CN101632459B - Application of pectic acid oligosaccharide in preparing health-care product treating gastric ulcer - Google Patents
Application of pectic acid oligosaccharide in preparing health-care product treating gastric ulcer Download PDFInfo
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Abstract
The invention relates to an application of pectic acid oligosaccharide in preparing a health-care product treating gastric ulcer. The invention adopts the technical scheme that firstly, pectin is dissolved in water, and a pectin decomposer is prepared by a decomposition reaction; the pectin decomposer is processed by using a hollow fibre film or a ceramic filtration film, an oligosaccharide mixture with the molecular weight of 200-6000 daltons is processed and recovered by using a nano filtration film after an oligosaccharide mixture with the molecular weight being below 6000 daltons is recovered, and the pectic acid oligosaccharide with the superposition degree of 2-20 is obtained by the chromatographic separation of a Bio-gel P-2 gel column and/or a Sephadex G-25 gel column or the filtration of DEAE-Sephadex A-25 anion exchange resin. The prepared pectic acid oligosaccharide and auxiliary materials are matched to prepare health-care products with various forms and components for treating the gastric ulcer. The invention adopts a congeneric theory of medicines and foods, has no toxic or side effect and can be taken for a long time. By verification, the invention has obvious curative effect to sour burning type gastric ulcer.
Description
Technical field
The invention belongs to the functional food field, relate to the application of acidity oligosaccharide of pectin on the health product of preparation treatment gastric ulcer particularly.
Background technology
Modern society because people's partial eclipse, eating and drinking too much at one meal, be satiated with food, life and living habit such as dietary is unbalance, hypomotility, operating pressure; And the variation of dietary structure; Make gastric ulcer become the able-bodied important diseases due to habit disturbance of harm humans, all brought huge burden for people's aspects such as health, spirit, economic life and social medical treatment.The genesis mechanism more complicated of ulcer it is generally acknowledged that gastric ulcer is a kind of chronic disease of multi-pathogenesis, and wherein the too much secretion of the hyperfunction property of gastric acid is to bring out one of major reason of ulcer generation.Treatment digestive tract ulcer medicine roughly is divided into two big types at present: one type is mucosa protective agent, and another kind of is H
2The inhibition medicine of receptor blocking agent or gastric acid, proton pump.These medicines have all been received better therapeutic effect, but after the drug withdrawal, the relapse rate of the state of an illness is very high.Simultaneously, secular maintenance drug therapy can bring other bad toxic and side effects again, and therefore, various countries are still striving to find good effect, novel anti medicine for ulcer that toxic and side effects is little.
Summary of the invention
In order to address the above problem, the objective of the invention is to overcome deficiency of the prior art, the application of a kind of acidity oligosaccharide of pectin on the health product of preparation treatment gastric ulcer is provided.
To achieve these goals, the technical scheme of the present invention's employing is: the application of acidity oligosaccharide of pectin on the health product of preparation treatment gastric ulcer.
Wherein, acidity oligosaccharide of pectin, process as follows:
(1) getting mass percentage concentration is 1%～2% pectin aqueous solution, and regulating pH is 2～4, at 95～120 ℃; Decomposition reaction 15min～24h, or to get mass percentage concentration be 1%～2% pectin solution adds pectin hydrolase or pectin lyase in the live ratio of unit of the enzyme of every gram pectin: 0.01～1.0Unit; At 30～50 ℃; PH is 2.5～4.5, and decomposition reaction 30min～24h obtains pectin decomposer;
Said pectin can be from plant tissue or its are squeezed the juice residue after the processing, the pectin that makes by common process.The common process of preparation pectin belongs to prior art.As: can be from plant (Fructus Mali pumilae, Citrus, Fructus Crataegi; Fructus Lycopersici esculenti, Fructus Solani melongenae etc.) in the residue after tissue or its processing of squeezing the juice through water (4～100 ℃), or acid (pH 2～6; 4～90 ℃), or saline solution (NaCl, EDTA; Oxalates, citrate etc.) extraction such as also can be adopted various commercially available commercial pectin.
