CN101708001A - Sterilizing composition containing active ester - Google Patents
Sterilizing composition containing active ester Download PDFInfo
- Publication number
- CN101708001A CN101708001A CN200910258688A CN200910258688A CN101708001A CN 101708001 A CN101708001 A CN 101708001A CN 200910258688 A CN200910258688 A CN 200910258688A CN 200910258688 A CN200910258688 A CN 200910258688A CN 101708001 A CN101708001 A CN 101708001A
- Authority
- CN
- China
- Prior art keywords
- acibenzolar
- composition
- methyl
- agent
- fluoxastrobin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000002148 esters Chemical class 0.000 title claims abstract description 12
- 230000001954 sterilising effect Effects 0.000 title abstract 3
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 34
- 239000003899 bactericide agent Substances 0.000 claims abstract description 29
- 239000005784 Fluoxastrobin Substances 0.000 claims abstract description 26
- UFEODZBUAFNAEU-NLRVBDNBSA-N fluoxastrobin Chemical compound C=1C=CC=C(OC=2C(=C(OC=3C(=CC=CC=3)Cl)N=CN=2)F)C=1C(=N/OC)\C1=NOCCO1 UFEODZBUAFNAEU-NLRVBDNBSA-N 0.000 claims abstract description 26
- 239000000843 powder Substances 0.000 claims abstract description 24
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- HZRSNVGNWUDEFX-UHFFFAOYSA-N pyraclostrobin Chemical compound COC(=O)N(OC)C1=CC=CC=C1COC1=NN(C=2C=CC(Cl)=CC=2)C=C1 HZRSNVGNWUDEFX-UHFFFAOYSA-N 0.000 claims abstract description 14
- VMNULHCTRPXWFJ-UJSVPXBISA-N enoxastrobin Chemical compound CO\C=C(\C(=O)OC)C1=CC=CC=C1CO\N=C(/C)\C=C\C1=CC=C(Cl)C=C1 VMNULHCTRPXWFJ-UJSVPXBISA-N 0.000 claims abstract description 13
- ZOTBXTZVPHCKPN-HTXNQAPBSA-N kresoxim-methyl Chemical compound CO\N=C(\C(=O)OC)C1=CC=CC=C1COC1=CC=CC=C1C ZOTBXTZVPHCKPN-HTXNQAPBSA-N 0.000 claims abstract description 13
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Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to a sterilizing composition containing active ester, which comprises effective components such as active ester (A) and a strobilurin bactericide (B), wherein the strobilurin bactericide is chosen from azoxystrobin, kresoxim-methyl, pyraclostrobine, metominostrobin, dimoxystrobin, trifloxystrobin, picoxystrobin, fluoxastrobin, enestroburin, 2-[2-(2,5-phenoxy-dimethyl) phenyl-methyl-3- methoxy acrylate (ZJ0712) or 2-imino-methyl-N-methyl-2-[[[[[[4-(2,6-dimethyl)phenyl]-3-butylene-2-yl]imino]epoxide]phenyl]amide (SYP-1620), the weight ratio of the A and B is 100:1-1:100, and the content of the active component in the composition is 5-80 in percentage by weight. The composition can be prepared into suspending agents, wetting powder, water dispersible granules, and the like. The sterilizing composition can be applied to farmlands, orchards and the like and is used for controlling various plantdiseases of grains, vegetables, fruit trees, flowers, and the like, in particular powdery mildew and downy mildew.
Description
Technical field
The present invention relates to a kind of bactericidal composition, especially contain the bactericidal composition of Acibenzolar and a kind of methoxy acrylate series bactericidal agent, belong to the disinfectant use in agriculture field.
Background technology
Powdery mildew is the plant disease that is caused by the Erysiphaceae in the fungi (Erysiphacesae).Mostly be ectoparasitism, the whole or big portion of mycelium is exposed to the surface of leaf, stem, the tender tip, bud, flower and the fruit of host plant, and produces the macroscopic white powder that is made of mycelium, conidiophore and conidium in a large number.
Powdery mildew is widely distributed in the whole world, and the dicotyledon of causing harm is particularly general.The main powdery mildew of China has the cereal class powdery mildew that is caused by standing grain powdery mildew (Ery-siphe graminis); The powdery mildew of various plants such as melon, the beans that causes by Siberian cocklebur monofilament shell (Sphaerotheca fuliginea), crudefiber crop; The grape powdery mildew that causes by grape snag shell (Uncinula necator); The powdery mildew of more than 80 kind of trees such as the mulberry that causes by hazel ball pin shell (Phyllactiniacorylea), pears, persimmon, walnut, chestnut, lichee, papaya papaw; Powdery mildew of the Rosa flowers that cause by rose monofilament shell (Sphaerotheca pannosa) etc.
Downy mildew is by the microbial plant disease of the downy mildew in the fungi.Downy mildew is an obligatory parasitic bacteria, and there is different bions in the kind that has, as causes the lettuce dish stalk mould (B.remiarlactucae) of downy mildew of lettuce and cause Cuba's vacation downy mildew (Pseudoperonospora cubensis) of cucumber downy mildew.Common downy mildew except that above-mentioned several, also have downy mildew of sugarcane and soybean downey mildew etc.Tobacco downy mildew is a destructive disease.
Downy mildew all can take place from seedling to each stage of results, is injured heavier to become strain.The blade of mainly causing harm is developed to upper leaf by base portion.Their early stage forms light yellow subcircular to the polygonal scab on the blade face, blade back produced the mould layer of white shape when there was dampness in the air, can spread to the blade face sometimes.The later stage scab is in flakes withered, is yellowish-brown, the withered and yellow death of whole siphonal lobes when serious.Morbidities easily such as field planting is overstocked, it is too early, excessive to water after the field planting, soil moisture big, impeded drainage.Spring is early summer or the easiest generation of continuous rainy weather in autumn not, can cause 20%～40% production loss when disease is serious.
