CN101216490A - Dry chemical method TORCH detection reagent kit and method of manufacture - Google Patents
Dry chemical method TORCH detection reagent kit and method of manufacture Download PDFInfo
- Publication number
- CN101216490A CN101216490A CNA2008100194815A CN200810019481A CN101216490A CN 101216490 A CN101216490 A CN 101216490A CN A2008100194815 A CNA2008100194815 A CN A2008100194815A CN 200810019481 A CN200810019481 A CN 200810019481A CN 101216490 A CN101216490 A CN 101216490A
- Authority
- CN
- China
- Prior art keywords
- antigen
- damping fluid
- sodium azide
- torch
- kit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000001514 detection method Methods 0.000 title claims abstract description 30
- 238000000034 method Methods 0.000 title claims abstract description 29
- 239000003153 chemical reaction reagent Substances 0.000 title claims description 32
- 239000000126 substance Substances 0.000 title claims description 13
- 238000004519 manufacturing process Methods 0.000 title claims description 7
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 claims abstract description 76
- 238000006243 chemical reaction Methods 0.000 claims abstract description 30
- 238000002360 preparation method Methods 0.000 claims abstract description 22
- 239000000376 reactant Substances 0.000 claims abstract description 19
- 102000002260 Alkaline Phosphatase Human genes 0.000 claims abstract description 15
- 108020004774 Alkaline Phosphatase Proteins 0.000 claims abstract description 15
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 14
- 239000000243 solution Substances 0.000 claims abstract description 11
- 239000011780 sodium chloride Substances 0.000 claims abstract description 7
- 239000007853 buffer solution Substances 0.000 claims abstract description 6
- 241000283707 Capra Species 0.000 claims abstract description 5
- 239000000020 Nitrocellulose Substances 0.000 claims abstract description 5
- 229920001220 nitrocellulos Polymers 0.000 claims abstract description 5
- 239000002274 desiccant Substances 0.000 claims abstract description 4
- 239000012528 membrane Substances 0.000 claims abstract description 3
- 239000000427 antigen Substances 0.000 claims description 49
- 102000036639 antigens Human genes 0.000 claims description 49
- 108091007433 antigens Proteins 0.000 claims description 49
- 238000013016 damping Methods 0.000 claims description 38
- 239000012530 fluid Substances 0.000 claims description 38
- 239000007788 liquid Substances 0.000 claims description 37
- 239000011159 matrix material Substances 0.000 claims description 25
- 102000004169 proteins and genes Human genes 0.000 claims description 18
- 108090000623 proteins and genes Proteins 0.000 claims description 18
- 239000003593 chromogenic compound Substances 0.000 claims description 16
- 239000003381 stabilizer Substances 0.000 claims description 16
- 241001465754 Metazoa Species 0.000 claims description 14
- 239000000463 material Substances 0.000 claims description 14
- 238000010790 dilution Methods 0.000 claims description 13
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- 241000710799 Rubella virus Species 0.000 claims description 11
- 238000011161 development Methods 0.000 claims description 11
- 241000700584 Simplexvirus Species 0.000 claims description 9
- 238000000465 moulding Methods 0.000 claims description 9
- 238000012856 packing Methods 0.000 claims description 9
- GEYOCULIXLDCMW-UHFFFAOYSA-N 1,2-phenylenediamine Chemical compound NC1=CC=CC=C1N GEYOCULIXLDCMW-UHFFFAOYSA-N 0.000 claims description 8
- 239000008363 phosphate buffer Substances 0.000 claims description 8
- 241000223996 Toxoplasma Species 0.000 claims description 7
- 241000701022 Cytomegalovirus Species 0.000 claims description 6
- 229910019142 PO4 Inorganic materials 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 6
- 239000010452 phosphate Substances 0.000 claims description 6
- 238000007789 sealing Methods 0.000 claims description 6