Preferably, pectin is pectin or the commercially available extensive stock pectin that fruit extracts in hawthorn pectin, apple pectin, the Citrus plant.
(2) pectin decomposer is handled with hollow-fibre membrane or ceramic filter membrane; After reclaiming the oligosaccharide mixture below molecular weight 6000 dalton; Reclaim the oligosaccharide mixture of molecular weight 200～6000 with nanofiltration membrane treatment, using Bio-gel P-2 gel column and/or Sephadex G-25 gel filtration chromatography to separate to obtain registration is 2～20 acidity oligosaccharide of pectin; Or pectin decomposer handled with hollow-fibre membrane or ceramic filter membrane; After reclaiming the oligosaccharide mixture below molecular weight 6000 dalton; Reclaim the oligosaccharide mixture of molecular weight 200～6000 with NF membrane; Cross DEAE-Sephadex A-25 anion exchange resin,, obtain registration and be 2～20 acidity oligosaccharide of pectin with the inorganic salt solution gradient elution of suitable bed volume 5-10 0.05～1M doubly.
Said inorganic salt is sodium chloride, sodium phosphate, ammonium bicarbonate or sodium citrate.
The acidity oligosaccharide of pectin that said method makes cooperates the health product of the treatment gastric ulcer that can process various forms and composition with other adjuvants, like electuary, and capsule, tablet, oral liquid etc.Wherein operable adjuvant has starch, cellulose, dextrin, lactose, lecithin, agar, sodium alginate, plant flavone, agar oligosaccharide, Fructus Lycii, Fructus Jujubae, Fructus Cucurbitae moschatae powder, Radix Glycyrrhizae, the Rhizoma Atractylodis Macrocephalae, Semen Coicis, Semen Nelumbinis, Rhizoma Dioscoreae, arabic gum or Konjac glucomannan etc.Adjuvant can adopt one or more combination.
The invention has the beneficial effects as follows: the present invention adopts the theory of integration of edible and medicinal herbs, and all the components is COF, and the non-poisonous material side effect can be taken for a long time.Empirical tests has significant curative effect to acid burning type gastric ulcer.Adopt the method for preparing of acidity oligosaccharide of pectin of the present invention, the acidity oligosaccharide of pectin of preparation has good dissolubility, is easy to absorption of human body.Development field at health functional food has great application prospect.
Description of drawings
Fig. 1 is rat ulcer healing figure fully.
Fig. 2 is the ulcer area graph of the rat ulcer of matched group.
The specific embodiment
Embodiment 1
(1) preparation of acidity oligosaccharide of pectin:
(1) acquisition of pectin: with Fructus Crataegi or the residue after squeezing the juice through oxalic acid solution (pH2～6,50～90 ℃), extracted 3 hours, by the pectin recovery method of routine, use ethanol precipitation, reclaim hawthorn pectin.
(2) getting mass percentage concentration is 1% hawthorn pectin aqueous solution, and regulating pH is 3, and at 110 ℃, decomposition reaction 3h obtains the hawthorn pectin analyte;
(3) the hawthorn pectin analyte is carried out ultrafiltration and nanofiltration processing with hollow-fibre membrane; After reclaiming the oligosaccharide mixture below molecular weight 6000 dalton; Reclaim the oligosaccharide mixture of molecular weight 200～6000 with NF membrane, using Bio-gel P-2 to separate with Sephadex G-25 gel filtration chromatography to obtain registration is 2～20 hawthorn pectin acidic oligosaccharide.
(2) preparation of treatment gastric ulcer health product
The health product of treating gastric ulcer with the hawthorn pectin acidic oligosaccharide preparation of above-mentioned preparation are following.
Acidity oligosaccharide of pectin 40%, agar oligosaccharide 5%,
Fructus Lycii 5%, Fructus Jujubae 20%,
Fructus Cucurbitae moschatae powder 20%, Radix Glycyrrhizae 2%,
The Rhizoma Atractylodis Macrocephalae 2%, Semen Coicis 2%,
Semen Nelumbinis 2%, Rhizoma Dioscoreae 2%.
After above composition is composite, process instant through conventional method.
