CN101579508A - Medicine for treating hyperplasia of mammary glands and preparation method thereof - Google Patents

Medicine for treating hyperplasia of mammary glands and preparation method thereof Download PDF

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Publication number
CN101579508A
CN101579508A CNA2009100740185A CN200910074018A CN101579508A CN 101579508 A CN101579508 A CN 101579508A CN A2009100740185 A CNA2009100740185 A CN A2009100740185A CN 200910074018 A CN200910074018 A CN 200910074018A CN 101579508 A CN101579508 A CN 101579508A
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medicine
radix
vinegar
treatment
cyclomastopathy
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CN101579508B (en
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路正平
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路正平
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Abstract

A medicine for treating hyperplasia of mammary glands is prepared by the following steps: processed pangolin, leech, earthworm, trogopterus dung, motherwort, trigone, zedoary, peach kernel, safflower, fiveleaf akebia, salvia miltiorrhiza, red paeonia, white paeony root, rhizoma ligustici wallichii, angelica, ordate houttuynia, honeysuckle, fructus liquidambaris and liquorice are evenly mixed; water is added to decoct the mixture so as to be concentrated to be extract; then the extract is dried and pulverized to be put into capsules; at last, capsules are sterilized to obtain capsule products. The medicine of the invention has the efficacies of nourishing blood and liver, regulating vital energy, alleviating pain, resolving hard lump, and tonifying kidney, and can be used for treating hyperplasia of mammary glands; the medicine of the invention has the characteristics of quick and determined curative effect, and convenient and safe eating. Through clinical observation, the effective rate of the medicine is 100%.

