CN101612349B - Medicine for treating coronary heart disease - Google Patents
Medicine for treating coronary heart disease Download PDFInfo
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- CN101612349B CN101612349B CN2009100673208A CN200910067320A CN101612349B CN 101612349 B CN101612349 B CN 101612349B CN 2009100673208 A CN2009100673208 A CN 2009100673208A CN 200910067320 A CN200910067320 A CN 200910067320A CN 101612349 B CN101612349 B CN 101612349B
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Abstract
The invention relates to a medicine for treating the coronary heart disease. In the invention, more than 10 natural Chinese herbal medicines such as peach kernel, radix psuedostellariae, astragalus root, snakegourd fruit, tuber pinellia, macrostem onion, dalbergia wood, radix salviae miltiorrhizae, villous anomum, rhizoma ligustici wallichii, red peony root, wild ginger, radix notoginseng, long pepper, saffron crocus and the like are adopted and scientifically and reasonably matched, and the effect of each medicine synergistically acts so as to achieve the purpose of effectively treating the coronary heart disease. The medicine promotes blood circulation, dissolves stasis, invigorates pulse, alleviates pain, is used for treating the coronary heart disease and angina pectoris and eliminates symptoms, such as depression caused by the non-smooth blood flow of people with the coronary heart disease, dismay or palpitation caused by ischemia and the like. The symptoms can be obviously relieved or eliminated after the medicine is taken for about a week, and normally, the symptoms can be cured within about 15 days. The total effective rate is more than 97%, and the cure (acting) rate is more than 84%. The property of the medicine is mild, the medicine is easy to take, no relapse occurs after the medicine is stopped being taken, the medicine has short treatment course, quick acting, high cure rate and no toxic or side effect and is safe and reliable, the source of raw materials is abundant, the manufacturing method is simple, the cost is cheap, and the medicine is a preferred choice for patients with the coronary heart disease.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of coronary heart disease, belong to the field of Chinese medicines.
Background technology
Coronary heart disease is a kind of common person in middle and old age's disease, and the traditional Chinese medical science claims " thoracic obstruction ".The women who suffers from this disease in China mostly is to cause owing to coronary atherosclerosis causes in various degree myocardial ischemia, ischemia more than the male.The traditional Chinese medical science thinks that the pathogenesis of coronary heart disease is that heart arteries and veins is obstructed, many owing to blood stasis, expectorant is turbid, the stagnation of QI causes, and is again the result of long-term visceral dysfunction, often with heavy meal, catch cold, fatigue, direct stimulation is pathogenesis etiology.Cardinal symptom is squeezing sense of sudden shirtfront or pain, or there is paroxysmal pain at left breastbone rear portion, also can feed through to positions such as most of pareordia.Pale complexion during outbreak, expression anxiety or agitation, palpitation and uneasiness, have palpitation, breathe hard, si dol urg can accompany and see cold sweat, often can cause sudden death.Since the Incidence of CHD height, the mortality rate height, and the healthy of the mankind in serious harm, b referred to as " the first human killers ".
The medicament categories of treatment coronary heart disease is a lot, and great majority are used western medicine, cure the symptoms, not the disease.Its treatment approach is many to adopt the medicine of coronary dilating and decreased heart rate, improves myocardial oxygen delivery and reduces myocardial oxygen consumption, thereby alleviate state of an illness symptom.Facts have proved, though this class medicine can be alleviated disease to a certain extent, exist impairment of YIN all the time, consumption gas, difficult Da Zhiben is sorry.Normally better during medication, in case the original state of an illness is just got back in drug withdrawal again, if inappropriate medication also may be failed to respond to any medical treatment even increased the weight of disease.
Summary of the invention
Modern medicine is thought: coronary heart disease is because coronary artery causes obliteration or spasm because of atherosis, and causes due to the of short duration ischemia of cardiac muscle, the anoxia.Motherland's traditional medicine demonstration: though the sick position of this disease in mind, but its whole pathological process invariably with all dirty close ties that have of liver,spleen,kidney, thereby pass through tcm therapy, adopt traditional Chinese medical science wholistic therapy idea, the advantage that the performance traditional Chinese medical science is effected a permanent cure, by adjusting the imbalance between YIN and YANG of whole body, coronary heart disease is fundamentally eliminated.
