CN101209396B - Blended polysulfone hollow fiber film and preparation method - Google Patents

Blended polysulfone hollow fiber film and preparation method Download PDF

Info

Publication number
CN101209396B
CN101209396B CN 200610156419 CN200610156419A CN101209396B CN 101209396 B CN101209396 B CN 101209396B CN 200610156419 CN200610156419 CN 200610156419 CN 200610156419 A CN200610156419 A CN 200610156419A CN 101209396 B CN101209396 B CN 101209396B
Authority
CN
Grant status
Grant
Patent type
Prior art keywords
parts
polysulfone
hollow fiber
blended
polysulphone
Prior art date
Application number
CN 200610156419
Other languages
Chinese (zh)
Other versions
CN101209396A (en )
Inventor
吴耀国
王铮
Original Assignee
山西金泉合成纤维制造有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Grant date

Links

Abstract

The invention relates to a hollow fibrous membrane with blended polysulphone and a preparation method thereof. The invention provides a hollow fibrous membrane with blended polysulphone which is characterized in that the hollow fibrous membrane with blended polysulphone is composed of following materials by weight: 15 to 30 units of polysulphone; 1 to 15 units of aromatic polyamide; 1 to 15 unitsof kollidon; 1 to 10 units of polyethyleneglycol and 70 to 85 units of dimethyl acetamide. The invention also provides the preparation method of the hollow fibrous membrane with blended polysulphone.The product which is composed of the materials and prepared by the method is the hollow fibrous membrane with blended polysulphone that consists of following materials by weight percentages: 55 to 99percent of polysulphone, 0.8 to 60 percent of aromatic polyamide, 0.1 to 1 percent of kollidon and 0.1 to 1 percent of polyethyleneglycol. The hollow fibrous membrane with blended polysulphone is a new material of hollow fibrous membranes which is more ideal, has low cost and is used for hemodialysis.

Description

共混聚砜中空纤维膜及制备方法 Blending polysulfone hollow fiber membrane and method of preparing

技术领域 FIELD

[0001] 本发明涉及共混聚砜中空纤维膜及制备方法。 [0001] The present invention relates to blends of polysulfone hollow fiber membrane and method of preparation. 背景技术 Background technique

[0002] 目前的血液透析器材多以聚砜膜为材料。 [0002] It hemodialysis equipment is mostly polysulfone membrane material. 聚砜膜具有优良的机械性能,化学性能、空隙率高价格便宜等特点,然而聚砜也是一种高疏水性材料,因而单纯用聚砜材料制成的膜亲水性较差,导致了该膜用与血液透析时血液相溶性差,为了提高聚砜膜的亲水性能国内外都是加入PVP(聚乙烯吡咯烷酮)。 Polysulfone membranes having excellent mechanical properties, chemical properties, high porosity cheap and so on, but also a highly hydrophobic polysulfone material, and thus the film simply made of a hydrophilic polysulfone is poor, causing the blood dialysis membranes with poor blood compatibility in order to improve the hydrophilic properties of polysulfone membranes and abroad are added PVP (polyvinylpyrrolidone). 如中国专利(公开号为CN1158273A),一文中指示,加入PVP以后会增大膜对血中补体的激活,其激活程度随PVP量的增加而增加,从而影响聚砜膜材料固有的生物相容性。 Chinese Patent (Publication No. CN1158273A), a text indication, increases for activation of blood complement after addition of PVP, the degree of activation increases PVP content is increased, thereby affecting the inherent biological polysulfone membrane material compatibility sex. 日本专利JP-A-300633/1992,JP-B-54373/1993, JP-A-23813/1994,公开的聚砜膜的制备方法即为上述方法。 Japanese Patent JP-A-300633/1992, JP-B-54373/1993, JP-A-23813/1994, preparation of the polysulfone membrane disclosed is the above-described method. 另上海东华大学公布的专利是用聚醚砜和纤维素及其酯类共混虽能达到较好的性能,但其价格高,而常州郎生医疗器械公司发明的专利CN1305865A)是由聚砜和聚醚砜组成的聚芳砜膜。 Another Shanghai Donghua University, published patent is polyether sulfone and cellulose esters and blends been able to achieve better performance, but its high price, and the patent Changzhou Lang Johnson medical device company invented CN1305865A) is made of poly sulfones and polyether sulfone film composition polyarylene sulfone.

