CN101279096A - Pullulan polysaccharide Vc coating combination - Google Patents
Pullulan polysaccharide Vc coating combination Download PDFInfo
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- CN101279096A CN101279096A CNA2008100164190A CN200810016419A CN101279096A CN 101279096 A CN101279096 A CN 101279096A CN A2008100164190 A CNA2008100164190 A CN A2008100164190A CN 200810016419 A CN200810016419 A CN 200810016419A CN 101279096 A CN101279096 A CN 101279096A
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Abstract
The invention discloses a combination of Pulullan polysaccharide Vc coating, which comprises 10 to 90 parts by weight of Pullullan polysaccharide and 90 to 10 parts by weight of cellulose ether. Ether substituents of the cellulose ether are chosen from alkyl or hydroxyalkyl. The invention also discloses a Vc coating method by using the Pullullan polysaccharide Vc combination, which is applicable to all existing Vc coating techniques, but a solvent for the method is pure water rather than ethanol; concentration of solution is controlled at 15 to 30 percent. The combination of the Pullullan polysaccharide and the cellulose ether used for Vc coating in the invention not only can prepare the aqueous solution with high concentration, but prevent 'adhesion'. The coating product of the invention has higher anti-oxidation ability and higher accumulation density and mechanical strength than that of using the cellulose ether alone.
Description
Technical field
The invention belongs to field of fine chemical, specifically relate to a kind of pullulan polysaccharide Vc coating combination and utilization said composition V
CCarry out the method for coating.
Background technology
V
CHave the dienol of company structure in the molecule, oxidation by air easily particularly is subject to influences such as moisture content, light, temperature, metal ion, makes V
CContent descends, color and luster flavescence etc.On technology, change V
CThe method of stability is a lot, forms, controls granulating process condition etc. as direct compression process, change prescription.In recent years, V
CManufacturing enterprise is in order to improve V
CStability, particularly non-oxidizability, mostly to V
CGranule coating is made the V of 97%, 98% content
CCoated granule is commonly called as 97,98 granules, remaining 2%～3%, cellulose ether etc.Cellulose ether can be dissolved in the alcohol-water solution, when coating, can reduce the remnants of water, its film has certain non-oxidizability, but because the common molecular weight of cellulose ether is bigger, be difficult to the aqueous solution of compounding high concentration,, cause organic solvent remnants so mostly adopt dissolve with ethanol, also be unfavorable for safety, its film still has bigger permeability to oxygen and moisture content.
Pulullan polysaccharide English name pullulan has another name called the mould polysaccharide of short stalk, pullulan.It is a kind of be raw material with starch or saccharide, the extracellular pure natural macromolecule polysaccharide that produces through microbial fermentation.Its chemical composition mainly is the poly-maltotriose that is connected by α-1.6 heteroside chain, and is soluble in water, safety non-toxic, tasteless; Plasticity, good film-forming property; Edible, low heat value also have purposes widely in industries such as cosmetics, medicine, food, pesticide, are classified as the food additive catalogue by 06 year national health system.Not only transparency is high and oxygen flow not highly for its thin film, and mechanical strength is also very high.But its aqueous solution has very high viscosity, produces " wire drawing " phenomenon during production, so be applied to coating Vc separately " adhesion " phenomenon takes place easily, causes that the Vc granule coating is inhomogeneous, the granule irregularity.
Summary of the invention
In order to solve the deficiencies in the prior art, one of purpose of the present invention provides a kind of pullulan polysaccharide Vc coating combination.
Two of purpose of the present invention provides utilizes this pullulan polysaccharide Vc coating combination to carry out the method for Vc coating.
Technical scheme of the present invention is such, a kind of pullulan polysaccharide Vc coating combination, it is characterized in that said composition comprises the pulullan polysaccharide of 10-90 weight portion and the cellulose ether of 90-10 weight portion, the ether substituent group of described cellulose ether is selected from alkyl or hydroxyalkyl.
