CN101530429A - New use of clarias lazera - Google Patents
New use of clarias lazera Download PDFInfo
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- CN101530429A CN101530429A CN200910110925A CN200910110925A CN101530429A CN 101530429 A CN101530429 A CN 101530429A CN 200910110925 A CN200910110925 A CN 200910110925A CN 200910110925 A CN200910110925 A CN 200910110925A CN 101530429 A CN101530429 A CN 101530429A
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- China
- Prior art keywords
- clarias
- fucsus
- fish flour
- fish
- medicine
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 241000721191 Clarias gariepinus Species 0.000 title abstract 7
- 239000003814 drug Substances 0.000 claims abstract description 20
- 239000002994 raw material Substances 0.000 claims abstract description 11
- 230000001093 anti-cancer Effects 0.000 claims abstract description 9
- 241000721179 Clarias Species 0.000 claims description 40
- 235000013360 fish flour Nutrition 0.000 claims description 36
- 239000000843 powder Substances 0.000 claims description 20
- 241000251468 Actinopterygii Species 0.000 claims description 12
- 241000222336 Ganoderma Species 0.000 claims description 12
- 206010028980 Neoplasm Diseases 0.000 claims description 11
- 210000004369 Blood Anatomy 0.000 claims description 9
- 239000008280 blood Substances 0.000 claims description 9
- 230000000259 anti-tumor Effects 0.000 claims description 8
- 238000010025 steaming Methods 0.000 claims description 8
- 239000009636 Huang Qi Substances 0.000 claims description 6
- 239000002775 capsule Substances 0.000 claims description 6
- 239000010985 leather Substances 0.000 claims description 6
- 235000013402 health food Nutrition 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 241000628997 Flos Species 0.000 claims description 3
- 229940023488 Pill Drugs 0.000 claims description 3
- 210000003491 Skin Anatomy 0.000 claims description 3
- 239000002671 adjuvant Substances 0.000 claims description 3
- 230000000240 adjuvant Effects 0.000 claims description 3
- 229940079593 drugs Drugs 0.000 claims description 3
- 230000001900 immune effect Effects 0.000 claims description 3
- 239000006187 pill Substances 0.000 claims description 3
- 239000000718 radiation-protective agent Substances 0.000 claims description 3
- 239000002131 composite material Substances 0.000 claims description 2
- 210000004215 spores Anatomy 0.000 claims 1
- 235000013305 food Nutrition 0.000 abstract description 6
- 230000000694 effects Effects 0.000 abstract description 5
- 235000020673 eicosapentaenoic acid Nutrition 0.000 abstract description 5
- SBJKKFFYIZUCET-JLAZNSOCSA-N Dehydro-L-ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(=O)C1=O SBJKKFFYIZUCET-JLAZNSOCSA-N 0.000 abstract description 4
- 235000020669 docosahexaenoic acid Nutrition 0.000 abstract description 4
- 238000002360 preparation method Methods 0.000 abstract description 2
- 230000003471 anti-radiation Effects 0.000 abstract 3
- 235000019733 Fish meal Nutrition 0.000 abstract 2
- 239000004467 fishmeal Substances 0.000 abstract 2
- 230000002349 favourable Effects 0.000 abstract 1
- 230000002588 toxic Effects 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 241000699670 Mus sp. Species 0.000 description 28
- 235000019197 fats Nutrition 0.000 description 9
- HVYWMOMLDIMFJA-DPAQBDIFSA-N (3β)-Cholest-5-en-3-ol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 8
- 210000002784 Stomach Anatomy 0.000 description 8
- 206010009802 Coagulopathy Diseases 0.000 description 7
- 230000035602 clotting Effects 0.000 description 7
- 230000015271 coagulation Effects 0.000 description 7
- 206010021143 Hypoxia Diseases 0.000 description 6
- 241000699666 Mus <mouse, genus> Species 0.000 description 6
- 241000276707 Tilapia Species 0.000 description 6
- 239000012153 distilled water Substances 0.000 description 6
- 230000001146 hypoxic Effects 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 102100010684 COG2 Human genes 0.000 description 4
- 108060001710 COG2 Proteins 0.000 description 4
- 229940107161 Cholesterol Drugs 0.000 description 4
- 210000003743 Erythrocytes Anatomy 0.000 description 4
- 235000012000 cholesterol Nutrition 0.000 description 4
- 210000001185 Bone Marrow Anatomy 0.000 description 3
- 210000001736 Capillaries Anatomy 0.000 description 3
- 150000002632 lipids Chemical class 0.000 description 3
- 235000013372 meat Nutrition 0.000 description 3
- 210000004279 Orbit Anatomy 0.000 description 2
- 230000023555 blood coagulation Effects 0.000 description 2
