CN101757338A - Medicament for treating digestive tract tumor and preparation method thereof - Google Patents
Medicament for treating digestive tract tumor and preparation method thereof Download PDFInfo
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- CN101757338A CN101757338A CN200910250118A CN200910250118A CN101757338A CN 101757338 A CN101757338 A CN 101757338A CN 200910250118 A CN200910250118 A CN 200910250118A CN 200910250118 A CN200910250118 A CN 200910250118A CN 101757338 A CN101757338 A CN 101757338A
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Abstract
The invention discloses a medicament for treating digestive tract tumor and a preparation method thereof. The medicament belongs to a pure traditional Chinese medicine preparation which is prepared from bezoar, musk, bear gall, Cordyceps sinensis, American ginseng, cassia twig, liquorice, roasted white paeony root, Pinellia ternate, rai nbow conk, and common phellinus fungus. The traditional Chinese medicine preparation which can relieve pain and treat digestive tract tumor by clearing heat and detoxicating, getting rid of swelling, eliminating phlegm and stasis is a better traditional Chinese medicine for treating digestive tract tumor.
Description
Technical field the present invention relates to a kind of medicine for the treatment of digestive tract tumor, be pure Chinese herbal medicine, specifically, be based on the detoxifcation, by the expectorant blood stasis dispelling, poly-, eliminate indigestion disappears, invigorating primordial QI, the Wei Weifu of accent battalion, the pharmaceutical preparation of the tumor of organs such as treatment liver and gall, pancreas, stomach, intestinal.The invention still further relates to the preparation method of this medicine.
Background technology digestive tract tumor mostly because of accumulate in the cold and heat expectorant poison, phlegm and blood stasis, internal injury liver and gall undermine taste and cause depression and stagnation of QI, the resistance of blood clots absorbing forms.The medicine, particularly Chinese patent medicine of existing treatment digestive tract tumor are very few, and curative effect is not remarkable, and the toxicity height can not be from detoxifcation, start with by expectorant blood stasis dispelling, poly-, the eliminate indigestion of disappearing, and reach the purpose for the treatment of both the principal and secondary aspects of a disease, thereby cure rate is low.
Summary of the invention the present invention is intended to improve above-mentioned deficiency, provide a kind of by accumulate in the treatment cold and heat expectorant poison, phlegm and blood stasis, internal injury liver and gall undermine taste and cause depression and stagnation of QI, the resistance of blood clots absorbing, QI and blood is wet to be tied mutually in taste, " gather " medicine of sending out the digestive tract tumor that forms in organ such as liver, gallbladder, pancreas, stomach, intestinal, with and preparation method thereof.The present invention is based on detoxifcation, by expectorant blood stasis dispelling, poly-, the eliminate indigestion that disappears, and Wei Weifu sought in invigorating primordial QI, accent, reach the purpose for the treatment of both the principal and secondary aspects of a disease.
In order to achieve the above object, the present invention is achieved in that
A kind of medicine for the treatment of digestive tract tumor, it is composed of the following components: natural Calculus Bovis 3-5 part, natural Moschus 3-5 part, natural Fel Ursi 8-12 part, Cordyceps 4-6 part, Radix Panacis Quinquefolii 22-28 part, Ramulus Cinnamomi 130-170 part, Radix Glycyrrhizae 130-170 part, Radix Paeoniae Alba (parched) 270-330 part, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 27-33 part, Phellinus igniarius (L. ex Fr.) Quel. 120-200 part, Coriolous Dersicolor (Fr.) Quel 120-200 part; Described part refers to weight portion.
More the set of dispense ratio of You Huaing is: 4 parts of natural Calculus Bovis, 4 parts of natural Moschuss, 10 parts of natural Fel Ursi, 5 parts of Cordyceps, 25 parts of Radix Panacis Quinquefoliis, 150 parts of Ramulus Cinnamomi, 150 parts in Radix Glycyrrhizae, 300 parts of Radix Paeoniae Alba (parched)s, 30 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 160 parts of Phellinus igniarius (L. ex Fr.) Quel., 160 parts of Coriolous Dersicolor (Fr.) Quel.
