CN101014380A - System and method for providing a breathing gas - Google Patents
System and method for providing a breathing gas Download PDFInfo
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- CN101014380A CN101014380A CNA2005800285912A CN200580028591A CN101014380A CN 101014380 A CN101014380 A CN 101014380A CN A2005800285912 A CNA2005800285912 A CN A2005800285912A CN 200580028591 A CN200580028591 A CN 200580028591A CN 101014380 A CN101014380 A CN 101014380A
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- 230000029058 respiratory gaseous exchange Effects 0.000 title claims abstract description 105
- 238000000034 method Methods 0.000 title claims abstract description 21
- 230000008859 change Effects 0.000 claims abstract description 20
- 230000004044 response Effects 0.000 claims abstract description 4
- 230000033228 biological regulation Effects 0.000 claims description 28
- 230000008569 process Effects 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 5
- 230000009466 transformation Effects 0.000 claims description 3
- 230000007704 transition Effects 0.000 abstract 2
- 230000006870 function Effects 0.000 description 19
- 239000003570 air Substances 0.000 description 8
- 210000004072 lung Anatomy 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 238000012545 processing Methods 0.000 description 7
- 230000000241 respiratory effect Effects 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 208000001797 obstructive sleep apnea Diseases 0.000 description 5
- 210000002345 respiratory system Anatomy 0.000 description 5
- 230000009471 action Effects 0.000 description 3
- 238000011513 continuous positive airway pressure therapy Methods 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000003434 inspiratory effect Effects 0.000 description 3
- 210000003205 muscle Anatomy 0.000 description 3
- 230000009897 systematic effect Effects 0.000 description 3
- 230000008901 benefit Effects 0.000 description 2
- 230000010354 integration Effects 0.000 description 2
- 238000012886 linear function Methods 0.000 description 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 239000012080 ambient air Substances 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000001447 compensatory effect Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 208000018360 neuromuscular disease Diseases 0.000 description 1
- 238000011022 operating instruction Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000002644 respiratory therapy Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/0057—Pumps therefor
- A61M16/0066—Blowers or centrifugal pumps
- A61M16/0069—Blowers or centrifugal pumps the speed thereof being controlled by respiratory parameters, e.g. by inhalation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/021—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes operated by electrical means
- A61M16/022—Control means therefor
- A61M16/024—Control means therefor including calculation means, e.g. using a processor
- A61M16/026—Control means therefor including calculation means, e.g. using a processor specially adapted for predicting, e.g. for determining an information representative of a flow limitation during a ventilation cycle by using a root square technique or a regression analysis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/10—Preparation of respiratory gases or vapours
- A61M16/105—Filters
- A61M16/106—Filters in a path
- A61M16/107—Filters in a path in the inspiratory path
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
- A61M2016/0015—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors
- A61M2016/0018—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical
- A61M2016/0021—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical with a proportional output signal, e.g. from a thermistor
Abstract
Systems and methods for providing a breathing gas are provided. In one embodiment, the method includes sensing a sensed parameter associated with delivery of the breathing gas, changing a control parameter associated with a flow/pressure control element in response to a difference between the sensed parameter and a first predetermined sensed parameter value during a first portion of a breathing cycle, determining a transition from the first portion to a second portion of the breathing cycle based at least in part on the changing control parameter, changing the control parameter to cause a first change in the sensed parameter during the second portion of the breathing cycle based at least in part on the determined transition, and changing the control parameter to cause a second change in the sensed parameter during a third portion of the breathing cycle based at least in part on the first predetermined sensed parameter value.
Description
The application requires to enjoy the U.S. Provisional Patent Application serial number No.60/580 that submitted on June 18th, 2004,845 priority.
Invention field
The present invention relates to substantially and carries breathing gas to the patient respiratory road, and relates in particular to patient's breathing cycle and carry breathing gas in phase.