发明内容 SUMMARY

[0003] 为了解决目前血液透析器材存在的上述弊端,本发明提供一种可用于血液透析器的共混聚砜中空纤维膜及制造方法。 [0003] In order to solve the above drawbacks of the existing hemodialysis equipment, the present invention provides a membrane blending polysulfone hollow fiber can be used in a method of manufacturing a hemodialyzer.

[0004] 本发明的技术方案如下: [0004] aspect of the present invention is as follows:

[0005] 本发明提供一种共混聚砜中空纤维膜,其特征在于,是由如下重量份数的原料制备而成: [0005] The present invention provides a blend of a polysulfone hollow fiber membrane, wherein the raw material is prepared from the following parts by weight:

[0006]聚砜 15-30 ; [0006] Polysulfone 15-30;

[0007] 芳香聚酰胺 1-15 ; [0007] The aromatic polyamide 1-15;

[0008] 聚乙烯吡咯烷酮 1-15; [0008] Polyvinylpyrrolidone 1-15;

[0009]聚乙二醇 1-10; [0009] polyethylene glycol 10;

[0010] 二甲基乙酰胺 70-85。 [0010] dimethylacetamide 70-85.

[0011] 本发明提供上述共混聚砜中空纤维膜的制备方法,其特征在于,步骤如下: [0011] The present invention provides the method for preparing a blend of the polysulfone hollow fiber membrane, characterized by the following steps:

[0012] (1)将上述重量份数的原料混合,制成纺丝原液; [0012] (1) parts by weight of the above raw material mixed to prepare a spinning dope;

[0013] (2)步骤(1)制备的纺丝原液经过滤、脱泡、纺丝、保孔、干燥成型。 [0013] (2) Step (1) Preparation of spinning solution was filtered, defoamed spinning, security holes, molded and dried.

[0014] 作为优化方案,上述共混聚砜中空纤维膜的制备方法,具体方法如下: [0014] As optimization, the above-described method for preparing a blend of the polysulfone hollow fiber membrane, specifically as follows:

[0015] (1)取所述重量份数的原料,在65°C -100°C溶解,制成纺丝原液; [0015] (1) taking the parts by weight of starting material, at 65 ° C -100 ° C is dissolved to prepare a spinning dope;

[0016] (2)步骤(1)制备的原液用100-300目滤网过滤,45 °C -85 °C真空脱泡, 0. 3-0. 6MPa的压力下,喷丝头挤出,喷出的丝以15-30米/分钟的速度经10cm-50cm空气程,进入纯化水程,凝固成中空纤维膜后,30°C -60°C水洗、离心干燥后,置甘油中12-M小时,最后在40°C -65°C条件下烘干。 [0016] (2) Step (1) Preparation of stock solution was filtered through a filter of 100-300 mesh, 45 ° C -85 ° C vacuum deaeration under a pressure of 0. 3-0. 6MPa, and extruded through a spinneret, after the discharged filaments at a speed of 15-30 m / min through the air path 10cm-50cm, purified water into the process, a hollow fiber membrane after solidification, 30 ° C -60 ° C washed with water, centrifuged and dried, set glycerol 12- M h, and finally dried at 40 ° C -65 ° C conditions.

[0017] 利用上述原料和方法制备的产品为共混聚砜中空纤维膜,其组成为:(重量百分比)聚砜含量为40-99 %,芳香聚酰胺为0. 8-60 %,聚乙烯吡咯烷酮为0. 1_5 %,聚乙二醇含量为0. 1-1%。 [0017] Preparation of starting material using the above methods and products for blending polysulfone hollow fiber membrane consisting of :( weight percent) content of 40-99% polysulfone, aromatic polyamide 0. 8-60% polyethylene 0. 1_5% polyvinylpyrrolidone, polyethylene glycol content of 0. 1-1%.