The objective of the invention is further to excavate and utilize effective prescription in the pools of traditional Chinese medicine, the medicine of a kind of prescription uniqueness, cost treatment coronary heart disease low, safe and reliable, evident in efficacy is provided.
Drug main of the present invention will be selected ten multi-flavor natural Chinese medicinal herb such as Semen Persicae, Radix Pseudostellariae, the Radix Astragali, Fructus Trichosanthis, the Rhizoma Pinelliae, Bulbus Allii Macrostemonis, Lignum Dalbergiae Odoriferae, Radix Salviae Miltiorrhizae, Fructus Amomi, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Herba Asari, Radix Notoginseng, Fructus Piperis Longi, Stigma Croci for use, through scientific and reasonable compatibility, make the effect of each medicine produce synergism, thereby reach the purpose of effective treatment coronary heart disease.
The objective of the invention is to be achieved through the following technical solutions.
The medicine of this treatment coronary heart disease, make by following raw medicaments in portion by weight:
Semen Persicae 10-30 part, Radix Pseudostellariae 20-40 part, Radix Astragali 20-40 part, Fructus Trichosanthis 20-40 part, Rhizoma Pinelliae 10-30 part, Bulbus Allii Macrostemonis 20-40 part, Lignum Dalbergiae Odoriferae 20-40 part, Radix Salviae Miltiorrhizae 20-60 part, Fructus Amomi 10-30 part, Rhizoma Chuanxiong 20-40 part, Radix Paeoniae Rubra 20-40 part, Herba Asari 4-8 part, Radix Notoginseng 20-40 part, Fructus Piperis Longi 10-30 part, Stigma Croci 4-8 part.
Each amounts of components all has better curative effect in the following weight parts scope:
Semen Persicae 15-25 part, Radix Pseudostellariae 25-35 part, Radix Astragali 25-35 part, Fructus Trichosanthis 25-35 part, Rhizoma Pinelliae 15-25 part, Bulbus Allii Macrostemonis 25-35 part, Lignum Dalbergiae Odoriferae 25-35 part, Radix Salviae Miltiorrhizae 30-50 part, Fructus Amomi 15-25 part, Rhizoma Chuanxiong 25-35 part, Radix Paeoniae Rubra 25-35 part, Herba Asari 5-7 part, Radix Notoginseng 25-35 part, Fructus Piperis Longi 15-25 part, Stigma Croci 5-7 part.
Be preferably:
20 parts in Semen Persicae, 30 parts of Radix Pseudostellariaes, 30 parts of the Radixs Astragali, 30 parts of Fructus Trichosanthis, 20 parts of the Rhizoma Pinelliaes, 30 parts of Bulbus Allii Macrostemonis, 30 parts of Lignum Dalbergiae Odoriferaes, 40 parts of Radix Salviae Miltiorrhizaes, 20 parts of Fructus Amomis, 30 parts of Rhizoma Chuanxiongs, 30 parts of Radix Paeoniae Rubra, 6 parts of Herba Asaris, 30 parts of Radix Notoginseng, 20 parts of Fructus Piperis Longi, 6 parts of Stigma Crocis.
Medicine of the present invention can adopt the conventional method of Chinese medicine preparation, and required various conventional adjuvant was prepared into any conventional oral preparations when the active component of medicine of the present invention was added the preparation different dosage form.For example these crude drug pulverize mix homogeneously can be made powder, pill or made capsule, tablet; Can or extract active component and make oral liquid these crude drug decoctings, condensed water decocting liquid, also can make powder, capsule etc. pulverizing behind the extracting solution concentrate drying.But these can not be used to limit protection scope of the present invention.
