CN101367744B - Method for extracting glutamic acid - Google Patents

Method for extracting glutamic acid Download PDF

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Publication number
CN101367744B
CN101367744B CN2008101397145A CN200810139714A CN101367744B CN 101367744 B CN101367744 B CN 101367744B CN 2008101397145 A CN2008101397145 A CN 2008101397145A CN 200810139714 A CN200810139714 A CN 200810139714A CN 101367744 B CN101367744 B CN 101367744B
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glutamic acid
stir
jar
liquid
settlement
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CN101367744A (en
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王均成
赵兰坤
李德衡
刘化丹
刘元涛
徐国华
李树标
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Baoji Fufeng Biotechnologies Co., Ltd.
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BAOJI FUFENG BIOTECHNOLOGIES Co Ltd
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Abstract

The present invention discloses a method of extracting glutamic acid, which is realized through an improvement based on the prior art. In the method, mixing and washing procedures are added; impurities adhered to the surface of crystallized glutamic acid are effectively dissolved in mother liquor; and thus the effects of purification and separation can be realized. Compared with the traditional technology, the stages of mechanical centrifugal separation and packaging and transportation of solid semi-finished products are reduced in the present invention; and the mixing and washing processes are added to fully eliminate the impurities adhered to the surface of the glutamic acid, so as to perform purification effects. The present invention can realize the wholly automatic and continuous transportation of mixture of solid materials and liquid materials, so as to completely eliminate the mechanical centrifuge and to avoid high-intensity manual labor of packaging, transportation, material feeding and so on; simultaneously, the loss of the glutanic acid is reduced, thereby improving the efficiency and saving a large quantity of labor power, material resources and equipment investment.