In the control of powdery mildew and downy mildew, mainly rely on benzimidazole, triazole type, metalaxyl and some protectiveness medicaments.These medicaments are because long-term use has produced pesticide resistance in various degree, and control efficiency reduces.A large amount of uses of medicament have simultaneously increased residue of pesticide, and the harm food security has increased the weight of environmental pollution.
Acibenzolar is a diazosulfide carboxylic acid esters plant disease-resistant activator.Acibenzolar English name: acibenzolar chemical name: benzo (1,2,3) thiadiazoles-7-carbothioic acid-S-methyl esters test code number CGA245704, be called for short BTH molecular formula: C
8H
6N
2OS
2
Acibenzolar obtains resistance by the defense response that activates crop self, thereby resists diseases such as powdery mildew, downy mildew, rust.Suitable crop has paddy rice, wheat, vegetables, banana, tobacco etc.
Pesticide active ingredient applied in any combination with Acibenzolar and other structure type, there is the composition of synergistic effect not only can obviously improve actual preventive effect, reduce dosage and cost, also help to avoid the generation and the suspension of pesticide resistance generation speed of germ resistance, can solve problems such as resistance in the present agricultural chemicals list agent application process and cost.
Summary of the invention
The object of the present invention is to provide that a kind of new resistance risk is little, cost is low, good drug efficacy, long bactericidal composition of lasting period.
The inventor is by a large amount of indoor biometrics and field control effectiveness tests, find that unexpectedly Acibenzolar and methoxy acrylate series bactericidal agent are mixed in certain proportion after, diseases such as powdery mildew, downy mildew are had significant synergistic effect.
Described methoxy acrylate series bactericidal agent comprises Fluoxastrobin, kresoxim-methyl, pyraclostrobin, SSF 126, ether bacterium amine, oxime bacterium ester, ZEN 90160, fluoxastrobin, Enestroburin, ZJ0712, alkene oxime amine etc.
Methoxy acrylic bactericide is that lead compound synthesizes to come with natural products Strobilurin, by block cell pigment b and C
1Between the electronics transmission, suppress mitochondrial breathing, belong to pathogen mitochondrial respiratory inhibitor.To downy mildew, anthracnose, gray mold, eqpidemic disease, powdery mildew, rust, rice blast, scab, white rot all has very high preventive effect, and using dosage is low, mechanism of action is unique, has the certain protection effect concurrently.
Fluoxastrobin: English common name Azoxystrobin, chemical name (E)-2-(2-(6-(2-cyano-benzene oxygen) pyrimidine-4-base oxygen) phenyl)-3-methoxy-methyl acrylate.Molecular formula: C
22H
17N
3O
5Methoxy acrylic bactericide by a kind of efficient, the wide spectrum of Syngenta Co.,Ltd exploitation has protection, treatment and eradicant action, permeability and systemic activity is arranged, to crop safeties such as cereal, vegetables, fruit trees.
Kresoxim-methyl: English common name kresoxim-methyl, chemical name (E)-2-methoxyimino-[2-(o-methyl-benzene oxygen ylmethyl) phenyl] methyl acetate.Molecular formula: C
18H
19NO
4Kresoxim-methyl is by a kind of efficient, the wide spectrum of BASF Aktiengesellschaft exploitation, novel methoxy acrylic bactericide; have excellent protection and therapeutic action; lasting period is long; there is not cross resistance with other bactericide commonly used; to crop, people and animals and beneficial organism safety, pollution-free substantially to environment.
SSF 126: English common name metominostrobin, chemical name (E)-2-methoxyimino-N-methyl-2-[(2-phenoxy phenyl) acetamide, molecular formula: C
18H
19N
2O
3
Ether bacterium amine: English common name Dimoxystrobin.Chemical name (E)-2-(methoxyimino)-N-methyl-2-[α-(2, the 5-dimethyl phenoxy) o-tolyl] acetamide, molecular formula: C
19H
22N
2O
3, also be a kind of methoxy acrylic bactericide of relative wide spectrum.
Oxime bacterium ester: English common name trifloxystrobin.Chemical name: (2Z)-2-methoxyimino-2-[2-[[1-[3-(trifluoromethyl) phenyl] ethyleneimino] the oxygen methyl] phenyl] methyl acetate, molecular formula: C
20H
19F
3N
2O
4, by a kind of methoxy acrylic bactericide of Bayer A.G's exploitation.
ZEN 90160: English common name picoxystrobin, chemical name: (E)-and 3-methoxyl group-2-{2-[6-(trifluoromethyl)-2-pyridine oxygen methyl] phenyl } methyl acrylate, molecular formula: C
18H
16F
3NO
4, be by a kind of methoxy acrylic bactericide of Syngenta Co.,Ltd's exploitation, downy mildew there is special efficacy.
Fluoxastrobin: English common name fluoxastrobin, chemical name: 2-[2-[6-(2-chlorophenoxy)-5-fluorine pyrimidine-4-base oxygen] phenyl] (5,6-dihydro-1,4,2-dioxazines-3-yl) ketone O-methyloxime, molecular formula: C
21H
16ClFN
4O
5, be a kind of methoxy acrylic bactericide that powdery mildew is had fine control efficiency.
Pyraclostrobin: be pyraclostrobin again, English common name pyraclostrobin, chemical name: N-{2-[1-(4-chlorphenyl)-1H-pyrazole-3-yl oxygen methyl] phenyl } (N-methoxyl group) methyl carbamate, molecular formula: C
19H
18ClN
3O
4, be the New-type wide-spectrum bactericide, have protection, treatment and blade infiltration conduction.