First kind of preparation method of medicine of the present invention is: first group of medicine: natural Calculus Bovis, natural Moschus, Cordyceps grind into 100 order fine powders, and is standby; Second group of medicine: other pulverizing medicinal materials becomes 100 order fine powders, with two groups of abundant mix homogeneously of medicine; Oven dry about 40 ℃, packing promptly.
Second kind of preparation method of medicine of the present invention is: first group of medicine: natural Calculus Bovis, natural Moschus, Cordyceps, natural Fel Ursi grind into 100 order fine powders, and be standby; Second group of medicine: other medical material is through the supercritical carbon dioxide extraction effective ingredient, and solvent for use is 90% ethanol, 50 ℃ of temperature, pressure 15 MPas, 60 liters/hour of extraction flows, 90 minutes extraction time; With two groups of abundant mix homogeneously of medicine; Oven dry about 40 ℃, packing promptly.
The third preparation method of medicine of the present invention is: first group of medicine: natural Calculus Bovis, natural Moschus, Cordyceps, natural Fel Ursi grind into 100 order fine powders, and be standby; Second group of medicine: other medical material is through the supercritical carbon dioxide extraction effective ingredient, and solvent for use is 90% ethanol, 50 ℃ of temperature, pressure 15 MPas, 60 liters/hour of extraction flows, 90 minutes extraction time; With two groups of abundant mix homogeneously of medicine; Sneak into proper ratio substrate again, make drop pill, packing promptly.
The main Chinese herbal medicine of prescription of the present invention is according to traditional medicine and modern medicine analysis, and the property of medicine and pharmacological action are as follows:
Calculus Bovis: property hardship, cold.Return liver, heart channel.Heat-clearing and toxic substances removing is arranged, endogenous wind stopping relieving convulsion, the effect of waking up the patient from unconsciousness by dissipating phlegm.Pharmacological research shows that this product has convulsion and refrigeration function.The rabbit ear perfusion that exsomatizes is vasorelaxation action, in blood pressure and isolated heart test adrenolytic effect is arranged all, and it is relevant with vasodilation and adrenolytic effect.Calculus Bovis also has function of gallbladder promoting and hepatoprotective effect.2 kinds of acidity peptide constituents SMC-S that its water soluble ingredient contains
2With SMC-F the small intestine of guinea pig that exsomatizes there is significant excitation.In addition, Calculus Bovis also has antiallergic, antiinflammatory action.
Moschus: property suffering, temperature.GUIXIN, spleen channel.The refreshment of having one's ideas straightened out is arranged, blood circulation promoting and dispersing pathogen accumulation, pain relieving, oxytocic effect.Pharmacological research shows that this product is low dose of excited to the central nervous system, and heavy dose then suppresses; Isolated heart there is excitation.Can make increased blood pressure, frequency of respiration increases.Can suppress escherichia coli, staphylococcus aureus in vitro.Moschus has stronger antiinflammatory action, and all there is positive effect early, middle and late phase of inflammation, especially to early, the effect in mid-term is stronger.The Moschus water extract is to the inhibitory action of mouse knoting oil ear inflammation, rat agar arthritis, yeast swollen joint, the equal tool highly significant of adjuvant type polyarthritis; Moschus water extract, aqueous extract can strengthen the contraction to cat heart papillary muscles of isoproterenol, epinephrine and norepinephrine, and Moschus has potentiation to the epinephrine beta receptor in the peripheral blood vessel.The musk water-soluble material has potentiation to humoral immunization and cellular immunization.Anti-allergy action is arranged, arthritic constitutional inflammatory damage of rat adjuvant type and the damage of Secondary cases immunity are all had significant inhibitory effect.
Cordyceps has the effect that improves animal monokaryon-macrophage system phagocytic function, is a kind of immunostimulant.Antitumor action has remarkable inhibitory action to the Hela cell, and mouse lymph lymphoma is had obvious inhibitory action, and the primary tumor of Mice Bearing Lewis Lung Cancer and spontaneous lung are shifted all remarkable inhibitory action.Antibacterial action has inhibitory action to tubercule bacillus, staphylococcus, streptococcus, common skin pathomycete etc.The water logging agent has tangible diastole effect to the guinea pig bronchial that exsomatizes, and can strengthen adrenergic effect.In addition, also have defying age, anti-stress effect.
