CN101780255B - Traditional Chinese medicine composition for treating epilepsy - Google Patents
Traditional Chinese medicine composition for treating epilepsy Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for treating epilepsy, wherein traditional Chinese medicine materials including bezoar, pearl powder, borneol, muskiness, scorpion, chilopod, grass-leaved sweetflag, radix curcumae, salvia miltiorrhiza, halloysitum rubrum, liquorice and the like are adopted and prepared into a honeyed pill to be used by a patient by adopting a traditional honeyed pill preparation method, and the honeyed pill facilitates the carry and taking of the patient, has the efficacy of soothing the nerves and calming the mind, stopping endogenous wind and relieving convulsion, eliminating heat and resolving stasis, cooling blood and promoting blood circulation, strengthening the spleen and stomach and dissipating phlegm for resuscitation, can be used for treating various types of epilepsy, mania, insomnia and tristimania and has broad market application prospect.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, be specifically related to a kind of Chinese medicine for the treatment of epilepsy.
Background technology
Epilepsy (epilepsy) is the discharge of cerebral neuron paroxysmal abnormality, causes a kind of chronic disease of of short duration cerebral disorder, is feature with the intermittent central nervous system function imbalance due to the unexpected repeatedly over-discharge of brain neuroblastoma unit.Be a kind of brain that originates from, and motion, sensation, autonomic nerve, consciousness and the mental status obstacle in various degree that shows effect repeatedly.Generally be divided into complete tetanus-grand mal and petit mal etc. during morbidity, grand mal is accompanied often and is screamed, purplish complexion, urinary incontinence, lisp, spit out white foams or blood foam, platycoria.Continued tens of seconds or after several minutes convulsion stop naturally, fall into a comatose state.Giddy, the agitation, tired of short time are arranged after waking up, can not recall episode process.If outbreak is constant, the person that do not lie in a comatose condition claims the grand mal persistent state, normal threat to life always.Therefore even other mode of onset also can bring great misery and inconvenience in life to the patient, be one of major disease of facing of human needs.
In the prior treatment method, generally adopt antiepileptic to treat, antiepileptic can be eliminated or alleviates epilepsy by dual mode, and the one, influence axoneuron, to prevent or to reduce their pathologic transition discharge; It two is the threshold of excitation that improves normal cerebral tissue, weakens the diffusion of focus excitement, prevents the epilepsy recurrence.Epilepsy uses Western medicine such as phenobarbital, phenytoin Sodium, carbamazepine, sodium valproate etc. more clinically, uses these medicines, though the outbreak of controlled restriction 80% still has 20% uncontrollable; Chinese medicine also is in the exploratory stage in the research in this field, though there is the part Chinese patent medicine to emerge on the market, unsatisfactory through discovery effect after the clinical use, and the drug effect performance is slowly, brings bigger misery to the patient.
Summary of the invention
Many weak points at existing antuepileptic existence; the inventor is in conjunction with motherland's traditional medical theory; a kind of Chinese medicine for the treatment of epilepsy is provided; adopt Calculus Bovis; Margarita powder; Borneolum Syntheticum; Moschus; Scorpio; Scolopendra; Rhizoma Acori Graminei; Radix Curcumae; Radix Salviae Miltiorrhizae; Halloysitum Rubrum; Chinese crude drugs such as Radix Glycyrrhizae; adopt traditional honeyed pill method for making to be made into the honeyed pill patients and use, make things convenient for carrying and taking of patient, have tranquilizing the mind; the endogenous wind stopping relieving convulsion; expel the heat-evil and separate the stasis of blood, removing heat from blood and promoting blood circulation, strengthening the spleen and stomach; the effect of waking up the patient from unconsciousness by dissipating phlegm; can be used for treating all types of epilepticss, manic, insomnia; depression, market application foreground is wide.
Treatment mechanism of the present invention is: by the effect of " replenishing the kidney(water)to nourish the liver(wood) ", make that liver-fire is not high, liver-wind does not rise, thereby reach the effect of treatment epilepsy, prevention epilepsy.