Description

A kind of medicine that is used for the treatment of cyclomastopathy and preparation method thereof
Technical field
The present invention relates to a kind of medicine for the treatment of cyclomastopathy, particularly relating to a kind of is the medicine of the treatment cyclomastopathy of feedstock production with Chinese medicine, and the preparation method of this medicine.
Background technology
Cyclomastopathy is the benign proliferative diseases of mammary gland tissue, neither inflammation, and also non-tumor, outstanding behaviours is mastalgia and lump clinically, its sickness rate accounts for the women of child-bearing age's about 40%, and accounts for all mastoticly 75%, is modal cystic hyperplasia of breast.Cyclomastopathy shows as mammary gland parenchyma and matter hypertrophy and subinvolution in various degree on pathomorphism, cause breast structure in quantity and modal unusual.Cyclomastopathy has been listed in the high risk factor of breast carcinoma, and effective control of cyclomastopathy has crucial meaning for Breast Cancer Prevention.
The treatment cyclomastopathy usually adopts methods such as life conditioning, vitamin medicaments, diuretic, tranquilizer, iodine preparation, hormone and operation at present, though can find that mastalgia alleviates after the treatment, tuberosity dwindles, breast relaxes or true mitigation symptoms temporarily in therapeutic process, but life-time service, will cause side effect such as unbalance grade and untoward reaction new between the hormone in vivo, the back relapse rate height of treatment simultaneously, curative effect is not consolidated.
Summary of the invention
The purpose of this invention is to provide a kind of medicine that is used for the treatment of cyclomastopathy, this medicine nourishing blood to suppress the hyperactive liver, regulating QI to relieve pain, hard masses softening and resolving, the kidney invigorating are transferred and are dashed, and can play treating both the principal and secondary aspects of a disease to the treatment of cyclomastopathy, and drug effect is rapid, the purpose that therapeutic effect is good.
Medicine of the present invention is that crude drug prepares by following parts by weight of traditional Chinese medicines:
Herba Leonuri 15~25 Squama Maniss 3~8
Pheretima 8~13 Hirudos 2~5
Rhizoma sparganic 8~13 Rhizoma Curcumae 3~8
Oletum Trogopterori 8~13 Semen Persicaes 4~8
Flos Carthami 4~8 Radix Salviae Miltiorrhizaes 15~25
Radix Paeoniae Rubra 8~13 Radix Paeoniae Albas 8~18
Rhizoma Chuanxiong 8~13 Radix Angelicae Sinensis 13~18
Herba Houttuyniae 13~18 Flos Loniceraes 15~25
Fructus Liquidambaris 8~13 Caulis Akebiaes 6~8
Radix Glycyrrhizae 2~4.
Said medicine can be made any dosage form on the pharmaceutics, as tablet, pill, powder, capsule etc., the preferred dosage form of the present invention is a capsule.
The concrete preparation method of medicine of the present invention being made capsule is:
Squama Manis is extremely golden yellow with stir-baking with sand, soak slightly with vinegar; With Hirudo with stir-baked in pulvis TALCI to little yellow, sprayed with vinegar; Pheretima is fried to little yellow, sprayed with vinegar; With the little stir-fry of Oletum Trogopterori back spray vinegar, fry to burned black again.
With the Squama Manis, Hirudo, Pheretima, Oletum Trogopterori and the Herba Leonuri that cook, rhizoma sparganic, Rhizoma Curcumae, Semen Persicae, Flos Carthami, Caulis Akebiae, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Herba Houttuyniae, Flos Lonicerae, Fructus Liquidambaris, Radix Glycyrrhizae according to above-mentioned parts by weight mix homogeneously, decoct with water 2~4 times, each 1~2 hour, collecting decoction, filter, being condensed into relative density is the clear paste of 1.0~1.2 (50 ℃), after 50~60 ℃ of dryings, be ground into 100~120 purpose medicated powder, in incapsulating, sterilization makes the capsule product.
Cyclomastopathy belongs to the category of Chinese medicine " nodules of the breast ", " newborn painful abdominal mass ", " nodule in the breast ", the cause of disease is feelings will not smooth, melancholy anger, diet internal injury, enjoys and compose not enough, seven emotions overstrain, characteristic of disease belongs to deficiency in origin and excess in superficiality, Chong and Ren channel disorder is for falling ill originally, depression of liver-QI, expectorant blood coagulation addiction are the mark of morbidity, and sick position is at liver,spleen,kidney.The liver failing to maintain the normal flow of QI, dysfunction of the spleen in transportation, deficiency of the kidney, so that stagnation of Qi and phelgm, the tired in bulk of blood, Chong and Ren channel disorder hinder in newborn network and form nodules of the breast.Treatment should be transferred based on nourishing blood to suppress the hyperactive liver, regulating QI to relieve pain, hard masses softening and resolving, the kidney invigorating and be dashed.In the prescription of the present invention, Herba Leonuri promoting blood flow to regulate menstruation, inducing diuresis to remove edema, heat-clearing and toxic substances removing; The Squama Manis Xiao Disorder that invigorates blood circulation, the stimulating milk secretion of stimulating the menstrual flow, detumescence and apocenosis; Pheretima clearing heat for calming endogenous wind collateral dredging; The Hirudo removing blood stasis stimulates the menstrual flow, Zhu Yu Xiao Disorder; Rhizoma sparganic, the promoting the circulation of blood of Rhizoma Curcumae removing blood stasis, removing food stagnancy pain relieving; Oletum Trogopterori promoting blood circulation and stopping pain, removing stasis to stop bleeding; Semen Persicae, Flos