
The co-toxicity coefficient of mixture (CTC value) calculates by following formula:
ATI---mixture actual measurement toxicity index;
S---standard insecticide LC
50, unit is every liter (mg/L) of milligram;
The LC of M---mixture
50, unit is every liter (mg/L) of milligram;
TTI=TI
A* P
A+ TI
B* P
B, in the formula:
The theoretical toxicity index of TTI---mixture;
TI
A---A medicament toxicity index;
P
A---the percentage composition of A medicament in mixture, unit are percentage (%);
TI
B---B medicament toxicity index;
P
B---the percentage composition of B medicament in mixture, unit are percentage (%);
CTC---co-toxicity coefficient;
ATI---mixture actual measurement toxicity index;
The theoretical toxicity index of TTI---mixture;
The co-toxicity coefficient of complex preparation (CTC) 〉=120 shows as synergistic effect; CTC≤80 show as antagonism; 80＜CTC＜120 show as summation action.
4) measurement result sees Table 1～6 respectively.
Table 1 methoxyfenozide metaflumizone is to rice-stem borer Toxicity Determination result
Table 2 methoxyfenozide metaflumizone is to cotton cotton bollworm Toxicity Determination result
Table 3 methoxyfenozide metaflumizone is to apple olethreutid Toxicity Determination result
Table 4 methoxyfenozide metaflumizone is to wild cabbage beet armyworm Toxicity Determination result
| Handle | Virulence regression equation | LC50 (mg/L) | Actual measurement toxicity index ATI | Theoretical toxicity index TTI | Co-toxicity coefficient (CTC) |
| Methoxyfenozide (A) | Y＝6.5811+2.0788X | 0.174 | 100 | - | - |
| Metaflumizone (B) | Y＝4.9269+1.9947X | 1.088 | 15.99 | - | - |
| A∶B＝1∶16 | Y＝5.3670+1.9385X | 0.647 | 26.89 | 20.93 | 128.5 |
| A∶B＝1∶8 | Y＝5.7921+2.0304X | 0.407 | 42.75 | 25.32 | 168.8 |
| A∶B＝1∶4 | Y＝6.3462+2.0839X | 0.226 | 76.99 | 32.79 | 234.8 |
| A∶B＝1∶2 | Y＝6.5909+2.0477X | 0.167 | 104.19 | 43.99 | 236.9 |
| A∶B＝1∶1 | Y＝6.4813+2.0226X | 0.185 | 94.05 | 58.00 | 162.2 |
| A∶B＝2∶1 | Y＝6.5967+2.0513X | 0.167 | 104.19 | 72.00 | 144.7 |
| A∶B＝4∶1 | Y＝6.6650+2.0796X | 0.158 | 110.13 | 83.20 | 132.4 |
| A∶B＝8∶1 | Y＝6.6455+2.0313X | 0.155 | 112.26 | 90.67 | 123.8 |
| A∶B＝16∶1 | Y＝6.6635+2.0295X | 0.151 | 115.23 | 95.06 | 121.2 |
Table 5 methoxyfenozide metaflumizone is to wild cabbage prodenia litura Toxicity Determination result
| Handle | Virulence regression equation | LC50 (mg/L) | Actual measurement toxicity index ATI | Theoretical toxicity index TTI | Co-toxicity coefficient (CTC) |
| Methoxyfenozide (A) | Y＝6.3347+1.8773X | 0.195 | 100 | - | - |
| Metaflumizone (B) | Y＝4.8365+1.9425X | 1.214 | 16.06 | - | - |
| A∶B＝1∶16 | Y＝5.3218+2.1189X | 0.705 | 27.66 | 20.99 | 131.8 |
| A∶B＝1∶8 | Y＝5.6284+1.9607X | 0.478 | 40.79 | 25.38 | 160.7 |
| A∶B＝1∶4 | Y＝6.3061+2.0153X | 0.225 | 86.67 | 32.85 | 263.8 |
| A∶B＝1∶2 | Y＝6.6247+2.0714X | 0.164 | 118.90 | 40.04 | 297.0 |
| A∶B＝1∶1 | Y＝6.4954+1.9699X | 0.174 | 112.07 | 58.03 | 193.1 |
| A∶B＝2∶1 | Y＝6.5130+1.9704X | 0.171 | 114.04 | 72.02 | 158.3 |
| A∶B＝4∶1 | Y＝6.5983+2.0567X | 0.167 | 116.77 | 83.21 | 140.3 |
