CN101244146B - Method for preparing Chinese medicine injection for treating high-pathogenicity blue-ear disease of pig - Google Patents
Method for preparing Chinese medicine injection for treating high-pathogenicity blue-ear disease of pig Download PDFInfo
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- CN101244146B CN101244146B CN2008100104556A CN200810010455A CN101244146B CN 101244146 B CN101244146 B CN 101244146B CN 2008100104556 A CN2008100104556 A CN 2008100104556A CN 200810010455 A CN200810010455 A CN 200810010455A CN 101244146 B CN101244146 B CN 101244146B
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Abstract
The invention relates to a making method of Chinese herbal medicine injection for treating highly pathogenic porcine reproductive and respiratory syndrome, honeysuckle 35 g, weeping forsythia 20 g, scutellaria 20 g, wild chrysanthemum 20 g, isatis root 35 g, astragalus 30 g, radix scrophulariae 15 g and dandelion 25 g are decocted and distilled with the mediator of water; a water decoction is concentrated; an alcohol solution is obtained after the ethanol dissolution; the alcohol solution is filtered; the ethanol is detached; the distillate is added; after fine filtration and sterilization the Chinese herbal medicine injection for treating highly pathogenic porcine reproductive and respiratory syndrome is prepared, which contains 1 g crude drug in whole per milliliter. The Chinese herbal medicine injection for treating highly pathogenic porcine reproductive and respiratory syndrome is prepared by the compound Chinese herbal medicine, which has the advantages of reasonable compatibility; the method of water distillation and decoction, alcohol dissolution and distillate mergence are adopted in the making method, and the effective ingredients are fully extracted and utilized, which has the advantages of reasonable technological process. The cure rate of highly pathogenic porcine reproductive and respiratory syndrome reaches to 82.9% using the Chinese herbal medicine injection for treating highly pathogenic porcine reproductive and respiratory syndrome made by the invention. No abnormal phenomenon is happened in the eye dropping test of rabbit, local irritation test of leg muscle and times amount poisoning test.
Description
Technical field
The present invention relates to a kind of manufacture method of injections of Chinese medicine, particularly a kind of manufacture method for the treatment of the high-pathogenicity blue-ear disease of pig injections of Chinese medicine.
Background technology
High-pathogenicity blue-ear disease of pig is a kind of serious viral disease of the pig that occurred in recent years; this disease is a kind of acute high lethal eqpidemic disease by the pig reproduction-the breathing syndrome virus variant causes; cause by lelystad virus; be a kind of spherical tremulous pulse virus with pod membrane; this viral infectivity is extremely strong; break out easily at high temperature season; main route of infection is a respiratory tract; air borne; contact transmission and vertical transmission are main circulation way; the pig of each age and kind all can infect; based on piglet respiratory symptom and sow breeding difficulty; the easy infection of piglet in one monthly age and in-pig; infected piglet heating; height symptoms of respiratory disease and pleuropneumonia symptom are arranged; because of the dyspnea anoxia; cause the conjunctiva skin cyanosis to be blue purple; so be " reproductive and respiratory syndrome "; infected in-pig lassitude; off feed; body temperature is temporary higher; cough; dyspnea in various degree, it is undesired or infertile to oestrus, the farrowing sow premature labor; miscarriage; stillborn fetus; monster; weak tire etc.The piglet sickness rate on infected pig farm can reach 100%, mortality rate can reach more than 50%, and the sow abortion ratio can reach more than 30%, the infected growing and fattening pigs death of also can falling ill.At present, high-pathogenicity blue-ear disease of pig does not have effective special for treating medicine, medicine for treatment commonly used is antiviral Western medicine, some antiviral Western medicine has certain therapeutic effect to high-pathogenicity blue-ear disease of pig, but in recent years, forbid using the Western medicine that contains the antiviral composition in veterinary drug, this increases the treatment difficulty of high-pathogenicity blue-ear disease of pig widely.Chinese medicine is traditional rarity of China, and is with a long history, wide material sources, and cheap, side effect is little, and Chinese medicine is used for the control of modern farming production to Animal diseases more and more.Traditional Chinese medicine is to use decoct, powder and extractum mostly, and nearly decades, some injections of Chinese medicine appear in China, but are the injection that is limited to one or two kind of folk prescription medicine mostly, in the prior art, is not specifically designed to the compound injection of Chinese medicine of treatment high-pathogenicity blue-ear disease of pig.