[0018] 本发明所提供的共混聚砜中空纤维膜可用于制备血液透析器。 [0018] The blending polysulfone hollow fiber membrane according to the present invention may be provided for the preparation of a hemodialyzer.

[0019] 本发明实现的技术效果如下: [0019] The present invention achieves the following technical effects:

[0020] 1.本发明所提供的原料和方法制备的产品为共混聚砜中空纤维膜,有优良的血液相溶性、蛋白吸附性及凝血性小,对补体激活小等优点。 Materials and Methods Preparation of the product [0020] 1. The present invention provides a blend of the polysulfone hollow fiber membrane, excellent in compatibility with blood, protein adsorption and small coagulation, complement activation is small.

[0021] 2.本发明共混聚砜中空纤维膜的性能均能达到国内外合成纤维膜的各项性能指标,具有优良的机械强度,高物化稳定性,高清除率,经测试四小时内肌酐尿素下降率均达到99%,中分子、维生素B12下降率达到70%。 Performance [0021] 2. The blend of the present invention, a polysulfone hollow fiber membranes can reach the synthetic membrane performance at home and abroad, has excellent mechanical strength, high chemical and physical stability, high clearance rate, four hours after the test urea creatinine decreased rate reached 99%, molecular, vitamin B12 decrease rate of 70%.

[0022] 3.本发明的共混聚砜中空纤维膜解决了纤维素膜不能清除血液中的中分子、有毒物质的问题,提高了肾病病人的透析效果。 Blending polysulfone hollow fiber membrane [0022] 3. The present invention solves the problem of the cellulose film can not clear the blood in the molecule, toxic substances, the effect of improving renal dialysis patients.

[0023] 4.本发明的共混聚砜中空纤维膜最大的特点是价格便宜,是聚醚砜膜价格的1/3,是进口聚砜类膜价格的1/2。 [0023] The greatest feature blend 4. The polysulfone hollow fiber membrane of the present invention is inexpensive, the price is 1/3 polyethersulfone membrane, polysulfone membrane imported price 1/2.

[0024] 共混高聚物为全芳香聚酰胺,由于全芳香聚酰胺为亲水性的高分子材料,其共混后产生的血液透析器新材料不但物化性能好机械强度高,溶质清除率高,且具有优良的血液相容性,较小的蛋白吸附及凝血性,对补体激活小等诸多优点,是一种较为理想的成本低的用于血液透析的中空纤维膜的新材料。 [0024] The wholly aromatic polyamide for the polymer blends, because wholly aromatic polyamide is a hydrophilic polymer material produced after blends hemodialyzer new material not only physical and chemical properties of high mechanical strength, solute clearance high, and has excellent blood compatibility, and a small protein adsorption clotting, complement activation of the small and many other advantages, it is an ideal low cost of new materials for the hollow fiber membrane in hemodialysis.

[0025] 具体实施方式 [0025] DETAILED DESCRIPTION

[0026] 实施例1 [0026] Example 1

[0027] 取聚砜(η = 0.6) 17份,芳香聚酰胺3份,聚乙烯吡咯烷酮3份,聚乙二醇2份, 二甲基乙酰胺75份。 [0027] Take polysulfone (η = 0.6) 17 parts, 3 parts of an aromatic polyamide, polyvinyl pyrrolidone 3 parts, 2 parts of polyethylene glycol, 75 parts of dimethylacetamide.

[0028] 以上组成配方,溶解制成纺丝原液,经过滤、脱泡、纺丝(水浸温度20°C)、保孔、干燥制成共混聚砜中空纤维膜,用作低通量人工肾血液透析膜。 [0028] The above composition formula, was dissolved make the spinning dope, filtered, defoamed spinning (flooding temperature of 20 ° C), security holes, and dried polysulfone hollow fiber is made of a blend membranes, as a low-flux artificial kidney hemodialysis membranes.