Medicine of the present invention is opened breast a surname numbness with logical heart-yang with Fructus Trichosanthis, and Bulbus Allii Macrostemonis leads to heart-yang with a surname's arthralgia due to stagnation of blood, this two flavors medicine, one expectorant knot, and a ventilator, complementing each other is monarch drug; The thoracic obstruction is many is got Rhizoma Pinelliae regulating the stomach and sending down the abnormal ascending QI and is reduced phlegm by the turbid superinverse of stomach, and falling cloudy is ministerial drug against holding up heart-yang; The adapted Radix Astragali, Radix Pseudostellariae Qi-benefiting and heart-nourishing, Radix Salviae Miltiorrhizae, Semen Persicae, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Stigma Croci blood circulation promoting and blood stasis dispelling, the pain relieving of Radix Notoginseng heart tonifying is an adjuvant drug; Adapted Lignum Dalbergiae Odoriferae, Fructus Amomi, Herba Asari, Fructus Piperis Longi eliminating turbid pathogen with aromatics again, warming spleen and stomach for dispelling cold be with pain relieving, can make just in the heart that yang-energy must fill, and YIN-cold must be loose, and mechanism of qi must relax, and unimpeded up and down is messenger drug.The general rule thoracic obstruction, all diseases such as coronary heart disease, angina pectoris are from removing.
Medicament composing prescription uniqueness of the present invention, prescription be rigorous, select YAOJING refining, and each component drug synergism complements each other, and has overcome the deficiency of in the past treating the difficult Da Zhiben of medicaments for coronary disease.Pharmacological testing proves: the existing adjusting cardiac function of this medicine, improve effects such as cardiac hemodynamic index and coronary blood flow increasing, myocardial nutritional flow amount and the supply of myocardium blood oxygen.Can regulate and keep the equilibrium of supply and demand of myocardium oxygen metabolism and energy again, ischemia and anoxybiotic cardiac muscle are improved and protect.
Show through clinical trial for many years, medicine activating blood circulation to dissipate blood stasis of the present invention, coronary circulation-promoting pain-relieving is used for the treatment of angina pectoris, makes feeling oppressed that the coronary heart disease human bloodstream freely do not cause, and the diseases such as nervous cardiopalmus that ischemia causes are eliminated.Take medicine about a week, symptom can obviously alleviate or disappear, and general about 15 days, can cure.Total effective rate is more than 97%, and (produce effects) rate of curing is more than 84%.The gentle easily clothes of the property of medicine, after the drug withdrawal not " bounce-back ", short treating period, instant effect, cure rate height, have no side effect, safe and reliable, and raw material sources enrich, manufacture method is simple, with low cost.
The specific embodiment
Below by embodiment and test example the present invention is further described.But the present invention is not limited to embodiment, and those of ordinary skills do some modification, all in protection domain of the present invention.
Embodiment 1-5: the preparation of medicine of the present invention " heart nourishing palpitation stabilizing looses "
(the unit: kilogram) see Table 1 of the consumption of each crude drug among each embodiment.
Preparation method: after described materials of weight proportions medicine screened purified treatment respectively by different pharmacological properties, be developed into fine powder according to a conventional method, cross the 100-120 mesh sieve after, the mix homogeneously packing, " heart nourishing palpitation stabilizing looses " of every bag 3.5 gram.
Medicine of the present invention is the yellowish-brown powder, gas fragrance, acrid in the mouth.
Usage and dosage: boiled water is taken after mixing it with water, and 3 times on the one, each 1 bag, 15 days is 1 course of treatment.