Summary of the invention
The objective of the invention is in order to overcome above-mentioned deficiency, propose a kind of manufacture method that is specifically designed to treatment high-pathogenicity blue-ear disease of pig injections of Chinese medicine.
The present invention is achieved using the following method.The invention scheme of the manufacture method of treatment high-pathogenicity blue-ear disease of pig injections of Chinese medicine is at first by the monarch of tcm theory, minister, assistant, make cooperation and dialectical executing control principle, select for use and have the virus of inhibition, the antiinflammatory bacterium that disappears, antipyretic-antalgic, enhance immunity, comprehensive adjustment animal internal milieu, repair the damage that virus infraction causes, duplicate the Chinese herbal medicine of effect in the body of viral interference and make herbal mixture, water is that the medium distillation decocts herbal mixture then, obtain decocting liquid and distillate after the filtration, reconcentration decocting liquid, fully dissolve with ethanol and to obtain alcoholic solution, filter alcoholic solution, isolate ethanol, add distillate, fine straining again, obtain injection after the sterilization.
For realizing the foregoing invention scheme, the manufacture method of treatment high-pathogenicity blue-ear disease of pig injections of Chinese medicine has the following steps:
1. get Chinese herbal medicine Flos Lonicerae 34～36 grams, Fructus Forsythiae 19～21 grams, Radix Scutellariae 19～21 grams, Herba Dendranthematis indici 19～21 grams, Radix Isatidis 34～36 grams, the Radix Astragali 25～35 grams, Radix Scrophulariae 14～16 grams, Herba Taraxaci 24～26 grams, said herbal medicine is ground into can be by the fine grained of 10 mesh sieves, mix homogeneously obtains mixed powder;
2. mixed powder is put into 1400 milliliters～1600 milliliters 70 ℃～75 ℃ distilled water or deionized water and soaked 2～3 hours, obtain water logging medicated powder;
3. water logging medicated powder being distilled in distillation-decocting device, decocts 60 minutes～80 minute, obtain decocting medicated powder and once-run distillate, is that filter medium filters a decocting medicated powder and obtains medicinal residues and a decocting liquid with 6～10 layers of gauze;
4. add 900 milliliters～1100 ml distilled water or deionized waters in medicinal residues, normal pressure boiled 60 minutes～70 minutes, obtained secondary decocting medicated powder, was that filter medium obtains secondary medicinal residues and secondary decocting liquid to the filtration of secondary decocting medicated powder with 6～10 layers of gauze;
5. decocting liquid and secondary decocting liquid are mixed, obtain full decocting liquid, full decocting liquid is heated be concentrated to 50 milliliters～60 milliliters, obtain dense condensed pulpous state concentrated solution;
6. add 400 milliliters～500 ml volumes concentration and be 95% ethanol in concentrated solution, mix homogeneously left standstill 48 hours under the condition of 2 ℃～5 ℃ of temperature then, and the supernatant after leaving standstill is filtered with charcoal filter, obtained alcoholic solution one time;
7. in an alcoholic solution, add 50 milliliters～60 ml distilled water or deionized waters, ethanol is reclaimed in distillation then, and an alcoholic solution is concentrated to 50 milliliters of volumes, obtain suspension one time, suspension in normal pressure insulation under 80 ℃ the condition of water bath heating after 2 hours, under the condition of 2 ℃～5 ℃ of temperature, left standstill 48 hours, the supernatant after leaving standstill is filtered with charcoal filter, obtain medicinal liquid one time;
8. add 300 milliliters～350 ml volumes concentration and be 95% ethanol in medicinal liquid, mix homogeneously left standstill 48 hours under the condition of 2 ℃～5 ℃ of temperature then, and the supernatant after leaving standstill is filtered with charcoal filter, obtained the secondary alcoholic solution;
9. in the secondary alcoholic solution, add 50 ml distilled waters or deionized water, ethanol is reclaimed in distillation, and the secondary alcoholic solution is concentrated to 50 milliliters of volumes, obtain the secondary mixing suspension, the secondary mixing suspension after normal pressure insulation under 80 ℃ the condition of water bath heating 2 hours, under the condition of 2 ℃～5 ℃ of temperature, left standstill 48 hours, supernatant after leaving standstill is filtered with charcoal filter, filtrate with centrifuge centrifugalize 10 minutes under 4000 rev/mins condition, supernatant after the centrifugalize was kept 15 minutes～20 minutes down at 95 ℃, obtain the secondary medicinal liquid;
10. do once more that distillation obtains 150 milliliters of secondary distillates to once-run distillate, if 150 milliliters of once-run distillate less thaies are not then made second distillation to once-run distillate, adding distil water or deionized water are supplied 150 milliliters and are obtained 150 milliliters of secondary distillates in once-run distillate;
11. secondary medicinal liquid and secondary distillate mix homogeneously, add 0.2 gram sodium thiosulfate mix homogeneously, under the condition of 2 ℃～5 ℃ of temperature, left standstill 48 hours, supernatant after leaving standstill is filtered with charcoal filter, filtrate is with centrifuge centrifugalize 10 minutes under 4000 rev/mins condition, add 0.5 milliliter of tween 80 reagent in the supernatant after centrifugalize, obtain medicinal liquid three times;
12. three liquid medicine filling envelope bottles, sterilized 15 minutes down at 100 ℃, the high-pathogenicity blue-ear disease of pig injections of Chinese medicine promptly obtains medical treatment.