Alkene oxime amine: test code number SYP-1620, chemical name: N-methyl-2-[2-((((1-methyl-3-(2, the 6-dichlorophenyl)-2-allylidene) amino) oxygen base) methyl) phenyl]-methoxyimino acetic amide, molecular formula: C
21H
21Cl
2N
3O
3
Enestroburin: English common name enestroburin, chemical name: (E)-and 2-[2-[[[[(3-(4-chlorphenyl)-1-metering system-2-yl] imido grpup] the oxygen base] methyl] phenyl]-the 3-methoxy-methyl acrylate, molecular formula: C
22H
22ClNO
4Alkene oxime amine and Enestroburin are that fungicidal spectrum is wide by the methoxy acrylic novel agrochemical kind of Shenyang Chemical Engineering Inst's exploitation, and the bactericidal activity height has protection and therapeutic action, and multiple diseases is had good control efficiency.
ZJ0712: test code number ZJ0712, chemical name: 2-[2-(2, the 5-dimethyl phenoxy)-benzylidene]-the 3-methoxy-methyl acrylate, molecular formula: C
20H
22O
4It is novel, efficient methoxy acrylic bactericide by the exploitation of Zhejiang chemical research institute.
Above-mentioned methoxy acrylic bactericide all is bactericide well known in the art, can obtain by various commercial channel.
On the basis of above-mentioned discovery, through composition is carried out symphyogenetic quantitative analysis, formed technical scheme of the present invention, that is: a kind of bactericidal composition, the mass ratio of Acibenzolar in the composition (A) and methoxy acrylic bactericide (B) is 100: 1～1: 100, and A is 40: 1～1: 40 with B quality optimization ratio.Active component gross mass percentage composition is 5～80% in the composition.
The present composition can be prepared into known method and be fit to any one formulation that agricultural is used, and formulation has suspending agent, wetting powder, water dispersible granules etc. preferably.These preparations can be prepared by method in common, for example, active substance is mixed with liquid flux and/or solid carrier, add surfactant such as emulsifier, dispersant, stabilizing agent, wetting agent simultaneously, can also add adhesive, defoamer, oxidant, dyestuff etc.
For suspending agent, one or more in spendable dispersant such as polycarboxylate, lignosulfonates such as lignin sulfonic acid sodium salt, the alkylnaphthalene sulfonate; Among emulsifier such as Nongru-700 # (common name alkyl phenol formaldehyde resin polyoxyethylene ether), nekal formaldehyde condensation products, agricultural newborn 2201#, this dish-60# (common name sorbitol anhydride monostearate), agricultural newborn 1601# (common name triphen ethyl-phenol polyoxyethylene polyoxypropylene block polymer), the TERSPERSE 4894 (2500) one or more; In wetting agent such as alkylphenol-polyethenoxy base ether formaldehyde condensation products phosphate, the withered powder of tea, alkylphenol-polyethenoxy base ether phosphate, phenethyl phenol polyethenoxy base ether phosphate, alkyl sulfate, alkylsulfonate, the naphthalene sulfonate one or more; In thickener such as xanthans, polyvinyl alcohol, the bentonite one or more; In preservative such as formaldehyde, benzoic acid, the Sodium Benzoate one or more; Defoamer such as organic silicon defoamer; In antifreezing agent such as ethylene glycol, propane diols, glycerine, urea, inorganic salts such as the sodium chloride one or more.
For water dispersible granules, one or more in spendable dispersant such as polycarboxylate, lignosulfonates, NNO4, the alkylnaphthalene sulfonate; In wetting agent such as polyoxyethylene nonylphenol ether, polyoxyethylene alcohol, alkyl sulfate, alkylsulfonate, the naphthalene sulfonate one or more; In disintegrant such as ammonium sulfate, urea, sucrose, the glucose one or more; In binding agent such as diatomite, corn starch, PVA, carboxymethyl (ethyl) cellulose one or more; In filler such as diatomite, calcium bicarbonate, kaolin, white carbon, talcum powder, the potter's clay one or more.
For wetting powder, in spendable dispersant such as polycarboxylate, lignosulfonates, the alkylnaphthalene sulfonate one or more; In wetting agent such as alkyl sulfate, alkylsulfonate, the naphthalene sulfonate one or more; In filler such as ammonium sulfate, urea, sucrose, glucose, diatomite, kaolin, white carbon, fine particle calcium carbonate, talcum powder, attapulgite, the potter's clay one or more.
The present composition can be the finished product preparation form to be provided, and promptly each material mixes in the composition; The composition of composition also can provide with single agent formulation, directly mixes in bucket (jar) before using.Concentrate of the present invention mixes the concentration that obtains required active substance usually with water.
Composition of the present invention can be used for preventing and treating the important disease that is caused by sac fungi, basidiomycetes, oomycetes etc., is particularly suitable for preventing and treating powdery mildew and downy mildew.It is farmland, orchard etc. that composition of the present invention is used the place.
Composition of the present invention also can with other compound with weeding, desinsection or bactericidal property particularly protective fungicide mix use, also can mix use with nematocide, protective agent, growth regulator, nutrient for plants or soil conditioner.
The present invention comprises that also a kind of scene kills the method for fungi, before or after crop and/or fruit are susceptible, uses composition of the present invention to the place of crop and/or fruit and growth or storage.Can use by common method, as cast, injection, spraying, dusting, distribution.Amount of application of the present invention is with weather condition or crop state variation.The duration of protective effect is usually relevant with the content of individualized compound in the composition, and is relevant with extraneous factor, weather for example, but by using suitable formulation can slow down climatic influences.
Composition of the present invention possesses following advantage: the one, and the composition synergistic effect is obvious, and drug effect significantly improves; The 2nd, the composition drug effect improves, and the field consumption descends, and has reduced production and use cost, reduces residue of pesticide and environmental pollution; The 3rd, composition is made up of the active ingredient of different mechanism of action, and action site increases, and helps overcoming and delays the drug-fast generation of germ.The 4th, enlarged fungicidal spectrum, can prevent and treat powdery mildew disease such as downy mildew in addition.