Test example: the clinical observation of medicine of the present invention " heart nourishing palpitation stabilizing looses " treatment coronary heart disease
1, physical data
Inventor 2001-2008 accepts outpatient service patients with coronary heart disease totally 402 examples for medical treatment, wherein: and male 175 examples,
Table 1
| Embodiment number | 1? | 2? | 3? | 4? | 5? |
| Semen Persicae | 1? | 1.6? | 2? | 2.6? | 3? |
| Radix Pseudostellariae | 4? | 3.5? | 3? | 2.5? | 2? |
| The Radix Astragali | 2? | 2.7? | 3? | 3.4? | 4? |
| Fructus Trichosanthis | 2? | 2.3? | 3? | 3.5? | 4? |
| The Rhizoma Pinelliae | 1? | 1.5? | 2? | 2.6? | 3? |
| Bulbus Allii Macrostemonis | 4? | 3.8? | 3? | 2.7? | 2? |
| Lignum Dalbergiae Odoriferae | 2? | 2.6? | 3? | 3.8? | 4? |
| Radix Salviae Miltiorrhizae | 6? | 5? | 4? | 6? | 2? |
| Fructus Amomi | 1? | 1.7? | 2? | 2.9? | 3? |
| Rhizoma Chuanxiong | 2? | 2.2? | 3? | 3.3? | 4? |
| Radix Paeoniae Rubra | 2? | 2.1? | 3? | 3.9? | 4? |
| Herba Asari | 0.4? | 0.4? | 0.6? | 0.5? | 0.8? |
| Radix Notoginseng | 2? | 2.2? | 3? | 3.4? | 4? |
| Fructus Piperis Longi | 1? | 1.6? | 2? | 2.3? | 3? |
| Stigma Croci | 0.4? | 0.5? | 0.6? | 0.7? | 0.8? |
Woman's 227 examples, 57.08 years old mean age.Patients with coronary heart disease 64 examples in 40-50 year wherein, nervous when disease is movable, fatigue and weak does not feel like a meal, and the course of disease is 1 month-1 year.Patients with coronary heart disease 241 examples in 51-60 year, disease be activity or night WA nervous, feel oppressed, breathing heavily does not feel like a meal, the course of disease is 13 years.Nervous when patients with coronary heart disease 97 examples in 61-80 year, disease are movable, to feel oppressed, breathing heavily can't be fallen asleep night, and after the paroxysm perspire in the whole body, do not feel like a meal, the lip pastiness, black eye, the course of disease is 1-5.All cases are by being divided into treatment group and matched group at 2: 1, and two groups all have comparability at age, sex, the course of disease, clinical setting.
2, Therapeutic Method
The treatment group, oral embodiment 3 gained every day " heart nourishing palpitation stabilizing looses ".Each 1 bag (3.5 gram), 2-3 time on the one, boiled water is taken after mixing it with water.
Matched group, take existing Chinese patent medicine: the safe ball of coronary disease, Shiyiting Pharmaceutical Factory, Harbin pharmaceutical Industry Group, the accurate word Z19991036 of traditional Chinese medicines, oral, each 6 grams, every day 2 times, warm water delivery service sooner or later.
Observation period is 45 days, and 15 days is a course of treatment, and totally 3 courses of treatment, drug withdrawal is checked after half a year, does not have recurrence for curing (produce effects), and sb.'s illness took a favorable turn is evident as effectively, and it is not obvious that sb.'s illness took a favorable turn is invalid.
3, therapeutic outcome
Observe treatment 45 days, follow up a case by regular visits to half a year after, two groups of therapeutic effect are relatively as table 2.
Table 2
| ? | Cure (produce effects) | Effectively | Invalid | Total effective rate % |
| 268 examples are organized in treatment | 226 examples | 34 examples | 8 examples | 97.02? |
| Matched group 134 examples | 85 examples | 29 examples | 20 examples | 85.07? |
In sum, curative effect of medication of the present invention is definite, and treatment group curative effect obviously is better than matched group, and total effective rate reaches 97.02%.
Show through clinical observation: this medicine has significant curative effect to heart diseases such as coronary heart disease, angina pectoriss, and curative effect is rapid, to angina pectoris, uncomfortable in chest, cardiopalmus, symptom such as weak, the patient generally take medicine once the week after can feel obviously to alleviate or disappear, its electrocardiogram, blood pressure, blood fat, blood glucose etc. also obviously improve, liver, renal function and hemopoietic system no abnormality seen to the patient change and untoward reaction, and " bounce-back " do not appear in the state of an illness after the drug withdrawal.
Model case:
Case 1: Zhang, man, 60 years old, cadre.Old property stabbing pain over the chest 11 days, a day light night is heavy, and uneasy sleeping at night was gone to a doctor on August 16th, 2006.Have a medical check-up: dark tongue quality, there is ecchymosis on sharp limit, and the tongue the lung-pulse is heavy.Traditional Chinese medical science disease type: stagnation of heart-blood.The rule of treatment: blood circulation promoting and blood stasis dispelling, collateral dredging regulating QI to relieve pain.Take " heart nourishing palpitation stabilizing looses ", each 1 bag (3.5 gram), 3 times on the one, boiled water is taken after mixing it with water.Treatment is 25 days continuously, transference cure.