The preferred value of the amount of the described Chinese herbal medicine of above step 1 is: Flos Lonicerae 35 grams, Fructus Forsythiae 20 grams, Radix Scutellariae 20 grams, Herba Dendranthematis indici 20 grams, Radix Isatidis 35 grams, the Radix Astragali 30 grams, Radix Scrophulariae 15 grams, Herba Taraxaci 25 grams.
The present invention makes treatment high-pathogenicity blue-ear disease of pig injections of Chinese medicine with compound Chinese herb, and compatibility is reasonable; Adopt the method for water distillation-decoction, alcohol dissolving, merging distillate in the manufacture method, extract and utilize active ingredient fully, technological process is reasonable.
The treatment high-pathogenicity blue-ear disease of pig injections of Chinese medicine of making of method of the present invention is through clinical trial, and cure rate is higher, and the clinical testing data result is as follows:
The treatment high-pathogenicity blue-ear disease of pig injections of Chinese medicine of making of method of the present invention is through to rabbit point eye test, leg muscle irritant test with doubly measure all no abnormal phenomenon of poisoning experiment.
The specific embodiment
Below in conjunction with specific embodiment, the present invention is further described.
The manufacture method of treatment high-pathogenicity blue-ear disease of pig injections of Chinese medicine has the following steps:
1. get Chinese herbal medicine Flos Lonicerae 35 grams, Fructus Forsythiae 20 grams, Radix Scutellariae 20 grams, Herba Dendranthematis indici 20 grams, Radix Isatidis 35 grams, the Radix Astragali 30 grams, Radix Scrophulariae 15 grams, Herba Taraxaci 25 grams, said herbal medicine is ground into can be by the fine grained of 10 mesh sieves, and mix homogeneously obtains mixed powder;
2. mixed powder is put into 1500 milliliters 70 ℃ distilled water and soaked 2 hours, obtain water logging medicated powder;
3. water logging medicated powder being weighed in distillation type and decocted distillation in the device, decocted 60 minutes～80 minutes, obtain decocting medicated powder and once-run distillate, is that filter medium obtains medicinal residues and a decocting liquid to a decocting medicated powder filtration with 6～10 layers of gauze;
4. add 1000 ml distilled waters in medicinal residues, normal pressure boiled 60 minutes, obtained secondary decocting medicated powder, was that filter medium obtains secondary medicinal residues and secondary decocting liquid to the filtration of secondary decocting medicated powder with 6～10 layers of gauze;
5. decocting liquid and secondary decocting liquid are mixed, obtain full decocting liquid, full decocting liquid is heated be concentrated to 50 milliliters～60 milliliters, obtain dense condensed pulpous state concentrated solution;
6. add 400 milliliters～500 ml volumes concentration and be 95% ethanol in concentrated solution, mix homogeneously left standstill 48 hours under the condition of 2 ℃～5 ℃ of temperature then, and the supernatant after leaving standstill is filtered with charcoal filter, obtained alcoholic solution one time;
7. in an alcoholic solution, add 50 milliliters～60 ml distilled waters, ethanol is reclaimed in distillation then, and an alcoholic solution is concentrated to 50 milliliters of volumes, obtain suspension one time, suspension in normal pressure insulation under 80 ℃ the condition of water bath heating after 2 hours, under the condition of 2 ℃～5 ℃ of temperature, left standstill 48 hours, the supernatant after leaving standstill is filtered with charcoal filter, obtain medicinal liquid one time;
8. add 300 milliliters～350 ml volumes concentration and be 95% ethanol in medicinal liquid, mix homogeneously left standstill 48 hours under the condition of 2 ℃～5 ℃ of temperature then, and the supernatant after leaving standstill is filtered with charcoal filter, obtained the secondary alcoholic solution;
