CN101394844A - 甲氧基聚乙二醇硫酯螯合物及其用途 - Google Patents

甲氧基聚乙二醇硫酯螯合物及其用途 Download PDF

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Publication number
CN101394844A
CN101394844A CNA200780007327XA CN200780007327A CN101394844A CN 101394844 A CN101394844 A CN 101394844A CN A200780007327X A CNA200780007327X A CN A200780007327XA CN 200780007327 A CN200780007327 A CN 200780007327A CN 101394844 A CN101394844 A CN 101394844A
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CN
China
Prior art keywords
compound
pharmaceutically acceptable
acid
patient
free radical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA200780007327XA
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English (en)
Chinese (zh)
Inventor
K·A·谢伦伯格
F·A·拉坦齐奥
J·谢弗
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eastern Virginia Medical School
Original Assignee
Eastern Virginia Medical School
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eastern Virginia Medical School filed Critical Eastern Virginia Medical School
Publication of CN101394844A publication Critical patent/CN101394844A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/28—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/18—Antioxidants, e.g. antiradicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/04—Chelating agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Steroid Compounds (AREA)
CNA200780007327XA 2006-02-14 2007-02-14 甲氧基聚乙二醇硫酯螯合物及其用途 Pending CN101394844A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77287406P 2006-02-14 2006-02-14
US60/772,874 2006-02-14

Publications (1)

Publication Number Publication Date
CN101394844A true CN101394844A (zh) 2009-03-25

Family

ID=38372058

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA200780007327XA Pending CN101394844A (zh) 2006-02-14 2007-02-14 甲氧基聚乙二醇硫酯螯合物及其用途

Country Status (8)

Country Link
US (3) US8008347B2 (https=)
EP (2) EP1986631B1 (https=)
JP (2) JP5138612B2 (https=)
CN (1) CN101394844A (https=)
AT (1) ATE552833T1 (https=)
AU (1) AU2007215211B2 (https=)
CA (1) CA2642453A1 (https=)
WO (1) WO2007095178A2 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1986631B1 (en) 2006-02-14 2012-04-11 Eastern Virginia Medical School Methoxypolyethylene glycol thioester chelate and uses thereof
WO2010035768A1 (ja) * 2008-09-25 2010-04-01 参天製薬株式会社 ポリアルキレングリコールを有効成分として含有する網膜疾患の予防又は治療剤
TWI568453B (zh) * 2011-11-22 2017-02-01 原創生醫股份有限公司 具有螯合型複合微胞之藥物載體及其應用
JP6086576B2 (ja) * 2012-04-24 2017-03-01 公立大学法人首都大学東京 抗酸化剤
WO2018236221A2 (en) * 2017-06-03 2018-12-27 Can Holding B.V. Neurodegenerative peptide deposit dissolution

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4352751A (en) * 1979-09-10 1982-10-05 Analytical Radiation Corporation Species-linked diamine triacetic acids and their chelates
JP2722250B2 (ja) 1989-05-30 1998-03-04 興和株式会社 新規なジアミン化合物及びこれを含有する脳機能障害改善剤
JPH0680964A (ja) * 1991-12-27 1994-03-22 Sogo Yatsukou Kk 活性酸素消去剤
EP0955044B1 (en) * 1995-06-26 2005-11-16 Chelator LLC Method of inhibiting bacterial or fungal growth using a complexing agent
AU7454796A (en) 1995-10-20 1997-05-07 Eastern Virginia Medical School Chelate derivatives as protectors against tissue injury
US6020373A (en) * 1995-10-20 2000-02-01 Eastern Virginia Medical School Chelate derivatives as protectors against tissue injury
NZ540885A (en) * 2002-12-20 2009-02-28 Chakshu Res Inc Ophthalmic formulation for the prevention and treatment of ocular conditions
EP1986631B1 (en) * 2006-02-14 2012-04-11 Eastern Virginia Medical School Methoxypolyethylene glycol thioester chelate and uses thereof

Also Published As

Publication number Publication date
CA2642453A1 (en) 2007-08-23
US20080039524A1 (en) 2008-02-14
EP1986631A4 (en) 2010-10-27
EP1986631A2 (en) 2008-11-05
JP2012031173A (ja) 2012-02-16
JP5138612B2 (ja) 2013-02-06
WO2007095178A3 (en) 2008-04-17
WO2007095178A2 (en) 2007-08-23
US7388028B2 (en) 2008-06-17
EP2428234A1 (en) 2012-03-14
US8008347B2 (en) 2011-08-30
US20120016030A1 (en) 2012-01-19
ATE552833T1 (de) 2012-04-15
US20090306205A1 (en) 2009-12-10
US8796336B2 (en) 2014-08-05
JP2009527474A (ja) 2009-07-30
AU2007215211B2 (en) 2010-08-26
EP1986631B1 (en) 2012-04-11
AU2007215211A1 (en) 2007-08-23

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Effective date of abandoning: 20151104

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