The Rhizoma Pinelliae: property suffering, temperature.Return spleen, stomach, lung meridian.The merit that drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass are arranged.Pharmacological research shows that the Rhizoma Pinelliae has the preventing or arresting vomiting effect, and can suppress glandular secretion, and the salivation that pilocarpine is caused has significant inhibitory effect, and the kinds of experiments tumor is had inhibitory action.
Radix Panacis Quinquefolii: sweet, the little hardship of property, cold.GUIXIN, lung, kidney channel.The effect that boosting qi and nourishing yin is arranged, relieve inflammation or internal heat and promote the production of body fluid.Pharmacological research shows that this product has sedation to brain, and vital center is had the moderate excitation.
Fel Ursi: property hardship, cold.Return liver, gallbladder, heart channel.The function that heat-clearing and toxic substances removing, endogenous wind stopping relieving convulsion, liver heat removing and eyesight improving are arranged.Pharmacological research shows that this product has certain sedation, also has tangible anticonvulsant action, and significant spasmolytic, choleretic effect are arranged, and its deoxycholic acid, taurine have certain analgesic activity.
The present invention sheerly prepared from traditional Chinese medicines forms, and is a kind of Chinese medicine for oral administration, and it is main that the side uses Calculus Bovis heat-clearing and toxic substances removing, dissipating phlegm and resolving masses; Moschus is scurried logical the dissipation, and the heap soil or fertilizer over and around the roots of invigorating blood circulation out is auxilliary; The Radix Panacis Quinquefolii boosting qi and nourishing yin relieves inflammation or internal heat and promotes the production of body fluid.Cordyceps kidney tonifying tonifying the lung, hemostasis and phlegm.The Ramulus Cinnamomi relieving the exterior syndrome by diaphoresis, warming the meridian for promoting the flow of YANG QI.The Radix Paeoniae Alba yin fluid astringing that nourishes blood, easing the affected liver to relieve pain, suppressing liver-YANG.The sharp the five internal organs of Phellinus igniarius (L. ex Fr.) Quel., softening the hard mass, toxin expelling, stomach function regulating antidiarrheal is invigorated blood circulation in hemostasis.The lung disease is dried, reduces phlegm, treated to Coriolous Dersicolor (Fr.) Quel.The Fel Ursi heat-clearing and toxic substances removing, relieving convulsion makes eye bright.Rhizoma Pinelliae drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.For accumulate in the treatment cold and heat expectorant poison, phlegm and blood stasis, internal injury liver and gall undermine taste and cause depression and stagnation of QI, the resistance of blood clots absorbing, QI and blood is wet to be tied mutually in taste, and it is evident in efficacy that " gathering " sends out the digestive tract tumor that forms in organ such as liver, gallbladder, pancreas, stomach, intestinal, and side effect is little.
The specific embodiment further specifies the present invention in order to understand better and to implement below in conjunction with embodiment.
[preparation example]
Preparation example one
Calculus Bovis (natural) 4 grams, Moschus (natural) 4 grams, Fel Ursi (natural) 10 grams, Cordyceps 5 grams, Radix Panacis Quinquefolii 25 grams, Ramulus Cinnamomi 150 grams, Radix Glycyrrhizae 150 grams, Radix Paeoniae Alba (parched) 300 grams, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 30 grams, Coriolous Dersicolor (Fr.) Quel 160 grams, Phellinus igniarius (L. ex Fr.) Quel. 160 grams.
Method for making one: in the above-mentioned medical material, Calculus Bovis, Moschus, Cordyceps grind into 100 order fine powders, and is standby.Other pulverizing medicinal materials becomes 100 order fine powders, with two groups of abundant mix homogeneously of medicine, by the specification of every gram 10 balls, the general ball of making.Oven dry about 40 ℃, packing promptly.