The result that this electuary is investigated the healing effect of ulcer model Wistar rat, the effect that has shown tangible repairing ulcer property gastric mucosa.
Embodiment 2
(1) preparation of acidity oligosaccharide of pectin:
(1) acquisition of pectin: after Fructus Mali pumilae was squeezed the juice and processed, the residue of squeezing the juice extracted after 3 hours through water (50～100 ℃), filtered, and filtrating is used ethanol precipitation by the pectin recovery method of routine, reclaimed and obtained apple pectin.
(2) getting mass percentage concentration is 2% apple pectin aqueous solution, and regulating pH is 2, and at 95 ℃, decomposition reaction 24h obtains the apple pectin analyte;
(3) the apple pectin analyte is handled with ceramic membrane; After reclaiming the oligosaccharide mixture below molecular weight 6000 dalton; Reclaim the oligosaccharide mixture of molecular weight 200～6000 with NF membrane, using Sephadex G-25 gel filtration chromatography to separate to obtain registration is 2～20 apple pectin acidic oligosaccharide.
(2) preparation of treatment gastric ulcer health product
The health product of treating gastric ulcer with the apple pectin acidic oligosaccharide preparation of above-mentioned preparation are following.
Acidity oligosaccharide of pectin 60%, agar oligosaccharide 1%,
Fructus Lycii 1%, Fructus Jujubae 7%,
Fructus Cucurbitae moschatae powder 6%, Radix Glycyrrhizae 5%,
The Rhizoma Atractylodis Macrocephalae 5%, Semen Coicis 5%,
Semen Nelumbinis 5%, Rhizoma Dioscoreae 5%.
Above composition is composite after the general food processing method is processed tablet.
The result that this tablet is investigated the healing effect of ulcer model Wistar rat with above-mentioned same method, the effect that has shown tangible repairing ulcer property gastric mucosa.
Embodiment 3
(1) preparation of acidity oligosaccharide of pectin:
(1) acquisition of pectin: the Citrus leather bag through hydrochloric acid (pH 2～6,50～90 ℃), is extracted after 3 hours, filter, filtrating is used ethanol precipitation by the pectin recovery method of routine, reclaims and obtains citrus pectin.
(2) getting mass percentage concentration is 1% citrus pectin aqueous solution, and regulating pH is 4, and at 120 ℃, decomposition reaction 15min obtains the citrus pectin analyte;
(3) the citrus pectin analyte is carried out ultrafiltration and nanofiltration processing with hollow-fibre membrane; After reclaiming the oligosaccharide mixture below molecular weight 6000 dalton; Reclaim the oligosaccharide mixture of molecular weight 200～6000 with NF membrane, using Bio-gel P-2 to separate with Sephadex G-25 gel filtration chromatography to obtain registration is 2～20 citrus pectin acidic oligosaccharide.
(2) preparation of treatment gastric ulcer health product
The health product of treating gastric ulcer with the citrus pectin acidic oligosaccharide preparation of above-mentioned preparation are following.
Acidity oligosaccharide of pectin 80%, agar oligosaccharide 4%,
Fructus Lycii 5%, Fructus Jujubae 5%,
Fructus Cucurbitae moschatae powder 1%, Radix Glycyrrhizae 1%,
Art 1%, Semen Coicis 1%,
Semen Nelumbinis 1%, Rhizoma Dioscoreae 1%.
Above composition is composite after conventional processing method is processed hard capsule.
The result that this hard capsule is investigated the healing effect of ulcer model Wistar rat with above-mentioned same method, the effect that has shown tangible repairing ulcer property gastric mucosa.
Embodiment 4
(1) preparation of acidity oligosaccharide of pectin:
(1) getting mass percentage concentration is 1% apple pectin (commercially available) solution, adds pectin hydrolase in the live ratio of unit of the enzyme of every gram pectin: 0.1Unit, and at 40 ℃, pH is 3.5, and decomposition reaction 3h obtains the apple pectin analyte;
(2) the apple pectin analyte is handled with ceramic filter membrane; After reclaiming the oligosaccharide mixture below molecular weight 6000 dalton; Reclaim the oligosaccharide mixture of molecular weight 200～6000 with NF membrane; Cross DEAE-Sephadex A-25 anion exchange resin,, obtain registration and be 2～20 apple pectin acidic oligosaccharide with the sodium-chloride water solution gradient elution of the 0.08M of 8 times of suitable bed volumes.