| A∶B＝8∶1 | Y＝6.6129+2.0315X | 0.161 | 121.12 | 90.67 | 133.6 |
| A∶B＝16∶1 | Y＝6.4916+1.9227X | 0.168 | 116.07 | 95.06 | 122.1 |
Table 6 methoxyfenozide metaflumizone is to wild cabbage diamond-back moth Toxicity Determination result
| Handle | Virulence regression equation | LC50 (mg/L) | Actual measurement toxicity index ATI | Theoretical toxicity index TTI | Co-toxicity coefficient (CTC) |
| Methoxyfenozide (A) | Y＝6.1848+2.3154X | 0.308 | 100 | - | - |
| Metaflumizone (B) | Y＝4.6128+2.0482X | 1.545 | 19.94 | - | - |
| A∶B＝1∶16 | Y＝4.9961+1.8628X | 1.005 | 30.65 | 24.65 | 124.3 |
| A∶B＝1∶8 | Y＝5.56524+2.0583X | 0.531 | 58.00 | 28.83 | 201.2 |
| A∶B＝1∶4 | Y＝6.2093+2.0307X | 0.254 | 121.26 | 35.95 | 337.3 |
| A∶B＝1∶2 | Y＝6.2561+2.2468X | 0.276 | 115.59 | 46.62 | 239.4 |
| A∶B＝1∶1 | Y＝5.9689+1.9243X | 0.314 | 98.09 | 59.97 | 163.6 |
| A∶B＝2∶1 | Y＝6.0748+1.9754X | 0.286 | 107.69 | 73.32 | 146.9 |
| A∶B＝4∶1 | Y＝6.1323+1.9718X | 0.266 | 115.79 | 83.99 | 137.9 |
| A∶B＝8∶1 | Y＝6.1601+1.9986X | 0.263 | 117.11 | 91.11 | 128.5 |
| A∶B＝16∶1 | Y＝6.1323+1.9718X | 0.267 | 115.36 | 95.29 | 121.1 |
Toxicity Determination result shows: methoxyfenozide and metaflumizone are used with has the better prevention effect to rice-stem borer, rice leaf roller, cotton cotton bollworm, apple skin worm, vegetables beet armyworm, prodenia litura, diamond-back moth, weight ratio is 16: 1～1: 16 o'clock, and it is remarkable to show as synergy.
Below in conjunction with embodiment content of the present invention is described further.
Example of formulations 1:
Take by weighing 10% methoxyfenozide, 40% metaflumizone, 3%TERSPERSE 2700 (polycarboxylate, U.S. Huntsman Corporation produces), 2% dispersing agent NNO (alkylnaphthalene sulfonate formaldehyde condensation products), 3% Nekal BX (nekal), 2%K-12 (lauryl sodium sulfate), 5% soluble starch, 5% glucose, kaolin adds to 100% weight portion.The method of the frequent regulation of above-mentioned raw materials water intaking dispersible granule is promptly mixed, ultra micro comminution by gas stream, mixing, granulation step are produced 50% methoxyfenozide metaflumizone water dispersible granules.
The part by weight of methoxyfenozide and metaflumizone can change between 16: 1～1: 16 in the present embodiment, and both total weight items still are 50%, form new embodiment.
Example of formulations 2
Take by weighing 20% methoxyfenozide, 60% metaflumizone, 4%TERSPERSE 2700 (polycarboxylate, U.S. Huntsman Corporation produces), 2% dispersing agent NNO (alkylnaphthalene sulfonate formaldehyde condensation products), 1% Nekal BX (nekal), 1%K-12 (lauryl sodium sulfate), 1% carboxymethyl cellulose, 3% urea, diatomite adds to 100% weight portion.The method of the frequent regulation of above-mentioned raw materials water intaking dispersible granule is promptly mixed, ultra micro comminution by gas stream, mixing, granulation step are produced 80% methoxyfenozide metaflumizone water dispersible granules.