9. in the secondary alcoholic solution, add 50 ml distilled waters, ethanol is reclaimed in distillation, and the secondary alcoholic solution is concentrated to 50 milliliters of volumes, obtain the secondary mixing suspension, the secondary mixing suspension after normal pressure insulation under 80 ℃ the condition of water bath heating 2 hours, under the condition of 2 ℃～5 ℃ of temperature, left standstill 48 hours, supernatant after leaving standstill is filtered with charcoal filter, filtrate with centrifuge centrifugalize 10 minutes under 4000 rev/mins condition, supernatant after the centrifugalize was kept 15 minutes～20 minutes down at 95 ℃, obtain the secondary medicinal liquid;
10. do once more that distillation obtains 150 milliliters of secondary distillates to once-run distillate, if 150 milliliters of once-run distillate less thaies are not then made second distillation to once-run distillate, adding distil water is supplied 150 milliliters and is obtained 150 milliliters of secondary distillates in once-run distillate;
11. secondary medicinal liquid and secondary distillate mix homogeneously, add 0.2 gram sodium thiosulfate mix homogeneously, under the condition of 2 ℃～5 ℃ of temperature, left standstill 48 hours, supernatant after leaving standstill is filtered with charcoal filter, filtrate is with centrifuge centrifugalize 10 minutes under 4000 rev/mins condition, add 0.5 milliliter of tween 80 reagent in the supernatant after centrifugalize, obtain medicinal liquid three times;
12. three liquid medicine filling envelope bottles, sterilized 15 minutes down at 100 ℃, the high-pathogenicity blue-ear disease of pig injections of Chinese medicine promptly obtains medical treatment.
Contain crude drug in whole 1 gram in every milliliter of treatment high-pathogenicity blue-ear disease of pig injections of Chinese medicine with the said method making, the treatment using dosage is 0.1 ml/kg, and medication is intramuscular injection or subcutaneous injection.
Claims (2)
1. manufacture method for the treatment of the high-pathogenicity blue-ear disease of pig injections of Chinese medicine is characterized in that: have the following steps:
(1) gets Chinese herbal medicine Flos Lonicerae 34～36 grams, Fructus Forsythiae 19～21 grams, Radix Scutellariae 19～21 grams, Herba Dendranthematis indici 19～21 grams, Radix Isatidis 34～36 grams, the Radix Astragali 25～35 grams, Radix Scrophulariae 14～16 grams, Herba Taraxaci 24～26 grams, said herbal medicine is ground into can be by the fine grained of 10 mesh sieves, mix homogeneously obtains mixed powder;
(2) mixed powder is put into 1400 milliliters～1600 milliliters 70 ℃～75 ℃ distilled water or deionized water and soaked 2～3 hours, obtain water logging medicated powder;
(3) water logging medicated powder being distilled in distillation-decocting device, decocts 60 minutes～80 minute, obtain decocting medicated powder and once-run distillate, is that filter medium filters a decocting medicated powder and obtains medicinal residues and a decocting liquid with 6～10 layers of gauze;
(4) in medicinal residues, add 900 milliliters～1100 ml distilled water or deionized waters, normal pressure boiled 60 minutes～70 minutes, obtaining secondary decocting medicated powder, is that filter medium obtains secondary medicinal residues and secondary decocting liquid to the filtration of secondary decocting medicated powder with 6～10 layers of gauze;
(5) decocting liquid and secondary decocting liquid are mixed, obtain full decocting liquid, full decocting liquid is heated be concentrated to 50 milliliters～60 milliliters, obtain dense condensed pulpous state concentrated solution;
(6) adding 400 milliliters～500 ml volumes concentration in concentrated solution is 95% ethanol, and mix homogeneously left standstill 48 hours under the condition of 2 ℃～5 ℃ of temperature then, and the supernatant after leaving standstill is filtered with charcoal filter, obtained alcoholic solution one time;
(7) in an alcoholic solution, add 50 milliliters～60 ml distilled water or deionized waters, ethanol is reclaimed in distillation then, and an alcoholic solution is concentrated to 50 milliliters of volumes, obtain suspension one time, suspension in normal pressure insulation under 80 ℃ the condition of water bath heating after 2 hours, under the condition of 2 ℃～5 ℃ of temperature, left standstill 48 hours, the supernatant after leaving standstill is filtered with charcoal filter, obtain medicinal liquid one time;