[0029] 具体步骤如下: [0029] The specific steps are as follows:

[0030] 取所述重量份数的原料,在65°C-100°C溶解,制成纺丝原液;原液用100-300目镍网过滤,在真空度-0. 05至-0. IMPa、温度45°C _85°C条件下脱泡,除去原液中的少量气泡。 [0030] Take the feedstock parts by weight, at 65 ° C-100 ° C was dissolved to prepare a spinning dope;. Dope was filtered 100-300 mesh nickel net, the degree of vacuum -005 to -0 IMPa. , at a temperature of 45 ° C _85 ° C degassing conditions, few bubbles in the liquid is removed. 脱泡后的纺丝原液在0. 3-0. 6MPa的压力下,经喷丝头挤出,喷出的丝以15-30米/分钟的速度经10cm-50cm空气程,进入纯化水程(纯化水温度20°C -60°C,水浸长度1米_2米) 凝固成中空纤维膜。 After deaeration the spinning dope at a pressure of 0. 3-0. 6MPa, and extruded through a spinneret, filaments ejected at a speed of 15-30 m / min through 10cm-50cm process air into the purified water path (purified water temperature of 20 ° C -60 ° C, _2 m flooding length 1 m) set into the hollow fiber membranes. 该膜经30°C-6(TC水洗,离心干燥后置甘油中保孔处理12-M小时,最后在40°C _65°C条件下烘干,即得。 The film was 30 ° C-6 (TC washed with water, centrifuged and dried mediator hole processing set glycerol 12-M h, and finally dried at 40 ° C _65 ° C conditions, i.e., too.

[0031] 其产品指标为=S = 1.3m2,壁厚40 μ m,内孔直径200-250 μ m。 [0031] which is the product index = S = 1.3m2, a wall thickness of 40 μ m, the hole diameter 200-250 μ m.

[0032] 利用上述原料和方法制备的产品为共混聚砜中空纤维膜,其组成为:(重量百分比)聚砜含量为68-90 %,芳香聚酰胺为5-12 %,聚乙烯吡咯烷酮为0. 1-1%,聚乙二醇含量为0. 1-1%。 [0032] Preparation of starting material using the above methods and products for blending polysulfone hollow fiber membrane consisting of :( weight percent) content of 68-90% polysulfone, aromatic polyamide is 5-12%, polyvinyl pyrrolidone 0. 1-1%, 1-1 polyethylene glycol content of 0.5%.

[0033] 产品的使用性能如下: [0033] product performance are as follows:

[0034]超滤率:10_16ml/h · Iffa ; [0034] ultrafiltration rate: 10_16ml / h · Iffa;

[0035]尿素清除率为:145-185ml/min ; [0035] The clearance of urea: 145-185ml / min;

[0036]肌酐清除率为:i;35-165ml/min ; [0036] The creatinine clearance: i; 35-165ml / min;

[0037] VB12 清除率为:40-50ml/min。 [0037] VB12 clearance rate: 40-50ml / min.

[0038]实例 2[0039] 取聚砜(η = 0. 6) 12份,芳香聚酰胺5份,聚乙烯吡咯烷酮1份,聚乙二醇2份, 二甲基乙酰胺75份。 [0038] Example 2 [0039] Take polysulfone (η = 0. 6) 12 parts, 5 parts of an aromatic polyamide, a polyvinyl pyrrolidone parts, 2 parts of polyethylene glycol, 75 parts of dimethylacetamide.

[0040] 以上组成配方,溶解制成纺丝原液,经过滤、脱泡、纺丝(水浸温度30-40°C )、保孔、干燥制成共混聚砜中空纤维膜,为高通量的血液透析膜。 [0040] The above composition formula, was dissolved make the spinning dope, filtered, defoamed spinning (flooding temperature of 30-40 ° C), security holes, and dried polysulfone hollow fiber is made of a blend membranes, Qualcomm amount of blood dialysis membrane.

[0041] 具体步骤参照实施例1。 [0041] Reference Example 1 Specific steps.

[0042] 产品指标为=S = 1. 3m2,壁厚40 μ m,内孔直径200-250 μ m。 [0042] Product indicators = S = 1. 3m2, a wall thickness of 40 μ m, the hole diameter 200-250 μ m.

