CN101095817A - 一种治疗糖尿病性末梢神经炎的中药制剂 - Google Patents
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Abstract
本发明涉及一种治疗糖尿病性末梢神经炎的中药制剂，它是以鹿角霜、枸杞子、狗脊和生地黄等10多味中草药为原料。具有滋补肝肾，祛风止痛的功效。本发明是在传统的中医辨证治疗的基础上结合现代最新科研成果研制而成的。本发明的目的是提供一种治疗糖尿病性末梢神经炎的中药制剂。具有疗效确切、安全方便、无毒副作用、价格低廉的特点。
Description
技术领域
本发明涉及一种治疗糖尿病性末梢神经炎的中药制剂，是一种治疗糖尿病性末梢神经炎以中草药为原料的中药制剂。属于中药领域。
背景技术
糖尿病周围神经病变多见于中年以上，糖尿病控制不满意或病程较长者。少数患者以神经病变为首发症状。最常见且症状较早出现的为下肢病变。糖尿病神经病变临床表现较复杂，其分类方法多种，尚未取得一致意见。为便于临床观察，故按病变部位结合病变性质分类。周围神经病变又称末梢神经性病变。按其临床表现分为对称性多发神经病变及非对称性多发单神经病变。其中对称性多发神经病变还包括：远端对称性感觉神经病变、对称性运动神经病变；非对称性多发性神经病变和单一神经病变，主要为神经干滋养血管供血不足所致。按照多发神经病变的临床表现，相当中医的“痹证”、“痛证”、“痿证”范围。本病系因糖尿病久病不愈，久病必虚，耗伤正气，引起气血不足，营卫不调，络脉空虚，气血运行不畅。《类证治裁》：“诸气血凝滞，久而成痹。”早在上古时代就认识到“大经空虚”，并认识到痿证的发生与五脏病变相关。中医在临床上分气虚血痹、肝肾两虚、脾虚痰阻、瘀阻脉络等症型辨证治疗，取得很好效果。发明一种既安全又有效的中药制剂，具有重大意义。
发明内容
本发明是在传统的中医辨证治疗的基础上结合现代最新科研成果研制而成的。本发明的目的是提供一种治疗糖尿病性末梢神经炎的中药制剂。具有疗效确切、安全方便、无毒副作用、价格低廉的特点。
本发明是由下述重量配比的原料制成的：
生地黄 1.5～6份 知母 1.5～6份 狗脊 1.0～4份
鹿角霜 1.5～6份 当归 1.0～4份 黄柏 0.1～2份
乌梢蛇 1.0～4份 白芍 1.0～4份 锁阳 0.1～2份
枸杞子 1.0～4份 龟甲 1.0～4份 木瓜 0.1～2份。
本发明的优选配方各原料的重量配比是：
生地黄2.5～3.5份 知母 2.5～3.5份 狗脊 1.5～2.5份
鹿角霜2.5～3.5份 当归 1.5～2.5份 黄柏 0.5～1.5份
乌梢蛇1.5～2.5份 白芍 1.5～2.5份 锁阳 0.5～1.5份
枸杞子1.5～2.5份 龟甲 1.5～2.5份 木瓜 0.5～1.5份。
本发明的最佳配方各原料的重量配比是：
生地黄3份 知母3份 狗脊2份
鹿角霜3份 当归2份 黄柏1份
乌梢蛇2份 白芍2份 锁阳1份
枸杞子2份 龟甲2份 木瓜1份。
本发明中的药物机理如下：
生地黄性味甘、寒。归心、肝、肾经。具有清热凉血，养阴，生津的功效。可治疗热病舌绛烦渴、阴虚内热、骨蒸劳热、内热消渴、吐血、衄血、发斑发疹等。(季宇彬主编《抗癌中药药理与应用》黑龙江科学技术出版社1999年版第514页)。