The part by weight of methoxyfenozide and metaflumizone can change between 16: 1～1: 16 in the present embodiment, and both total weight items still are 80%, form new embodiment.
Example of formulations 3:
Take by weighing 30% methoxyfenozide, 60% metaflumizone, 4%TERSPERSE 2700 (polycarboxylate, U.S. Huntsman Corporation produces), 1% Nekal BX (nekal), 1%K-12 (lauryl sodium sulfate), 0.5% dextrin starch, 2% ammonium sulfate, attapulgite adds to 100% weight portion.The method of the frequent regulation of above-mentioned raw materials water intaking dispersible granule is promptly mixed, ultra micro comminution by gas stream, mixing, granulation step are produced 90% methoxyfenozide metaflumizone water dispersible granules.
The part by weight of methoxyfenozide and metaflumizone can change between 16: 1～1: 16 in the present embodiment, and both total weight items still are 90%, form new embodiment.
Example of formulations 4:
Take by weighing 20% methoxyfenozide, 20% metaflumizone, 4%Morwet D-425 (alkylnaphthalene sulfonate, Akzo Nobel N.V. produces), 3% dispersing agent NNO (alkylnaphthalene sulfonate formaldehyde condensation products), 2% Nekal BX (nekal), 2%K-12 (lauryl sodium sulfate), 2% polyvinylpyrrolidone, 0.5% xanthans, kaolin adds to 100% weight portion.The method of the frequent regulation of above-mentioned raw materials water intaking dispersible granule is promptly mixed, ultra micro comminution by gas stream, mixing, granulation step are produced 40% methoxyfenozide metaflumizone water dispersible granules.
The part by weight of methoxyfenozide and metaflumizone can change between 16: 1～1: 16 in the present embodiment, and both total weight items still are 40%, form new embodiment.
Example of formulations 5
Take by weighing 5% methoxyfenozide, 80% metaflumizone, 5% calcium lignosulfonate, 2% Nekal BX (nekal), 1%K-12 (lauryl sodium sulfate), 3% white carbon black, kaolin and add to 100% weight portion.Above-mentioned raw materials makes 85% methoxyfenozide metaflumizone wetting powder through mixing behind the comminution by gas stream.
The part by weight of methoxyfenozide and metaflumizone can change between 16: 1～1: 16 in the present embodiment, and both total weight items still are 85%, form new embodiment.
Example of formulations 6
Take by weighing 5% methoxyfenozide, 40% metaflumizone, 4% calcium lignosulfonate, 3%TERSPERSE2700 (polycarboxylate, U.S. Huntsman Corporation produces), 2% Nekal BX (nekal), 1%K-12 (lauryl sodium sulfate), 3% white carbon black, precipitated calcium carbonate adds to 100% weight portion.Above-mentioned raw materials makes 45% methoxyfenozide metaflumizone wetting powder through mixing behind the comminution by gas stream.
The part by weight of methoxyfenozide and metaflumizone can change between 16: 1～1: 16 in the present embodiment, and both total weight items still are 45%, form new embodiment.
Example of formulations 7
Take by weighing 40% methoxyfenozide, 10% metaflumizone, 4% calcium lignosulfonate, 4% dispersing agent NNO (alkylnaphthalene sulfonate formaldehyde condensation products), 2% Nekal BX (nekal), 2%K-12 (lauryl sodium sulfate), 5% white carbon black, attapulgite and add to 100% weight portion.Above-mentioned raw materials makes 50% methoxyfenozide metaflumizone wetting powder through mixing behind the comminution by gas stream.
The part by weight of methoxyfenozide and metaflumizone can change between 16: 1～1: 16 among the embodiment, and both total weight items still are 50%, form new embodiment.
Example of formulations 8
Take by weighing 64% methoxyfenozide, 4% metaflumizone, 4% sodium lignin sulfonate, 2%TERSPERSE2700 (polycarboxylate, U.S. Huntsman Corporation produces), 2%K-12 (lauryl sodium sulfate), 3% white carbon black, potter's clay adds to 100% weight portion.Above-mentioned raw materials makes 68% methoxyfenozide metaflumizone wetting powder through mixing behind the comminution by gas stream.