[0043] 利用上述原料和方法制备的产品为共混聚砜中空纤维膜,其组成为:(重量百分比)聚砜含量为60-86%,芳香聚酰胺为15-25%,聚乙烯吡咯烷酮为0. 1_1%,聚乙二醇含量为0. 1-1%。 [0043] Preparation of starting material using the above methods and products for blending polysulfone hollow fiber membrane consisting of :( weight percent) content of 60-86% polysulfone, aromatic polyamide is 15-25%, polyvinyl pyrrolidone 0. 1_1%, polyethylene glycol content of 0. 1-1%.

[0044] 产品的使用性能如下: [0044] product performance are as follows:

[0045]超滤率:200-300ml/h · KPa ; [0045] ultrafiltration rate: 200-300ml / h · KPa;

[0046]尿素清除率为:145-185ml/min ; [0046] The clearance of urea: 145-185ml / min;

[0047]肌酐清除率为:i;35-165ml/min ; [0047] The creatinine clearance: i; 35-165ml / min;

[0048] VB12 清除率为:50-60ml/min。 [0048] VB12 clearance rate: 50-60ml / min.

[0049]实例 3 [0049] Example 3

[0050] 取聚砜(η = 0. 6) 15份,芳香聚酰胺1份,聚乙烯吡咯烷酮4份,聚乙二醇5份, 二甲基乙酰胺75份。 [0050] Take polysulfone (η = 0. 6) 15 parts, 1 part of aromatic polyamide, 4 parts of polyvinylpyrrolidone, 5 parts of polyethylene glycol, 75 parts of dimethylacetamide.

[0051] 以上组成配方,溶解制成纺丝原液,经过滤、脱泡、纺丝(水浸温度50-60°C )、保孔、干燥制成共混聚砜中空纤维膜,用作高通量的血液透析。 [0051] The above composition formula, was dissolved make the spinning dope, filtered, defoamed spinning (flooding temperature of 50-60 ° C), security holes, and dried blend made polysulfone hollow fiber membrane, as a high flux hemodialysis. 该膜也可用于血液滤过器,血浆分离等血液透析的新材料。 The film may also be used for hemofiltration, a plasma separation hemodialysis and other new materials.

[0052] 具体步骤参照实施例1。 [0052] Reference Example 1 Specific steps.

[0053] 利用上述原料和方法制备的产品为共混聚砜中空纤维膜,其组成为:(重量百分比)聚砜含量为60-95 %,芳香聚酰胺为2-5%,聚乙烯吡咯烷酮为0. 1 -1 %,聚乙二醇含量为0. 1-1%。 [0053] Preparation of starting material using the above methods and products for blending polysulfone hollow fiber membrane consisting of :( wt%) polysulfone content is 60-95%, 2-5% of aromatic polyamide, polyvinyl pyrrolidone 0. 1-1%, 1-1 polyethylene glycol content of 0.5%.

[0054] 其产品指标为=S = 1. 3M2,壁厚40 μ m,内孔直径200-250 μ m。 [0054] which is the product index = S = 1. 3M2, a wall thickness of 40 μ m, the hole diameter 200-250 μ m.

[0055] 产品的使用性能如下: [0055] product performance are as follows:

[0056]超滤率:300-2000ml/h · KPa ; [0056] ultrafiltration rate: 300-2000ml / h · KPa;

[0057]尿素清除率为:145-185ml/min ; [0057] The clearance of urea: 145-185ml / min;

[0058]肌酐清除率为:i;35-165ml/min ; [0058] The creatinine clearance: i; 35-165ml / min;

[0059] VB12 清除率为:50-100ml/min。 [0059] VB12 clearance rate: 50-100ml / min.

[0060] 实例4 [0060] Example 4

[0061] 配方如下: [0061] formula is as follows:

[0062]聚砜(η = 0. 6) 15 ; [0062] Polysulfone (η = 0. 6) 15;

[0063] 芳香聚酰胺 15 ; [0063] Aromatic polyamide 15;

[0064] 聚乙烯吡咯烷酮 1 ; [0064] a polyvinyl pyrrolidone;

[0065]聚乙二醇 10; [0065] 10 polyethylene glycol;

[0066] 二甲基乙酰胺 70。 [0066] 70-dimethylacetamide.