- 210000002798 bone marrow cell Anatomy 0.000 description 2
- 210000004027 cells Anatomy 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000004223 radioprotective Effects 0.000 description 2
- 231100000486 side effect Toxicity 0.000 description 2
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 2
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 1
- 241000581650 Ivesia Species 0.000 description 1
- 210000001562 Sternum Anatomy 0.000 description 1
- 238000010241 blood sampling Methods 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 230000001488 breeding Effects 0.000 description 1
- ODINCKMPIJJUCX-UHFFFAOYSA-N calcium monoxide Chemical compound [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 235000019387 fatty acid methyl ester Nutrition 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000003000 nontoxic Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000001902 propagating Effects 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
Abstract
The invention provides a new use of clarias lazera, the clarias lazera is directly used as a medicine having anticancer and anti-radiation effect, or the clarias lazera, as a raw material, is used for the preparation of the medicine having anticancer and anti-radiation effect; or fishmeal of the clarias lazera is directly used as health care food or health care product. The invention sufficiently utilizes the characteristic of high DHA and EPA contents of the clarias lazera to prepare the medicine having anticancer and anti-radiation effect, and the medicine is hardly toxic and side-effected for human body and can be taken in for a long time; the fishmeal of the clarias lazera can also be directly used as or processed to the health care food, which is convenient for eating and favorable for the health of the human body.
Description
Technical field
The invention belongs to Fish comprehensive application technology field, more specifically relate to a kind of new purposes of Clarias fucsus.
Background technology
More rich DMA is arranged in the marine fish, EPA content, but most DHA and EPA content fewer in the fresh-water fishes of China's cultivating large area, and Clarias fucsus is an ominivore-fish, require low to growing environment, anti-condition of disease power is strong, is easy to a large amount of propagating and breedings, and fine and tender taste, fish spicule is less, very popular, but general how directly eating still do not seen the report of this fish medical value.More do not see might be applied to prepare anticancer,, the report of the medicine of radiation resistance, and existing anticancer,, the medicine Chinese medicine of radiation resistance is also few, mostly is Western medicine, has the shortcoming that human body is had certain toxicity, side effect.
Summary of the invention
The new purposes that the purpose of this invention is to provide a kind of Clarias fucsus makes full use of the fish flour preparation of Clarias fucsus, prepares the medicine of anticancer, antitumor, radiation resistance, or health product, and, side effect almost non-toxic to human body can eat for a long time.
The new purposes of Clarias fucsus of the present invention: described leather beard Nian * fish as raw material be used to prepare have anticancer, antitumor, the purposes of the medicine of radiation resistance; Perhaps the fish flour of described Clarias fucsus is directly as health food or health product.
Remarkable advantage of the present invention is: the present invention has good accent blood fat and prolongs clotting time of mice by discovering in the Clarias fucsus powder, improves mice hypoxia-bearing capability and swimming time, and good radioprotective and antitumor action are arranged; The deep processing of Clarias fucsus powder can be made dried fish floss, fillet, food and health product such as fish pill, to being engaged in computer for a long time, radar, the people of work high above the ground is edible to have the good effect of protecting of possessing, and particularly is that the low EPA content Clarias fucsus meat that DHA content is high again is more suitable for infants; Children ' s intelligence development there is effect.
The specific embodiment
With Clarias fucsus according to the method for routine (as with Clarias fucsus meat through steaming and decocting, squeeze, dry or dry, pulverize and make fish flour) be prepared into fish flour: with this fish flour as making raw material, medicine with anticancer, antitumor, radiation resistance, or health product.