Background
Obstructive sleep apnea be by upper respiratory tract of flaccid muscles to upper respiratory tract degree depleted or that block by these identical muscle gradually and the respiratory tract disordered breathing that causes.Known obstructive sleep apnea can be treated by the nasal meatus that air pressurized is applied to the patient.This of forced air is applied in patient's the upper respiratory tract and formed gas clamping plate (pneumatic splint), stops upper respiratory tract depleted or block thus.
In the treatment of obstructive sleep apnea, have multiple known CPAP therapy, comprise for example other CPAP of single-stage and the other CPAP of twin-stage.The other CPAP of single-stage comprises and uses single curative or medical specified CPAP rank consistently.That is, in the whole breathing cycle, single treatment positive air pressure is transported to the patient.Though this therapy is successful in the treatment obstructive sleep apnea, owing to just be transported to the positive air pressure rank in the patient respiratory road in exhalation process, some patients experience discomfort when exhaling.
In response to this discomfort, developed the other CPAP therapy of twin-stage.The other CPAP of twin-stage is included in the higher treatment CPAP of intake period conveying and carries lower treatment CPAP during exhaling.This higher treatment CPAP rank is known usually to be air-breathing positive airway pressure or " IPAP ".This lower treatment CPAP rank is known usually to be exhale positive airway pressure or " EPAP ".Because EPAP is lower than IPAP, compare with the other CPAP therapy of single-stage, the patient needs the less power of expense to exhale during exhaling and therefore experiences less discomfort.
Yet the exploitation of the other CPAP of twin-stage has significantly increased the complexity of CPAP equipment, because these equipment must accurately determine when the air-breathing and expiration of patient, and coordinates its IPAP and EPAP rank suitably.A kind of method be determine just to be transported to the patient air instant and mean flow rate and then relatively both to determine that the patient is air-breathing or in expiration.If instant flow velocity thinks that greater than mean flow rate the patient is air-breathing.If instant flow velocity, thinks that the patient is exhaling less than mean flow rate.
Though in treatment obstructive sleep apnea and other disease relevant with breathing such as the neuromuscular disorder of chronic obstructive pulmonary disease and influence breathing muscle and tissue, CPAP is success, and also being starved of provides the addition method of delivering therapeutic breathing gas to the patient.
General introduction
On the one hand, provide a kind of method that breathing gas is provided.In one embodiment, this method comprises: a) the sensing sensor parameter relevant with the conveying of breathing gas, b) change the control parameter relevant in response to the difference between the sensor parameter during the first of current breathing cycle and the first predetermined sensor parameter value with the flow/pressure control element, c) determine to be converted to second portion according to changing the control parameter at least in part from the first of current breathing cycle, d) at least in part according to fixed transformation, changing first of the sensor parameter of control parameter during with the second portion that causes the current breathing cycle changes, and e), changes second of the sensor parameter of control parameter during and change with the third part that causes the current breathing cycle at least in part according to the first predetermined sensor parameter value.
The accompanying drawing summary
In being included in description and constitute in its a part of accompanying drawing, show embodiments of the invention, it is with general description of the present invention that provides above and detailed description given below, as the example the principles of the invention.
Fig. 1 is the functional block diagram that an embodiment of the system that is used to carry breathing gas is shown.
Fig. 2 is the flow chart that the embodiment of the control treatment that is used for this system is shown.
Fig. 3 illustrates the valve gear positions in time of an embodiment who is used for this system and the figure of cover pressure.
Fig. 4 illustrates the valve gear positions in time of another embodiment that is used for this system and the figure of cover pressure.
Fig. 5 illustrates the valve gear positions in time of the another embodiment that is used for this system and the figure of cover pressure.
Fig. 6 is another embodiment that is used to carry the breathing gas system.
Fig. 7 A-7C illustrates another embodiment of the control treatment that is used for this system.
Fig. 8 A-8C shows the lung flow in time, valve gear positions, controlled pressure and the pressure sensor that are used for system embodiment shown in Fig. 6.