- YHVQIDWAIRCSOQ-UHFFFAOYSA-N 1-nitrotetrazol-2-ium chloride Chemical compound [Cl-].[O-][N+](=O)N1C=[NH+]N=N1 YHVQIDWAIRCSOQ-UHFFFAOYSA-N 0.000 claims description 5
- 238000001179 sorption measurement Methods 0.000 claims description 5
- YRNWIFYIFSBPAU-UHFFFAOYSA-N 4-[4-(dimethylamino)phenyl]-n,n-dimethylaniline Chemical compound C1=CC(N(C)C)=CC=C1C1=CC=C(N(C)C)C=C1 YRNWIFYIFSBPAU-UHFFFAOYSA-N 0.000 claims description 4
- 241000283074 Equus asinus Species 0.000 claims description 4
- 241000283973 Oryctolagus cuniculus Species 0.000 claims description 4
- 239000002033 PVDF binder Substances 0.000 claims description 4
- 238000004140 cleaning Methods 0.000 claims description 4
- 238000005520 cutting process Methods 0.000 claims description 4
- 229920002981 polyvinylidene fluoride Polymers 0.000 claims description 4
- 108091003079 Bovine Serum Albumin Proteins 0.000 claims description 3
- 241000233855 Orchidaceae Species 0.000 claims description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 3
- 229930006000 Sucrose Natural products 0.000 claims description 3
- 241000223997 Toxoplasma gondii Species 0.000 claims description 3
- 229940098773 bovine serum albumin Drugs 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 3
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- 239000005720 sucrose Substances 0.000 claims description 3
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- 208000009889 Herpes Simplex Diseases 0.000 claims description 2
- 239000008351 acetate buffer Substances 0.000 claims description 2
- 238000012360 testing method Methods 0.000 abstract description 8
- 229940124272 protein stabilizer Drugs 0.000 abstract 2
- FJWGYAHXMCUOOM-QHOUIDNNSA-N [(2s,3r,4s,5r,6r)-2-[(2r,3r,4s,5r,6s)-4,5-dinitrooxy-2-(nitrooxymethyl)-6-[(2r,3r,4s,5r,6s)-4,5,6-trinitrooxy-2-(nitrooxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-3,5-dinitrooxy-6-(nitrooxymethyl)oxan-4-yl] nitrate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O)O[C@H]1[C@@H]([C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@@H](CO[N+]([O-])=O)O1)O[N+]([O-])=O)CO[N+](=O)[O-])[C@@H]1[C@@H](CO[N+]([O-])=O)O[C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O FJWGYAHXMCUOOM-QHOUIDNNSA-N 0.000 abstract 1
- 238000001311 chemical methods and process Methods 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
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- 238000005406 washing Methods 0.000 description 9
- 241000700605 Viruses Species 0.000 description 5
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- 238000012946 outsourcing Methods 0.000 description 5
- 210000002966 serum Anatomy 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 230000009385 viral infection Effects 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 230000002596 correlated effect Effects 0.000 description 2
- 230000000875 corresponding effect Effects 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
- 229910052737 gold Inorganic materials 0.000 description 2
- 239000010931 gold Substances 0.000 description 2
- 230000028993 immune response Effects 0.000 description 2
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 2
- 229910052753 mercury Inorganic materials 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 210000002381 plasma Anatomy 0.000 description 2
- 230000035935 pregnancy Effects 0.000 description 2
- 238000011285 therapeutic regimen Methods 0.000 description 2
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 206010018910 Haemolysis Diseases 0.000 description 1
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 description 1
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
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- 238000013461 design Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000035931 haemagglutination Effects 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 238000010166 immunofluorescence Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- FSVCQIDHPKZJSO-UHFFFAOYSA-L nitro blue tetrazolium dichloride Chemical compound [Cl-].[Cl-].COC1=CC(C=2C=C(OC)C(=CC=2)[N+]=2N(N=C(N=2)C=2C=CC=CC=2)C=2C=CC(=CC=2)[N+]([O-])=O)=CC=C1[N+]1=NC(C=2C=CC=CC=2)=NN1C1=CC=C([N+]([O-])=O)C=C1 FSVCQIDHPKZJSO-UHFFFAOYSA-L 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 238000005325 percolation Methods 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