(2) preparation of treatment gastric ulcer health product
The health product of treating gastric ulcer with the apple pectin acidic oligosaccharide preparation of above-mentioned preparation are following.
Acidity oligosaccharide of pectin 40%, Mel 20%,
Radix Ginseng 0.5%, sucrose 20%,
Poria 4.5%, the Radix Astragali 5%,
The Rhizoma Atractylodis Macrocephalae 5%, Semen Coicis 5%.
After above composition is composite, process soft capsule through conventional method.
The result that this soft capsule is investigated the healing effect of ulcer model Wistar rat, the effect that has shown tangible repairing ulcer property gastric mucosa.
Embodiment 5
(1) preparation of acidity oligosaccharide of pectin:
(1) getting mass percentage concentration is 2% hawthorn pectin (with embodiment 1) solution, adds pectin lyase in the live ratio of unit of the enzyme of every gram pectin: 0.01Unit, and at 50 ℃, pH is 2.5, and decomposition reaction 24h obtains the hawthorn pectin analyte;
(2) the hawthorn pectin analyte is carried out ultrafiltration and nanofiltration processing with hollow-fibre membrane; After reclaiming the oligosaccharide mixture below molecular weight 6000 dalton; Reclaim the oligosaccharide mixture of molecular weight 200～6000 with NF membrane; Cross DEAE-Sephadex A-25 anion exchange resin,, obtain registration and be 2～20 hawthorn pectin acidic oligosaccharide with the sodium phosphate aqueous solution gradient elution of the 0.05M of 10 times of suitable bed volumes.
(2) preparation of treatment gastric ulcer health product
The health product of treating gastric ulcer with the hawthorn pectin acidic oligosaccharide preparation of above-mentioned preparation are following.
Acidity oligosaccharide of pectin 60%, Mel 15%,
Radix Ginseng 1%, sucrose 12%,
Poria 3%, the Radix Astragali 3%,
The Rhizoma Atractylodis Macrocephalae 3%, Semen Coicis 3%.
After above composition is composite, process syrup type oral liquid through conventional method.
The result that this syrup type oral liquid is investigated the healing effect of ulcer model Wistar rat, the effect that has shown tangible repairing ulcer property gastric mucosa.
Embodiment 6
(1) preparation of acidity oligosaccharide of pectin:
(1) getting mass percentage concentration is 1% citrus pectin (commercially available) solution, adds pectin hydrolase in the live ratio of unit of the enzyme of every gram pectin: 1.0Unit, and at 30 ℃, pH is 4.5, and decomposition reaction 30min obtains the citrus pectin analyte;
(2) the citrus pectin analyte is carried out ultrafiltration and nanofiltration processing with hollow-fibre membrane; After reclaiming the oligosaccharide mixture below molecular weight 6000 dalton; Reclaim the oligosaccharide mixture of molecular weight 200～6000 with NF membrane; Cross DEAE-Sephadex A-25 anion exchange resin,, obtain registration and be 2～20 citrus pectin acidic oligosaccharide with the ammonium bicarbonate aqueous solution gradient elution of the 1M of 5 times of suitable bed volumes.
(2) preparation of treatment gastric ulcer health product
The health product of treating gastric ulcer with the citrus pectin acidic oligosaccharide preparation of above-mentioned preparation are following.
Acidity oligosaccharide of pectin 80%, Mel 10%,
Radix Ginseng 1%, sucrose 5%,
Poria 1%, the Radix Astragali 1%,
The Rhizoma Atractylodis Macrocephalae 1%, Semen Coicis 1%.
After above composition is composite, process soft capsule through conventional method.
The result that this soft capsule is investigated the healing effect of ulcer model Wistar rat, the effect that has shown tangible repairing ulcer property gastric mucosa.