According to above treatment mechanism, the each component of this medicine is according to the weight portion meter, and its proportioning is: 4 parts of Calculus Boviss, 24 parts of Margarita powder; 4 parts of Borneolum Syntheticums, 2 parts in Moschus, 60 parts of Scorpios, 60 parts of Scolopendras; 100 parts of Periostracum Cicadaes, 40 parts of Zaocyss, 60 parts of Pheretimas, 100 parts of Arisaema Cum Bile; 18 parts in Cinnabaris, 100 parts of Rhizoma Acori Graminei, 100 parts of Radix Curcumaes, Bulbus Fritillariae Cirrhosae 115-125 part; Radix Ophiopogonis 145-155 part, 120 parts of Radix Salviae Miltiorrhizaes, 100 parts of Ramulus Uncariae Cum Uncis; 120 parts of Massa Medicata Fermentata, 120 parts of Pericarpium Citri Reticulataes, 20 parts in Radix Glycyrrhizae.
In order to improve the drug effect of said medicine, make honeyed pill after the method that generally adopts honeyed pill to prepare is mixed each component and use.
Be monarch drug with Margarita, tranquilizing cinnabar sedate in the said components;
Assist a ruler in governing a country with the Calculus Bovis waking up the patient from unconsciousness by clearing away heat, Scorpio, Scolopendra, Pheretima, Periostracum Cicadae, Zaocys, Ramulus Uncariae Cum Uncis suppressing the hyperactive liver to relieve the wind syndrome relieving convulsion, Radix Curcumae, Radix Salviae Miltiorrhizae removing heat from blood and promoting blood circulation, clearing away heart-fire for tranquillization, Arisaema Cum Bile, Rhizoma Acori Graminei waking up the patient from unconsciousness by clearing away phlegm, join the Bulbus Fritillariae Cirrhosae moistening the lung and resolving phlegm Radix Ophiopogonis, Pericarpium Citri Reticulatae, Massa Medicata Fermentata spleen invigorating activating QI to eliminate phlegm are ministerial drug altogether;
Borneolum Syntheticum, the refreshment of Moschus causing resuscitation with aromatic drugs can be drawn and reached on all medicines clearly that key is a messenger drug; The Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.
Simultaneously by adjusting the proportioning between each component, make full side's monarch clearly demarcated, the compatibility purpose is rigorous, wherein particularly Radix Ophiopogonis compatibility Bulbus Fritillariae Cirrhosae use, medicine than existing treatment epilepsy has great improvement, played splendid effect, reason is as follows: the main pathogenesis of epilepsy is moving in the Liver Channel wind-fire, clear (heart) key of priming pertinacious phlegm impatency, thereby causes the generation of epilepsy.Join Bulbus Fritillariae Cirrhosae Radix Ophiopogonis, by removing heat from the lung and dissipating phlegm, nourishing YIN and moistening the lung, make lung qi fill Sheng, lung qi a surname send out respectful to fall function normally bring into play, lung qi is vigorous, can make irritability be restricted (lung gold gram edema with the liver involved), suppresses the high Sheng of edema with the liver involved, thereby prevent that liver-fire from disturbing the pathogenesis of the heart, liver-wind stirring up internally and taking place, thereby reduced the occurrence probability of epilepsy.Simultaneously heavy dose of effect that can play the YIN nourishing moisturizing Radix Ophiopogonis of using by the effect of " replenishing the kidney(water)to nourish the liver(wood) ", makes that liver-fire is not high, liver-wind does not rise, thereby reaches the effect of treatment epilepsy, prevention epilepsy.As seen among the present invention a large amount of use Radix Ophiopogonis and the Bulbus Fritillariae Cirrhosae of not used in the ancient prescription, improved the drug effect of whole medicine greatly, better be in harmonious proportion simultaneously effect between each herbal medicine, played the effect of gain, made the performance of drug effect obtain great lifting.In order to reach best result of use, the consumption of preferred this two flavors medicine of inventor is 120 parts of Bulbus Fritillariae Cirrhosaes, 150 parts of Radix Ophiopogonis.