(8) adding 300 milliliters～350 ml volumes concentration in medicinal liquid is 95% ethanol, and mix homogeneously left standstill 48 hours under the condition of 2 ℃～5 ℃ of temperature then, and the supernatant after leaving standstill is filtered with charcoal filter, obtained the secondary alcoholic solution;
(9) in the secondary alcoholic solution, add 50 ml distilled waters or deionized water, ethanol is reclaimed in distillation, and the secondary alcoholic solution is concentrated to 50 milliliters of volumes, obtain the secondary mixing suspension, the secondary mixing suspension after normal pressure insulation under 80 ℃ the condition of water bath heating 2 hours, under the condition of 2 ℃～5 ℃ of temperature, left standstill 48 hours, supernatant after leaving standstill is filtered with charcoal filter, filtrate with centrifuge centrifugalize 10 minutes under 4000 rev/mins condition, supernatant after the centrifugalize was kept 15 minutes～20 minutes down at 95 ℃, obtain the secondary medicinal liquid;
(10) do once more that distillation obtains 150 milliliters of secondary distillates to once-run distillate, if 150 milliliters of once-run distillate less thaies are not then made second distillation to once-run distillate, adding distil water or deionized water are supplied 150 milliliters and are obtained 150 milliliters of secondary distillates in once-run distillate;
(11) secondary medicinal liquid and secondary distillate mix homogeneously, add 0.2 gram sodium thiosulfate mix homogeneously, under the condition of 2 ℃～5 ℃ of temperature, left standstill 48 hours, supernatant after leaving standstill is filtered with charcoal filter, filtrate is with centrifuge centrifugalize 10 minutes under 4000 rev/mins condition, add 0.5 milliliter of tween 80 reagent in the supernatant after centrifugalize, obtain medicinal liquid three times;
(12) three liquid medicine filling envelope bottles, sterilized 15 minutes down at 100 ℃, the high-pathogenicity blue-ear disease of pig injections of Chinese medicine promptly obtains medical treatment.
2. by the manufacture method of the described treatment high-pathogenicity blue-ear disease of pig of claim 1 injections of Chinese medicine, it is characterized in that: the amount of the Chinese herbal medicine in the described mixed powder is: Flos Lonicerae 35 grams, Fructus Forsythiae 20 grams, Radix Scutellariae 20 grams, Herba Dendranthematis indici 20 grams, Radix Isatidis 35 grams, the Radix Astragali 30 grams, Radix Scrophulariae 15 grams, Herba Taraxaci 25 grams.
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| CN101711801B (en) * | 2008-10-08 | 2011-10-05 | 上海朝翔生物技术有限公司 | Natural galenical preparation for preventing and treating blue-ear disease and hyperpyrexia of unknown origin and preparation method thereof |
| CN102512536B (en) * | 2011-12-16 | 2013-10-23 | 青岛绿曼生物工程有限公司 | Compound propolis composition for treating haemophilus parasuis and preparation method for same |
| CN103142702A (en) * | 2013-03-21 | 2013-06-12 | 河北科技师范学院 | Chinese herbal medicine injection liquid for treating porcine reproductive and respiratory syndrome and preparation method thereof |
| CN103860749B (en) * | 2014-03-18 | 2016-06-15 | 安徽科技学院 | A kind of preparation method treating the sick Chinese medicine composition of Ungula Sus domestica and Chinese medicine thereof |
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| CN1559470A (en) * | 2004-03-01 | 2005-01-05 | 王原成 | Chinese patent drug for livestock |
| CN1682843A (en) * | 2005-03-15 | 2005-10-19 | 华南农业大学 | Chinese medicine composition for preventing bird flu |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1559470A (en) * | 2004-03-01 | 2005-01-05 | 王原成 | Chinese patent drug for livestock |
| CN1682843A (en) * | 2005-03-15 | 2005-10-19 | 华南农业大学 | Chinese medicine composition for preventing bird flu |
| CN101112446A (en) * | 2007-08-10 | 2008-01-30 | 邓世平 | Prescription for treating porcine respiratory and reproductive syndrome (PRRS), the method for making the same and use method of the medicine liquid thereof |
Non-Patent Citations (2)
| Title |
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| 刘克俭等.猪"高热病"的中药疗法.河南畜牧兽医.2007,第28卷(第8期),第22-23页. |
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