Embodiment 7
(1) preparation of acidity oligosaccharide of pectin:
(1) getting mass percentage concentration is 1% citrus pectin (commercially available) aqueous solution, and regulating pH is 3, and at 110 ℃, decomposition reaction 3h obtains the citrus pectin analyte;
(2) the citrus pectin analyte is handled with ceramic filter membrane; After reclaiming the oligosaccharide mixture below molecular weight 6000 dalton; Reclaim the oligosaccharide mixture of molecular weight 200～6000 with NF membrane; Cross DEAE-Sephadex A-25 anion exchange resin,, obtain registration and be 2～20 citrus pectin acidic oligosaccharide with the 0.07M sodium citrate aqueous solution gradient elution of 8 times of suitable bed volumes.
(2) preparation of treatment gastric ulcer health product
The health product of treating gastric ulcer with the citrus pectin acidic oligosaccharide preparation of above-mentioned preparation are following.
Acidic oligosaccharide 70%, Oleum Hippophae 10%,
Poria 5%, the Radix Astragali 5%,
The Rhizoma Atractylodis Macrocephalae 5%, Semen Coicis 5%.
After above composition is composite, process soft capsule through conventional method.
The result that this soft capsule is investigated the healing effect of ulcer model Wistar rat, the effect that has shown tangible repairing ulcer property gastric mucosa.
Embodiment 8
(1) preparation of acidity oligosaccharide of pectin:
(1) getting mass percentage concentration is 1% hawthorn pectin (with embodiment 1) aqueous solution, and regulating pH is 3, and at 110 ℃, decomposition reaction 3h obtains the hawthorn pectin analyte;
(2) the hawthorn pectin analyte is handled with ceramic filter membrane; After reclaiming the oligosaccharide mixture below molecular weight 6000 dalton; Reclaim the oligosaccharide mixture of molecular weight 200～6000 with NF membrane; Cross DEAE-Sephadex A-25 anion exchange resin,, obtain registration and be 2～20 hawthorn pectin acidic oligosaccharide with the sodium citrate aqueous solution gradient elution of the 0.08M of 8 times of suitable bed volumes.
(2) preparation of treatment gastric ulcer health product
The health product of treating gastric ulcer with the hawthorn pectin acidic oligosaccharide preparation of above-mentioned preparation are following.
Acidic oligosaccharide 80%, Oleum Hippophae 8%,
Poria 3%, the Radix Astragali 3%,
The Rhizoma Atractylodis Macrocephalae 3%, Semen Coicis 3%.
After above composition is composite, process capsule through conventional food-processing method.
The result that this capsule is investigated the healing effect of ulcer model Wistar rat, the effect that has shown tangible repairing ulcer property gastric mucosa.
Embodiment 9
(1) preparation of acidity oligosaccharide of pectin:
(1) getting mass percentage concentration is 1% apple pectin (commercially available) aqueous solution, and regulating pH is 3, and at 110 ℃, decomposition reaction 3h obtains the apple pectin analyte;
(2) the apple pectin analyte is handled with ceramic filter membrane; After reclaiming the oligosaccharide mixture below molecular weight 6000 dalton; Reclaim the oligosaccharide mixture of molecular weight 200～6000 with NF membrane; Cross DEAE-Sephadex A-25 anion exchange resin,, obtain registration and be 2～20 apple pectin acidic oligosaccharide with the sodium citrate aqueous solution gradient elution of the 0.08M of 8 times of suitable bed volumes.
(2) treatment gastric ulcer health product preparation
The health product of treating gastric ulcer with the apple pectin acidic oligosaccharide preparation of above-mentioned preparation are following.
Acidic oligosaccharide 95%, Oleum Hippophae 1%,
Poria 1%, the Radix Astragali 1%,
The Rhizoma Atractylodis Macrocephalae 1%, Semen Coicis 1%.
Above composition is composite after the general food processing method is processed tablet.
The result that this tablet is investigated the healing effect of ulcer model Wistar rat, the effect that has shown tangible repairing ulcer property gastric mucosa.