Clarias fucsus is passed through steaming and decocting, squeezes, dries or dry, pulverizes and make fish flour, with this fish flour as raw material, in fish flour, add the smart powder of Ganoderma cryptogam and Ganoderma, by fish flour: the Ganoderma cryptogam: the smart powder weight ratio of Ganoderma is 4: 2: 4, mix after micronizing is made capsule, to become the tumor adjuvant drug or can be used for blood fat reducing, improve the medicine of immunologic function.
Clarias fucsus passes through steaming and decocting, squeezes, dries or dry, pulverizes and make fish flour, with this fish flour as raw material, in fish flour, add Fructus Mali pumilae center and the skin portion and the Radix Astragali, according to percentage by weight: fish flour 30%, the Fructus Mali pumilae center becomes dry powder 30% with leather, the Radix Astragali 40% mixes after extracting and makes the antiradiation drug composite capsule.
Below be several embodiments of the present invention, but the present invention is not limited only to this:
Embodiment 1
Clarias fucsus is passed through steaming and decocting, squeezes, dries or dry, pulverizes and make fish flour, with this fish flour as raw material, in fish flour, add Fructus Mali pumilae center and the skin and the Radix Astragali, according to mass percent: fish flour 30%, Fructus Mali pumilae center become dry powder 30%, the Radix Astragali 40% with leather, mix, after extracting, make capsule, become antiradiation drug.
Embodiment 2
Clarias fucsus is passed through steaming and decocting, squeezes, dries or dry, pulverizes and make fish flour, with this fish flour as raw material, in fish flour, add the smart powder of Ganoderma cryptogam and Ganoderma, by fish flour: the Ganoderma cryptogam: the smart powder mass ratio of Ganoderma is 4: 2: 4, mix after micronizing is made capsule, to become the tumor adjuvant drug or can be used for blood fat reducing, improve the medicine of immunologic function.
Embodiment 3
Clarias fucsus passes through steaming and decocting, squeezes, dries or dry, pulverizes and make fish flour, and further dried fish floss is made in deep processing, and health foods such as fillet or fish pill are edible.
Experimental section:
1 experimental technique
1.1 content of fatty acid: adopt the gas chromatographic analysis of animal and plant fat fatty acid methyl ester.
1.2 give the fish flour method: the fish flour adding distil water is mixed well, Clarias fucsus powder group (sample 1) is divided high dose group 6g/kg and low dose group 3g/kg, and tilapia powder (sample 2) 6g/.kg is after during administration the sample adding distil water being mixed well, the mouse stomach administration is irritated the stomach amount and is 0.3ml10g
-1, once a day, continuous 30 days.
1.3 experiment grouping
1.3.1 influence to mice Blood clotting and blood fat: 70 of cleaning level mices, be divided into 5 groups at random, promptly normal group is given normal feedstuff and is irritated the stomach distilled water, and high lipid food sub-model group is irritated stomach distilled water, sample 1 high dose group and low dose group 3g/kg; 2 groups in sample, 2h does the puncture of mouse orbit endocanthion with the capillary glass-tube after the administration in the 30th day, obtains 5 blood post, and capillary glass-tube one trifle that fractureed every 30 seconds is then observed to have or not and is glued filament (clotting strands) appearance.Record to the time that clotting strands occurs, is clotting time from the blood sampling of capillary glass-tube.Eye socket is got blood and is surveyed blood fat in addition, and carries out statistical procedures.
1.3.2 the influence to the mice hypoxia endurance time: 50 of kunming mices are divided into 4 groups at random, all to normal feedstuff, be that negative control group is irritated the stomach distilled water, sample 1 high dose group and low dose group, 2 groups in sample, 2h drops into mice and is equipped with in the 250ml port grinding bottle of 15g sodica calx after the administration in the 30th day, the record mouse diing time.
1.3.3 the influence to the mice swimming time: the kunming mice grouping reaches to the same 1.3.2 of sample method, 2h fastens mouse tail the load of body weight 10% after the administration in the 30th day, put into depth of water 30cm, 25 ℃ of water temperatures, mouse head submerged 10s carries out swimming test in the diameter 30cm drum, clocks, when can't emerge, be and be perfectly exhausted, (being the mice swimming time this moment) stops to clock.
