CN101772498A - 作为p2x7拮抗剂的杂芳基酰胺类似物 - Google Patents

作为p2x7拮抗剂的杂芳基酰胺类似物 Download PDF

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Publication number
CN101772498A
CN101772498A CN200880019683A CN200880019683A CN101772498A CN 101772498 A CN101772498 A CN 101772498A CN 200880019683 A CN200880019683 A CN 200880019683A CN 200880019683 A CN200880019683 A CN 200880019683A CN 101772498 A CN101772498 A CN 101772498A
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alkyl
pyrazolo
pyridine
ylmethyl
adamantan
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CN200880019683A
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Chinese (zh)
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D·C·伊勒
Q·郭
K·霍杰茨
J·原
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H Lundbeck AS
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H Lundbeck AS
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    • C07—ORGANIC CHEMISTRY
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • C—CHEMISTRY; METALLURGY
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    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN200880019683A 2007-04-10 2008-04-09 作为p2x7拮抗剂的杂芳基酰胺类似物 Pending CN101772498A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91086407P 2007-04-10 2007-04-10
US60/910,864 2007-04-10
PCT/US2008/004563 WO2008124153A1 (en) 2007-04-10 2008-04-09 Heteroaryl amide analogues as p2x7 antagonists

Related Child Applications (1)

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CN2013101274201A Division CN103204852A (zh) 2007-04-10 2008-04-09 作为p2x7拮抗剂的杂芳基酰胺类似物

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CN101772498A true CN101772498A (zh) 2010-07-07

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CN200880019683A Pending CN101772498A (zh) 2007-04-10 2008-04-09 作为p2x7拮抗剂的杂芳基酰胺类似物
CN2013101274201A Pending CN103204852A (zh) 2007-04-10 2008-04-09 作为p2x7拮抗剂的杂芳基酰胺类似物

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US (2) US8580812B2 (https=)
EP (2) EP2155744A1 (https=)
JP (1) JP2010523668A (https=)
KR (1) KR20090130109A (https=)
CN (2) CN101772498A (https=)
AU (1) AU2008236649B2 (https=)
BR (1) BRPI0809567A2 (https=)
CA (1) CA2682925A1 (https=)
CO (1) CO6241110A2 (https=)
EA (1) EA200970931A1 (https=)
IL (1) IL201356A0 (https=)
MX (1) MX2009010523A (https=)
MY (1) MY148461A (https=)
NZ (1) NZ580394A (https=)
UA (1) UA99610C2 (https=)
WO (1) WO2008124153A1 (https=)

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EP2592082A1 (en) 2013-05-15
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IL201356A0 (en) 2010-05-31
MY148461A (en) 2013-04-30
KR20090130109A (ko) 2009-12-17
BRPI0809567A2 (pt) 2014-09-23
UA99610C2 (en) 2012-09-10
JP2010523668A (ja) 2010-07-15
US8580812B2 (en) 2013-11-12
AU2008236649B2 (en) 2013-05-02
AU2008236649A1 (en) 2008-10-16
NZ580394A (en) 2011-10-28
US20100266509A1 (en) 2010-10-21
CO6241110A2 (es) 2011-01-20
US20140038955A1 (en) 2014-02-06
EP2155744A1 (en) 2010-02-24
CN103204852A (zh) 2013-07-17
WO2008124153A1 (en) 2008-10-16
CA2682925A1 (en) 2008-10-16

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