Embodiment 10 acidity oligosaccharide of pectin are verified at the effect of treatment gastric ulcer:
Laboratory animal and processing method:
Cleaning level Wistar rat in 6 age in week is divided into matched group and 7 groups of sample sets (dividing into groups according to mouse filling hello sample and dosage), 9 every group at random by body weight.Sample sets, every rat is pressed the dosage filling stomach of 150mg/kg body weight every day, and matched group is irritated the distilled water of stomach and sample sets equal volume every day.Once a day, the continuous irrigation stomach utilizes the acetic acid calcination method of national regulation to set up gastric ulcer model two days later.Promptly under etherization rat abdominal cavity is cut, injection 40 μ L between the placenta percreta of rat stomach and sarolemma layer sew up stomach wall behind 20% the acetic acid, set up gastric ulcer model.Operation finishes continuation in back second day and irritates stomach one week of sample solution.
Wherein, sample sets is respectively the hawthorn pectin acidic oligosaccharide of embodiment 1 preparation, and the molecular weight that is trapped when hawthorn pectin and preparation acidity oligosaccharide of pectin is greater than 6000 macromolecule pectin polysaccharide.
Sample collecting and processing:
After ulcer modeling operation back is to one week of rat continuous irrigation stomach; Stop the filling stomach of oligosaccharide solution and put to death rat taking off cervical vertebra behind the rat fasting 24h; Cut the abdominal cavity open; Ligation pylorus and cardia, the formalin solution of in rat stomach, injecting 10～15mL10% is the shape of stomach fixedly, so that measure the size of ulcer surface.The stomach of rat is cut in the formalin solution of immersion 10%, made stomach outer fixing.
Cut off stomach along greater gastric curvature, wash gastric content gently with tap water.The coat of the stomach inner face is open and flat on glass plate, with the length and width footpath of miking ulcerate the stomach lining, calculate the ulcer area.
The result that experiment finishes the back each processing rat stomach to be separated the plane inspection shows; Still having large-area ulcer (as shown in Figure 2) with matched group compares; The ulcer of acidity oligosaccharide of pectin group rat is healing (as shown in Figure 1) fully nearly all; And average ulcer surface actively significant (p＜0.01) is lower than matched group level (table 1), explains that acidity oligosaccharide of pectin has significant repair to ulcer property gastric mucosa.Result by table 1 can know simultaneously; The average ulcer area of acidity oligosaccharide of pectin will be lower than molecular weight and be higher than 6000 the pectin polysaccharide or the ulcer area of Pectin, proto group; And its complete healing rate also shows very high level, that is to say, low molecule oligosaccharide has good curative effect to gastric ulcer.
Table 1 fruit acidic oligosaccharide is to rat ulcer area (cm
2) influence
* the complete healing rate of ulcer=(each group heal fully number of elements/respectively organize rat sum) * 100
The embodiment that provides above, they just realize reliable illustration of the present invention, the purpose of enumerating the foregoing description is to specify the present invention, and and unrestricted interest field of the present invention.The present invention can have various ways in the scope that does not exceed its technical thought.The health product that prepare in the foregoing description, employed pectin is not limited to given pectin, can use other pectin or commercially available pectin.
Claims (5)
1. the application of acidity oligosaccharide of pectin on the health product of preparation treatment gastric ulcer is characterized in that the method for preparing of described acidity oligosaccharide of pectin is following:
(1) getting mass percentage concentration is 1%～2% hawthorn pectin aqueous solution, and regulating pH is 2～4, at 95～120 ℃, and decomposition reaction 15min～24h; Or to get mass percentage concentration be 1%～2% hawthorn pectin aqueous solution; In every Keshan short, bristly hair or beard pectin: the live ratio of unit of 0.01～1.0Unit enzyme adds pectin hydrolase or pectin lyase, and at 30～50 ℃, pH is 2.5～4.5; Decomposition reaction 30min～24h obtains pectin decomposer;
(2) pectin decomposer is handled with hollow-fibre membrane or ceramic filter membrane; After reclaiming the oligosaccharide mixture below molecular weight 6000 dalton; Reclaim the oligosaccharide mixture of molecular weight 200～6000 with nanofiltration membrane treatment, using Bio-gel P-2 gel column and/or Sephadex G-25 gel filtration chromatography to separate to obtain registration is 2～20 acidity oligosaccharide of pectin; Or pectin decomposer handled with hollow-fibre membrane or ceramic filter membrane; After reclaiming the oligosaccharide mixture below molecular weight 6000 dalton; Reclaim the oligosaccharide mixture of molecular weight 200～6000 with NF membrane; Cross DEAE-Sephadex A-25 anion exchange resin,, obtain registration and be 2～20 acidity oligosaccharide of pectin with sodium chloride, sodium phosphate, ammonium bicarbonate or the sodium citrate aqueous solution gradient elution of 0.05～1M of 5～10 times of suitable bed volumes.