Embodiment
Different pesticide active ingredients shows three kinds of type of action: summation action, synergistic effect and antagonism after mixing usually.But be specially which kind of effect, unpredictable, have only by a large amount of tests and just can know.Compound synergic is well filled a prescription, owing to obviously improved actual control efficiency, reduced the usage amount of agricultural chemicals, thereby delayed the drug-fast generation speed of germ widely, and be the important means of scientific prevention and cure disease.
The inventor has carried out a large amount of indoor bioassay test and field control effectiveness test, find that Acibenzolar and above-mentioned any one methoxy acrylic ester compounds combination have remarkable role in synergy to white powder germ, Pseudoperonospora cubensis etc., and be not only the simple addition (seeing biologicall test example 1,2 for details) of two kinds of medicaments.Biologicall test embodiment 1: the composite Toxicity Determination of Acibenzolar and methoxy acrylic bactericide to the powdery mildew of cucumber bacterium
Subjects: powdery mildew of cucumber bacterium (picking up from the field)
Test method: with reference to " the agricultural industry criteria NY/T1156.4-2006 of the People's Republic of China (PRC) ".Choose potted plant two leaf period cucumber seedlings of growth potential unanimity, 5 basins are selected in each processing for use, number standby.Under 50PSI pressure, spray every basin 5mL with the Potter spray tower.Test is handled referring to table 1, table 2, table 3, and each medicament is provided with 5 concentration gradients.Inoculum density is 3 * 10 behind the 24h
5The powdery mildew of cucumber bacterium conidial suspension of individual spore/mL.With the cucumber seedling that sprays the equivalent clear water is blank.After the inoculation cucumber seedling being put into the greenhouse cultivates.Behind the 10d,, and calculate control efficiency according to the morbidity grade scale complete stool investigation disease index of powdery mildew of cucumber.
Powdery mildew of cucumber state of an illness grade scale:
0 grade: blade does not have scab;
1 grade: lesion area accounts for the area of whole blade below 5%;
3 grades: lesion area account for whole blade area 6%～10%;
5 grades: lesion area accounts for 11%～25% of whole blade area;
7 grades: lesion area accounts for 25%～50% of whole blade area;
9 grades: lesion area accounts for more than 50% of whole blade area.
Calculate concentration EC in the inhibition with method of least squares
50, calculate co-toxicity coefficient (CTC) according to the abundant method of Sun Yun again.
Actual measurement toxicity index (ATI)=(standard medicament EC
50/ reagent agent EC
50) * 100
The percentage composition of B in percentage composition+B medicament toxicity index * mixture of A in theoretical toxicity index (TTI)=A medicament toxicity index * mixture
Co-toxicity coefficient (CTC)=[mixture actual measurement toxicity index (the ATI)/theoretical toxicity index (TTI) of mixture] * 100.
CTC≤80 are antagonism, and 80＜CTC＜120 are summation action, and CTC 〉=120 are synergistic effect.
As can be known from Table 1, the proportioning of Acibenzolar and Fluoxastrobin has synergistic effect to the powdery mildew of cucumber bacterium between 100: 1～1: 100 the time, and in the time of especially between 40: 1～1: 40, co-toxicity coefficient is more than 200.
Table 1 Acibenzolar and azoxystrobin compound are to the results from pot experiment test of powdery mildew of cucumber bacterium
| Handle | ??EC 50??(μg/ml) | ??ATI | ??TTI | Co-toxicity coefficient (CTC) |
| Acibenzolar (A) | ??5.71 | ??100 | ??/ | ??/ |
| Fluoxastrobin (B) | ??7.23 | ??78.97 | ??/ | ??/ |
| ??A∶B(100∶1) | ??4.18 | ??136.60 | ??99.79 | ??136.88 |
| ??A∶B(70∶1) | ??4.39 | ??130.07 | ??99.70 | ??130.45 |
| ??A∶B(40∶1) | ??2.81 | ??203.20 | ??99.49 | ??204.25 |
| ??A∶B(15∶1) | ??2.89 | ??197.58 | ??98.68 | ??200.21 |
| ??A∶B(1∶1) | ??3.17 | ??180.13 | ??89.49 | ??201.28 |
| ??A∶B(1∶15) | ??3.36 | ??169.94 | ??80.29 | ??211.66 |
| ??A∶B(1∶40) | ??3.57 | ??159.94 | ??79.49 | ??201.21 |
| ??A∶B(1∶70) | ??4.82 | ??118.46 | ??79.27 | ??149.44 |
| ??A∶B(1∶100) | ??5.28 | ??108.14 | ??79.18 | ??136.57 |
As can be known from Table 2, Acibenzolar and kresoxim-methyl are composite, are between 100: 1～1: 100 the time in proportioning, and co-toxicity coefficient has synergistic effect all more than 120 to the powdery mildew of cucumber bacterium, and in the time of especially between 40: 1～1: 40, co-toxicity coefficient is more than 200.