知母药性苦，寒。归肺、胃、肾经。具有清热泻火，滋阴润燥的功效。可治疗温热病高热烦渴，肺热咳嗽，骨蒸潮热，遗精，盗汗，虚烦不眠，消渴等。(《中药大辞典》南京中医药大学编著上海科学技术出版社第二版第1924页)。
鹿角霜 药性咸、涩，温。归肾、肝经。具有补肾助阳，收敛止血的功效。可治疗肾虚遗精，盗汗，食少便溏，久泻久痢，崩漏，带下，小便频数，遗尿，尿后余沥，疮疡久不愈合，创伤出血等。(《中药大辞典》南京中医药大学编著上海科学技术出版社第二版第3118页)。
乌梢蛇药性甘，平。归肺、脾、肝经。具有祛风湿，通经络，止痉的功效。可治疗风湿顽痹，肌肤麻木，筋脉拘挛，肢体瘫痪，破伤风，麻风，风疹疥癣等。(《中药大辞典》南京中医药大学编著上海科学技术出版社第二版第667页)。
枸杞子药性甘、平。归肝、肾、肺经。具有养肝，滋肾，润肺的功效。可治疗肝肾亏虚，头晕目眩，目视不清，腰膝酸软，阳痿遗精，虚劳咳嗽，消渴引饮等。(《中药大辞典》南京中医药大学编著上海科学技术出版社第二版第2248页)。
当归 药性甘、辛、苦，温。归肝、心、脾经。具有补血活血，调经止痛，润燥滑肠的功效。可治疗血虚诸证，月经不调，经闭，痛经，癥瘕结聚，崩漏，虚寒腹痛，痿痹，肌肤麻木，肠燥便难，赤痢后重，痈疽疮疡，跌扑损伤等。(《中药大辞典》南京中医药大学编著 上海科学技术出版社第二版第1210页)。
白芍 药性苦、酸，微寒。归肝、脾经。具有养血和营，缓急止痛，敛阴平肝的功效。可治疗血虚寒热，脘腹疼痛，胁痛，肢体痉挛疼痛，痛经，月经不调，崩漏，自汗，盗汗，下痢泄泻，头痛眩晕等。(《中药大辞典》南京中医药大学编著 上海科学技术出版社第二版第948页)。
龟甲 药性咸、甘，微寒。归肝、肾、心经。具有滋阴潜阳，补肾健骨，补心安神，固经止血的功效。可治疗阴虚潮热，骨蒸盗汗，头晕目眩，虚风内动，手足蠕动，筋骨痿弱，小儿卤门不合，惊悸失眠，健忘，月经过多，崩中漏下。(《中药大辞典》南京中医药大学编著 上海科学技术出版社第二版第1608页)。
狗脊 药性苦、甘，温。具有强腰膝，祛风湿，利关节的功效。可治疗肾虚腰痛脊强，足膝软弱无力，风湿痹痛，小便过多，遗精，妇女白带过多等。(《中药大辞典》南京中医药大学编著 上海科学技术出版社 第二版第2020页)。
黄柏药性苦，寒。归肾、膀胱、大肠经。具有清热燥湿，泻火解毒的功效。可治疗湿热痢疾、泄泻、黄疸，梦遗、淋浊、带下，骨蒸劳热，痿躃，以及口舌生疮，目赤肿痛，痈疽疮毒，皮肤湿疹等。(《中药大辞典》南京中医药大学编著上海科学技术出版社第二版第2823页)。
锁阳 药性甘，温。归肾、肝、大肠经。具有补肾阳，益精血，润肠的功效。可治疗肾虚阳痿，遗精早泄，下肢痿软，虚入便秘等。(《中药大辞典》南京中医药大学编著上海科学技术出版社第二版第3347页)。
木瓜药性酸，温。归肝、脾、胃经。具有舒筋活络，和胃化湿的功效。可治疗风湿痹痛，肢体酸重，筋脉拘挛，吐泻转筋，脚气，水肿，痢疾等。(《中药大辞典》南京中医药大学编著上海科学技术出版社第二版第474页)。