Fig. 9 is the another embodiment that is used to carry the breathing gas system.
The embodiment that illustrates describes in detail
Before various embodiment were discussed, the definition of looking back some exemplary term of using in the whole open text was suitable.The odd number of all terms and plural form fall into definition separately:
" logic " includes, without being limited to hardware, firmware, software and/or the combination of each as used herein, with execution function or action, and/or causes another functions of components or action.For example, according to required application or demand, logic can comprise the microprocessor of software control, such as discrete logic or other programmed logic equipment of application-specific IC (ASIC).Logic can also embed as software fully.
" software " includes, without being limited to one or more computer-readables and/or executable instruction as used herein, its cause computer or other electronic equipment with required mode carry out function, action or/behavior.Instruction can embed with various forms, such as program, algorithm, piece or comprise each application or from the program of the code of dynamic link library.Software can be also implemented with various forms, such as stand-alone program, funcall, JAVA service small routine (Servlet), applet, be stored in the executable instruction of instruction, part operation system or other type in the memorizer.The form that persons of ordinary skill in the art will recognize that software is the demand according to the environment of for example required demands of applications, its operation and/or designer/programmer etc.
" breathing state " comprises any state or combinations of states as used herein, and wherein gas is introduced lung and/or discharged from lung.For example, first breathing state can be with that air is introduced lung be relevant, and second breathing state can with from lung, discharge air relevant.In addition, breathing state can have one or more sub-states.For example, air-breathing beginning can be a kind of breathing state, and air-breathing end can be another kind of breathing state, has the scope that defines one or more other breathing states therebetween.Similar, the beginning of expiration and end, and scope therebetween also can be by one or more breathing state definition.
System and method described here is particularly suited for assisting general breathing patient's breathing, though they can also be applied to other respiratory therapy, comprises for example acute and the home care ventilation.With reference now to Fig. 1,, shows the block diagram 100 of an embodiment of system shown.System comprises controller 102, the hair-dryer 106 with control logic 104, the variable position lift valve 108 with two-way stepper motor and pressure transducer 112.Flow channel 110 provides from valve 102 to patient interface 114 path for breathable gas.Patient interface 114 can be any nose cup, face shield, intubate or similar devices.Pressure transducer 112 sensings are such as the breathing gas parameter of pressure in the flow channel 110, and it is relevant with the pressure in the patient interface 114 and indicate this pressure.Controller 102 is preferably based on processor, and can comprise various input/output circuitries, comprises that modulus (A/D) input and digital-to-analogue (D/A) export.Controller 102 sends to valve 108 with valve gear positions data 116, pressure data 118 is sent it back controller 102 reads being used to control its position and pick off 112.
The valve gear positions is preferably by stepper motor description definition and can comprise and be less than 1 shelves or the gear positions of whole shelves.Usually, the scope of valve gear positions can be from any negative to any positive number.A preferred valve gear positions scope comprises 0 to 100, and wherein gear positions 0 is relevant with the valve position of complete closed, and gear 100 is relevant with the valve position of opening fully.Therefore, be blower speed and the valve constitution that provides, each valve gear positions can be confirmed as changing with approximate pressure and equate (for example, valve gear positions equal the 0.2cm water column pressure variation).
Though with reference to the flow/pressure control element of variable position valve 108 forms with the sensor element of pressure transducer 112 forms, described the embodiment of Fig. 1, flow/pressure control and sensor element can comprise the equipment of other type.For example, the flow/pressure control element can be the variable-ratio hair-dryer, with the variable-ratio hair-dryer of linear valve or solenoid valve combination, with the variable-ratio hair-dryer of the variable position valve combination of stepper motor control, with the variable-ratio hair-dryer of the variable position valve combination of linear valve or solenoid valve or stepper motor control or any other appropriate combination of these parts.Sensor element can comprise flow transducer, temperature sensor, infrared light emission/pick off, motor current sensor or separately or with the motor speed sensor of pressure transducer combination.The data that produce from these pick offs feed back to controller 102 and are used for handling.