The composite results from pot experiment test of table 2 Acibenzolar and kresoxim-methyl to the powdery mildew of cucumber bacterium
| Handle | ??EC 50??(μg/ml) | ??ATI | ??TTI | Co-toxicity coefficient (CTC) |
| Acibenzolar (A) | ??5.43 | ??100 | ??/ | ??/ |
| Kresoxim-methyl (B) | ??6.15 | ??88.29 | ??/ | ??/ |
| ??A∶B(100∶1) | ??4.02 | ??135.07 | ??99.88 | ??135.23 |
| ??A∶B(70∶1) | ??4.17 | ??130.22 | ??99.84 | ??130.43 |
| ??A∶B(40∶1) | ??2.53 | ??214.62 | ??99.71 | ??215.24 |
| ??A∶B(15∶1) | ??2.62 | ??207.25 | ??99.27 | ??208.78 |
| ??A∶B(1∶1) | ??2.79 | ??194.62 | ??94.15 | ??206.72 |
| ??A∶B(1∶15) | ??2.86 | ??189.86 | ??89.02 | ??213.27 |
| ??A∶B(1∶40) | ??3.01 | ??180.40 | ??88.58 | ??203.66 |
| ??A∶B(1∶70) | ??4.16 | ??130.53 | ??88.46 | ??147.56 |
| ??A∶B(1∶100) | ??4.65 | ??116.77 | ??88.41 | ??132.08 |
Biologicall test example 2: Acibenzolar and methoxy acrylic bactericide are composite to the cucumber downy mildew Toxicity Determination
Subjects: bacterium of downy mildew of cucumber (Pseudoperonospora cubensis)
Pot-culture method is adopted in this test.Choose two leaf period cucumber seedlings of growing way unanimity, each processing selects for use 5 basins for examination melon seedling, numbers standby.Under 50PSI pressure, spray every basin 5mL with the Potter spray tower.Each medicament is provided with 5 concentration gradients, is blank with what spray the equivalent clear water.Spray inoculation bacterium of downy mildew of cucumber sporangia suspension behind the chemicals treatment 24h, the layoutprocedure of sporangia suspension is as follows: get the cucumber leaves that has Pseudoperonospora cubensis that picks up from the field, dip in the sporangium that the distilled water of getting about 10 ℃ washes the back side with writing brush, being made into concentration is 3 * 10
5The sporangia suspension of individual/mL.Place climatic cabinate (relative moisture 100%, temperature 15-20 ℃) to cultivate cucumber seedling after the inoculation, keep 15-24 ℃ of temperature, relative moisture about 90% to preserve moisture and bring out behind the 24h, 10d " Invest, Then Investigate " record incidence calculates disease index and control efficiency.
The cucumber downy mildew grade scale:
0 grade: blade does not have scab;
1 grade: lesion area accounts for below 5% of whole blade area;
3 grades: lesion area accounts for the 6-10% of whole blade area;
5 grades: lesion area accounts for the 11-25% of whole blade area;
7 grades: lesion area accounts for the 26-50% of whole blade area;
9 grades: lesion area accounts for more than 50% of whole blade area.
Concentration EC in disease index, control efficiency, the inhibition
50, co-toxicity coefficient computational methods with biologicall test example 1.
As can be known from Table 3, Acibenzolar and pyraclostrobin are composite, are between 100: 1～1: 100 the time in proportioning, and co-toxicity coefficient all more than 120, has synergistic effect to bacterium of downy mildew of cucumber, and in the time of especially between 40: 1～1: 40, co-toxicity coefficient is more than 200.
The composite results from pot experiment test of table 3 Acibenzolar and pyraclostrobin to bacterium of downy mildew of cucumber
| Handle | ??EC 50??(μg/ml) | ??ATI | ??TTI | Co-toxicity coefficient (CTC) |
| Acibenzolar (A) | ??6.27 | ??100 | ??/ | ??/ |
| Pyraclostrobin (B) | ??9.45 | ??66.35 | ??/ | ??/ |
| ??A∶B(100∶1) | ??4.62 | ??135.71 | ??99.67 | ??136.17 |
| ??A∶B(70∶1) | ??4.75 | ??132.00 | ??99.53 | ??132.63 |
| ??A∶B(40∶1) | ??3.09 | ??202.91 | ??99.18 | ??204.59 |
| ??A∶B(15∶1) | ??3.15 | ??199.05 | ??97.89 | ??203.32 |
| ??A∶B(1∶1) | ??3.47 | ??180.69 | ??83.17 | ??217.24 |
| ??A∶B(1∶15) | ??4.18 | ??150.00 | ??68.45 | ??219.13 |
| ??A∶B(1∶40) | ??4.39 | ??142.82 | ??67.17 | ??212.63 |
| ??A∶B(1∶70) | ??6.38 | ??98.27 | ??66.82 | ??147.07 |
| ??A∶B(1∶100) | ??7.05 | ??88.94 | ??66.68 | ??133.37 |
As can be known from Table 4, Acibenzolar and oxime bacterium ester are composite, are between 100: 1～1: 100 the time in proportioning, and co-toxicity coefficient all more than 120, has synergistic effect to bacterium of downy mildew of cucumber, and in the time of especially between 40: 1～1: 40, co-toxicity coefficient is more than 190.
The composite results from pot experiment test of table 4 Acibenzolar and oxime bacterium ester to bacterium of downy mildew of cucumber
| Handle | ??EC 50??(μg/ml) | ??ATI | ??TTI | Co-toxicity coefficient (CTC) |
| Acibenzolar (A) | ??6.75 | ??100 | ??/ | ??/ |
| Handle | ??EC 50??(μg/ml) | ??ATI | ??TTI | Co-toxicity coefficient (CTC) |
| Oxime bacterium ester (B) | ??12.03 | ??56.11 | ??/ | ??/ |
| ??A∶B(100∶1) | ??4.85 | ??139.18 | ??99.56 | ??139.78 |
| ??A∶B(70∶1) | ??5.13 | ??131.58 | ??99.38 | ??132.39 |
| ??A∶B(40∶1) | ??3.45 | ??195.65 | ??98.93 | ??197.77 |
| ??A∶B(15∶1) | ??3.59 | ??188.02 | ??97.26 | ??193.33 |
| ??A∶B(1∶1) | ??4.28 | ??157.71 | ??78.05 | ??202.05 |
| ??A∶B(1∶15) | ??5.76 | ??117.19 | ??58.85 | ??199.12 |
| ??A∶B(1∶40) | ??6.15 | ??109.76 | ??57.18 | ??191.95 |
| ??A∶B(1∶70) | ??8.06 | ??83.75 | ??56.73 | ??147.63 |
| ??A∶B(1∶100) | ??9.25 | ??72.97 | ??56.54 | ??129.05 |
Below further specify the present invention with specific embodiment, but the present invention is limited to these examples absolutely not.The following stated only is the present invention embodiment preferably, only in order to explain the present invention, can not therefore be interpreted as the restriction to claim of the present invention.Should be pointed out that all any modifications of being made within the spirit and principles in the present invention, be equal to replacement and improvement etc., all should be included within protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Percentage composition is mass percent in all preparation proportionings.