本发明遵循中医“君臣佐使”的组方原则，用知母、生地黄和鹿角霜为君药；用当归、白芍、龟甲、狗脊、乌梢蛇和枸杞子为臣药；用黄柏、锁阳和木瓜为佐使药。诸药相合，共具滋补肝肾，祛风止痛的功效。治疗糖尿病性末梢神经炎具有疗效确切，无毒副作用，服用方便，价格低廉的特点。
本发明药物临床使用结果表明，有如下优点：
1、本发明选用的中草药各组份符合中华人民共和国药典的规定，利用各味中药的综合作用治疗糖尿病性末梢神经炎，对人体无毒无害。经动物急、慢性毒性实验表明被实验的动物未见任何毒性反应，其主要脏器也无明显的改变，药物安全可靠。
2、本发明药中富含蛋白质，葡萄糖，葡萄糖醛酸，挥发油，果胶，果糖，有机酸，卵磷脂，维生素，氨基酸，还含皂甙，植物甾醇和钙等多种微量元素，利于人体吸收，增强体质。
3、本发明不仅可有效的治疗糖尿病性末梢神经炎，对糖尿病性末梢神经炎的预防也有很好的作用，治疗糖尿病性末梢神经炎具有疗效确切，无毒副作用，服用方便，价格低廉的特点。
为表明本发明药物对治疗糖尿病性末梢神经炎的治疗效果，经临床试验结果如下；治疗糖尿病性末梢神经炎患者26例。服用实施例汤剂，每次1袋，一日二至三次，饭前半小时服用。一个月为一个疗程，连续服用三个疗程观察疗效。痊愈13例占50％，好转10例占38.46％，无效3例占11.54％，总有效率达88.46％。经三个疗程治疗后，病人无任何不良反应，三大常规化验及肝肾功能检测未发现异常。
具体实施方式
实施例 汤剂 按下述重量称取原料：
生地黄3份 知母3份 狗脊2份
鹿角霜3份 当归2份 黄柏1份
乌梢蛇2份 白芍2份 锁阳1份
枸杞子2份 龟甲2份 木瓜1份。
制备方法是取上述原料洗净去杂，晾干，粉碎成颗粒，加水浸泡1小时，置多功能提取罐中加水煎煮二次，第一次加总药材10倍量的水，煎煮1.5～2小时，取煎液，滤过。第二次加总药材7倍量的水，煎煮1～1.2小时，取两次煎液，滤过，热封袋中，105℃高温灭菌，包装即得。本发明制成的治疗糖尿病性末梢神经炎的汤剂为塑封袋装，每袋210ml，口服，一次一袋，每日二至三次。一个月为一个疗程。
Claims (3)
1、一种治疗糖尿病性末梢神经炎的中药制剂，其特征在于它是由下述重量配比的原料制成的：
生地黄 1.5～6份 知母 1.5～6份 狗脊 1.0～4份
鹿角霜 1.5～6份 当归 1.0～4份 黄柏 0.1～2份
乌梢蛇 1.0～4份 白芍 1.0～4份 锁阳 0.1～2份
枸杞子 1.0～4份 龟甲 1.0～4份 木瓜 0.1～2份。
2、根据权利要求1所述的一种治疗糖尿病性末梢神经炎的中药制剂，其中各原料的重量配比是：
生地黄 2.5～3.5份 知母 2.5～3.5份 狗脊 1.5～2.5份
鹿角霜 2.5～3.5份 当归 1.5～2.5份 黄柏 0.5～1.5份
乌梢蛇 1.5～2.5份 白芍 1.5～2.5份 锁阳 0.5～1.5份
枸杞子 1.5～2.5份 龟甲 1.5～2.5份 木瓜 0.5～1.5份。
3、根据权利要求1所述的一种治疗糖尿病性末梢神经炎的中药制剂，其中各原料的重量配比是：
生地黄 3份 知母 3份 狗脊 2份
鹿角霜 3份 当归 2份 黄柏 1份
乌梢蛇 2份 白芍 2份 锁阳 1份
枸杞子 2份 龟甲 2份 木瓜 1份。
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