[0067] 以上组成配方,溶解制成纺丝原液,经过滤、脱泡、纺丝(水浸温度50-60°C )、保孔、干燥制成共混聚砜中空纤维膜,用作高通量的血液透析。 [0067] The above composition formula, was dissolved make the spinning dope, filtered, defoamed spinning (flooding temperature of 50-60 ° C), security holes, and dried blend is made of polysulfone hollow fiber membrane, as a high flux hemodialysis. 该膜也可用于血液滤过器,血浆分离等血液透析的新材料。 The film may also be used for hemofiltration, a plasma separation hemodialysis and other new materials.

[0068] 具体步骤参照实施例1。 [0068] Reference Example 1 Specific steps.

[0069] 利用上述原料和方法制备的产品为共混聚砜中空纤维膜,其组成为:(重量百分比)聚砜含量为40-70%,芳香聚酰胺为40-60%,聚乙烯吡咯烷酮为0. 1-1%,聚乙二醇含量为0. 1-1%。 [0069] Preparation of starting material using the above methods and products for blending polysulfone hollow fiber membrane consisting of :( weight percent) content of 40-70% polysulfone, aromatic polyamide is 40-60%, polyvinyl pyrrolidone 0. 1-1%, 1-1 polyethylene glycol content of 0.5%.

[0070] 其产品指标为=S = 1. 3M2,壁厚40 μ m,内孔直径200-250 μ m。 [0070] which is the product index = S = 1. 3M2, a wall thickness of 40 μ m, the hole diameter 200-250 μ m.

[0071] 产品的使用性能如下: [0071] product performance are as follows:

[0072]超滤率:300-2000ml/h · KPa ; [0072] ultrafiltration rate: 300-2000ml / h · KPa;

[0073]尿素清除率为:145-185ml/min ; [0073] Urea clearance rate: 145-185ml / min;

[0074]肌酐清除率为:i;35-165ml/min ; [0074] The creatinine clearance: i; 35-165ml / min;

[0075] VB12 清除率为:50-100ml/min。 [0075] VB12 clearance rate: 50-100ml / min.

[0076] 实例5 [0076] Example 5

[0077]聚砜(η = 0. 6) 30 ; [0077] Polysulfone (η = 0. 6) 30;

[0078] 芳香聚酰胺 1 ; [0078] an aromatic polyamide;

[0079] 聚乙烯吡咯烷酮 15; [0079] Polyvinylpyrrolidone 15;

[0080] 聚乙二醇 1 ; [0080] a polyethylene glycol;

[0081] 二甲基乙酰胺 85。 [0081] 85-dimethylacetamide.

[0082] 以上组成配方,溶解制成纺丝原液,经过滤、脱泡、纺丝(水浸温度50-60°C )、保孔、干燥制成共混聚砜中空纤维膜,用作高通量的血液透析。 [0082] The above composition formula, was dissolved make the spinning dope, filtered, defoamed spinning (flooding temperature of 50-60 ° C), security holes, and dried blend made polysulfone hollow fiber membrane, as a high flux hemodialysis. 该膜也可用于血液滤过器,血浆分离等血液透析的新材料。 The film may also be used for hemofiltration, a plasma separation hemodialysis and other new materials.

[0083] 具体步骤参照实施例1。 [0083] Reference Example 1 Specific steps.

[0084] 利用上述原料和方法制备的产品为共混聚砜中空纤维膜,其组成为:(重量百分比)聚砜含量为90-99%,芳香聚酰胺为0. 8-3%,聚乙烯吡咯烷酮为2-5%,聚乙二醇含量为0. 1-1%。 [0084] Preparation of starting material using the above methods and products for blending polysulfone hollow fiber membrane consisting of :( weight percent) content of 90-99% polysulfone, aromatic polyamide 0. 8-3% polyethylene 2-5% polyvinylpyrrolidone, polyethylene glycol content of 0. 1-1%.

[0085] 其产品指标为:S = 1. 3M2,壁厚40 μ m,内孔直径200-250 μ m。 [0085] Products which indicators: S = 1. 3M2, a wall thickness of 40 μ m, the hole diameter 200-250 μ m.