With reference now to Fig. 2,, will be with reference to the wherein operation of illustrated flow chart description system.In the flow chart hereinafter, rectangular element is represented processing block and is showed software instruction or the instruction group.The tetragon element is represented data I/O processing block, and representative relates to the input of data or reads or the output of data or the software instruction or the instruction group of transmission.This flow chart shown and described herein is not represented the grammer of any special programming language.On the contrary, flow chart shows those skilled in the art and can be used to make circuit or produce the function information of software with the processing of executive system.It should be noted that such as many routine program elements of the use of circulation and the initialization of variable and temporary variable not shown.
In piece 200, controller 102 is opened valve 108 and hair-dryer 106 is set for produce the speed of predetermined pressure in its output.Via the pressure in the memorizer that is stored in controller 102-speed question blank, this predetermined pressure is set to the normal pressure that medical treatment is given for the patient basically and adds for example additonal pressure of 5cm water column.Though described the additonal pressure of 5cm water column, also can select not comprise other pressure of additonal pressure.The normal pressure of medical treatment regulation normally is higher than the pressure of ambient pressure.For example, the scope of predetermined pressure can be from 4 to 20cm water columns.In case hair-dryer 106 is provided with so that the pressure of this setting to be provided, it changes during the valid function of equipment hardly.Instead, controller 102 uses the gear positions of valve 108 to regulate output pressure to control both by closed loop and open loop.Closed loop control is the function of pressure sensor, and open loop control is the function of time.Jointly, the operation of these control loops guidance system in patient's the whole breathing cycle.Should also be noted that closed loop and open loop control can also be based on such as gas temperature and/or (for example, the CO of the gas in the patient interface in instant and mean flow rate, the patient interface
2) other parameter of composition.
At piece 202, for subsequent treatment reads and store pressure.At piece 204, average valve gear positions is determined and keeps or upgrade.In step 206, controller 102 determines whether that pressure sensor descends.This preferably realizes by current pressure sensor is compared with last pressure sensor.If current pressure sensor is less, pressure descends and to take place and flow process advances to piece 208 so.At piece 208, controller 102 increases the valve gear positions and descends with compensatory pressure.Increase the valve gear positions and have increase from the flow of the breathing gas of valve output conveying and the effect of pressure.Gear positions crossover ground changes up to the error or the difference that minimize between the pressure sensor.During this stage of operation, controller 102 tries hard to keep in flow channel 112 constant pressure to exhale up to sensing the patient.
At piece 210, the difference between the instant and average valve position is integrated in time and is stored in the memorizer.The summation of six this integrations is by determining whether the beginning (piece 212 and 214) of this summation greater than air-breathing threshold value, and is used to determine the beginning of air-breathing breathing state.If summation is greater than threshold value, the beginning of air-breathing breathing state has taken place and intervalometer begins to measure air-breathing breathing state at piece 216.This measurement continues up to having been found that peak value valve gear positions in piece 218.Determine peak value valve gear positions by last valve gear positions being compared with current valve gear positions and will bigger gear positions being stored in the memorizer as peak value valve gear positions.(for example, 80ms), controller 102 hypothesis peak value valve gear positions in this expiratory phase takes place so, and the breathing state measure of time that stops suction in piece 220 if peak value valve gear positions is in remaining unchanged of certain hour cycle.Peak value valve gear positions is a threshold value that the air-breathing breathing state of indication closes to an end.
At piece 222, controller 102 tests are to determine whether that by reading pressure signal the pressure increase takes place.If the pressure increase takes place after having been found that peak value valve gear positions, so air-breathing breathing state is approaching end.Piece 224 reduces flow that valve positions provide with reduction and pressure so that keep constant pressure in the air flow passage.This handles again by crossover and realizes, handle by this crossover, current pressure sensor and formerly the error between the pressure sensor be minimized.Piece 226 tests are to pass through relatively two variable V AR
1And VAR
2And determine whether that air-breathing breathing state finishes.These variablees are as giving a definition:
VAR
1=(instant gear positions)-(average gear positions)
VAR
2=[(peak value gear positions)-(average gear positions)] * threshold value variable " threshold value " is 85% or 0.85 a percent value for example, but can also select other percent value.If VAR
1＜VAR
2, so air-breathing breathing state has finished and the expiration breathing state or has just been prepared beginning.