The part by weight of methoxyfenozide and methoxyfenozide can change between 16: 1～1: 16 in the present embodiment, and both total weight items still are 68%, form new embodiment.
Example of formulations 9
Take by weighing 10% methoxyfenozide, 15% metaflumizone, 3%TERSPERSE 4894 (U.S. Huntsman Corporation product), 2%TERSPERSE 2500 (U.S. Huntsman Corporation product), 1%TERSPERSE2425 (U.S. Huntsman Corporation product), 0.2% xanthans, 5% ethylene glycol, 0.3% benzoic acid, 0.5% silicone defoaming agent (trade name: s-29 Nanjing "four news" (new ideas applied chemistry product company produces) deionized water and add to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear is disperseed 30min, with making 25% methoxyfenozide metaflumizone suspending agent behind the sand mill sand milling.
The part by weight of methoxyfenozide and metaflumizone can change between 16: 1～1: 16 in the present embodiment, and both total weight items still are 25%, form new embodiment.
Example of formulations 10:
Take by weighing 10% methoxyfenozide, 30% metaflumizone, 1.5%NNO (alkylnaphthalene sulfonate formaldehyde condensation products), 1%TERSPERSE 2500 (U.S. Huntsman Corporation product), 2% emulsifier T-60,3% Nongru-700 #, 0.1% xanthans, 5% propane diols, 0.5% formaldehyde, 0.3% silicone defoaming agent (trade name: s-29 Nanjing "four news" (new ideas applied chemistry product company produces) deionized water and add to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear is disperseed 30min, with making 40% methoxyfenozide metaflumizone suspending agent behind the sand mill sand milling.
The part by weight of methoxyfenozide and metaflumizone can change between 16: 1～1: 16 in the present embodiment, and both total weight items still are 40%, form new embodiment.
Example of formulations 11:
Take by weighing 15% methoxyfenozide, 15% metaflumizone, 3%TERSPERSE 4894 (U.S. Huntsman Corporation product), 1%TERSPERSE 2500 (U.S. Huntsman Corporation product), 1%TERSPERSE2425 (U.S. Huntsman Corporation product), 0.2% xanthans, 1% aluminium-magnesium silicate, 5% ethylene glycol, 0.3% Sodium Benzoate, 0.5% silicone defoaming agent (trade name: s-29 Nanjing "four news" (new ideas applied chemistry product company produces) deionized water and add to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear is disperseed 30min, with making 30% methoxyfenozide metaflumizone suspending agent behind the sand mill sand milling.
The part by weight of methoxyfenozide and metaflumizone can change between 16: 1～1: 16 in the present embodiment, and both total weight items still are 30%, form new embodiment.
Example of formulations 12:
Take by weighing 20% methoxyfenozide, 10% metaflumizone, 3% Nongru-700 #, 2% agricultural newborn 1601#, 1.5%TERSPERSE 2500 (U.S. Huntsman Corporation product), 0.5%TERSPERSE 2425 (U.S. Huntsman Corporation product), 0.2% xanthans, 3% white carbon, 5% ethylene glycol, 0.3% benzoic acid, 0.5% silicone defoaming agent (trade name: s-29 Nanjing "four news" (new ideas applied chemistry product company produces) deionized water and add to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear is disperseed 30min, with making 30% methoxyfenozide metaflumizone suspending agent behind the sand mill sand milling.
The part by weight of methoxyfenozide and methoxyfenozide can change between 16: 1～1: 16 in the present embodiment, and both total weight items still are 30%, form new embodiment.
Example of formulations 13
Take by weighing 5% methoxyfenozide, 15% metaflumizone, 2%TERSPERSE 2425 (U.S. Huntsman Corporation product), 4% this dish-60#, 3% Tween-60 #, 2% Nongru-700 #, 1%TERSPERSE 2500 (U.S. Huntsman Corporation product), 0.5% white carbon, 5% propane diols, 1% epoxychloropropane, methyl oleate and add to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear is disperseed 30min, but with making 20% methoxyfenozide metaflumizone dispersed oil suspending agent behind the sand mill sand milling.
