CN101304756A - 用于炎性病症的草药组合物 - Google Patents
用于炎性病症的草药组合物 Download PDFInfo
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- CN101304756A CN101304756A CNA2006800407702A CN200680040770A CN101304756A CN 101304756 A CN101304756 A CN 101304756A CN A2006800407702 A CNA2006800407702 A CN A2006800407702A CN 200680040770 A CN200680040770 A CN 200680040770A CN 101304756 A CN101304756 A CN 101304756A
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Landscapes
- Medicines Containing Plant Substances (AREA)
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Abstract
Description
样品 | 浓度(μg/ml) | TNF的抑制% | 5小时的毒性% |
实施例1的提取物 | 0.1110100 | 0.014.096.097.0 | 0070 |
实施例2的提取物 | 0.1110100 | 0.034.097.097.0 | 2013228 |
实施例3的提取物 | 0.1110100 | 0.00.04.096.0 | 01100 |
咯利普兰(μM) | 100300 | 84.090.0 | 221 |
序号 | 促炎性细胞因子 | 实施例1的提取物,IC50μM,(hPBMC) |
01 | TNF-α | 5.1 |
02 | IL1β | 4.9 |
03 | IL-6 | 26.8 |
04 | IL-8 | 31.0 |
序号 | 促炎性细胞因子 | 化合物1,IC50μM,(hPBMC) |
01 | TNF-α | 0.7 |
02 | IL1β | 0.4 |
03 | IL-6 | 1.6 |
04 | IL-8 | 8.9 |
序号 | 促炎性细胞因子 | 化合物1,IC50(μM),滑膜 |
01 | TNF-α | 0.8 |
03 | IL-6 | 1.4 |
04 | IL-8 | 10.9 |
实施例1的提取物IC50(μg/ml) | 化合物1IC50(μM) | |
ICAM-1 | 7.6 | 0.52 |
VCAM-1 | 6.4 | 0.4 |
E-选择蛋白 | 3.5 | 0.2 |
序号 | 试验样品 | 浓度 | 荧光强度 | 对照的倍数 |
01 | 实施例1的提取物 | 1(μg/ml)3(μg/ml)10(μg/ml)30(μg/ml) | 39768353021318310236 | 232165 |
02 | 化合物1 | 0.1(μM)0.3(μM)1(μM)3(μM) | 3342134024101955728 | 131342 |
03 | BAY 11-7082 | 0.5(μM)1(μM) | 1844214271 | 108 |
04 | 未刺激的DMSO对照刺激的DMSO对照 | 254430791 | 118 |
序号 | 成分 | 量%W/W |
01 | 实施例1的提取物 | 69.72 |
02 | 对羟基苯甲酸甲酯钠 | 0.39 |
03 | 对羟基苯甲酸丙酯钠 | 0.13 |
04 | Bromerol | 0.18 |
05 | 苯甲酸钠 | 0.39 |
06 | 滑石 | 2.61 |
07 | 硬脂酸镁 | 1.74 |
08 | Aerosil | 0.87 |
09 | 乙醇酸淀粉钠 | 2.18 |
10 | 乳糖 | 8.72 |
11 | 磷酸氢钙 | 13.07 |
序号 | 成分 | 量%W/W |
01 | 实施例1的提取物 | 66.53 |
02 | 对羟基苯甲酸甲酯钠 | 0.37 |
03 | 对羟基苯甲酸丙酯钠 | 0.12 |
04 | Bromerol | 0.17 |
05 | 苯甲酸钠 | 0.37 |
06 | 滑石 | 2.50 |
07 | 硬脂酸镁 | 1.66 |
08 | Aerosil | 0.83 |
09 | 乙醇酸淀粉钠 | 2.50 |
10 | 乳糖 | 8.32 |
11 | 磷酸氢钙 | 12.47 |
12 | 淀粉 | 4.16 |
13 | 异丙醇 | * |
序号 | 成分 | 量%W/W |
01 | 实施例1的提取物 | 4 |
02 | 胡椒薄荷粉 | 0.025 |