Case 2: Liu, man, 62 years old, workman.The sky increased the weight of in nearly 5 days surplus the sensation of oppression over the chest with shortness of breath 10, and JIUYUE was gone to a doctor on the 12nd in 2006.Disease is seen: chest pain radiating to the back, and meet cold and increase the weight of coolness of extremities.Have a medical check-up: white and thin fur, purplish tongue, pulse condition is heavy thin and puckery.Traditional Chinese medical science disease type: YIN-cold stagnates.The rule of treatment: activating YANG with pungent and warm drugs, dispersing cold for relieving pain.Take " heart nourishing palpitation stabilizing looses ", each 1 bag (3.5 gram), 3 times on the one, boiled water is taken after mixing it with water.Treatment is 24 days continuously, transference cure.
Case 3: Zhao, the man, the cadre surplus the sensation of oppression over the chest with shortness of breath 20 day, increases the weight of in the recent period, and on May 8th, 2007 went to a doctor.Disease is seen: the time shirtfront pain in the shoulder and back arranged, the fixing of pain do not move, the body constitution obesity, limbs are heavy.Have a medical check-up: body of the tongue is deep red, and tongue is greasy in vain, rolling pulse.Traditional Chinese medical science disease type: expectorant is turbid to be jammed, with blood stasis.The rule of treatment: activating yang, it is turbid to let out, eliminating phlegm relieving accumulation of pathogens, blood circulation promoting and blood stasis dispelling.Take " heart nourishing palpitation stabilizing looses ", each 1 bag (3.5 gram), 3 times on the one, boiled water is taken after mixing it with water.Treatment is 30 days continuously, transference cure.The check of early work electrocardiogram has recovered normal.
Case 4: Lee, woman, 54 years old, cadre.Suffocating pain over the chest 8 days, in JIUYUE, 2008 is gone to a doctor.Disease is seen: cardiopalmus, breathe hard, and weak, insomnia, dreaminess, dizziness.Have a medical check-up: red tongue, light stripping no fur, indentations at the margin of the tongue, deep,thready and forceless pulse.Traditional Chinese medical science disease type: deficiency of both QI and YIN.The rule of treatment: supplementing QI and nourishing YIN, promoting blood circulation to remove obstruction in the collateral.Take " heart nourishing palpitation stabilizing looses ", each 1 bag (3.5 gram), 3 times on the one, boiled water is taken after mixing it with water.Treatment is 23 days continuously, and symptom is relieved to disappearance gradually.
Case 5: the Wang, the man, 65 years old, suffocating pain over the chest was surplus March, and go to a doctor in October, 2008.Disease is seen: dizziness is dizzy, ear toot as silkworm, soreness of waist and knee, cardiopalmus is insomnia, susceptible to lose temper due to restlessness.Have a medical check-up: dimly red tongue, deep pulse is counted accurately.Traditional Chinese medical science disease type: heart deficiency of the kidney yin.The rule of treatment: nourishing YIN for benefiting the kidney, tranquilizing by nourishing the heart.Take " heart nourishing palpitation stabilizing looses ", each 1 bag (3.5 gram), 3 times on the one, boiled water is taken after mixing it with water, and suitably takes QIJU DIHUANG WAN or ZHIBAI DIHUANG WAN auxiliary treatment, treats continuously 45 days, and sick the announcement fully recovered.
Case 6: the marquis, the man, 55 years old, the peasant, sensation of oppression over the chest with shortness of breath, January surplus, nearly Zhou Jiachong, go to a doctor in November, 2007.Disease is seen: the time chest pain radiating to the back, the soreness of waist is weak, aversion to cold and cold limbs, cardiopalmus, pale complexion.Have a medical check-up: pale tongue is dark, deep-slow pulse.Traditional Chinese medical science disease type: deficient and weak YANG QI.The rule of treatment: QI invigorating warming YANG, promoting blood circulation to remove obstruction in the collateral.Take " heart nourishing palpitation stabilizing looses ", each 1 bag (3.5 gram), 3 times on the one, boiled water is taken after mixing it with water.Treatment is 20 days continuously, and symptom obviously alleviates, and obeys recovery from illness in 10 days again, favourable prognosis.