The suspending agent example
Press formula rate, the ratio of each component such as active component, dispersant, wetting agent, thickener, antifreeze and water in prescription mixed, after grinding or high speed shear, make suspending agent.
Embodiment 1:30.3% Acibenzolar Fluoxastrobin suspending agent
Acibenzolar 30%, Fluoxastrobin 0.3%, methyl naphthalene sulfonate formaldehyde condensate (dispersant) 10%, lauryl sodium sulfate (wetting agent) 3%, xanthans (thickener) 2%, bentonite (thickener) 1%, glycerine (antifreeze) 5%, water complements to 100%.
Embodiment 2:20.2% Acibenzolar Enestroburin suspending agent
Acibenzolar 0.2%, Enestroburin 20%, polycarboxylate (dispersant) 10%, the withered powder of tea (wetting agent) 3%, polyvinyl alcohol (thickener) 2%, bentonite (thickener) 1%, ethylene glycol (antifreeze) 5%, water complements to 100%.
Embodiment 3:5% Acibenzolar pyraclostrobin suspending agent
Acibenzolar 4%, pyraclostrobin 1%, methyl naphthalene sulfonate formaldehyde condensate (dispersant) 10%, lauryl sodium sulfate (wetting agent) 3%, xanthans (thickener) 2%, bentonite (thickener) 1%, urea (antifreeze) 5%, water complements to 100%.
Embodiment 4:41% activation lactazone bacterium ester suspending agent
Acibenzolar 40%, oxime bacterium ester 1%, polycarboxylate (dispersant) 10%, the withered powder of tea (wetting agent) 3%, polyvinyl alcohol (thickener) 2%, bentonite (thickener) 1%, propane diols (antifreeze) 5%, water complements to 100%.
The wetting powder example
Pesticide activity component, auxiliary agent, filler are mixed the mixed again wetting powder that gets behind comminution by gas stream in proportion.Capital equipment: mixer, airslide disintegrating mill.
Embodiment 5:80% Acibenzolar alkene oxime amine wetting powder
Acibenzolar 50%, alkene oxime amine 30%, lauryl sodium sulfate (wetting agent) 2%, sodium lignin sulfonate (dispersant) 3%, white carbon black 10% (filler), kaolin complements to 100%.
Embodiment 6:41% Acibenzolar ZJ0712 wetting powder
Acibenzolar 1%, ZJ0712 40%, alkyl sulfate (wetting agent) 3%, polycarboxylate (dispersant) 3%, white carbon black (filler) 11%, bentonite complements to 100%.
Embodiment 7:62% Acibenzolar ZEN 90160 wetting powder
Acibenzolar 60%, ZEN 90160 2%, alkylsulfonate (wetting agent) 3%, sodium lignin sulfonate (dispersant) 3%, white carbon black (filler) 11%, potter's clay complements to 100%.
The water dispersible granules example
Press formula rate, former medicine and powder carrier, moistening spreader-sticker and binding agent etc. are mixed pulverizing, after adding water again and mediating, add in the comminutor that the certain specification screen cloth is housed and carry out granulation.And then drying, screening (pressing the screen cloth scope) promptly get granular product.
Embodiment 8:20.5% Acibenzolar SSF 126 water dispersible granules
Acibenzolar 0.5%, SSF 126 20%, polycarboxylate (dispersant) 5%, sodium lignin sulfonate (dispersant) 7%, lauryl sodium sulfate (wetting agent) 2%, ammonium sulfate (disintegrant) 5%, precipitated calcium carbonate complements to 100%.
Embodiment 9:41% Acibenzolar fluoxastrobin water dispersible granules
Acibenzolar 40%, fluoxastrobin 1%, Negel (dispersant) 5%, sodium lignin sulfonate (dispersant) 7%, lauryl sodium sulfate (wetting agent) 2%, urea (disintegrant) 5%, precipitated calcium carbonate complements to 100%.
Embodiment 10:50.5% Acibenzolar water dispersion granules agent of Kresoxim
Acibenzolar 50%, kresoxim-methyl 0.5%, Negel (dispersant) 5%, sodium lignin sulfonate (dispersant) 7%, lauryl sodium sulfate (wetting agent) 2%, glucose (disintegrant) 5%, precipitated calcium carbonate complements to 100%.
Embodiment 11:50% Acibenzolar ether bacterium amine water dispersible granules
Acibenzolar 25%, ether bacterium amine 25%, polycarboxylate (dispersant) 5%, sodium lignin sulfonate (dispersant) 7%, lauryl sodium sulfate (wetting agent) 2%, ammonium sulfate (disintegrant) 5%, precipitated calcium carbonate complements to 100%.