The part by weight of methoxyfenozide and metaflumizone can change between 16: 1～1: 16 among the embodiment, and both total weight items still are 20%, form new embodiment.
Example of formulations 14
Take by weighing 5% methoxyfenozide, 5% metaflumizone, 2% dispersing agent NNO, 3% agricultural newborn 2201#, 8%BY-110,1%TERSPERSE 2500 (U.S. Huntsman Corporation product), 1% aluminium-magnesium silicate, 3% propane diols, 15% epoxidized soybean oil, soybean oil and add to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear is disperseed 30min, but with making 10% methoxyfenozide metaflumizone dispersed oil suspending agent behind the sand mill sand milling.
The part by weight of methoxyfenozide and metaflumizone can change between 16: 1～1: 16 among the embodiment, and both total weight items still are 10%, form new embodiment.
Example of formulations 15
Take by weighing 4% methoxyfenozide, 20% metaflumizone, 3%TERSPERSE 2425 (U.S. Huntsman Corporation product), 3% this dish-60#, 3% Tween-60 #, 8%BY-110,1%TERSPERSE 2500 (U.S. Huntsman Corporation product), 0.5% white carbon, 5% propane diols, 20% epoxidized soybean oil, methyl oleate and add to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear is disperseed 30min, but with making 24% methoxyfenozide metaflumizone dispersed oil suspending agent behind the sand mill sand milling.
The part by weight of methoxyfenozide and metaflumizone can change between 16: 1～1: 16 among the embodiment, and both total weight items still are 24%, form new embodiment.
Example of formulations 16
Take by weighing 16% methoxyfenozide, 4% metaflumizone, 3% dispersing agent NNO, 5%BY-125,4% this dish-60#, 4% agricultural newborn 1601#, 1% phenethyl phenol polyethenoxy base ether phosphate, 0.5% bentonite, 5% glycerine, 3% triphenyl phosphate, rapeseed oil and add to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear is disperseed 30min, but with making 20% methoxyfenozide metaflumizone dispersed oil suspending agent behind the sand mill sand milling.
The part by weight of methoxyfenozide and metaflumizone can change between 16: 1～1: 16 among the embodiment, and both total weight items still are 20%, form new embodiment.
Example of formulations 17
Take by weighing 3% methoxyfenozide, 24% metaflumizone, 3%TERSPERSE 2425 (U.S. Huntsman Corporation product), 4% agricultural newborn 2201#, 2% Nongru-700 #, 5%BY-110,1%TERSPERSE 2500 (U.S. Huntsman Corporation product), 0.5% white carbon, 5% propane diols, 20% epoxidized soybean oil, methyl oleate and add to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear is disperseed 30min, but with making 27% methoxyfenozide metaflumizone dispersed oil suspending agent behind the sand mill sand milling.
The part by weight of methoxyfenozide and metaflumizone can change between 16: 1～1: 16 among the embodiment, and both total weight items still are 27%, form new embodiment.
Biological Examples 1: control rice-stem borer field trial
The inventor carried out the field control effectiveness test of control rice-stem borer on June 20th, 2009 in Hubei Province's Shishou county, verified that this medicament is to the control efficiency of striped rice borer, effective dose and to the safety of paddy rice.Trial crops is a paddy rice, controlling object striped rice borer (Chilo supperssalis).Adopt conventional spray-on process, in rice plant of tillering stage, generation striped rice borer egg development is incubated the initial stage to ovum latter stage, adopts the conventional spraying of manual sprayer, and 45 liters of every mu of spouting liquids are investigated the control efficiency of each sub-district when generation striped rice borer borer pest is stablized.Take the random sampling of balance great-jump-forward, 25 clumps of rice of every sub-district investigation are added up withered heart rate and lethality.While is 2,7,14 days observation paddy growth situations behind medicine, and the visual test medicament has or not poisoning to produce to paddy rice.