Method for making two: in the above-mentioned medical material, Calculus Bovis, Moschus, Cordyceps, Fel Ursi grind into 100 order fine powders, and be standby.Other medical material is through the supercritical carbon dioxide extraction effective ingredient, and 90% ethanol is used in extraction, 50 ℃ of temperature, pressure 15 MPas, 60 liters/hour of extraction flows, 90 minutes extraction time.With two groups of abundant mix homogeneously of medicine, by the specification of every gram 10 balls, the general ball of making.Oven dry about 40 ℃, packing promptly.
Method for making three: in the above-mentioned medical material, Calculus Bovis, Moschus, Cordyceps, Fel Ursi grind into 100 order fine powders, and be standby.Other medical material is through the supercritical carbon dioxide extraction effective ingredient, and 90% ethanol is used in extraction, 50 ℃ of temperature, pressure 15 MPas, 60 liters/hour of extraction flows, 90 minutes extraction time.With two groups of abundant mix homogeneously of medicine, sneak into Polyethylene Glycol heating mix homogeneously again, medicine: Polyethylene Glycol=1: 6 (mass ratio), make drop pill, packing is promptly.
Preparation example two
Calculus Bovis (natural) 3 grams, Moschus (natural) 5 grams, Fel Ursi (natural) 12 grams, Cordyceps 4 grams, Radix Panacis Quinquefolii 22 grams, Ramulus Cinnamomi 170 grams, Radix Glycyrrhizae 130 grams, Radix Paeoniae Alba (parched) 330 grams, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 27 grams, Coriolous Dersicolor (Fr.) Quel 120 grams, Phellinus igniarius (L. ex Fr.) Quel. 120 grams.
Method for making is with example one.
Preparation example three
Calculus Bovis (natural) 5 grams, Moschus (natural) 3 grams, Fel Ursi (natural) 8 grams, Cordyceps 6 grams, Radix Panacis Quinquefolii 28 grams, Ramulus Cinnamomi 130 grams, Radix Glycyrrhizae 170 grams, Radix Paeoniae Alba (parched) 270 grams, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 33 grams, Coriolous Dersicolor (Fr.) Quel 200 grams, Phellinus igniarius (L. ex Fr.) Quel. 200 grams.
Method for making is with example one.
[character] this product is the watered pill or the drop pill of yellowish-brown to pitchy; Feeble QI, mildly bitter flavor.
[function with cure mainly] eliminate indigestion looses poly-, the removing blood stasis detoxifcation, and invigorating primordial QI transfers battalion to defend.Be used for few, the diseases such as body void, jaundice of becoming thin of lump, local pain, the decreased food intake of receiving that digestive system tumor occurs.
[consumption and usage] is oral, every day three times, each 3 the gram or follow the doctor's advice and take.
[specification] 3g/ bag
Crude drug source is bought by medical material company, and the medical material standard meets the Pharmacopoeia of the People's Republic of China and " the Sanitation Ministry medicine standard " etc.
This invention medicine that preparation adopts is not violated " eighteen incompatible medicaments ", " nineteen medicaments of mutual restraint ", mutual compatibility, no mutual inhibition reverse situation.Untoward reaction is not found in clinical practice.
Treat digestive tract tumor's 100 examples with medicine of the present invention, and do contrast with 30 examples with fenofibrate treatment.The result shows medicine group obvious effective rate 67% of the present invention, total effective rate 93%; Between matched group obvious effective rate 36.66%, 66.67%, two group of total effective rate relatively (P＜0.01), significant difference is arranged.Medicine of the present invention is being eliminated clinical symptoms, and aspects such as recovery liver spleen and stomach function all are better than fenofibrate.
1, clinical data; All case is long grace hospital of in JIUYUE, 1 2009 Yantai Laishan July in 2008 and ward patient, be divided into test group 100 examples by the completely random principle, with matched group 30 examples of fenofibrate (.0802112 of Wei'erman Pharmaceutic Co. Ltd., Guangzhou) oral medication with medicine oral medication of the present invention.
Table one case source
Learn to handle by statistics, P＞0.05 is so think two groups of cases there was no significant differences of originating.
Table two liang group patient tcm symptom situation relatively
Learn by statistics and handle, the main tcm symptom of P＞0.05, two group patient compares no significant difference.
Table three liang group patient TCM Syndrome Type situation relatively
Learn by statistics and handle P＞0.05, two-stage patient's pattern of syndrome distribution there was no significant difference.
