CN101111240B - N-丁基苯磺酰胺的分离，苯磺酰胺衍生物的合成，以及n-丁基苯磺酰胺和苯磺酰胺衍生物用于制备治疗良性前列腺增生和/或前列腺癌药物的用途 - Google Patents

N-丁基苯磺酰胺的分离，苯磺酰胺衍生物的合成，以及n-丁基苯磺酰胺和苯磺酰胺衍生物用于制备治疗良性前列腺增生和/或前列腺癌药物的用途 Download PDF

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Publication number
CN101111240B
CN101111240B CN2006800037419A CN200680003741A CN101111240B CN 101111240 B CN101111240 B CN 101111240B CN 2006800037419 A CN2006800037419 A CN 2006800037419A CN 200680003741 A CN200680003741 A CN 200680003741A CN 101111240 B CN101111240 B CN 101111240B
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China
Prior art keywords
benzsulfamide
trifluoromethyl
butyl
treatment
sulfonamide
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Expired - Fee Related
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CN2006800037419A
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English (en)
Chinese (zh)
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CN101111240A (zh
Inventor
汉斯来纳·霍夫曼
鲁多弗·马土许
阿里亚·巴尼亚马达
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LTS Lohmann Therapie Systeme AG
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LTS Lohmann Therapie Systeme AG
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
CN2006800037419A 2005-02-05 2006-01-28 N-丁基苯磺酰胺的分离，苯磺酰胺衍生物的合成，以及n-丁基苯磺酰胺和苯磺酰胺衍生物用于制备治疗良性前列腺增生和/或前列腺癌药物的用途 Expired - Fee Related CN101111240B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102005005397.1 2005-02-05
DE102005005397A DE102005005397B4 (de) 2005-02-05 2005-02-05 Isolierung von N-Butylbenzolsulfonamid, Synthese von Benzolsulfonamid-Derivaten sowie Verwendung von N-Butylbenzolsulfonamid und Benzolsulfonamid-Derivaten zur Behandlung der benignen Prostatahyperplasie und/oder des Prostatakarzinoms
PCT/EP2006/000746 WO2006081994A2 (de) 2005-02-05 2006-01-28 Isolierung von n-butylbenzolsulfonamid, synthese von benzolsulfonamid-derivaten sowie verwendung von n-butylbenzolsulfonamid und benzolsulfonamid-derivaten zur behandlung der benignen prostatahyperplasie und/oder des prostatakarzinoms

Publications (2)

Publication Number Publication Date
CN101111240A CN101111240A (zh) 2008-01-23
CN101111240B true CN101111240B (zh) 2011-09-21

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CN2006800037419A Expired - Fee Related CN101111240B (zh) 2005-02-05 2006-01-28 N-丁基苯磺酰胺的分离，苯磺酰胺衍生物的合成，以及n-丁基苯磺酰胺和苯磺酰胺衍生物用于制备治疗良性前列腺增生和/或前列腺癌药物的用途

Country Status (12)

Country Link
US (1) US7700654B2 (enExample)
EP (1) EP1845963A2 (enExample)
JP (1) JP5191238B2 (enExample)
KR (1) KR20070100844A (enExample)
CN (1) CN101111240B (enExample)
AU (1) AU2006210040B9 (enExample)
BR (1) BRPI0606563A2 (enExample)
CA (1) CA2596618C (enExample)
DE (1) DE102005005397B4 (enExample)
MX (1) MX2007009402A (enExample)
WO (1) WO2006081994A2 (enExample)
ZA (1) ZA200706061B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2734215B1 (en) * 2011-07-22 2019-06-05 Goel, Pawan Kumar Improved process for pygeum extraction
US20130085283A1 (en) * 2011-10-04 2013-04-04 Coyote Pharmaceuticals, Inc. Geranylgeranylacetone derivatives
WO2013157926A1 (en) * 2012-04-19 2013-10-24 Nyken Holding B.V. Geranyl geranyl acetone analogs and uses thereof
CN104892470B (zh) * 2015-06-11 2017-04-12 嘉兴学院 制备n‑烷基对甲苯磺酰胺的方法
US9782370B2 (en) * 2015-12-21 2017-10-10 Gongwin Biopharm Holdings Co., Ltd. Pharmaceutical compositions of benzenesulfonamide derivatives for treatment of adenoid cystic carcinoma