Carthami promoting blood circulation to restore menstrual flow, stasis-dispelling and pain-killing; Caulis Akebiae inducing diuresis for treating stranguria syndrome, clearing away heart-fire, stimulate the menstrual flow; Radix Salviae Miltiorrhizae promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, relieving restlessness are calmed the nerves; Radix Paeoniae Rubra clearing away heat and cooling blood, eliminating stasis to stop pain; The Radix Paeoniae Alba nourish blood yin fluid astringing, easing the affected liver to relieve pain; Rhizoma Chuanxiong, Herba Houttuyniae, Fructus Liquidambaris, Flos Lonicerae heat-clearing and toxic substances removing, blood-activating and qi-promoting, wind-expelling pain-stopping, heat clearing away sterilization, eliminating carbuncle evacuation of pus; Chinese angelica blood supplementing regulating menstruation, promoting blood circulation and stopping pain; The Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.All medicines share, and nourishing blood to suppress the hyperactive liver, regulating QI to relieve pain, hard masses softening and resolving, the kidney invigorating are transferred and dashed, and are used for the treatment of the cyclomastopathy curative effect really, rapidly, conveniently, take safety.
For further investigating the clinical efficacy and the safety of medicine of the present invention, select 200 routine cyclomastopathy patients that the curative effect of Drug therapy cyclomastopathy of the present invention has been carried out clinical observation.
200 routine cases are divided into two groups at random, every group 100 example.18~71 years old matched group age, the course of disease 3 months~5 years; One-sided 54 examples, bilateral 46 examples, all medium hardness.20~69 years old treatment group age, the course of disease 4 months~6 years; One-sided 58 examples, bilateral 42 examples, all medium hardness.All cases are all made a definite diagnosis with reference to breast disease Professional Committee of Chinese surgery of Chinese medicine association in 2002 diagnostic criteria that the 8th time meeting is passed through diagnosis.
The oral Tamoxifen of matched group, 10mg/ time, 2 times/day, menstrual phase is withdrawn, and taking medicine continuously 3 months is 1 course of treatment.The treatment group adopts medicine of the present invention to treat, and 2 weeks were 1 course of treatment, took 6 courses of treatment altogether.
Criterion of therapeutical effect is judged according to breast disease Professional Committee of the Chinese surgery of Chinese medicine association curative effect determinate standard that the 8th time meeting is passed through in 2002.Calculate treatment front and back integration improvement rate, improvement rate=[(total mark before the treatment-treatment back total mark)/preceding total mark of treatment] * 100%.Cure: improvement rate 90%.Produce effects: improvement rate 70~89%.Effectively: improvement rate 30~69%.Invalid: improvement rate<30%.
Two groups of case treatment back curative effect comparative results see Table 1.
Table 1 liang thin case treatment back curative effect relatively
The specific embodiment
Embodiment 1
Get Squama Manis 100g and put into marmite, to expanded fully extremely crisp, drop into when being golden yellow and soak the back airing in the vinegar slightly with stir-baking with sand; 60g puts into marmite with Hirudo, to little yellow, sprays later airing with vinegar with stir-baked in pulvis TALCI; 160g puts into marmite with Pheretima, fries to little yellow, sprays airing with vinegar; 160g puts into pot with Oletum Trogopterori, with the little stir-fry of slow fire, sprays vinegar immediately, takes out when stir-fry is extremely burned black again to cool.
With Chinese medicine and the Herba Leonuri 300g that cooks, rhizoma sparganic 160g, Rhizoma Curcumae 100g, Semen Persicae 100g, Flos Carthami 100g, Caulis Akebiae 100g, Radix Salviae Miltiorrhizae 300g, Radix Paeoniae Rubra 160g, Radix Paeoniae Alba 200g, Rhizoma Chuanxiong 160g, Radix Angelicae Sinensis 300g, Herba Houttuyniae 300g, Flos Lonicerae 300g, Fructus Liquidambaris 200g, Radix Glycyrrhizae 40g mix homogeneously decocts with water 3 times, each 2 hours, merge 3 times decocting liquid, filter, being condensed into relative density is the clear paste of 1.2 (50 ℃), after 50 ℃ of dryings, be ground into 120 purpose medicated powder, in incapsulating, sterilization makes the capsule product.
Embodiment 2
Get Squama Manis 80g and put into marmite, to expanded fully extremely crisp, drop into when being golden yellow and soak the back airing in the vinegar slightly with stir-baking with sand; 50g puts into marmite with Hirudo, to little yellow, sprays later airing with vinegar with stir-baked in pulvis TALCI; 130g puts into marmite with Pheretima, fries to little yellow, sprays airing with vinegar; 130g puts into pot with Oletum Trogopterori, with the little stir-fry of slow fire, sprays vinegar immediately, takes out when stir-fry is extremely burned black again to cool.
With Chinese medicine and the Herba Leonuri 250g that cooks, rhizoma sparganic 130g, Rhizoma Curcumae 80g, Semen Persicae 80g, Flos Carthami 80g, Caulis Akebiae 80g, Radix Salviae Miltiorrhizae 250g, Radix Paeoniae Rubra 130g, Radix Paeoniae Alba 180g, Rhizoma Chuanxiong 130g, Radix Angelicae Sinensis 180g, Herba Houttuyniae 180g, Flos Lonicerae 250g, Fructus Liquidambaris 130g, Radix Glycyrrhizae 40g mix homogeneously decocts with water 3 times, each 1 hour, merge 3 times decocting liquid, filter, being condensed into relative density is the clear paste of 1.0 (50 ℃), after 60 ℃ of dryings, be ground into 100 purpose medicated powder, in incapsulating, sterilization makes the capsule product.