By this way, during the expiratory phase of breathing cycle, provide normal pressure, and during the expiration phase of breathing cycle, provide lower pressure lower pressure to be exhaled to allow the patient with assisting patients in air-breathing.This system carries with respect to the continuously positive airway pressure of other types comfort level to a certain degree is provided, because for any appreciable time cycle, the uniform pressure that the patient does not need to use facing to intake period is exhaled.
With reference now to Fig. 3,, shows diagram valve gear positions curve 300 and output pressure curve 302 figure as time function.Article two, curve overlapping with more clearly illustrate between pressure and the valve gear positions synchronously.Curve referring now to Fig. 3 is looked back operating instruction.
Before state 0, system is in the closed loop control and via the pressure of positive its output place of sensing of its pressure transducer.Because existed very little pressure to change before state 0, this system keeps constant valve gear positions, this has caused constant output pressure (normal pressure of preferably, medical treatment regulation).This usually occurs in the latter stage that the patient exhales, and the very little pressure that wherein exists the patient to cause in system changes.
When the patient begins when air-breathing, sense pressure by pressure transducer 112 and descend.This pressure descends and causes system further to open valve 108 with the air-breathing pressure decline that causes of compensation patient in the gear mode.In this intake period, system attempts keeping output pressure to equal the normal pressure of medical treatment regulation substantially.Each gear positions of valve equals known approximate pressure and changes (for example, 0.2cm water column).The pressure of pressure sensor and setting (promptly, the normal pressure of medical treatment regulation) difference between has produced error amount, system attempts by suitably adjusting the valve gear positions to minimize this error amount, and the described valve gear positions of suitably adjusting has suitably been adjusted the pressure of carrying.
When the valve gear positions increases, the time cycle that state 0 takes place and triggering is determined, its guiding state 1.During this determined the time cycle, the difference between instant valve gear positions and the average gear positions was along with 6 intervals are integrated.For clarity sake, Fig. 3 only shows 3 intervals.Air-breathing and air-breathing timer begins if the summation of these 6 integrations, is supposed the patient so greater than threshold value, and it measures inspiratory duration.
When peak value valve gear positions has reached state 2, this inspiratory duration is measured and is stopped.Peak value valve gear positions by will be formerly valve gear positions and the comparison of current valve gear positions and will bigger gear positions be stored in the memorizer and determine peak value valve gear positions as peak value valve gear positions.(for example, 80ms) do not change, system postulation takes place for this expiratory phase peak value valve gear positions so if peak value valve gear positions keeps the certain hour cycle.
After state 2, system looks is exhaled and is triggered.This realizes that by comparing two variablees two variablees are all based on the valve gear positions.This equation has been defined as VAR in the above
1And VAR
2If VAR
1≤ VAR
2, trigger existence and system so and move to state 3.
At state 3, the closed variable position valve 108 of system is so that provide lower pressure in its output.By reducing the valve gear positions to for example position 0 (that is, closure) or other certain positions, valve 108 can be fast and linear closed (the definite slope that for example, has the 3ms/ gear).During the pith of exhaling, system provides now than employed pressure that will be lower of intake period.It is easier that this makes that the patient exhales.
From state 3 to state 4, system is in the open loop control, and do not change the valve gear positions according to pressure or any other parameter.During this determined the time cycle, valve remained on its gear positions.As mentioned above, the time cycle can be 2.5 times of the inspiratory duration (that is 2 the time from state 1 to state) formerly determined.This is the discharge degree part of system's operation.
