CN101422430A

CN101422430A - Ketoconazole m-thymol liquor for treating skin tinea

Info

Publication number: CN101422430A
Application number: CNA2008101839244A
Authority: CN
Inventors: 张小冬
Original assignee: Individual
Current assignee: Individual
Priority date: 2008-12-09
Filing date: 2008-12-09
Publication date: 2009-05-06
Anticipated expiration: 2028-12-09
Also published as: CN101422430B

Abstract

The invention discloses ketoconazole thymol liquid for curing itches. Ketoconazole and thymol are dissolved in dimethyl sulfoxide and ethanol, thus forming compound liquid with stable characteristics; and the liquid is used for curing various skin tineas diseases and is a compound external preparation aiming at fast effect and non-recurrence after healing.

Description

Ketoconazole m-thymol liquor for treating skin tinea

Affiliated technical field

The present invention relates to treat a kind of externally used compound preparation of dermatophytosis.Strengthen the penetrance of medicine by solvent, fill part antibacterial and germ-resistant double pharmacological action of performance medicine, do not taking and/or during the injectable drug treatment, reaching treatment and stop the purpose that dermatophytosis recurs human body skin.

Background technology

At present, the known external that contains ketoconazole is controlled the tinea preparation and is adopted happy shampoo and suitable peak health king cream.Ketoconazole is a kind of broad-spectrum antifungal medicine, breeds the purpose that reaches treatment to suppress fungi growth.In order to improve antiphlogistic effects, normal and corticosteroid medication is compatible.In clinical practice, find:

1, dermatophytosis Chang Fanfu outbreak is not easy thorough healing, analyzes its reason:

(1) may can not be penetrated into Intradermal well with medicine:

(2) antifungal drug can not thoroughly be killed fungus.Prolonged and repeated application very easily produces drug resistance, makes the reduction of antifungal drug curative effect or loses therapeutical effect.

2, some suffers from the people of dermatophytosis, and external application contains the corticosteroid hormone medicine, can cause contact hypersensitivity, and skin capillary vascular expansion can appear in prolonged application, untoward reaction such as epidermis attenuation, striae atrophicae.

In sum, the treatment dermatophytosis is badly in need of a kind of instant effect of research and development, curative effect is medicament completely.

Summary of the invention

The core that solves the dermatophytosis treatment is thoroughly to cure to stop recurrence.Studied a kind for the treatment of both the principal and secondary aspects of a disease for this reason, based on the prescription that effects a permanent cure, promptly antibacterial, sterilization and usefulness, itch stopping and diminish inflammation again simultaneously.

The formation of prescription: this prescription is by the stable transparent mixture solution of ketoconazole, thymol, dimethyl sulfoxide and ethanol composition and property.

The technical scheme that is adopted: prove that through clinical practice more than 2 years concentration (quality) scope of three kinds of major constituents of this compound preparation is: ketoconazole 0.5-3%, thymol 0.5-1%, dimethyl sulfoxide 30-70%.All the other are ethanol, and concentration is 26%-69%.Three kinds of compound preparations that major constituent adopts the mutual compatibility of any concentration (content) to form in its concentration range, the therapeutic effect that its therapeutic effect is used than independent component is more remarkable.

Embodiment: ketoconazole, the thymol that will set concentration weigh up after the weight, are dissolved in earlier in the dimethyl sulfoxide of setting concentration, after waiting to dissolve, are diluted with ethanol to full dose, and mixing can be used.In these three kinds of component concentration ranges, can prepare the medicable ketoconazole m-thymol liquor for treating skin tinea that concentration of component more than ten kinds (content) has nothing in common with each other through permutation and combination.

Specific embodiment 1: 5 gram ketoconazoles, 5 gram thymols are dissolved in the 300 gram dimethyl sulfoxide, treat to dissolve fully the back and add 690 gram ethanol, stir evenly can packing standby.

Specific embodiment 2: 5 gram ketoconazoles, 5 gram thymols are dissolved in the 700 gram dimethyl sulfoxide, treat to dissolve fully the back and add 290 gram ethanol, stir evenly can packing standby.

Specific embodiment 3: 30 gram ketoconazoles, 10 gram thymols are dissolved in the 300 gram dimethyl sulfoxide, treat to dissolve fully the back and add 660 gram ethanol, stir evenly can packing standby.