And other each medicines in the prescription all have different effects: activating blood circulation to dissipate blood stasis collateral dredging class Chinese medicine such as Radix Curcumae, Radix Salviae Miltiorrhizae, can significantly improve the circulation of brain blood emblem, improve ischemia and Developmental and Metabolic Disorder state, promote that local cicatrix disappears, adhesion is alleviated, the calm inhibitory action of reinforcement maincenter, can increase simultaneously the permeability of blood brain barrier again, promote the antiepileptic composition to enter focus, thereby help the Taking Control of Epilepsy outbreak; In stage of attack or outbreak frequent period, then based on activating blood circulation to dissipate blood stasis, expectorant, and with relieve dizziness, high fever, infantile convulsions, epilepsy, etc. decide epilepsy, method such as the refreshment of having one's ideas straightened out and using; Then consolidate timid heresy at resting stage, with all methods such as kidney tonifying, essence replenishing, activating blood circulation to dissipate blood stasis and usefulness based on tonify deficiency.SHIGEPU is the dry rhizome of Araeceae herbaceos perennial SHIGEPU, experimentation confirms, its main component is α-Herba Asari enzyme, it is a kind of splendid antuepileptic, and with regard to SHIGEPU, its acrid in the mouth, hardship, temperature are gone into the heart, stomach warp, effect is eliminated phlegm for resuscitation, the refreshment Fructus Alpiniae Oxyphyllae, cures mainly epilepsy, syncope due to accumulation of phlegm, calentura coma etc.; Rhizoma Gastrodiae can be by influencing the different brains of maincenter district the metabolism of catecholamines neurotransmitter coordinate the balance that brain is excited and suppress; Scorpio, Scolopendra have convulsion, reduce the effect of spontaneous activity.
This shows prescription provided by the present invention, select medicine evident in efficacy to cooperate patent medicine, can make drug effect reach best rapidly, simultaneously used the mode of compatibility Bulbus Fritillariae Cirrhosae Radix Ophiopogonis to increase drug effect especially, improve the compatibility between each medicine, this still is that head sees that it has improved therapeutic effect in epilepsy class Chinese medicine preparation, shorten treatment time, reduced the toxic and side effects of medicine.
For the various prescriptions of the present invention can better play its drug effect and help patient's use, the inventor has selected the mode of existing traditional preparation process honeyed pill, is made into portable easily edible honeyed pill, and its procedure of processing is as follows:
It is standby with the Margarita powder mix homogeneously of equal fineness that Cinnabaris, Calculus Bovis, Borneolum Syntheticum, the Moschus of getting recipe quantity was ground into the fine powder of 80 mesh sieves respectively; All medicated powder of other recipe quantities is broken into same mistake 80 mesh sieves of fine powder, above fine powder is mixed, sieve, mixing adds Mel according to conventional honeyed pill preparation method and makes honeyed pill, the heavy 3g of ball.Why succinum, Camphora, Borneolum Syntheticum, the independent grinding of Moschus are valuable drug mainly due to these medicine kinds, particularly succinum and Moschus, in order to reduce the loss in the process of lapping, the inventor grinds it in the hope of reducing cost separately.
The effective ingredient that had both kept medicine in this way; strengthened its mouthfeel; made things convenient for carrying and preserving of patient again; medicine provided by the present invention in sum adopts Calculus Bovis; Margarita powder; Borneolum Syntheticum; Moschus; Scorpio; Scolopendra; Rhizoma Acori Graminei; Radix Curcumae; Radix Salviae Miltiorrhizae; Halloysitum Rubrum; Chinese crude drugs such as Radix Glycyrrhizae adopt traditional honeyed pill method for making to be made into the honeyed pill patients and use; make things convenient for carrying and taking of patient; have tranquilizing the mind, the endogenous wind stopping relieving convulsion expels the heat-evil and separates the stasis of blood; removing heat from blood and promoting blood circulation; strengthening the spleen and stomach, the effect of waking up the patient from unconsciousness by dissipating phlegm can be used for treating all types of epilepticss; manic; insomnia, depression, market application foreground is wide.