Description

A kind of method of extracting glutamic acid
Technical field the invention belongs to the glutamic acid fermentation production technical field, relates to a kind of method of extracting glutamic acid.
Background technology is extracted L-glutamic acid both at home and abroad has a lot of process for extracting, and glutamic acid extraction method commonly used has isoelectric point method, ion exchange method, metal-salt method and ion-exchange membrane electrodialysis method etc.At present, domestic many producers adopt isoelectric point method to extract L-glutamic acid, mainly utilize L-glutamic acid be amphotericeledrolyte character, fermentating liquid acidification is transferred the isoelectric pH 3.22 of pH to L-glutamic acid, the L-glutamic acid deposition is separated out.
In galvanic process such as traditional; Carry out once after finishing with clear liquid solidliquid mixture to be pumped in the high-order basin when settlement separate Deng charge neutrality; Flow into angle type centrifuge from high-order basin then and carry out centrifugal purification; Solid after the separation will pass through hand-filling and be transported to and dissolve brilliant operation, packaged solid L-glutamic acid is put into dissolved in brilliant jar then, to obtain higher, the better L-glutamic acid of quality of purity.
Galvanic process such as traditional is extracted L-glutamic acid and is had following shortcoming:
1), according to 10,000 tons of L-glutamic acid meters of spinning: power consumption 300,000 is spent, and not only facility investment is big, and energy consumption is high;
2), consume 15 pairs of screen clothes, be worth about 20,000 yuan, pack, transport and the link that feeds intake is wanted recruitment about 6000 work days, 360,000 yuan of expenses need in the wrapping process to consume 200,000 of packing materials, are worth about 400,000 yuan, the material consumption height;
3), in the entire operation process, the rate of loss of L-glutamic acid is about 0.3%, about 180,000 yuan of loss.
Summary of the invention the objective of the invention is to solve the technical problem that the prior art power consumption is high, production cost is high and the L-glutamic acid rate of loss is high, a kind of method of extracting glutamic acid is provided, to overcome the deficiency of prior art.
Technical scheme of the present invention is to improve realization on the basis of existing technology, in this method, has set up to mix and has stirred washing procedure, can the impurity attached to crystallization L-glutamic acid surface effectively be dissolved in the mother liquor, therefore can play the isolating effect of purifying.The concrete operations step of novel method is following:
Charge neutrality cooling such as 1): after fermented liquid changes over to and waits the electricity jar; Convert and add an amount of high stream according to producing sour situation, volume is 15~20%, slowly transfers pH to 3.2 with hydrolyzed solution or the high stream of pH1.5 acidizing fluid; And be cooled to 5~10 ℃ gradually, let the L-glutamic acid sufficient crystallising in the fermented liquid separate out;
2) once settlement separate: fermented liquid stops to stir after isoelectric point crystallization finishes, and leaves standstill 6~10 hours; Supernatant liquid is pumped into ion-exchange process to be handled; Bottom negative area clear liquid pumps into the cooling jar, is cooled to 5~10 ℃, is transported to settlement separator and carries out once settlement separate;
3) mix and to stir washing: the solid glutamic acid after the first separation is pumped into to mix stir jar; Transferring a mixed weight ratio of stirring the feed liquid solid content in the jar with the metacrystal mother liquor is 50%; Transfer pH3.8~4.0 with sodium hydroxide lye; Stir 30~60min; Speed of agitator is controlled at 30r/min, impurity attached to glutamic acid surface fully is dissolved in the mother liquor goes;
4) secondary settlement separates: mix and stir after washing finishes, stop to stir, left standstill 3.5~4.5 hours, pump into the hydrolyzing process processing that is hydrolyzed to supernatant liquid, the clear liquid in the bottom feed liquid pumps into the secondary settlement jar;
5) dissolve crystalline substance: pour the solid L-glutamic acid of secondary settlement with the filter washing lotion and dissolve in brilliant jar, transfer pH4.6 ± 0.2 with sodium hydroxide lye or sodium glutamate mother liquid, the adjusting feed concentration is 28~30Be ', 50 ± 5 ℃ of feeding steam attemperation;
6) metacrystal: dissolve behind brilliant the end again through the secondary purification processes, draw cold cooling after, separate to obtain quality L-glutamic acid preferably with filter, directly get into the monosodium glutamate refining step.
Novel process of the present invention has reduced mechanical spinning and packing solid work in-process transit link than traditional technology, has increased to mix and has stirred washing process, mixes to stir washing and can remove the impurity attached to the L-glutamic acid surface fully, plays the effect of purification.This technology can realize the solidliquid mixture material conveying of full-automatic serialization; Thereby it is centrifugal to give up machinery fully; Avoid high-intensity manpower work such as hand-filling, transportation and manual work feed intake; Thereby the loss that reduces L-glutamic acid simultaneously improves yield, has saved great amount of manpower and material resources and facility investment.
Compare with traditional technology; Ten thousand tons of L-glutamic acid production capacities reduce by 500,000 yuan of facility investments, practice thrift power consumption 300,000 kilowatt-hours, can reduce 5000 work days of recruitment; Practice thrift 200,000 of packing materials; The loss 0.3% that reduces cost, promptly ten thousand tons of L-glutamic acid production capacities are annual cost-saved more than 106 ten thousand yuan, have favorable economic benefit and social benefit.
Practice thrift pricing:
Ten thousand yuan of 300000 kilowatt-hours * 0.6 yuan+5000 work day * 60 yuan+200000 * 2 yuan+10000 * 0.3%=106
This invention simultaneously can directly be transformed on traditional technology basis, and ten thousand tons of throughput improvement costs only need several ten thousand yuan, and the cycle is short, therefore in whole glutamic acid fermentation industry, has high promotional value.
Appended drawings is a process flow diagram of the present invention.
Embodiment
The method concrete operations step of embodiment 1 extracting glutamic acid of the present invention is following:
Charge neutrality cooling such as 1): fermented liquid is slowly transferred pH to 3.2 with hydrolyzed solution, and is cooled to 5 ℃ gradually after changing over to and waiting the electricity jar, lets the L-glutamic acid sufficient crystallising in the fermented liquid separate out;
2) once settlement separate: fermented liquid stops to stir after isoelectric point crystallization finishes, and leaves standstill 8 hours; Supernatant liquid is pumped into ion-exchange process to be handled; Bottom negative area clear liquid pumps into the cooling jar, is cooled to 6 ℃, is transported to settlement separator and carries out once settlement separate;
3) mix and to stir washing: the solid glutamic acid after the first separation is pumped into to mix stir jar; Transferring a mixed weight ratio of stirring the feed liquid solid content in the jar with the metacrystal mother liquor is 50%; Transfer pH3.8 with sodium hydroxide lye; Stir 50min; Speed of agitator is controlled at 30r/min, impurity attached to glutamic acid surface fully is dissolved in the mother liquor goes;
4) secondary settlement separates: mix and stir after washing finishes, stop to stir, left standstill 4 hours, pump into the hydrolyzing process processing that is hydrolyzed to supernatant liquid, the clear liquid in the bottom feed liquid pumps into the secondary settlement jar;
5) dissolve crystalline substance: pour the solid L-glutamic acid of secondary settlement with the filter washing lotion and dissolve in brilliant jar, transfer pH4.6 ± 0.2 with sodium hydroxide lye, the adjusting feed concentration is 28Be ', feeds 50 ± 5 ℃ of steam attemperation;
6) metacrystal: dissolve behind brilliant the end again through the secondary purification processes, draw cold cooling after, with filter separate L-glutamic acid, get into the monosodium glutamate refining step.
Embodiment 2 is according to embodiment 1, and the concrete operations step is following:
Charge neutrality cooling such as 1): fermented liquid flows acidizing fluid with the pH1.5 height and slowly transfers pH to 3.2, and be cooled to 9 ℃ gradually after changing over to and waiting electricity jar, lets the L-glutamic acid sufficient crystallising in the fermented liquid separate out;
2) once settlement separate: fermented liquid stops to stir after isoelectric point crystallization finishes, and leaves standstill 10 hours; Supernatant liquid is pumped into ion-exchange process to be handled; Bottom negative area clear liquid pumps into the cooling jar, is cooled to 5 ℃, is transported to settlement separator and carries out once settlement separate;
3) mix and to stir washing: the solid glutamic acid after the first separation is pumped into to mix stir jar; Transferring a mixed weight ratio of stirring the feed liquid solid content in the jar with the metacrystal mother liquor is 50%; Transfer pH4.0 with sodium hydroxide lye; Stir 60min; Speed of agitator is controlled at 30r/min, impurity attached to glutamic acid surface fully is dissolved in the mother liquor goes;
4) secondary settlement separates: mix and stir after washing finishes, stop to stir, left standstill 4 hours, pump into the hydrolyzing process processing that is hydrolyzed to supernatant liquid, the clear liquid in the bottom feed liquid pumps into the secondary settlement jar;
5) dissolve crystalline substance: pour the solid L-glutamic acid of secondary settlement with the filter washing lotion and dissolve in brilliant jar, transfer pH4.6 ± 0.2 with sodium glutamate mother liquid, the adjusting feed concentration is 28Be ', feeds 50 ± 5 ℃ of steam attemperation;
6) metacrystal: dissolve behind brilliant the end again through the secondary purification processes, draw cold cooling after, separate to obtain quality L-glutamic acid preferably with filter, directly get into the monosodium glutamate refining step.