1.3.4 the influence to raying mouse bone marrow cells micronuclear rates: 48 of ICR mices are divided into 4 groups at random, be normal group (non-radiating is irritated the stomach distilled water), the radiation component model group is irritated the stomach distilled water, high dose group and low dose group, the 27th day with 60C0 gamma-rays 3GY total irradiation once after the administration, continue to be administered to 30 days then (shining the back the 3rd day), mice is put to death, get bone marrow of sternum and survey bone marrow polychromatic erythrocyte micronuclear rates, 1000 polychromatic erythrocytes of every mice counting, micronuclear rates refers to contain the polychromatic erythrocyte number of micronucleus, and carries out * 2 statistical dispositions.
1.3.5 the influence heavy to the tumor-bearing mice tumor: 33 of ICR mices are divided into 3 groups at random, be that model group is irritated the stomach distilled water, high dose group and low dose group, successive administration 30 days, the 30th day inoculated tumour continues to be administered to the 10th day (totally 40 days), separates lump behind the execution mice, weigh, calculate tumor control rate.
2, experimental result:
Table 1 leather beard Nian and bolti unsaturated fatty acid relative amount (%)
| Fatty acid is formed | Leather beard Nian | Tilapia |
| C?140：0 | 0.8 | 2.3 |
| C?16：0 | 19.8 | 20.4 |
| C?16：1n7c | 3.2 | 3.9 |
| C?18；0 | 6.4 | 4.0 |
| C?18：1n7c | 3.5 | 2.2 |
| C?18：1n9c | 18.1 | 31.0 |
| C?18：2n6c | 10.3 | 19.6 |
| C?18：3n3c | 0.4 | 1.3 |
| C?18：3n6c | 0.1 | 1.0 |
| C?20：0 | 0.2 | 0.4 |
| C?20：1n9c | 2.2 | 1.7 |
| C?20：2n6c | 0.8 | 1.1 |
| C?20：3n6c | 0.5 | 0.9 |
| C?20：4n6c | 1.6 | 1.2 |
| C?20：5n3c | 1.9 | 0.1 |
| C?22：1n9c | 0.2 | 0.7 |
| C?22：5n3c | 3.4 | 0.7 |
| C?22：6n3c | 20.3 | 1.2 |
| C?24：1 | 0.3 | 0.0 |
| Other | 6.0 | 6.4 |
The influence of table 2 pair mice blood fat (X ± S)
The influence of table 3 pair mice Blood clotting (X ± S)
The result shows high lipid food model group cholesterol, and HDL and LDLC are remarkable, and height gives normal group, and the cholesterol of the high low dose group of Clarias fucsus powder and LDLC all significantly are lower than model group, and HDL is significantly higher than model group.Tilapia and model group be cholesterol relatively, and HDL and LDLC all do not have significant difference.High lipid food model group clotting time significantly is shorter than normal group, and compares the high low dose group utmost point of Clarias fucsus meat significant prolongation clotting time with model group.Tilapia and model group relatively do not have significant difference.
The influence of table 4 pair mice hypoxia endurance time (X ± S)
The result shows Clarias fucsus powder height, the equal significant prolongation mice of low dose group hypoxia endurance time.Tilapia also can significant prolongation mice hypoxia endurance time.
The influence of table 5 pair mice swimming time (X ± S)
The result shows the anti-swimming time of Clarias fucsus powder high dose group significant prolongation mice.Tilapia and model group be no significant difference relatively.
The influence of table 6 pair raying PCEMNR micronuclear rates
| Group | Micronucleus negative cells example number | Micronucleus positive cell example number | Add up to | P |
| Normal group | 10975 | 25 | 11000 | |
| Model group | 10835 | 165 | 11000 | △△P<0.01 |
| Sample 1 high dose group | 9916 | 84 | 10000 | **P<0.01 |
| Sample 1 low dose group | 10911 | 89 | 11000 | **P<0.01 |
Annotate: compare with model group,
*P＜0.05,
*P＜0.01
Compare △ P＜0.05, △ △ P＜0.01 with normal group
The result shows and is subjected to
60C
0Model group mouse bone marrow cells survey bone marrow polychromatic erythrocyte micronuclear rates significantly raises after the radiation.And Clarias fucsus powder height, low dose group all extremely significantly reduces micronuclear rates.