2. according to the application of the described acidity oligosaccharide of pectin of claim 1 on the health product of preparation treatment gastric ulcer; It is characterized in that described health product are made up of acidity oligosaccharide of pectin and adjuvant that the method for preparing by the described acidity oligosaccharide of pectin of claim 1 makes, described adjuvant is the one or more combination of starch, cellulose, dextrin, lactose, lecithin, agar, sodium alginate, plant flavone, agar oligosaccharide, Fructus Lycii, Fructus Jujubae, Fructus Cucurbitae moschatae powder, Radix Glycyrrhizae, the Rhizoma Atractylodis Macrocephalae, Semen Coicis, Semen Nelumbinis, Rhizoma Dioscoreae, arabic gum or Konjac glucomannan.
3. according to the application of the described acidity oligosaccharide of pectin of claim 2 on the health product of preparation treatment gastric ulcer, it is characterized in that health product are made up of following raw materials by weight:
Acidity oligosaccharide of pectin 40～80%, agar oligosaccharide 1～10%,
Fructus Lycii 1～10%, Fructus Jujubae 5～20%,
Fructus Cucurbitae moschatae powder 1～20%, Radix Glycyrrhizae 1～5%,
The Rhizoma Atractylodis Macrocephalae 1～5%, Semen Coicis 1～5%,
Semen Nelumbinis 1～5%, Rhizoma Dioscoreae 1～5%.
4. according to the application of the described acidity oligosaccharide of pectin of claim 1 on the health product of preparation treatment gastric ulcer; It is characterized in that described health product are made up of acidity oligosaccharide of pectin and adjuvant that the method for preparing by the described acidity oligosaccharide of pectin of claim 1 makes, described adjuvant is Mel, Radix Ginseng, sucrose, Poria, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae and Semen Coicis; Form as follows by weight percentage:
Acidity oligosaccharide of pectin 40～80%, Mel 10～20%,
Radix Ginseng 0.5～1%, sucrose 5～20%,
Poria 1～5%, the Radix Astragali 1～5%,
The Rhizoma Atractylodis Macrocephalae 1～5%, Semen Coicis 1～5%.
5. according to the application of the described acidity oligosaccharide of pectin of claim 1 on the health product of preparation treatment gastric ulcer; It is characterized in that described health product are made up of acidity oligosaccharide of pectin and adjuvant that the method for preparing by the described acidity oligosaccharide of pectin of claim 1 makes, described adjuvant is Oleum Hippophae, Poria, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae and Semen Coicis; Form as follows by weight percentage:
Acidic oligosaccharide 70～95%, Oleum Hippophae 1～10%,
Poria 1～5%, the Radix Astragali 1～5%,
The Rhizoma Atractylodis Macrocephalae 1～5%, Semen Coicis 1～5%.
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| CN1327752A (en) * | 2000-08-10 | 2001-12-26 | 北京贝拉芦荟开发研究中心 | Aloe chewing gun using natural aloe as main raw material and its preparing process |
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| CN1327752A (en) * | 2000-08-10 | 2001-12-26 | 北京贝拉芦荟开发研究中心 | Aloe chewing gun using natural aloe as main raw material and its preparing process |
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| Title |
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| 金山等.山楂果胶脱色工艺的研究.《食品研究与开发》.2008,第29卷(第3期), * |
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