[0086] 产品的使用性能如下: [0086] product performance are as follows:

[0087]超滤率:300-2000ml/h · KPa ; [0087] ultrafiltration rate: 300-2000ml / h · KPa;

[0088]尿素清除率为:145-185ml/min ; [0088] Urea clearance rate: 145-185ml / min;

[0089]肌酐清除率为:i;35-165ml/min ; [0089] The creatinine clearance: i; 35-165ml / min;

[0090] VB12 清除率为:50-100ml/min。 [0090] VB12 clearance rate: 50-100ml / min.

Claims (2)

  1. 1. 一种共混聚砜中空纤维膜,其特征在于,由如下重量份数的原料:η =0.6的聚砜15份,芳香聚酰胺1份,聚乙烯吡咯烷酮4份,聚乙二醇5份,二甲基乙酰胺75份;或者,η =0.6的聚砜15份,芳香聚酰胺15份,聚乙烯吡咯烷酮1份,聚乙二醇10份, 二甲基乙酰胺70份;或者,η = 0. 6聚砜30份,芳香聚酰胺1份,聚乙烯吡咯烷酮15份,聚乙二醇1份,二甲基乙酰胺85份;经下列步骤制成:(1)取所述重量份数的原料,在65°C -10(TC溶解,制成纺丝原液,(2)步骤(1)制备的原液用100-300目滤网过滤,45°C _85°C真空脱泡,0. 3-0. 6MPa 的压力下,喷丝头挤出,喷出的丝以15-30米/分钟的速度经10cm-50cm空气程,进入纯化水程,凝固成中空纤维膜后,30°C -60°C水洗、离心干燥后,置甘油中12-M小时,最后在40 0C -65 °C条件下烘干。 A blend of a polysulfone hollow fiber membrane, characterized by the following raw materials in parts by weight: η = 0.6 polysulfone of 15 parts, 1 part of aromatic polyamide, 4 parts of polyvinyl pyrrolidone, polyethylene glycol 5 parts, 75 parts of dimethylacetamide; or, η = 15 0.6 parts of polysulfone, aromatic polyamide 15 parts, 1 part of polyvinylpyrrolidone, 10 parts of polyethylene glycol, 70 parts of dimethylacetamide; or η = 0. 6 30 parts of polysulfone, aromatic polyamide parts 1, 15 parts of polyvinylpyrrolidone, 1 part of polyethylene glycol, 85 parts of dimethylacetamide; made by the following steps: (1) taking the weight parts of the raw material, at 65 ° C -10 (TC dissolved to prepare a spinning dope (2) step (1) preparation of stock solution was filtered through a filter of 100-300 mesh, 45 ° C _85 ° C vacuum defoaming, under a pressure of 0. 3-0. 6MPa, and extruded through a spinneret, filaments ejected at a speed of 15-30 m / min through the air path 10cm-50cm, purified water into the process, coagulated into a hollow fiber membrane, 30 ° C -60 ° C washed with water, centrifuged and dried, 12-M counter glycerol hours and finally dried at 40 0C -65 ° C conditions.
  2. 2.包含权利要求1所述共混聚砜中空纤维膜的血液透析器。 2. The blend of claim 1 comprising a polysulfone hollow fiber membrane hemodialyzer.
CN 200610156419 2006-12-31 2006-12-31 Blended polysulfone hollow fiber film and preparation method CN101209396B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN 200610156419 CN101209396B (en) 2006-12-31 2006-12-31 Blended polysulfone hollow fiber film and preparation method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN 200610156419 CN101209396B (en) 2006-12-31 2006-12-31 Blended polysulfone hollow fiber film and preparation method

Publications (2)

Publication Number Publication Date
CN101209396A true CN101209396A (en) 2008-07-02
CN101209396B true CN101209396B (en) 2011-07-06

Family

ID=39609754

Family Applications (1)

Application Number Title Priority Date Filing Date
CN 200610156419 CN101209396B (en) 2006-12-31 2006-12-31 Blended polysulfone hollow fiber film and preparation method

Country Status (1)