Vc is meant 97 and 98 granules, but is not limited only to this, also comprises by the tablet of VC compacting, granule, capsule etc.Pulullan polysaccharide is meant by the pullulan strain fermentation and gets.Though pulullan polysaccharide has variation in various degree along with the different of the difference of character of its bacterium of preparation and fermentation condition, but any pulullan polysaccharide may be used to the present invention, the weight that is used for the pulullan polysaccharide molecule of the present invention does not have special qualification, but normally low-molecular-weight is more suitable.
In the optimized technical scheme, described cellulose ether is selected from methylcellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose, hydroxyethylmethyl-cellulose, hydroxyethyl ethylcellulose or hydroxypropyl emthylcellulose.
In the optimized technical scheme, described pulullan polysaccharide 10% viscosity in aqueous solution by weight is 2～500mPaS in the time of 20 ℃.In the optimized technical scheme, the alkyl of described cellulose ether or hydroxyalkyl substitution value have 1.4 alkyl or hydroxyl at least in each glucose chain link.In the optimized technical scheme, described cellulose ether 2% viscosity in aqueous solution by weight is 2～150mPaS in the time of 20 ℃.
Method of carrying out the Vc coating according to the arbitrary described pullulan polysaccharide Vc coating combination in front provided by the invention, be applicable to all Vc art for coating now, in art for coating, be to make solution with adding pure water in the pullulan polysaccharide Vc coating combination, compositions and pure water weight ratio are: (30-15): (70-85).
Owing to the present invention is with pulullan polysaccharide and the composite Vc coating that carries out of cellulose ether together, not only can prepare to contain the aqueous solution that compositions is 15%～30% high concentration, can also prevent " adhesion ".Its coating finished product has bulk density, the mechanical strength of higher non-oxidizability and Geng Gao than using cellulose ether separately.Because solution is mixed with pure water, avoided the organic solvent remnants that cause with dissolve with ethanol, be more conducive to safety.
The specific embodiment
Further specify technology contents of the present invention below in conjunction with reference examples and embodiment:
Reference examples: with 30g viscosity is that 50mPaS hydroxypropyl emthylcellulose (60RT50 auspicious safe produce) is dissolved in 500ml, 80% the ethanol, the film forming solution of preparation 6%, in the FLP-Mini type (good product) of then the Vc powder of 970g being packed into the fluidized bed coating equipment, be warmed up to about 40 ℃ and begin coating, sprayed fully to filmogen.
Embodiment:
Get following cellulose ether:
1, hydroxypropyl emthylcellulose (HPMC), technical specification is: DS=1.88, MS=0.19, viscosity is 50mPaS.
2, methylcellulose (MC), technical specification is: DS=1.73, viscosity is 15mPaS.
3, hydroxyethyl-cellulose (HEC), technical specification is: MS=1.80, viscosity is 100mPaS.
The alkyl of above-mentioned cellulose ether or hydroxyalkyl substitution value have 1.4 alkyl or hydroxyl at least in each glucose chain link.
Get pulullan polysaccharide (pull), technical specification is: molecular weight is 20000～100000 dalton, or 10% viscosity in aqueous solution is 2～500mPaS in the time of 20 ℃ by weight.
With above-mentioned pulullan polysaccharide and cellulose ether, according to the form below Different Weight ratio is made into different components, and being dissolved in and making concentration in the pure water is that the aqueous solution of 15-30% is stand-by, by the method for reference examples Vc is carried out coating again, the results are shown in following table:
From above table as can be seen in the hydroxypropyl emthylcellulose coating of routine because of pullulan-containing not, so contain oxygen atom is 70, and the permeability that is mixed with the compositions oxygen of Pullulan obviously reduces, and just non-oxidizability is strong, and Pullulan adds the more, and the antioxygen permeability is stronger.Three kinds of Vc film compositions contain oxygen atom and are 0 when the ratio that reaches 1: 9, and the apparent specific gravity (gd) of the Vc that wraps is also high, helps packed and transported.
In addition, it is that 40 ℃, relative humidity are in 75% the environment that the product of the product of reference examples and embodiment is placed on temperature simultaneously, places after seven days, perusal, the obvious blackening of reference examples product colour as a result, illustrate oxidized, thereby proof embodiment product antioxidation.