The influence that table 7 pair S180 mice with tumor tumor weighs (X ± S)
| Group | Dosage (g/kg) | Tumor heavy (g) | Suppression ratio (%) |
| Model group | 30ml | 1.62±0.28 | |
| Sample 1 high dose group | 6 | 1.28±0.80 | 27 |
| Sample 1 low dose group | 3 | 1.00±0.24 | 36 |
To S
180The influence of tumor-bearing mice tumor: (seeing Table 7) result shows Clarias fucsus powder height, and the tumour inhibiting rate of low dose group reaches 27% and 36% respectively.
3, conclusion:
Clarias fucsus powder unsaturated fatty acid particularly DHA and EPA content is higher, can significantly reduce cholesterol and the LDLC content of high fat mice, significantly improves HDL content.The clotting time of the high fat mice of significant prolongation.Significant prolongation mice hypoxia endurance time, and have certain radioprotective and antitumor action.
Claims (7)
1. the new purposes of a Clarias fucsus is characterized in that: described Clarias fucsus is directly as the medicine with antitumor, radiation resistance, perhaps Clarias fucsus as raw material be used to prepare have, the purposes of the medicine of antitumor, radiation resistance.
2. the new purposes of Clarias fucsus according to claim 1 is characterized in that: described Clarias fucsus is made into fish flour, the pharmacy type that refabrication becomes to use always.
3. the new purposes of Clarias fucsus according to claim 1, it is characterized in that: the flesh of fish of described Clarias fucsus is made into fish flour, is used to prepare the medicine of anticancer, antitumor, radiation resistance as raw material.
4. the new purposes of Clarias fucsus according to claim 3, it is characterized in that: Clarias fucsus passes through steaming and decocting, squeezes, dries or dry, pulverizes and make fish flour, with this fish flour as raw material, in fish flour, add the smart powder of Ganoderma cryptogam and Ganoderma, by fish flour: Ganoderma spore powder: the smart powder weight ratio of Ganoderma is 4: 2: 4, mix after micronizing is made capsule, will become the tumor adjuvant drug or can be used for blood fat reducing, improve the medicine of immunologic function.
5. the new purposes of Clarias fucsus according to claim 3, it is characterized in that: Clarias fucsus passes through steaming and decocting, squeezes, dries or dry, pulverizes and make fish flour, with this fish flour as raw material, in fish flour, add Fructus Mali pumilae center and the skin portion and the Radix Astragali, according to percentage by weight: fish flour 30%, the Fructus Mali pumilae center becomes dry powder 30% with leather, the Radix Astragali 40% mixes after extracting and makes the antiradiation drug composite capsule.
6. the new purposes of a Clarias fucsus, it is characterized in that: the fish flour of described Clarias fucsus is as health food or health product.
7. the new purposes of Clarias fucsus according to claim 2, it is characterized in that: the fish flour of described Clarias fucsus is processed into dried fish floss, fillet or fish pill health food.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009101109250A CN101530429B (en) | 2009-01-20 | 2009-01-20 | New use of clarias lazera |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009101109250A CN101530429B (en) | 2009-01-20 | 2009-01-20 | New use of clarias lazera |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101530429A true CN101530429A (en) | 2009-09-16 |
| CN101530429B CN101530429B (en) | 2011-07-20 |
Family
ID=41101424
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009101109250A Expired - Fee Related CN101530429B (en) | 2009-01-20 | 2009-01-20 | New use of clarias lazera |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101530429B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102178280A (en) * | 2011-04-22 | 2011-09-14 | 朱劲丰 | Dry-braised catfish meat with leaf mustard |
| WO2012006934A1 (en) * | 2010-07-12 | 2012-01-19 | 深圳精益油脂技术有限公司 | Pangasianodon gigas oil, use thereof, and method of preparing human milk fat substitute |
-
2009
- 2009-01-20 CN CN2009101109250A patent/CN101530429B/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012006934A1 (en) * | 2010-07-12 | 2012-01-19 | 深圳精益油脂技术有限公司 | Pangasianodon gigas oil, use thereof, and method of preparing human milk fat substitute |
| CN102178280A (en) * | 2011-04-22 | 2011-09-14 | 朱劲丰 | Dry-braised catfish meat with leaf mustard |
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| Publication number | Publication date |
|---|---|
| CN101530429B (en) | 2011-07-20 |
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Granted publication date: 20110720 Termination date: 20140120 |