Country Link
CN (1) CN101209396B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103721575B (en) * 2012-10-11 2016-03-30 中国石油化工股份有限公司 A method for preparing a composite polysulfone ultrafiltration flat membrane

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1257434A (en) 1997-05-19 2000-06-21 旭医学株式会社 Polysulfone-base hollow-fiber hemocathartic membrane and processes for the production thereof
CN1375351A (en) 2001-12-28 2002-10-23 上海益尔康医用设备有限公司 Production process of hollow blended polyether sulphone fiber dialysis membrane
CN1380130A (en) 2002-02-07 2002-11-20 尉福生 Preparation method of hollow fibre supermicro filtration membrane
CN1633329A (en) 2000-11-13 2005-06-29 美国污水过滤器集团公司 Modified membranes
CN1683059A (en) 2005-03-03 2005-10-19 上海一鸣过滤技术有限公司 Reinforced hollow fiber super filter film and its preparing method
WO2006106133A1 (en) 2005-04-07 2006-10-12 Gambro Lundia Ab Filtration membrane

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1257434A (en) 1997-05-19 2000-06-21 旭医学株式会社 Polysulfone-base hollow-fiber hemocathartic membrane and processes for the production thereof
CN1633329A (en) 2000-11-13 2005-06-29 美国污水过滤器集团公司 Modified membranes
CN1375351A (en) 2001-12-28 2002-10-23 上海益尔康医用设备有限公司 Production process of hollow blended polyether sulphone fiber dialysis membrane
CN1380130A (en) 2002-02-07 2002-11-20 尉福生 Preparation method of hollow fibre supermicro filtration membrane
CN1683059A (en) 2005-03-03 2005-10-19 上海一鸣过滤技术有限公司 Reinforced hollow fiber super filter film and its preparing method
WO2006106133A1 (en) 2005-04-07 2006-10-12 Gambro Lundia Ab Filtration membrane

Also Published As

Publication number Publication date Type
CN101209396A (en) 2008-07-02 application

Similar Documents

Publication Publication Date Title
US4935141A (en) Selectively permeable asymmetric membranes suitable for use in hemodialysis and processes for manufacturing such membranes
US6355730B1 (en) Permselective membranes and methods for their production
US5232601A (en) High flux hollow fiber membrane
US4780205A (en) Permselective hollow fiber membrane, process for the preparation thereof, method and apparatus for plasma components separation
US5938929A (en) Polysulfone hollow fiber semipermeable membrane
US4906375A (en) Asymmetrical microporous hollow fiber for hemodialysis
US4874522A (en) Polysulfone hollow fiber membrane and process for making the same
WO2004056460A1 (en) Perm selective asymmetric hollow fibre membrane for the separation of toxic mediators from blood
US6042783A (en) Hollow yarn membrane used for blood purification and blood purifier
JP2006198611A (en) Production method of separation membrane, and production method of separation membrane module using the separation membrane
JPH06165926A (en) Polysulfone hollow fabric membrane and production therefor
JP2000254222A (en) Hollow fiber membrane for hematocatharsis and hollow fiber membrane type artificial kidney
CN1883779A (en) Process for preparing composite hollow fiber membrane
US20060108288A1 (en) Plasma purification membrane and plasma purification system
JP2001170167A (en) Method of manufacturing dialyzer and method of sterilization
US5891338A (en) Heat-sterilizable membrane
JP2000140589A (en) Porous polysulfone film
US4459210A (en) Porous membrane
US7087168B2 (en) Hollow fiber membrane for purifying blood
JPH08108053A (en) Cellulose acetate hollow-fiber separation membrane and its production
US6013182A (en) Selectively permeable hollow fiber membrane and process for producing same
JP2700170B2 (en) Membrane oxygenator
JP2004525755A (en) Asymmetric hollow fiber membranes
EP0012630A1 (en) Process for producing a cellulose acetate-type permselective membrane, permselective membrane thus produced, and use of such membrane in artificial kidney
WO1998052683A1 (en) Polysulfone-base hollow-fiber hemocathartic membrane and processes for the production thereof

Legal Events

Date Code Title Description
C06 Publication
C10 Request of examination as to substance
C14 Granted
C17 Cessation of patent right