Claims (3)
1. medicine for the treatment of coronary heart disease is characterized in that being made by following bulk drugs:
Semen Persicae 10-30 part, Radix Pseudostellariae 20-40 part, Radix Astragali 20-40 part, Fructus Trichosanthis 20-40 part, Rhizoma Pinelliae 10-30 part, Bulbus Allii Macrostemonis 20-40 part, Lignum Dalbergiae Odoriferae 20-40 part, Radix Salviae Miltiorrhizae 20-60 part, Fructus Amomi 10-30 part, Rhizoma Chuanxiong 20-40 part, Radix Paeoniae Rubra 20-40 part, Herba Asari 4-8 part, Radix Notoginseng 20-40 part, Fructus Piperis Longi 10-30 part, Stigma Croci 4-8 part.
2. the medicine of treatment coronary heart disease according to claim 1 is characterized in that being made by following bulk drugs:
Semen Persicae 15-25 part, Radix Pseudostellariae 25-35 part, Radix Astragali 25-35 part, Fructus Trichosanthis 25-35 part, Rhizoma Pinelliae 15-25 part, Bulbus Allii Macrostemonis 25-35 part, Lignum Dalbergiae Odoriferae 25-35 part, Radix Salviae Miltiorrhizae 30-50 part, Fructus Amomi 15-25 part, Rhizoma Chuanxiong 25-35 part, Radix Paeoniae Rubra 25-35 part, Herba Asari 5-7 part, Radix Notoginseng 25-35 part, Fructus Piperis Longi 15-25 part, Stigma Croci 5-7 part.
3. the medicine of treatment coronary heart disease according to claim 1 is characterized in that being made by following bulk drugs:
20 parts in Semen Persicae, 30 parts of Radix Pseudostellariaes, 30 parts of the Radixs Astragali, 30 parts of Fructus Trichosanthis, 20 parts of the Rhizoma Pinelliaes, 30 parts of Bulbus Allii Macrostemonis, 30 parts of Lignum Dalbergiae Odoriferaes, 40 parts of Radix Salviae Miltiorrhizaes, 20 parts of Fructus Amomis, 30 parts of Rhizoma Chuanxiongs, 30 parts of Radix Paeoniae Rubra, 6 parts of Herba Asaris, 30 parts of Radix Notoginseng, 20 parts of Fructus Piperis Longi, 6 parts of Stigma Crocis.
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| CN102293821A (en) | 2010-06-28 | 2011-12-28 | 天津天士力制药股份有限公司 | Application of traditional Chinese medicine composite in preparing medicine for relieving acute myocardial postinfarction angina pectoris |
| CN103690619A (en) * | 2013-11-26 | 2014-04-02 | 安徽三超药业有限公司 | Chewing tablet for treating coronary heart disease |
| CN103735801A (en) * | 2013-12-07 | 2014-04-23 | 济南新起点医药科技有限公司 | Traditional Chinese medicine for treating coronary heart disease |
| CN104587181A (en) * | 2015-02-05 | 2015-05-06 | 王显勇 | Traditional Chinese medicine composition for treating coronary heart disease |
| CN104689026A (en) * | 2015-03-23 | 2015-06-10 | 张春 | Pharmaceutical composition for treating stable angina |
| CN106491958B (en) * | 2015-09-08 | 2020-04-17 | 上海中医药大学附属曙光医院 | Chinese medicinal compound preparation for treating coronary heart disease and angina pectoris and preparation method thereof |
| CN105663651A (en) * | 2016-02-25 | 2016-06-15 | 太和县中医院 | Traditional Chinese medicine granules for treating coronary heart disease |
| CN106943566A (en) * | 2017-05-05 | 2017-07-14 | 张古权 | A kind of medicine for treating coronary heart disease |
| CN111870645B (en) * | 2020-07-09 | 2022-04-29 | 何庆勇 | Composition for treating coronary heart disease, traditional Chinese medicine composition and application thereof |
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| 郑丽等.当代名老中医治疗急性心肌梗死经验总结.《北京中医》.2007,第26卷(第04期),第221-223页. * |
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