Computational methods:
In the formula: Pt
0Withered heart rate behind-----chemicals treatment district medicine;
CK
0Withered heart rate behind-----blank district medicine
Table 7 control rice-stem borer result of the test
| Handle numbering | Chemicals treatment | Dispenser dosage (amount of formulation) (gram/mu) | Seedling protecting effect (%) | Insecticidal effect (%) |
| 1 | 10% methoxyfenozide+40% metaflumizone WG | 10 | 71.15 | 73.86 |
| 2 | 10% methoxyfenozide+40% metaflumizone WG | 15 | 85.42 | 89.53 |
| 3 | 10% methoxyfenozide+40% metaflumizone WG | 20 | 90.31 | 93.85 |
| 4 | 10% methoxyfenozide+30% metaflumizone SC | 15 | 76.28 | 77.08 |
| 5 | 10% methoxyfenozide+30% metaflumizone SC | 20 | 87.23 | 89.54 |
| 6 | 10% methoxyfenozide+30% metaflumizone SC | 25 | 93.46 | 94.32 |
| 7 | 4% methoxyfenozide+20% metaflumizone OF | 30 | 76.87 | 80.98 |
| 8 | 4% methoxyfenozide+20% metaflumizone OF | 40 | 89.76 | 91.34 |
| 9 | 4% methoxyfenozide+20% metaflumizone OF | 50 | 94.02 | 95.89 |
| 10 | 5% methoxyfenozide+40% metaflumizone WP | 20 | 83.65 | 84.76 |
| 11 | 5% methoxyfenozide+40% metaflumizone WP | 30 | 91.67 | 93.09 |
| 12 | 5% methoxyfenozide+40% metaflumizone WP | 40 | 94.62 | 95.98 |
| 13 | 24% methoxyfenozide SC | 30 | 73.21 | 76.37 |
| 17 | 24% metaflumizone SC | 80 | 75.54 | 78.65 |
| 18 | The clear water contrast | / | / | / |
As can be seen from Table 7, the combination of methoxyfenozide and metaflumizone is composite, incubates the initial stage dispenser in striped rice borer egg development latter stage to ovum and once can effectively control striped rice borer and cause harm, and dosage is less than the contrast dosing, tangible synergistic effect is arranged, can be used for the control of rice-stem borer, and to rice safety.
Biological Examples 2: control paddy rice rice leaf roller field trial
The inventor carried out the field control effectiveness test of control paddy rice rice leaf roller on July 26th, 2009 in Zhejiang Province's fairy house county, verified that this medicament is to the control efficiency of rice leaf roller, effective dose and to the safety of paddy rice.Trial crops is a paddy rice, controlling object rice leaf roller (Cnaphalocrocis medinalis).Adopt the conventional spraying of manual sprayer, 30 liters of every mu of spouting liquids, control paddy rice three generations rice leaf roller was investigated behind medicine in 3 days, 7 days, 10 days.Take the random sampling of balance great-jump-forward, 25 clumps of rice are looked in 5 samplings in every sub-district altogether, and statistics leaf roll rate compares with check plot leaf roll rate, calculates relative control effect, and investigating simultaneously has the worm rate in the leaf roll.While is 3,7,10 days observation paddy growth situations behind medicine, and the visual test medicament has or not poisoning to produce to paddy rice.
Computational methods:
In the formula: leaf roll rate behind the Pt-----chemicals treatment district medicine;
Leaf roll rate behind the CK-----blank district medicine
Table 8 control paddy rice rice leaf roller result of the test
As can be seen from Table 8,10% methoxyfenozide+40% metaflumizone WG, 10% methoxyfenozide+30% metaflumizone SC, 4% methoxyfenozide+20% metaflumizone OF, 5% methoxyfenozide+40% metaflumizone WP have preventive effect preferably to rice leaf roller under test dose, quick-acting and lasting period are better than contrasting single agent, can effectively reduce the consumption of each active ingredient, has tangible synergistic effect, to rice safety.