At state 4, the expiratory duration cycle stops and system progressively applies pressure to its output reaches the medical treatment regulation again up to pressure normal pressure.System reloads pressure in its output now.This pressure by sense conditions 4 realizes that it causes mainly due to the patient exhales, and changes the valve gear positions fast to meet this pressure.Therefore this expiration phase begins with a pressure that depends on patient's breath pressure.From state 4 to state 5, system progressively changes the valve gear positions with linear mode (for example, having definite slope of 40ms/ gear), progressively opens valve reaches higher medical treatment regulation again up to output pressure normal pressure thus.It is air-breathing that system has been ready to next patient now, wherein repeats this processing.
Fig. 4 shows the embodiment of the invention that relates to the control that triggers based on exhaling.In this, except inspiration trigger is not provided, this control is similar to above-mentioned.Especially, the breathing cycle measure of time is as the function of peak value valve gear positions.Time between two peak value valve gear positions (state 2) is measuring of time breathing cycle.The expiration of state 3 triggers, from the unloading part of state 3 to 4 with from the loading section of state 4 to 5 with as above described identical with reference to figure 3.Unloading part (state 3 to 4) and loading section (state 4 to 5) are defined the conduct percentage ratio of time breathing cycle of breathing cycle formerly.These percentage range can be very wide, but common chosen feasible unloading and loading section are from about 50% to 85% of time breathing cycle together.The advantage of this embodiment is its less processing that needs controller 102.
Illustrated among Fig. 5 is one embodiment of the present of invention, and it uses instant and average valve gear positions with breathing state that detects the patient and the pressure of carrying according to the state coordination that has detected.In this embodiment, system is for closed loop control mode, wherein its pressure sensor and adjust its output based on this pressure always.More particularly,,, increase to promote, determined average valve gear positions to the air-breathing pressure of carrying and valve gear positions reduce to be reduced to the pressure that expiration is carried by the valve gear positions according to the pressure that feeds back to controller 102 along with patient respiratory.By instant valve gear positions and average valve gear positions are compared, can detect patient's breathing state.If instant valve gear positions is on average valve gear positions, the patient is just air-breathing.If instant valve gear positions is under average valve gear positions, the patient exhales.In order to reduce too early or unsettled triggering, average valve gear positions can be offset to the actual value that is higher than air-breathing detection and be lower than the actual value that it is exhaled and detects.
In Fig. 5, the instant valve gear positions of Reference numeral 502 indications is passed through average valve gear positions with positive slope.This indication patient descends with the air-breathing pressure that causes of compensation patient because valve is increasing its gear positions just air-breathing.The instant valve gear positions of Reference numeral 504 indications is passed through average valve gear positions with negative slope.This indication patient exhales, because valve is reducing the pressure rising that its gear positions is exhaled and caused with the compensation patient.According to this detection, can use the IPAP rank in intake period, and during exhaling, can use the EPAP rank.The next air-breathing detection of Reference numeral 506 indications.
Shown in Fig. 6 is the another embodiment of the present invention of system's 600 forms.Except variable position valve 108 was in vent position about flow channel 110, system 600 was similar to system 100 (Fig. 1).And controller 102 comprises control logic 602.In this, the breathing gas of hair-dryer 106 outputs advances to patient interface 114 in flow channel 110.Variable position valve 108 is placed to it can shift breathing gas from flow channel 110 and patient interface 114.The gear positions of valve 108 is subjected to logic 602 controls.Though described the embodiment of Fig. 6 with reference to the sensor element of the flow/pressure control element of variable position valve 108 forms and pressure transducer 112 forms, flow/pressure control element and sensor element can comprise the equipment of other types.For example, the flow/pressure control element can be the variable-ratio hair-dryer, with the variable-ratio hair-dryer of linear valve or solenoid valve combination, with the variable-ratio hair-dryer of the variable position valve combination of stepper motor control, with the variable-ratio hair-dryer of the variable position valve combination of linear valve or solenoid valve and stepper motor control or any other appropriate combination of these parts.Sensor element can comprise flow transducer, temperature sensor, infrared light emission/pick off, motor current sensor or separately or with the motor speed sensor of pressure transducer combination.The data that produce from these pick offs feed back to controller 102 and are used for handling.