Field application examples 1: the composite field control effectiveness test of Acibenzolar and methoxy acrylate series bactericidal agent to powdery mildew of cucumber
Choose the powdery mildew of cucumber heavier plot of morbidity throughout the year.The control efficiency of general bactericide list agent is undesirable.Test medicine and consumption see Table 4, and 20 square metres of each sub-district areas are repeated in 4 sub-districts of every processing.Carry out the dispenser first time at the disease initial stage of origination, the complete stool even spraying till being sprayed onto blade and dripping, is treated to blank with clear water.Execute medicine for the second time after 7 days.The incidence of 7 days investigation powderys mildew of cucumber behind the medicine before first time medicine and for the second time.5 samplings are adopted in every sub-district, every some investigation two strains, and all blades are investigated in every strain, and the percentage that accounts for whole leaf area with lesion area comes the classification record.Calculate and respectively handle disease index and control efficiency.
Grade scale:
0 grade: no scab;
1 grade: lesion area accounts for below 5% of whole leaf area;
3 grades: lesion area accounts for the 6%-15% of whole leaf area;
5 grades: lesion area accounts for the 16%-25% of whole leaf area;
7 grades: lesion area accounts for the 26%-50% of whole leaf area;
9 grades: lesion area accounts for more than 50% of whole leaf area.
The drug effect computational methods:
As can be seen from Table 5: Acibenzolar, Fluoxastrobin, Enestroburin, kresoxim-methyl, alkene oxime amine, fluoxastrobin, each single agent of ZJ0712 are respectively 75.94%, 79.45%, 76.08%, 78.47%, 78.08%, 79.07% and 76.74% to the preventive effect of powdery mildew of cucumber, and embodiment of the invention bactericidal composition all is significantly increased on preventive effect, minimum preventive effect is 86.49%, has been up to 89.07%.The result of field trial shows that fully the composite back of Acibenzolar and methoxy acrylate series bactericidal agent has remarkable role in synergy to powdery mildew of cucumber, and under the situation that the mu effective ingredient consumption reduces, control efficiency significantly improves.Field investigation finds, the composition melon downy mildew of can also doublely harnessing the Yellow River.Therefore, the present composition have reducing cost, reduce spraying times and residue of pesticide, the beneficial effect of delaying drug resistance, expanding prevention spectrum.
The composite field test results of table 5 Acibenzolar and methoxy acrylate series bactericidal agent to powdery mildew of cucumber
| Reagent agent | Dosage (ga.i./ha) | Disease index before the medicine | 7 days disease indexs behind the 2nd medicine | Preventive effect (%) |
| 50% Acibenzolar wetting powder | ??45 | ??5.1 | ??8.9 | ??75.94 |
| 25% Fluoxastrobin suspending agent | ??150 | ??5.5 | ??8.2 | ??79.45 |
| 25% Enestroburin suspending agent | ??200 | ??4.9 | ??8.5 | ??76.08 |
| 30% kresoxim-methyl wetting powder | ??150 | ??5.7 | ??8.9 | ??78.47 |
| 20% alkene oxime amine missible oil | ??200 | ??6.1 | ??9.7 | ??78.08 |
| 10% fluoxastrobin missible oil | ??200 | ??5.4 | ??8.2 | ??79.07 |
| Reagent agent | Dosage (ga.i./ha) | Disease index before the medicine | 7 days disease indexs behind the 2nd medicine | Preventive effect (%) |
| 10% ZJ0712 suspending agent | ??150 | ??4.8 | ??8.1 | ??76.74 |
| Example of formulations 1 (30.3% Acibenzolar Fluoxastrobin suspending agent) | ??35 | ??5.3 | ??4.2 | ??89.07 |
| Example of formulations 2 (20.2% Acibenzolar Enestroburin suspending agent) | ??40 | ??4.7 | ??4.3 | ??87.39 |
| Example of formulations 5 (80% Acibenzolar alkene oxime amine wetting powder) | ??30 | ??5.5 | ??4.7 | ??88.22 |
| Example of formulations 6 (41% Acibenzolar ZJ0712 wetting powder) | ??40 | ??4.9 | ??4.8 | ??86.49 |
| Example of formulations 9 (41% Acibenzolar fluoxastrobin water dispersible granules) | ??40 | ??5.2 | ??4.6 | ??87.81 |
| Example of formulations 10 (50.5% Acibenzolar water dispersion granules agent of Kresoxim) | ??40 | ??6.1 | ??5.3 | ??88.02 |
| ??CK | ??- | ??5.9 | ??42.8 | ??- |
Field application examples 2: the composite field control effectiveness test of Acibenzolar and methoxy acrylate series bactericidal agent to cucumber downy mildew
Choose the cucumber downy mildew heavier plot of morbidity throughout the year.Test medicine and consumption see Table 6, and 20 square metres of each sub-district areas are repeated in 4 sub-districts of every processing.Carry out the dispenser first time at the disease initial stage of origination, the complete stool even spraying till being sprayed onto blade and dripping, is treated to blank with clear water.Execute medicine for the second time after 7 days.The incidence of 7 days investigation cucumber downy mildews behind the medicine before first time medicine and for the second time.5 samplings are adopted in every sub-district, every some investigation 5 strains, and all blades are investigated in every strain, and the percentage that accounts for whole leaf area with lesion area comes the classification record.Calculate and respectively handle disease index and control efficiency.
Grade scale:
0 grade: no scab;
1 grade: lesion area accounts for below 5% of whole leaf area;
3 grades: lesion area accounts for the 6%-15% of whole leaf area;
5 grades: lesion area accounts for the 16%-25% of whole leaf area;
7 grades: lesion area accounts for the 26%-50% of whole leaf area;
9 grades: lesion area accounts for more than 50% of whole leaf area.