Claims (3)

1, a kind of medicine that is used for the treatment of cyclomastopathy is that the Chinese medicine by following portions by weight is that crude drug prepares:
Herba Leonuri 15~25 Squama Maniss 3~8
Pheretima 8~13 Hirudos 2~5
Rhizoma sparganic 8~13 Rhizoma Curcumae 3~8
Oletum Trogopterori 8~13 Semen Persicaes 4~8
Flos Carthami 4~8 Radix Salviae Miltiorrhizaes 15~25
Radix Paeoniae Rubra 8~13 Radix Paeoniae Albas 8~18
Rhizoma Chuanxiong 8~13 Radix Angelicae Sinensis 13~18
Herba Houttuyniae 13~18 Flos Loniceraes 15~25
Fructus Liquidambaris 8~13 Caulis Akebiaes 6~8
Radix Glycyrrhizae 2~4.
2, the medicine that is used for the treatment of cyclomastopathy according to claim 1 is characterized in that described medicine is made capsule.
3, the described preparation method that is used for the treatment of the medicine of cyclomastopathy of claim 2 may further comprise the steps:
Squama Manis is extremely golden yellow with stir-baking with sand, soak slightly with vinegar; With Hirudo with stir-baked in pulvis TALCI to little yellow, sprayed with vinegar; Pheretima is fried to little yellow, sprayed with vinegar; With the little stir-fry of Oletum Trogopterori back spray vinegar, fry again to burned black;
With the Squama Manis, Hirudo, Pheretima, Oletum Trogopterori and the Herba Leonuri that cook, rhizoma sparganic, Rhizoma Curcumae, Semen Persicae, Flos Carthami, Caulis Akebiae, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Herba Houttuyniae, Flos Lonicerae, Fructus Liquidambaris, Radix Glycyrrhizae according to above-mentioned parts by weight mix homogeneously, decoct with water 2~4 times, each 1~2 hour, collecting decoction, filter, be condensed into 50 ℃ of relative densities and be 1.0~1.2 clear paste, after 50~60 ℃ of dryings, be ground into 100~120 purpose medicated powder, in incapsulating, sterilization makes the capsule product.
CN2009100740185A 2009-03-23 2009-03-23 Medicine for treating hyperplasia of mammary glands and preparation method thereof Expired - Fee Related CN101579508B (en)

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102188654A (en) * 2011-05-13 2011-09-21 刘爱美 Traditional Chinese medicine composition for treating multiple neurofibromatosis
CN103041305A (en) * 2012-12-30 2013-04-17 青岛恒波仪器有限公司 Traditional Chinese medicine composition for curing hyperplasia of mammary glands and preparation method thereof
CN104524454A (en) * 2014-12-22 2015-04-22 况喜才 Tinospora sinensis pain-relieving tincture
CN106540154A (en) * 2016-12-29 2017-03-29 广州智润生物制药科技有限公司 A kind of medicine for treating cyclomastopathy
CN108434403A (en) * 2018-05-22 2018-08-24 河南济回堂健康管理有限公司 Treat the patch and preparation method thereof of the proliferation of mammary gland
CN110354206A (en) * 2019-08-16 2019-10-22 何雨霖 It is a kind of for treating the potent type cream good jade health medicament of newborn numbness

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1157737A (en) * 1996-10-24 1997-08-27 张文善 ''Shanzhiai'' oral dosage
CN1895434B (en) * 2006-06-14 2010-05-12 李悦来 Medicine for treating hysteromyoma

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102188654A (en) * 2011-05-13 2011-09-21 刘爱美 Traditional Chinese medicine composition for treating multiple neurofibromatosis
CN102188654B (en) * 2011-05-13 2012-07-18 刘会国 Traditional Chinese medicine composition for treating multiple neurofibromatosis
CN103041305A (en) * 2012-12-30 2013-04-17 青岛恒波仪器有限公司 Traditional Chinese medicine composition for curing hyperplasia of mammary glands and preparation method thereof
CN103041305B (en) * 2012-12-30 2014-07-16 青岛恒波仪器有限公司 Traditional Chinese medicine composition for curing hyperplasia of mammary glands and preparation method thereof
CN104524454A (en) * 2014-12-22 2015-04-22 况喜才 Tinospora sinensis pain-relieving tincture
CN106540154A (en) * 2016-12-29 2017-03-29 广州智润生物制药科技有限公司 A kind of medicine for treating cyclomastopathy
CN108434403A (en) * 2018-05-22 2018-08-24 河南济回堂健康管理有限公司 Treat the patch and preparation method thereof of the proliferation of mammary gland
CN110354206A (en) * 2019-08-16 2019-10-22 何雨霖 It is a kind of for treating the potent type cream good jade health medicament of newborn numbness

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