The specific embodiment
Embodiment 1
A kind of medicine for the treatment of epilepsy, the each component of this medicine are according to the weight portion meter, and its proportioning is: Calculus Bovis 4g, Margarita powder 24g; Borneolum Syntheticum 4g, Moschus 2g, Scorpio 60g, Scolopendra 60g; Periostracum Cicadae 100g, Zaocys 40g, Pheretima 60g, Arisaema Cum Bile 100g; Cinnabaris 18g, Rhizoma Acori Graminei 100g, Radix Curcumae 100g, Bulbus Fritillariae Cirrhosae 115g; Radix Ophiopogonis 155g, Radix Salviae Miltiorrhizae 120g, Ramulus Uncariae Cum Uncis 100g; Massa Medicata Fermentata 120g, Pericarpium Citri Reticulatae 120g, Radix Glycyrrhizae 20g.
Be prepared as honeyed pill, preparation method is:
It is standby with the Margarita powder mix homogeneously of equal fineness that Cinnabaris, Calculus Bovis, Borneolum Syntheticum, the Moschus of getting recipe quantity was ground into the fine powder of 80 mesh sieves respectively; All medicated powder of other recipe quantities is broken into same mistake 80 mesh sieves of fine powder, above fine powder is mixed, sieve, mixing adds Mel according to conventional honeyed pill preparation method and makes honeyed pill, the heavy 3g of ball, big honeyed pills brownish black, mildly bitter flavor, suffering.
Embodiment 2
A kind of medicine for the treatment of epilepsy, the each component of this medicine are according to the weight portion meter, and its proportioning is: Calculus Bovis 4g, Margarita powder 24g; Borneolum Syntheticum 4g, Moschus 2g, Scorpio 60g, Scolopendra 60g; Periostracum Cicadae 100g, Zaocys 40g, Pheretima 60g, Arisaema Cum Bile 100g; Cinnabaris 18g, Rhizoma Acori Graminei 100g, Radix Curcumae 100g, Bulbus Fritillariae Cirrhosae 120g; Radix Ophiopogonis 150g, Radix Salviae Miltiorrhizae 120g, Ramulus Uncariae Cum Uncis 100g; Massa Medicata Fermentata 120g, Pericarpium Citri Reticulatae 120g, Radix Glycyrrhizae 20g.
Be prepared as honeyed pill, preparation method is:
It is standby with the Margarita powder mix homogeneously of equal fineness that Cinnabaris, Calculus Bovis, Borneolum Syntheticum, the Moschus of getting recipe quantity was ground into the fine powder of 80 mesh sieves respectively; All medicated powder of other recipe quantities is broken into same mistake 80 mesh sieves of fine powder, above fine powder is mixed, sieve, mixing adds Mel according to conventional honeyed pill preparation method and makes honeyed pill, the heavy 3g of ball, big honeyed pills brownish black, mildly bitter flavor, suffering.
Embodiment 3
A kind of medicine for the treatment of epilepsy, the each component of this medicine are according to the weight portion meter, and its proportioning is: Calculus Bovis 4g, Margarita powder 24g; Borneolum Syntheticum 4g, Moschus 2g, Scorpio 60g, Scolopendra 60g; Periostracum Cicadae 100g, Zaocys 40g, Pheretima 60g, Arisaema Cum Bile 100g; Cinnabaris 18g, Rhizoma Acori Graminei 100g, Radix Curcumae 100g, Bulbus Fritillariae Cirrhosae 125g; Radix Ophiopogonis 145g, Radix Salviae Miltiorrhizae 120g, Ramulus Uncariae Cum Uncis 100g; Massa Medicata Fermentata 120g, Pericarpium Citri Reticulatae 120g, Radix Glycyrrhizae 20g.