The drug effect computational methods:
As can be seen from Table 6: Acibenzolar, Fluoxastrobin, Enestroburin, kresoxim-methyl, alkene oxime amine, fluoxastrobin, ZJ0712, pyraclostrobin, each single agent of ZEN 90160 are respectively 75.06%, 78.69%, 76.04%, 78.35%, 78.09%, 79.45%, 77.75%, 79.57% and 79.34% to the preventive effect of powdery mildew of cucumber, and embodiment of the invention bactericidal composition all is significantly increased on preventive effect, minimum preventive effect is 86.27%, has been up to 88.40%.The result of field trial shows that fully the composite back of Acibenzolar and methoxy acrylate series bactericidal agent has remarkable role in synergy to cucumber downy mildew, and under the situation that the mu effective ingredient consumption reduces, control efficiency significantly improves.Therefore, the present composition have reduce cost, the beneficial effect of delaying drug resistance, minimizing spraying times and residue of pesticide.
The composite field test results of table 6 Acibenzolar and methoxy acrylate series bactericidal agent to cucumber downy mildew
| Reagent agent | Dosage (ga.i./ha) | Disease index before the medicine | 7 days disease indexs behind the 2nd medicine | Preventive effect (%) |
| 50% Acibenzolar wetting powder | ??45 | ??3.9 | ??10.2 | ??75.06 |
| 25% Fluoxastrobin suspending agent | ??150 | ??4.7 | ??10.5 | ??78.69 |
| 25% Enestroburin suspending agent | ??200 | ??3.9 | ??9.8 | ??76.04 |
| 30% kresoxim-methyl wetting powder | ??150 | ??4.8 | ??10.9 | ??78.35 |
| 20% alkene oxime amine missible oil | ??200 | ??3.7 | ??8.5 | ??78.09 |
| Reagent agent | Dosage (ga.i./ha) | Disease index before the medicine | 7 days disease indexs behind the 2nd medicine | Preventive effect (%) |
| 10% fluoxastrobin missible oil | ??200 | ??4.5 | ??9.7 | ??79.45 |
| 10% ZJ0712 suspending agent | ??150 | ??5.1 | ??11.9 | ??77.75 |
| 200 grams per liter pyraclostrobin emulsifiable concentrates | ??200 | ??4.9 | ??10.5 | ??79.57 |
| 25% ZEN 90160 suspending agent | ??200 | ??4.2 | ??9.1 | ??79.34 |
| Example of formulations 1 (30.3% Acibenzolar Fluoxastrobin suspending agent) | ??35 | ??3.7 | ??4.5 | ??88.40 |
| Example of formulations 2 (20.2% Acibenzolar alkene | ??40 | ??3.9 | ??5.1 | ??87.53 |
| Oxime bacterium ester suspending agent) | ||||
| Example of formulations 3 (5% Acibenzolar pyraclostrobin suspending agent) | ??40 | ??4.4 | ??5.9 | ??87.21 |
| Example of formulations 5 (80% Acibenzolar alkene oxime amine wetting powder) | ??30 | ??5.3 | ??6.9 | ??87.58 |
| Example of formulations 6 (41% Acibenzolar ZJ0712 wetting powder) | ??40 | ??4.1 | ??5.9 | ??86.27 |
| Example of formulations 7 (62% Acibenzolar ZEN 90160 wetting powder) | ??35 | ??3.8 | ??5.1 | ??87.20 |
| Example of formulations 9 (41% Acibenzolar fluoxastrobin water dispersible granules) | ??40 | ??3.5 | ??4.9 | ??86.65 |
| Reagent agent | Dosage (ga.i./ha) | Disease index before the medicine | 7 days disease indexs behind the 2nd medicine | Preventive effect (%) |
| Example of formulations 10 (50.5% Acibenzolar water dispersion granules agent of Kresoxim) | ??40 | ??4.2 | ??5.5 | ??87.51 |
| ??CK | ??- | ??4.3 | ??45.1 | ??- |
Claims (7)
1. bactericidal composition, it is characterized in that: active ingredient is Acibenzolar (A) and a kind of methoxy acrylate series bactericidal agent (B).
2. bactericidal composition according to claim 1 is characterized in that: preferred 100: 1～1: 100 of the mass ratio of effective constituents A and B.
3. bactericidal composition according to claim 2 is characterized in that: preferred 40: 1～1: 40 of the mass ratio of effective constituents A and B.
4. according to each described bactericidal composition of claim 1-3, it is characterized in that: described methoxy acrylate series bactericidal agent is selected from Fluoxastrobin, kresoxim-methyl, pyraclostrobin, SSF 126, ether bacterium amine, oxime bacterium ester, ZEN 90160, fluoxastrobin, Enestroburin, ZJ0712 or alkene oxime amine.
5. according to each described bactericidal composition of claim 1-3, it is characterized in that: active component quality percentage composition is 5～80% in the composition.
6. bactericidal composition according to claim 1 is characterized in that: said composition can be mixed with suspending agent, wetting powder, water dispersible granules.
7. the described bactericidal composition of claim 1 is used to prevent and treat the disease on cereal, vegetables, fruit tree, the flowers.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102047875A (en) * | 2010-12-21 | 2011-05-11 | 威海韩孚生化药业有限公司 | Trifloxystrobin suspending agent and preparation method thereof |
| CN102246772A (en) * | 2011-05-20 | 2011-11-23 | 海利尔药业集团股份有限公司 | Pesticide composition containing sufluoxime and active ester |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102047875A (en) * | 2010-12-21 | 2011-05-11 | 威海韩孚生化药业有限公司 | Trifloxystrobin suspending agent and preparation method thereof |
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| CN102246772B (en) * | 2011-05-20 | 2013-03-13 | 海利尔药业集团股份有限公司 | Pesticide composition containing sufluoxime and active ester |
| CN103518741A (en) * | 2012-07-06 | 2014-01-22 | 陕西美邦农药有限公司 | Fluopyram-containing high-efficiency bactericidal composition |
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| CN103651460B (en) * | 2012-09-25 | 2015-07-08 | 陕西美邦农药有限公司 | Pesticide composition containing fluorine azole activated ester and methoxy acrylic esters |
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