03 | 蜂蜜 | 0.25 |
04 | 糖 | 50 |
05 | 山梨醇溶液70% | 5 |
06 | 液体葡萄糖 | 10 |
07 | 丙二醇 | 5 |
08 | 一水柠檬酸 | 0.5 |
09 | 对羟基苯甲酸甲酯钠 | 0.2 |
10 | 对羟基苯甲酸丙酯钠 | 0.02 |
11 | 苯甲酸钠 | 0.2 |
12 | 溴硝丙二醇 | 0.02 |
13 | 清凉薄荷′S′味 | 0.25 |
14 | 焦糖色素 | 0.75 |
15 | 纯化水 | 补足至10ml |
序号 | 成分 | 量%W/W |
01 | 实施例1的提取物 | 05.00 |
02 | 鲸蜡硬脂醇-12.0g | 12.00 |
03 | Cetomacragol-1000 | 03.00 |
04 | 单油酸失水山梨醇酯 | 02.00 |
05 | S.E.单硬脂酸甘油酯 | 03.00 |
06 | 内豆蔻酸异丙酯 | 02.50 |
07 | 硬脂酸 | 02.50 |
08 | 对羟基苯甲酸甲酯钠 | 00.40 |
09 | 对羟基苯甲酸丙酯钠 | 00.08 |
10 | 苯氧乙醇 | 00.52 |
11 | EDTA二钠 | 00.02 |
12 | 卡波姆-940 | 00.75 |
13 | 月桂基硫酸钠 | 00.75 |
14 | 聚二甲硅氧烷 | 01.00 |
15 | 三乙醇胺 | 01.00 |
16 | 丙二醇 | 05.00 |
17 | 异丙醇 | 10.00 |
18 | 水 | 50.48 |
序号 | 成分 | 量%W/W |
01 | 实施例1的提取物 | 05.00 |
02 | 二丁基羟基甲苯 | 00.025 |
03 | 丁基羟基茴香醚 | 00.025 |
04 | 卡波姆-940 | 02.95 |
05 | 聚乙二醇-400 | 30.00 |
06 | 异丙醇 | 05.00 |
07 | 丙二醇 | 55.00 |
08 | 单油酸失水山梨醇酯 | 02.00 |
序号 | 成分 | 量%W/W |
01 | 实施例1的提取物 | 5.00 |
02 | 白蜂蜡 | 15.00 |
03 | 固体石蜡 | 25.00 |
04 | 微晶蜡 | 15.00 |
05 | 白软石蜡 | 30.00 |
06 | 轻质液体石蜡 | 09.95 |
07 | 二丁基羟基甲苯 | 0.025 |
08 | 丁基羟基茴香醚 | 0.025 |
序号 | 成分 | 量%W/W |
01 | 化合物1 | 58.33 |
02 | 微晶纤维素 | 35.97 |
03 | 滑石 | 2.50 |
04 | 乙醇酸淀粉钠 | 1.60 |
05 | 胶体二氧化硅 | 0.80 |
06 | 硬脂酸镁 | 0.50 |
07 | 喹啉黄色素 | 0.30 |
序号 | 成分 | 量%W/W |
01 | 化合物1 | 61.40 |
02 | 一水乳糖 | 35.15 |
03 | 交联羧甲基纤维素钠 | 1.40 |
04 | 聚乙烯吡咯烷酮 | 0.85 |
05 | 胶体二氧化硅 | 0.35 |
06 | 硬脂酸镁 | 0.50 |
07 | 喹啉黄色素 | 0.35 |
08 | 异丙醇 | 足量 |
序号 | 成分 | 量%W/W |
01 | 化合物1 | 98.59 |
02 | 微晶纤维素 | 0.75 |
03 | 胶体二氧化硅 | 0.47 |
04 | 硬脂酸镁 | 0.19 |
Claims (24)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
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IN1226MU2005 | 2005-09-30 | ||
IN1226/MUM/2005 | 2005-09-30 | ||
US73644305P | 2005-11-14 | 2005-11-14 | |
US60/736,443 | 2005-11-14 | ||
PCT/IB2006/053540 WO2007036900A2 (en) | 2005-09-30 | 2006-09-28 | Herbal composition for inflammatory disorders |
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CN101304756A true CN101304756A (zh) | 2008-11-12 |
CN101304756B CN101304756B (zh) | 2013-03-20 |
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CN (1) | CN101304756B (zh) |