Claims (1)

1. the method for an extracting glutamic acid is characterized in that by following process step operation:
Charge neutrality cooling such as 1): fermented liquid is slowly transferred pH to 3.2 with hydrolyzed solution or the high acidizing fluid that flows of pH1.5, and is cooled to 5~10 ℃ gradually after changing over to and waiting electricity jar, lets the L-glutamic acid sufficient crystallising in the fermented liquid separate out;
2) once settlement separate: fermented liquid stops to stir after isoelectric point crystallization finishes, and leaves standstill 6~10 hours; Supernatant liquid is pumped into ion-exchange process to be handled; Bottom negative area clear liquid pumps into the cooling jar, is cooled to 5~10 ℃, is transported to settlement separator and carries out once settlement separate;
3) mix and to stir washing: the solid glutamic acid after the first separation is pumped into to mix stir jar; Transferring a mixed weight ratio of stirring the feed liquid solid content in the jar with the metacrystal mother liquor is 50%; Transfer pH3.8~4.0 with sodium hydroxide lye; Stir 30~60min; Speed of agitator is controlled at 30r/min, impurity attached to glutamic acid surface fully is dissolved in the mother liquor goes;
4) secondary settlement separates: mix and stir after washing finishes, stop to stir, left standstill 3.5~4.5 hours, pump into the hydrolyzing process processing that is hydrolyzed to supernatant liquid, the clear liquid in the bottom feed liquid pumps into the secondary settlement jar;
5) dissolve crystalline substance: pour the solid L-glutamic acid of secondary settlement with the filter washing lotion and dissolve in brilliant jar, transfer pH4.6 ± 0.2 with sodium hydroxide lye or sodium glutamate mother liquid, the adjusting feed concentration is 28~30Be ', 50 ± 5 ℃ of feeding steam attemperation;
6) metacrystal: dissolve behind brilliant the end again through the secondary purification processes, draw cold cooling after, separate to obtain quality L-glutamic acid preferably with filter, directly get into the monosodium glutamate refining step.
CN2008101397145A 2008-08-30 2008-08-30 Method for extracting glutamic acid Active CN101367744B (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102028179B (en) * 2009-09-30 2013-10-30 湖州欣和环境科技有限公司 Method for refining gourmet powder mother liquor
CN105111097A (en) * 2015-09-14 2015-12-02 宝鸡阜丰生物科技有限公司 Refining technology for glutamic acid
CN113072457A (en) * 2021-04-07 2021-07-06 华东理工大学 Method for freezing, concentrating and isoelectric point crystallizing glutamic acid

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1063024A (en) * 1992-02-14 1992-07-29 姚书婷 The production method of a kind of baste and extraction glutamic acid
CN1312245A (en) * 2001-02-13 2001-09-12 盛自华 Glutamic acid extracting process from fermentation liquid
CN1429812A (en) * 2002-01-03 2003-07-16 刘世斋 Glutamic acid extraction method
CN101103803A (en) * 2007-07-30 2008-01-16 山东阜丰生物科技开发有限公司 Glutamic acid crystalloblastic technology

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1063024A (en) * 1992-02-14 1992-07-29 姚书婷 The production method of a kind of baste and extraction glutamic acid
CN1312245A (en) * 2001-02-13 2001-09-12 盛自华 Glutamic acid extracting process from fermentation liquid
CN1429812A (en) * 2002-01-03 2003-07-16 刘世斋 Glutamic acid extraction method
CN101103803A (en) * 2007-07-30 2008-01-16 山东阜丰生物科技开发有限公司 Glutamic acid crystalloblastic technology

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