Claims (7)
1, a kind of pullulan polysaccharide Vc coating combination is characterized in that, said composition comprises the pulullan polysaccharide of 10-90 weight portion and the cellulose ether of 90-10 weight portion, and the ether substituent group of described cellulose ether is selected from alkyl or hydroxyalkyl.
2, pullulan polysaccharide Vc coating combination according to claim 1 is characterized in that, it is 20000～100000 daltonian pulullan polysaccharides that described pulullan polysaccharide is selected molecular weight for use.
3, pullulan polysaccharide Vc coating combination according to claim 1, it is characterized in that described cellulose ether is selected from methylcellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose, hydroxyethylmethyl-cellulose, hydroxyethyl ethylcellulose or hydroxypropyl emthylcellulose.
4, pullulan polysaccharide Vc coating combination according to claim 1 is characterized in that, described pulullan polysaccharide 10% viscosity in aqueous solution by weight is 2～500mPaS in the time of 20 ℃.
5, pullulan polysaccharide Vc coating combination according to claim 1 is characterized in that, the alkyl of described cellulose ether or hydroxyalkyl substitution value have 1.4 alkyl or hydroxyl at least in each glucose chain link.
6, pullulan polysaccharide Vc coating combination according to claim 1 is characterized in that, described cellulose ether 2% viscosity in aqueous solution by weight is 2～150mPaS in the time of 20 ℃.
7, carry out the method for Vc coating according to the arbitrary described pullulan polysaccharide Vc coating combination of claim 1-7, it is characterized in that, in art for coating, pullulan polysaccharide Vc coating combination is added pure water, and to make concentration be 15～30% aqueous solution.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008100164190A CN101279096B (en) | 2008-05-29 | 2008-05-29 | Pullulan polysaccharide Vc coating combination |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008100164190A CN101279096B (en) | 2008-05-29 | 2008-05-29 | Pullulan polysaccharide Vc coating combination |
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| CN101279096A true CN101279096A (en) | 2008-10-08 |
| CN101279096B CN101279096B (en) | 2011-04-06 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526050A (en) * | 2011-12-29 | 2012-07-04 | 山东省医药工业研究所 | Stable simvastatin compound preparation and preparation method thereof |
| CN108926546A (en) * | 2018-07-04 | 2018-12-04 | 天津嘉汇捷瑞医药科技有限公司 | A kind of enteric solubility film coating pre-mix dose and preparation method thereof |
| US10568839B2 (en) | 2011-01-11 | 2020-02-25 | Capsugel Belgium Nv | Hard capsules |
| US11319566B2 (en) | 2017-04-14 | 2022-05-03 | Capsugel Belgium Nv | Process for making pullulan |
| US11576870B2 (en) | 2017-04-14 | 2023-02-14 | Capsugel Belgium Nv | Pullulan capsules |
-
2008
- 2008-05-29 CN CN2008100164190A patent/CN101279096B/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10568839B2 (en) | 2011-01-11 | 2020-02-25 | Capsugel Belgium Nv | Hard capsules |
| CN102526050A (en) * | 2011-12-29 | 2012-07-04 | 山东省医药工业研究所 | Stable simvastatin compound preparation and preparation method thereof |
| US11319566B2 (en) | 2017-04-14 | 2022-05-03 | Capsugel Belgium Nv | Process for making pullulan |
| US11576870B2 (en) | 2017-04-14 | 2023-02-14 | Capsugel Belgium Nv | Pullulan capsules |
| US11878079B2 (en) | 2017-04-14 | 2024-01-23 | Capsugel Belgium Nv | Pullulan capsules |
| CN108926546A (en) * | 2018-07-04 | 2018-12-04 | 天津嘉汇捷瑞医药科技有限公司 | A kind of enteric solubility film coating pre-mix dose and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN101279096B (en) | 2011-04-06 |
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Granted publication date: 20110406 Termination date: 20130529 |