CN1011660B - Drug composition containing trinitrobenzene and river snail - Google Patents
Drug composition containing trinitrobenzene and river snailInfo
- Publication number
- CN1011660B CN1011660B CN86102861A CN86102861A CN1011660B CN 1011660 B CN1011660 B CN 1011660B CN 86102861 A CN86102861 A CN 86102861A CN 86102861 A CN86102861 A CN 86102861A CN 1011660 B CN1011660 B CN 1011660B
- Authority
- CN
- China
- Prior art keywords
- powder
- river snail
- trinitrobenzene
- added
- composition containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to a medicine composition containing trinitrobenzene and river snail. 2.4-dinitro-chlorobenzene is dissolved in water, and sodium hydroxide is added and stirred; when crystals are separated out to form dinitrophenol, concentrated nitric acid is added, and the mixture is stirred until no nitrogen dioxide gas occurs; upper yellow liquid is taken out, hydrochloric acid is added to the upper yellow liquid until no crystal occurs, and crystal powder of trinitrophenol is formed by filtration and baking. Biologic river snail meat is dipped in yellow wine; the mixture is steamed, baked, and pulverized into river snail powder; finally, the river snail powder, the trinitrophenol crystal powder and starch are mixed into powder or made into tablets.
Description
A kind of medicine synthetic method that contains trinitrobenzene, Cipangopaludina chinensis.
The invention belongs to the synthetic process of medicine.
At present, China does not all have special effect medicine therapeutic to all types of nephritis and uremia.After patient morbidity, generally be medicine symptomatic treatment routinely, can only reach the state of an illness is alleviated to some extent, mainly later on be careful in one's diet by rest, recover healthy gradually.But relapse rate is than higher, transfers to chronicly by acute, and chronicity patient is a lot, brings very big misery to patient.The present invention has studied a kind of trinitrobenzene and synthetic medicine of Cipangopaludina chinensis of containing, and treats all types of nephritis victims example surplus in the of 600 altogether, and the cure rate height is subjected to numerous patients' welcome deeply.
Main points of the present invention add 2.4 dinitrochlorobenzenes when being to make water to reach 40-90 ℃ of temperature and are heated to 80-100 ℃, treat 2.4 dinitrochlorobenzenes all after the dissolving, and hydro-oxidation sodium added once every 5 minutes, stir 1.5 hours after being heated to 90-100 ℃.Separate out the dinitrophenol,DNP crystallization after cooling and carry out suction strainer, under 30-50 ℃ temperature, dry by the fire dinitrophenol,DNP crystallization to water content 30%, till adding water again and stirring, add nitric acid post-heating to 100 ℃ and stirred 1-2 hour, cannot see smog (nitrogen dioxide) to naked eyes till.The yellow liquid in taking-up upper strata adds concentrated hydrochloric acid and carries out chemical combination, separates out crystalline solid after cooling, filters, and dries under 30-50 ℃ of temperature, and the trinitrobenzene crystalline powder is white in color.
Another main points of the present invention are that meat is taken out in the clean back of biological Cipangopaludina chinensis, add yellow wine, cooperate with 1: 0.5 ratio, till the 70-90 ℃ of temperature therapeutic method to keep the adverse QI flowing downwards cooks, dry 1-2 hour under 50-90 ℃ of temperature then, pulverize.
With trinitrobenzene crystalline powder and Cipangopaludina chinensis powder, the starch proportioning mixing and stirring with 1: 0.25: 0.5, being made into tablet or powder can take.
The animal toxicology test:
White mice: once oral maximum safety is 50 milligrams.
Intravenous injection: 72 milligrams of lethal doses, 20 milligrams of safe doses.
Execute example:
Water adds 2.4 dinitrochlorobenzenes, 75 grams for 150 milliliters and is heated to 100 ℃.Add 30 gram sodium hydroxide after waiting to dissolve, added 5 grams every 5 minutes, stirred after being heated to 90 ℃ 1.5 hours, separate out the dinitro benzene crystalline solid after the cooling, suction strainer, oven dry back reuse 100 ml waters stir and add 108 gram nitric acid and be heated to 100 ℃ and stir and occurred to there not being nitrogen dioxide smog in 2 hours, the yellow liquid in taking-up upper strata adds concentrated hydrochloric acid and carries out chemical combination, and crystalline solid is separated out in cooling, filters, dries the trinitrobenzene crystalline powder that is white in color.Cipangopaludina chinensis 100 restrains the yellow wine gas that adds 50 milliliters and cooks in the pulverizing after 2 hours of oven dry under 90 ℃ of temperature.Trinitrobenzene crystalline powder 100 grams, Cipangopaludina chinensis powder 25 grams, starch 50 grams are made into powder or tablet.
The adult obeys three times every day, and each 0.5 milligram, one after each meal drinks water more.Example surplus the treatment patient 600, nephritis treatment 400 examples, cure rate reaches 90%, and nephropyelitis is treated 100 examples, and cure rate reaches 95%, and uremia's 100 routine cure rates reach 70%.
Claims (1)
1, a kind of trinitrobenzene, Cipangopaludina chinensis medicament preparation method of containing, it is characterized in that Cipangopaludina chinensis and yellow wine are cooperated with 1: 0,5 ratio, cook and dry pulverizing the 70-90 ℃ of temperature therapeutic method to keep the adverse QI flowing downwards, again trinitrobenzene crystalline powder, Cipangopaludina chinensis powder, starch are made tablet or powder with 1: 0,25: 0,5 mixed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN86102861A CN1011660B (en) | 1986-04-23 | 1986-04-23 | Drug composition containing trinitrobenzene and river snail |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN86102861A CN1011660B (en) | 1986-04-23 | 1986-04-23 | Drug composition containing trinitrobenzene and river snail |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN86102861A CN86102861A (en) | 1987-11-11 |
| CN1011660B true CN1011660B (en) | 1991-02-20 |
Family
ID=4801869
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN86102861A Expired CN1011660B (en) | 1986-04-23 | 1986-04-23 | Drug composition containing trinitrobenzene and river snail |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1011660B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10457629B2 (en) | 2013-08-30 | 2019-10-29 | Yale University | Therapeutic DNP derivatives and methods using same |
| JP6706204B2 (en) * | 2013-08-30 | 2020-06-03 | イエール ユニバーシティ | Novel 2,4-dinitrophenol preparation and its use |
-
1986
- 1986-04-23 CN CN86102861A patent/CN1011660B/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CN86102861A (en) | 1987-11-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C13 | Decision | ||
| GR02 | Examined patent application | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |