CN101366875B - Quality control method and uses of antirheumatic medicament - Google Patents
Quality control method and uses of antirheumatic medicament Download PDFInfo
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- CN101366875B CN101366875B CN2008100164383A CN200810016438A CN101366875B CN 101366875 B CN101366875 B CN 101366875B CN 2008100164383 A CN2008100164383 A CN 2008100164383A CN 200810016438 A CN200810016438 A CN 200810016438A CN 101366875 B CN101366875 B CN 101366875B
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- antirheumatic
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- 239000003435 antirheumatic agent Substances 0.000 title claims abstract description 26
- 239000003814 drug Substances 0.000 title claims abstract description 26
- 230000003356 anti-rheumatic effect Effects 0.000 title claims abstract description 18
- 238000003908 quality control method Methods 0.000 title abstract description 14
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims abstract description 96
- 238000002360 preparation method Methods 0.000 claims abstract description 33
- 239000003826 tablet Substances 0.000 claims abstract description 28
- 238000000034 method Methods 0.000 claims abstract description 27
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 25
- 239000002775 capsule Substances 0.000 claims abstract description 20
- 239000008187 granular material Substances 0.000 claims abstract description 19
- 239000000284 extract Substances 0.000 claims abstract description 17
- 239000006187 pill Substances 0.000 claims abstract description 17
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- 238000012360 testing method Methods 0.000 claims description 25
- 238000005303 weighing Methods 0.000 claims description 25
- JRHMMVBOTXEHGJ-UHFFFAOYSA-N daphnoretin Chemical compound C1=CC(=O)OC2=CC(OC3=CC=4C=C(C(=CC=4OC3=O)O)OC)=CC=C21 JRHMMVBOTXEHGJ-UHFFFAOYSA-N 0.000 claims description 23
- UJRSXAFBORHKBS-UHFFFAOYSA-N daphnoretin Natural products COC1=CC2C=C(Oc3ccc4C=CC(=O)Oc4c3)C(=O)OC2C=C1O UJRSXAFBORHKBS-UHFFFAOYSA-N 0.000 claims description 23
- LFBIHCZSRPAPHS-UHFFFAOYSA-N rutamontine Natural products COc1cc2OC(=O)C(=Cc2cc1O)Oc3ccc4C=CC(=O)Oc4c3 LFBIHCZSRPAPHS-UHFFFAOYSA-N 0.000 claims description 23
- 238000000605 extraction Methods 0.000 claims description 21
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- 239000007788 liquid Substances 0.000 claims description 12
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- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 9
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 9
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 9
- 238000000227 grinding Methods 0.000 claims description 9
- 239000002904 solvent Substances 0.000 claims description 9
- 230000004580 weight loss Effects 0.000 claims description 9
- 238000001816 cooling Methods 0.000 claims description 8
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 6
- 241000628997 Flos Species 0.000 claims description 5
- 239000000469 ethanolic extract Substances 0.000 claims description 5
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims description 4
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims description 4
- 239000012088 reference solution Substances 0.000 claims description 4
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 3
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 3
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- 239000000945 filler Substances 0.000 claims description 3
- 239000010410 layer Substances 0.000 claims description 3
- YTJSFYQNRXLOIC-UHFFFAOYSA-N octadecylsilane Chemical compound CCCCCCCCCCCCCCCCCC[SiH3] YTJSFYQNRXLOIC-UHFFFAOYSA-N 0.000 claims description 3
- 239000000377 silicon dioxide Substances 0.000 claims description 3
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 3
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 3
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims description 2
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- 239000007791 liquid phase Substances 0.000 claims 1
- 239000008188 pellet Substances 0.000 claims 1
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- ATEFPOUAMCWAQS-UHFFFAOYSA-N 7,8-dihydroxycoumarin Chemical compound C1=CC(=O)OC2=C(O)C(O)=CC=C21 ATEFPOUAMCWAQS-UHFFFAOYSA-N 0.000 abstract description 19
- YBGKGTOOPNQOKH-UHFFFAOYSA-N daphnetin Natural products OC1=CC=CC2=C1OC(=O)C=C2O YBGKGTOOPNQOKH-UHFFFAOYSA-N 0.000 abstract description 19
- 238000004128 high performance liquid chromatography Methods 0.000 abstract description 8
- 238000001514 detection method Methods 0.000 abstract description 6
- 241001104043 Syringa Species 0.000 abstract description 3
- 235000004338 Syringa vulgaris Nutrition 0.000 abstract description 3
- 229940079593 drug Drugs 0.000 abstract description 3
- 238000002137 ultrasound extraction Methods 0.000 abstract description 3
- 239000000126 substance Substances 0.000 abstract description 2
- 238000002386 leaching Methods 0.000 abstract 2
- 239000000401 methanolic extract Substances 0.000 abstract 1
- 239000000523 sample Substances 0.000 description 35
- 241001310717 Daphne genkwa Species 0.000 description 10
- 239000000843 powder Substances 0.000 description 7
- 238000011084 recovery Methods 0.000 description 7