Specific embodiment 4: 30 gram ketoconazoles, 10 gram thymols are dissolved in the 700 gram dimethyl sulfoxide, treat to dissolve fully the back and add 260 gram ethanol, stir evenly can packing standby.

Specific embodiment 5: 10 gram ketoconazoles, 8 gram thymols are dissolved in the 500 gram dimethyl sulfoxide, treat to dissolve fully the back and add 482 gram ethanol, stir evenly can packing standby.

The characteristics of this prescription:

1, the proportioning of each composition of this prescription obtains through test of many times, can obtain best therapeutic effect.

2, each component compatibility is good in the solution, forms clear solution;

3, ketoconazole not only suppresses fungal spore but also has the spore of inhibition to change mycelial effect into.The thymol bactericidal action is strong, and is especially stronger to fungus and actinomycetic effect, and itching-relieving action is arranged;

4, dimethyl sulfoxide as solvent and transdermal agent, not only is dissolved in the solvent ketoconazole and thymol, and makes it penetrate epidermis in this prescription, strengthens at the antibacterial and germ-resistant double pharmacological action of Intradermal.In addition, dimethyl sulfoxide also has antiinflammatory, pain relieving, antibacterial, promotes effects such as wound healing.

5, this prescription does not contain corticosteroid medication, can not produce untoward reaction such as contact allergy and steroid-dependent dermatitis to skin.

Beneficial effect of the present invention is to use this prescription treatment dermatophytosis in clinical practice, instant effect, discovery recurrence after the healing.From 18,2 years 18 days to 2008 on January of January in 2006, use this prescription, treat example surplus the various dermatophytosis patients 400 at random in outpatient service.Simple small size dermatophytosis generally can reach clinical basic healing about 72 hours.Serious dermatophytosis generally can be cured in three months fully.Have only 3 examples in the example because of suffering from the dermatophytosis patient of chronic disease surplus 400, healing time surpasses three months, accounts for 0.7% of total routine number

Now be exemplified below:

Example 1 week * *, man 35 years old, the Yongji County peasant suffers from pityriasis versicolor go to a doctor on January 28th, 2006 treatment three weeks recovery from illness, recurrence so far.2 maos of examples * *, the man, 45 years old, plentiful Er Dao township peasant, suffer from Pasfulosis palmaris et plantaris type tinea manus and pedis, merge tinea unguium, chap, fall ill and to work in nearly 2 years, do not heal through multi-treatment, go to a doctor on February 5th, 2006, treated less than 3 months with this prescription, tinea manus and pedis, tinea unguium, all healings of chapping, not recurrence in existing 20 months so far.

Example 3 Xu * *, the woman, 32 years old, the workman of minicar factory suffered from tinea corporis for many years, goes to a doctor on February 26th, 2007, and patient's tinea corporis whole body is sent out, and uses this medicine through treatment recovery from illness in 37 days, not recurrence so far.

Example 4 left sides *, man, 29 years old, teacher, tinea cruris.When going to a doctor on July 10th, 2007,1/3 inboard on the pubis, on the pudendum, two buttocks, both thighs is dispersed in the distribution beans to the facies palmaris size, circular scarlet the edge is with papulovesicle to the kermesinus speckle, and the rash face has scratch and blood crusts, lie awake all night, through two weeks treatment recovery from illness not recurrence so far.

Example 5 Lee * *, man, 20 years old, the workman, the head kerion, December was gone to a doctor on the 8th in 2007, and full head is covered with the alopecia areata of beans to the monobasic coin-size, and the lump of 3 Ovum Columba livia sizes arranged, have pus and blood to flow out during extruding, further consultation part alopecia areata begins to grow hair after ten days, and lump dwindles, there is not new pustulation to occur, through a treatment recovery from illness in month.

In addition, this prescription also has better curative effect to some cureless eczema (external ear, scrotum, crissum etc.), pruritus vulvae, Perioral Dermatitis etc.

Claims

1, a kind of ketoconazole m-thymol liquor for treating skin tinea, by ketoconazole, two kinds of medicine dissolutions of thymol in dimethyl sulfoxide and alcohol solvent, form the solution of treatment dermatophytosis, it is characterized in that: each concentration of component is ketoconazole 0.5-3%, thymol 0.5-1%, dimethyl sulfoxide 30-70%, ethanol 26%-69%.