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Abstract
Description
Claims (8)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2008100194815A CN101216490B (en) | 2008-01-16 | 2008-01-16 | Dry chemical method TORCH detection reagent kit and method of manufacture |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2008100194815A CN101216490B (en) | 2008-01-16 | 2008-01-16 | Dry chemical method TORCH detection reagent kit and method of manufacture |
Publications (2)
Publication Number | Publication Date |
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CN101216490A true CN101216490A (en) | 2008-07-09 |
CN101216490B CN101216490B (en) | 2012-05-30 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN2008100194815A Active CN101216490B (en) | 2008-01-16 | 2008-01-16 | Dry chemical method TORCH detection reagent kit and method of manufacture |
Country Status (1)
Country | Link |
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CN (1) | CN101216490B (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103018443A (en) * | 2012-12-15 | 2013-04-03 | 北京金豪制药股份有限公司 | IgG antibody detection kit of TORCH five items and preparation of kit |
CN103033612A (en) * | 2012-12-15 | 2013-04-10 | 北京金豪制药股份有限公司 | IgM antibody detection kit for five TORCH tests and preparation of IgM antibody detection kit |
CN103399149A (en) * | 2013-08-22 | 2013-11-20 | 青岛中仁药业有限公司 | Family-planning four-item combined kit employing enzyme linked immunosorbent spot assay |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1987461B (en) * | 2006-12-12 | 2011-09-28 | 盛青松 | Dry chemical quick detecting reagent strip for glutamic-pyruvic transaminase and its producing method |
CN101038258A (en) * | 2007-04-02 | 2007-09-19 | 上海和盛生物科技有限公司 | Qualitative testing kit with dry chemical method and manufacturing method thereof |
CN101074954A (en) * | 2007-06-07 | 2007-11-21 | 盛青松 | Chlorhydric-acid clenbuterol fast inspection reagent kit and its production |
-
2008
- 2008-01-16 CN CN2008100194815A patent/CN101216490B/en active Active
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103018443A (en) * | 2012-12-15 | 2013-04-03 | 北京金豪制药股份有限公司 | IgG antibody detection kit of TORCH five items and preparation of kit |
CN103033612A (en) * | 2012-12-15 | 2013-04-10 | 北京金豪制药股份有限公司 | IgM antibody detection kit for five TORCH tests and preparation of IgM antibody detection kit |
CN103399149A (en) * | 2013-08-22 | 2013-11-20 | 青岛中仁药业有限公司 | Family-planning four-item combined kit employing enzyme linked immunosorbent spot assay |
Also Published As
Publication number | Publication date |
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CN101216490B (en) | 2012-05-30 |
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Legal Events
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20080709 Assignee: Wuxi Shenrui Bio-Pharmaceuticals Co., Ltd. Assignor: Sheng Qingsong Contract record no.: 2013320000045 Denomination of invention: Dry chemical method TORCH detection reagent kit and method of manufacture Granted publication date: 20120530 License type: Exclusive License Record date: 20130220 |
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LICC | Enforcement, change and cancellation of record of contracts on the licence for exploitation of a patent or utility model | ||
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20201224 Address after: 5 / F, c30303, C5, area C, Wuxi Huishan Life Science Park, 1699 Huishan Avenue, Huishan District, Wuxi City, Jiangsu Province Patentee after: WUXI SHENRUI BIO-PHARMACEUTICALS Co.,Ltd. Address before: 214058 Shen Rui Biological Products Co., Ltd., Huang Xiang hospital, 118 Fengxiang Road, Beitang District, Wuxi, Jiangsu Patentee before: Sheng Qingsong |