Biological Examples 3: control apple olethreutid field trial
The inventor carried out the field control effectiveness test of control apple rouleau leaf worm in April, 2010 in the Liquan County, Shaanxi Province, verified that this medicament is to the control efficiency of apple rouleau leaf worm, effective dose and to the safety of apple.Trial crops is an apple, controlling object apple rouleau leaf worm (Adoxophyes orana).Adopt the conventional spraying of power driven sprayer, in spending preceding medication, control apple rouleau leaf worm was investigated behind medicine in 3 days, 7 days, 10 days.Two strains are investigated in every sub-district, the worm bag number of record top tree crown 100～200 branches, before the medicine during radix investigation, in whole test block in addition stripping look into 100 worms bags the worm rate arranged, to proofread and correct worm bag radix.Investigation after the dispenser, what then 30～50 worms bag was looked in stripping in time corresponding and sub-district has worm (larva, a pupa and puparium) rate, and to proofread and correct corresponding worm bag number, last investigation also need be write down killed branch number.While is 3,7,10 days observation apple development situations behind medicine, and the visual test medicament has or not poisoning to produce to apple.
Computational methods:
In the formula: Pt-----chemicals treatment district borer population; CK-----blank district borer population.
Table 9 control apple olethreutid result of the test
As can be seen from Table 9,10% methoxyfenozide+40% metaflumizone WG, 10% methoxyfenozide+30% metaflumizone SC, 4% methoxyfenozide+20% metaflumizone OF, 5% methoxyfenozide+40% metaflumizone WP have preventive effect preferably to the apple olethreutid under test dose, quick-acting and lasting period are better than contrasting single agent, can effectively reduce the consumption of each active ingredient, has tangible synergistic effect, to apple safety.
In sum, composition of the present invention is to adopt two kinds of active component compound schemes, its activity and insecticidal effect are not the simple superposition of each composition activity, compare with existing unitary agent, except that rice-stem borer, rice leaf roller, cotton cotton bollworm, apple skin worm, vegetables beet armyworm, prodenia litura, plutella maculipennis insect are had the significant insecticidal effect, and significant synergistic effect arranged, can slow down the generation of resistance, good to crop safety, drug cost is low, meets the security requirement of pesticidal preparations.
Claims (5)
1. a Pesticidal combination that contains methoxyfenozide and metaflumizone is characterized in that the composition active component is methoxyfenozide and metaflumizone, and the weight ratio of methoxyfenozide and metaflumizone is 4:1 ~ 1:8.
2. Pesticidal combination according to claim 1 is characterized in that: the cumulant of methoxyfenozide and metaflumizone is 5%～90% of a described composition total weight.
3. Pesticidal combination according to claim 2 is characterized in that: the cumulant of methoxyfenozide and metaflumizone is 10%～50% of a described composition total weight.
4. Pesticidal combination according to claim 1 is characterized in that: the preparation formulation that described composition can be prepared is water dispersible granules, wetting powder or suspending agent.
5. the application of the described Pesticidal combination of claim 1 in control rice-stem borer, rice leaf roller, cotton cotton bollworm, apple skin worm, vegetables beet armyworm, prodenia litura, diamond-back moth insect.
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| CN103651474A (en) * | 2011-05-28 | 2014-03-26 | 陕西韦尔奇作物保护有限公司 | Insecticidal composition containing furan tebufenozide |
| CN102630669A (en) * | 2012-03-07 | 2012-08-15 | 福建农林大学 | Tebufenozide water dispersible granules and preparation method thereof |
| CN102657201A (en) * | 2012-03-31 | 2012-09-12 | 广西田园生化股份有限公司 | Ultra low-volume liquid containing metaflumizone and insect growth regulator pesticide |
| CN102960356A (en) * | 2012-12-12 | 2013-03-13 | 海利尔药业集团股份有限公司 | Parasiticide composite containing bistrifluron and methoxyfenozide |
| CN105685076A (en) * | 2014-11-28 | 2016-06-22 | 陕西美邦农药有限公司 | A pesticide composition containing a pesticide named as Chinese characters 'Wufuchongzong' by the inventor |
| CN105685051A (en) * | 2016-04-20 | 2016-06-22 | 陕西上格之路生物科学有限公司 | Dispersible oil suspension agent with methoxyfenozide |
| CN108739846A (en) * | 2018-07-19 | 2018-11-06 | 广东广康生化科技股份有限公司 | A kind of composition pesticide containing methoxyfenozide and fenbutatin oxide |
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