Be prepared as honeyed pill, preparation method is:
It is standby with the Margarita powder mix homogeneously of equal fineness that Cinnabaris, Calculus Bovis, Borneolum Syntheticum, the Moschus of getting recipe quantity was ground into the fine powder of 80 mesh sieves respectively; All medicated powder of other recipe quantities is broken into same mistake 80 mesh sieves of fine powder, above fine powder is mixed, sieve, mixing adds Mel according to conventional honeyed pill preparation method and makes honeyed pill, the heavy 3g of ball, big honeyed pills brownish black, mildly bitter flavor, suffering.
Experimental example
1. epileptic 244 people, man, 166 people; The woman, 78 people.Age, 1-65 year, average: 28.6 ± 17.4 years old.Medical history: below 3 years, 75 people; 3-5,83 people; 5-10,55 people; More than 10 years, 31 people.All cases are all carried out conventional video EEG (electrocardiogram) examination before treatment, and part patient adds and makes sphenoidal electrode and sleep monitor.
2. image check sufferer: 224 examples wardrobe CT or MRI are respectively arranged, unusual 32 examples (13.1%), cerebral infarction wherein, 8 examples among the 244 routine patients; Cerebral trauma, 5 examples; Cerebral hemorrhage, 4 examples; Cerebral dysgenesis, 4 examples; Cerebral cyst, 2 examples, encephalitis, 2 examples; Hypoxic-ischemic encephalopathy (HIE) 2 examples; Cerebrovascular malformation 2 examples, cerebroma, 2 examples; Microcrania 1 example, and according to international epilepsy alliance criteria for classification in 1989, the patient was divided into simple partial seizures 28 examples, complex partial seizures 95 examples, tonic-clonic seizures 121 examples.
3. Therapeutic Method embodiment 2 gained are treated the medicine of epilepsy: the child, and 0.25 ball-0.5 ball/time, every day 2-3 time.The adult, the 1-2 ball/time, every day 2-3 time.3 months is a course of treatment, check electroencephalogram when finish the course of treatment, and according to attack degree and number of times judgement curative effect.Individual patient fails to check electroencephalogram, and in the locality check, phone is followed up a case by regular visits to curative effect.
4. curative effect determinate standard:
Be clearly better: clinical can't the work.
Take a turn for the better: clinical episodes treatment is preceding with cycle minimizing 75%, and degree alleviates.
Effectively: clinical episodes treatment is preceding with cycle minimizing 50%, and degree alleviates.
Invalid: clinical episodes treatment is preceding with cycle minimizing less than 50%, or no change.
5 clinical test results are as follows:
5.1 clinical manifestation sees table 1 for details before and after the treatment;
The variation example (%) of clinical main forms before and after table 1 treatment
5.2 seizure frequency and the preceding outbreak of degree treatment are most of at 5-10 time/month, but it is inferior surplus in the of 20 to show effect every day at most.Outbreak accounts for 84.1% of outbreak to be in the nighttime sleep more.Duration of seizure was many with 3-5 minute, but the short several seconds, long have 10 surplus minute outbreak.Treatment back attack times obviously reduces, and with prolonging medicine time, attack times is decrescence few, and degree alleviates, and sees table 2 for details;
The variation example (%) of attack times before and after table 2 treatment
5.3 EEG (electrocardiogram) examination: before the medication unusual performance based in--long-range sharp wave, sharp slow wave comprehensively, wave amplitude based in high wave amplitude, alpha rhythm is not obvious.Through medication treatment, the main performance alpha rhythm evident regularity that takes a turn for the better, sharp wave, sharp slow wave comprehensively obviously reduce or only occur once in a while, and part patient has the short distance slow wave to occur.The result sees table 3 for details:
The variation example (%) of EEG results before and after table 3 treatment
Simultaneously check routine blood test, liver function, renal function in patient's medication after 3,6,12 months, platelet no abnormality seen, erythrocyte, leukocyte there is no and be higher than normally the kidney function test no abnormality seen.