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- 235000011293 Brassica napus Nutrition 0.000 description 1
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- 238000000944 Soxhlet extraction Methods 0.000 description 1
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- 239000008298 dragée Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- PQPKPCPUSAPERC-UHFFFAOYSA-N ethyl acetate;formic acid;hexane Chemical compound OC=O.CCCCCC.CCOC(C)=O PQPKPCPUSAPERC-UHFFFAOYSA-N 0.000 description 1
- 239000007941 film coated tablet Substances 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
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- 239000002994 raw material Substances 0.000 description 1
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- 239000007940 sugar coated tablet Substances 0.000 description 1
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- 230000009469 supplementation Effects 0.000 description 1
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Abstract
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Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2008100164383A CN101366875B (en) | 2008-05-31 | 2008-05-31 | Quality control method and uses of antirheumatic medicament |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CN2008100164383A CN101366875B (en) | 2008-05-31 | 2008-05-31 | Quality control method and uses of antirheumatic medicament |
Publications (2)
Publication Number | Publication Date |
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CN101366875A CN101366875A (en) | 2009-02-18 |
CN101366875B true CN101366875B (en) | 2011-09-21 |
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CN2008100164383A Active CN101366875B (en) | 2008-05-31 | 2008-05-31 | Quality control method and uses of antirheumatic medicament |
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CN (1) | CN101366875B (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN101884706B (en) * | 2010-07-01 | 2014-05-28 | 广州市花城制药厂 | Method for detecting phlegm eliminating and cough relieving granules |
CN108776191A (en) * | 2018-06-15 | 2018-11-09 | 四川逢春制药有限公司 | A kind of detection method of flos ionicerae and fructus forsythiae infusion for detoxication |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1444976A (en) * | 2003-04-16 | 2003-10-01 | 王朝岭 | Preparation of Chinese herbal medicine for treating cold injury, various indurations and swelling, pain as well as its preparing method |
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2008
- 2008-05-31 CN CN2008100164383A patent/CN101366875B/en active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1444976A (en) * | 2003-04-16 | 2003-10-01 | 王朝岭 | Preparation of Chinese herbal medicine for treating cold injury, various indurations and swelling, pain as well as its preparing method |
Non-Patent Citations (2)
Title |
---|
卫生部.消络痛胶囊.《卫生部颁药品标准 中药成方制剂第十二册》.1997, * |
吕武清等.高效液相色谱法测定了哥王中西瑞香素含量.《中华中医药学会制剂分会学术交流会论文汇编》.2003, * |
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CN101366875A (en) | 2009-02-18 |
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Date | Code | Title | Description |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Yantai Rongchang Pharmaceutical Co., Ltd. Assignor: RONGCHANG PHARMACEUTICAL (ZIBO) CO., LTD. Contract record no.: 2011370000439 Denomination of invention: Quality control method and uses of antirheumatic medicament Granted publication date: 20110921 License type: Exclusive License Open date: 20090218 Record date: 20110923 |
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EC01 | Cancellation of recordation of patent licensing contract |
Assignee: Yantai Rongchang Pharmaceutical Co., Ltd. Assignor: RONGCHANG PHARMACEUTICAL (ZIBO) CO., LTD. Contract record no.: 2011370000439 Date of cancellation: 20120822 |
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EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20090218 Assignee: Yantai Rongchang Pharmacy Co., Ltd. Assignor: RONGCHANG PHARMACEUTICAL (ZIBO) CO., LTD. Contract record no.: 2013370000254 Denomination of invention: Quality control method and uses of antirheumatic medicament Granted publication date: 20110921 License type: Exclusive License Record date: 20131205 |
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LICC | Enforcement, change and cancellation of record of contracts on the licence for exploitation of a patent or utility model | ||
EC01 | Cancellation of recordation of patent licensing contract |
Assignee: Yantai Rongchang Pharmacy Co., Ltd. Assignor: RONGCHANG PHARMACEUTICAL (ZIBO) CO., LTD. Contract record no.: 2013370000254 Date of cancellation: 20141226 |
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LICC | Enforcement, change and cancellation of record of contracts on the licence for exploitation of a patent or utility model | ||
CB03 | Change of inventor or designer information |
Inventor after: Guo Guiqiu Inventor after: Di Yong Inventor after: Wang Liqing Inventor after: Li Xuemei Inventor after: Zhang Meng Inventor after: Shen Zeqiang Inventor after: Geng Min Inventor before: Guo Guiqiu Inventor before: Di Yong Inventor before: Wang Liqing Inventor before: Li Xuemei |
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COR | Change of bibliographic data |