2, Therapeutic Method: test group: oral medicine of the present invention, each 10 grams, every day three times, logotype 45 days was a course of treatment; Matched group: with fenofibrate (.0802112 of Wei'erman Pharmaceutic Co. Ltd., Guangzhou), oral each 0.1g, day three times, 45 days is a course of treatment.
3, therapeutic outcome, curative effect relatively has significant difference after treatment group and the treatment of control group.
The clinical experiment result: the medicine that the present invention makes is observed through clinical case, and it is half an hour after meal that this medicine is taken Best Times.Can effectively treat various digestive tract tumor.
Claims (5)
1. medicine for the treatment of digestive tract tumor, it is characterized in that: it is composed of the following components, natural Calculus Bovis 3-5 part, natural Moschus 3-5 part, natural Fel Ursi 8-12 part, Cordyceps 4-6 part, Radix Panacis Quinquefolii 22-28 part, Ramulus Cinnamomi 130-170 part, Radix Glycyrrhizae 130-170 part, Radix Paeoniae Alba (parched) 270-330 part, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 27-33 part, Phellinus igniarius (L. ex Fr.) Quel. 120-200 part, Coriolous Dersicolor (Fr.) Quel 120-200 part; Described part refers to weight portion.
2. according to the medicine of the described treatment of claim 1 digestive tract tumor, it is characterized in that: 4 parts of natural Calculus Bovis, 4 parts of natural Moschuss, 10 parts of natural Fel Ursi; 5 parts of Cordyceps, 25 parts of Radix Panacis Quinquefoliis, 150 parts of Ramulus Cinnamomi, 150 parts in Radix Glycyrrhizae; 300 parts of Radix Paeoniae Alba (parched)s, 30 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 160 parts of Phellinus igniarius (L. ex Fr.) Quel., 160 parts of Coriolous Dersicolor (Fr.) Quel.
3. according to claim 1 or 2 described preparation methoies for the treatment of the medicine of digestive tract tumor, it is characterized in that: first group of medicine: natural Calculus Bovis, natural Moschus, Cordyceps grind into 100 order fine powders, and is standby; Second group of medicine: other pulverizing medicinal materials becomes 100 order fine powders, with two groups of abundant mix homogeneously of medicine; Oven dry about 40 ℃, packing promptly.
4. according to claim 1 or 2 described preparation methoies for the treatment of the medicine of digestive tract tumor, it is characterized in that: first group of medicine: natural Calculus Bovis, natural Moschus, Cordyceps, natural Fel Ursi grind into 100 order fine powders, and be standby; Second group of medicine: other medical material is through the supercritical carbon dioxide extraction effective ingredient, and solvent for use is 90% ethanol, 50 ℃ of temperature, pressure 15 MPas, 60 liters/hour of extraction flows, 90 minutes extraction time; With two groups of abundant mix homogeneously of medicine; Oven dry about 40 ℃, packing promptly.
5. according to claim 1 or 2 described a kind of preparation methoies for the treatment of the medicine of digestive tract tumor, it is characterized in that: first group of medicine: natural Calculus Bovis, natural Moschus, Cordyceps, natural Fel Ursi grind into 100 order fine powders, and be standby; Second group of medicine: other medical material is through the supercritical carbon dioxide extraction effective ingredient, and solvent for use is 90% ethanol, 50 ℃ of temperature, pressure 15 MPas, 60 liters/hour of extraction flows, 90 minutes extraction time; With two groups of abundant mix homogeneously of medicine; With two groups of abundant mix homogeneously of medicine; Sneak into proper ratio substrate again, make drop pill, packing promptly.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910250118A CN101757338A (en) | 2009-11-27 | 2009-11-27 | Medicament for treating digestive tract tumor and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN200910250118A CN101757338A (en) | 2009-11-27 | 2009-11-27 | Medicament for treating digestive tract tumor and preparation method thereof |
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| CN101757338A true CN101757338A (en) | 2010-06-30 |
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| CN200910250118A Pending CN101757338A (en) | 2009-11-27 | 2009-11-27 | Medicament for treating digestive tract tumor and preparation method thereof |
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Open date: 20100630 |