BR (1) | BRPI0616724A2 (zh) |
DK (1) | DK1931366T3 (zh) |
ES (1) | ES2426174T3 (zh) |
PT (1) | PT1931366E (zh) |
SI (1) | SI1931366T1 (zh) |
UA (1) | UA95612C2 (zh) |
ZA (1) | ZA200803632B (zh) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102292093A (zh) * | 2009-02-02 | 2011-12-21 | 莱拉营养食品有限公司 | 用于代谢综合症控制的选自绒毛戴星草和莽吉柿的混合物 |
CN104853761A (zh) * | 2012-10-23 | 2015-08-19 | 皮拉马尔企业有限公司 | 用于预防及治疗由肿瘤坏死因子-α介导的疾病的中药组合物 |
CN106467564A (zh) * | 2015-08-18 | 2017-03-01 | 赵庆春 | 一种谷精草酚酸类富集流分及在制备抗肿瘤药物中的应用 |
CN108865991A (zh) * | 2018-08-14 | 2018-11-23 | 广州市番禺区中心医院 | 一种模拟糖尿病足炎症微环境的培养基的制备工艺 |
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2006
- 2006-09-28 DK DK06809434.1T patent/DK1931366T3/da active
- 2006-09-28 ES ES06809434T patent/ES2426174T3/es active Active
- 2006-09-28 UA UAA200804923A patent/UA95612C2/ru unknown
- 2006-09-28 SI SI200631640T patent/SI1931366T1/sl unknown
- 2006-09-28 CN CN2006800407702A patent/CN101304756B/zh not_active Expired - Fee Related
- 2006-09-28 ZA ZA200803632A patent/ZA200803632B/xx unknown
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Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102292093A (zh) * | 2009-02-02 | 2011-12-21 | 莱拉营养食品有限公司 | 用于代谢综合症控制的选自绒毛戴星草和莽吉柿的混合物 |
CN102292093B (zh) * | 2009-02-02 | 2015-01-28 | 莱拉营养食品有限公司 | 用于代谢综合症控制的选自绒毛戴星草和莽吉柿的混合物 |
CN104853761A (zh) * | 2012-10-23 | 2015-08-19 | 皮拉马尔企业有限公司 | 用于预防及治疗由肿瘤坏死因子-α介导的疾病的中药组合物 |
CN106467564A (zh) * | 2015-08-18 | 2017-03-01 | 赵庆春 | 一种谷精草酚酸类富集流分及在制备抗肿瘤药物中的应用 |
CN106467564B (zh) * | 2015-08-18 | 2020-03-31 | 中国人民解放军北部战区总医院 | 一种谷精草酚酸类富集流分及在制备抗肿瘤药物中的应用 |
CN108865991A (zh) * | 2018-08-14 | 2018-11-23 | 广州市番禺区中心医院 | 一种模拟糖尿病足炎症微环境的培养基的制备工艺 |
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ZA200803632B (en) | 2009-11-25 |
ES2426174T3 (es) | 2013-10-21 |
UA95612C2 (ru) | 2011-08-25 |
ES2426174T8 (es) | 2014-01-29 |
SI1931366T1 (sl) | 2013-10-30 |
DK1931366T3 (da) | 2013-09-08 |
CN101304756B (zh) | 2013-03-20 |
BRPI0616724A2 (pt) | 2011-06-28 |
PT1931366E (pt) | 2013-09-04 |
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