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2948186A1 (de) * 1979-11-30 1981-07-23 Henkel KGaA, 4000 Düsseldorf Neue sulfonamide, ihre herstellung und ihre verwendung als antimikrobielle substanzen
US5891454A (en) * 1997-03-28 1999-04-06 Alexander Wu Anti-cancer drug and special tumor necrotizing agent

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US3518075A (en) * 1963-01-28 1970-06-30 Stauffer Chemical Co Method of controlling weeds
JPS5829784B2 (ja) * 1975-08-22 1983-06-24 萬有製薬株式会社 オメガ − （ アリ−ルスルホンアミド ）− アルキルアミンノ セイホウ
CA1241967A (en) * 1984-05-11 1988-09-13 George C. Buzby Jr. Sulfonamides useful as anti-arrhythmic agents
HU208113B (en) * 1987-08-20 1993-08-30 Smith Kline French Lab Process for producing sulfonamide derivatives and pharmaceutical compositions comprising same as active ingredient
US5962490A (en) * 1987-09-25 1999-10-05 Texas Biotechnology Corporation Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
JPH02266351A (ja) * 1989-04-06 1990-10-31 Fuji Photo Film Co Ltd ハロゲン化銀カラー写真感光材料の処理方法
ES2125468T3 (es) * 1993-08-16 1999-03-01 Meiji Seika Kaisha Derivado de sulfonilsemicarbazida y composicion para mantener la frescura de las flores cortadas.
ATE169298T1 (de) * 1994-03-28 1998-08-15 Pfizer Benzisothiazol-derivate als inhibitoren der 5- lipoxygenase biosynthese
FR2764890B1 (fr) * 1997-06-24 1999-08-27 Adir Nouveaux derives chromeniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6121252A (en) * 1998-03-30 2000-09-19 Guilford Pharmaceuticals Inc. Phosphinic acid derivatives
JP2000338660A (ja) * 1999-05-27 2000-12-08 Toray Ind Inc ポジ型電子線レジスト組成物およびこれを用いたレジストパターンの製造法
CA2318004A1 (en) * 1999-09-15 2001-03-15 Oridigm Corporation Novel polyamine analogues as therapeutic and diagnostic agents
CA2422767A1 (en) * 1999-10-22 2001-04-22 Glaxo Group Limited In vivo imaging
US6727287B2 (en) * 2001-04-16 2004-04-27 Pts International, Inc. Toluene sulfonamide-containing anti-tumor composition and method of use thereof
US7332525B2 (en) * 2003-01-17 2008-02-19 Castle Erik P Method of treatment of prostate cancer and composition for treatment thereof
ATE291413T1 (de) * 2003-07-17 2005-04-15 3M Espe Ag Dentalzusammensetzungen mit ethyleniminverbindungen und nicht-reaktiven beschleunigern
US7576206B2 (en) * 2003-08-14 2009-08-18 Cephalon, Inc. Proteasome inhibitors and methods of using the same
US7223745B2 (en) * 2003-08-14 2007-05-29 Cephalon, Inc. Proteasome inhibitors and methods of using the same
TW200600091A (en) * 2004-05-21 2006-01-01 Telik Inc Sulfonylethyl phosphorodiamidates
AR050552A1 (es) * 2004-09-02 2006-11-01 Osi Pharm Inc Mercaptoamidas como inhibidores de histona desacetilasa

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2948186A1 (de) * 1979-11-30 1981-07-23 Henkel KGaA, 4000 Düsseldorf Neue sulfonamide, ihre herstellung und ihre verwendung als antimikrobielle substanzen
US5891454A (en) * 1997-03-28 1999-04-06 Alexander Wu Anti-cancer drug and special tumor necrotizing agent

Also Published As

Publication number Publication date
WO2006081994A2 (de) 2006-08-10
JP5191238B2 (ja) 2013-05-08
WO2006081994A3 (de) 2007-03-22
JP2008528647A (ja) 2008-07-31
AU2006210040B2 (en) 2011-04-14
MX2007009402A (es) 2007-09-25
ZA200706061B (en) 2008-07-30
US7700654B2 (en) 2010-04-20
DE102005005397B4 (de) 2008-08-21
BRPI0606563A2 (pt) 2009-11-17
CA2596618A1 (en) 2006-08-10
DE102005005397A1 (de) 2006-08-10
US20080177107A1 (en) 2008-07-24
CN101111240A (zh) 2008-01-23
CA2596618C (en) 2013-05-07
AU2006210040A1 (en) 2006-08-10
AU2006210040B9 (en) 2011-05-26
EP1845963A2 (de) 2007-10-24
KR20070100844A (ko) 2007-10-11

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