Final through among the statistics patient:
Take medicine March: be clearly better 78.28%, take a turn for the better 6.56%, effective 15.16%, invalid 0%;
Take medicine June: be clearly better 90.57%, take a turn for the better 7.38%, effective 2.05%, invalid 0%;
The JIUYUE of taking medicine: be clearly better 92.62%, take a turn for the better 5.33%, effective 2.05%, invalid 0%;
The December of taking medicine: be clearly better 92.62%, take a turn for the better 5.33%, effective 2.05%, invalid 0%;
As seen use the Drug therapy partial epilepsy of treatment epilepsy provided by the present invention, evident in efficacy, the clinical episodes control rate is: 92.62%, and hemopoietic system, liver function, renal function do not had tangible toxicity.
Claims (4)
1. Chinese medicine composition for the treatment of epilepsy, it is characterized in that: this Chinese medicine composition is made by the following raw material medicaments material: according to the weight portion meter, 4 parts of Calculus Boviss, 24 parts of Margarita powder; 4 parts of Borneolum Syntheticums, 2 parts in Moschus, 60 parts of Scorpios, 60 parts of Scolopendras; 100 parts of Periostracum Cicadaes, 40 parts of Zaocyss, 60 parts of Pheretimas, 100 parts of Arisaema Cum Bile; 18 parts in Cinnabaris, 100 parts of Rhizoma Acori Graminei, 100 parts of Radix Curcumaes, Bulbus Fritillariae Cirrhosae 115-125 part; Radix Ophiopogonis 145-155 part, 120 parts of Radix Salviae Miltiorrhizaes, 100 parts of Ramulus Uncariae Cum Uncis; 120 parts of Massa Medicata Fermentata, 120 parts of Pericarpium Citri Reticulataes, 20 parts in Radix Glycyrrhizae.
2. Chinese medicine composition according to claim 1 is characterized in that: the Bulbus Fritillariae Cirrhosae that is adopted is 120 parts, and be 150 parts Radix Ophiopogonis.
3. the method for Chinese medicine composition of epilepsy is treated in processing according to claim 1, and its step is as follows: it is standby with the Margarita powder mix homogeneously of equal fineness that Cinnabaris, Calculus Bovis, Borneolum Syntheticum, the Moschus of getting recipe quantity was ground into the fine powder of 80 mesh sieves respectively; All medicated powder of other recipe quantities is broken into same mistake 80 mesh sieves of fine powder, above fine powder is mixed, sieve, mixing adds Mel according to conventional honeyed pill preparation method and makes honeyed pill.
4. preparation method according to claim 3 is characterized in that: the heavy 3g of the every ball of gained honeyed pill.
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| CN2010101223672A CN101780255B (en) | 2010-03-12 | 2010-03-12 | Traditional Chinese medicine composition for treating epilepsy |
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| CN2010101223672A CN101780255B (en) | 2010-03-12 | 2010-03-12 | Traditional Chinese medicine composition for treating epilepsy |
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| CN101780255B true CN101780255B (en) | 2011-12-28 |
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101897936B (en) * | 2010-08-06 | 2012-06-20 | 李贤德 | Traditional Chinese medicinal preparation for treating mental disease and preparation method thereof |
| CN104436002A (en) * | 2014-08-08 | 2015-03-25 | 赵国贤 | Quick-acting antiepileptic pill |
| CN105816653A (en) * | 2016-04-30 | 2016-08-03 | 何佑兵 | Traditional Chinese medicine composition for treating epilepsy and preparation method thereof |
| CN108815469A (en) * | 2018-08-16 | 2018-11-16 | 贵州苗之源苗药中药饮片有限公司 | A kind of Chinese medicine composition and preparation method thereof for treating epilepsy |
| CN110101804A (en) * | 2019-05-30 | 2019-08-09 | 厦门梓素生物科技有限公司 | A kind of epilepsy drugs combination of the extract containing cannabidiol and preparation method thereof |
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| CN1165332C (en) * | 2002-07-24 | 2004-09-08 | 李如元 | Composite medicine for treating epilepsy |
| CN101559195B (en) * | 2008-04-16 | 2011-09-21 | 苗卫萍 | Epilepsy therapy capsule and preparation method thereof |
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