Fig. 7 A-C shows the flow chart of the embodiment that relates to control logic 602.In piece 700, controller 102 draught excluders 108 and hair-dryer 106 is set for produce the speed of predetermined pressure in its output.Via the pressure in the memorizer that is stored in controller 102-speed question blank, this predetermined pressure is generally the normal pressure that the patient is set to the medical treatment regulation, adds the additonal pressure composition.The additonal pressure composition can be percentage ratio or some other values that pressure is set.The additonal pressure composition is provided, thereby, can carrying the medical normal pressure of stipulating under the situation mostly if not a plurality of schemes of all needs of patients.The normal pressure of medical treatment regulation normally is higher than the pressure of ambient pressure.For example, the scope of the pressure of regulation can be from 4 to 20cm water columns.In case hair-dryer 106 is configured to provide required pressure, it does not change during the valid function of equipment hardly.Instead, controller 102 uses the gear positions of valve 108 to regulate output pressure.
At piece 702, read and store pressure.At piece 704, logic is determined intermediate value valve gear positions, breathing rate (Fig. 7 C) and upper and lower breathing rate threshold value.In one embodiment, intermediate value valve gear positions and upper and lower breathing rate threshold value can followingly be determined:
Intermediate value valve gear=(current * 0.0003)+(formerly * 0.9997)
Breathing rate upper threshold value=intermediate value+(intermediate value * 0.1)
Breathing rate lower threshold value=intermediate value-(intermediate value * 0.1)
Wherein " current " represents current valve gear positions, and " formerly " represents intermediate value valve gear positions formerly, and " intermediate value " expression intermediate value valve gear positions.Logic can initially circulate to determine above-mentioned value by several breathing states.
In case determine upper and lower breathing rate threshold value, monitor that the valve gear positions is used for determining of breathing rate.With reference to figure 7C, determine the slope of valve gear change at piece 742.This can realize by in time current and one or more gear positions of valve formerly being compared.If the slope of valve gear positions is for negative in piece 744, then logic advances to piece 746.Otherwise logic loops is got back to piece 742 or 704 to continue processing up to next valve gear change.At piece 746, logic testing has been reduced to breathing rate (BR) threshold value (referring to Fig. 8 B) down to determine whether the valve gear positions.If logic advances to piece 748, wherein its test is to determine whether that the valve gear positions has been reduced to down breathing rate (BR) threshold value (referring to Fig. 8 B) down.If logic advances to piece 750, wherein be the current breathing record end time and be that next breathes recording start time.According to the start and end time of each breathing, can calculate and store breathing rate (for example, frequency of respiration/minute) to be used for follow-up use.
Back, by the pressure that is provided with is compared with the pressure that is read by pressure transducer 112, produce pressure error at piece 706 with reference to figure 7A.In piece 708, pressure error is used to produce valve gear error, and it can be according to following formula:
V
error＝(P
error*P)+(D
error*D)+(S
error*S)
" V wherein
Error" be valve gear error, " P
Error" be pressure error, " D
Error" be current and the pressure error difference between formerly pressure error is calculated, " S
Error" be the summation of pressure error, and " P ", " D ", " S " are constants." V
Error" equation General Definition proportional integral difference quotient (hereafter PID) servo controller.Usually, experience studied systematic function after, the constant of selected " P ", " D ", " S ".In addition, can also be these constant theory of selection values.This PID SERVO CONTROL is effective substantially in whole logical operation, although also can accept operation intermittently in during the part of patient respiratory state.As will be described, patient's respiratory characteristic to the given situation of the effect of systematic function under, logic utilizes the pressure setting of the various PID of being used for controllers to produce suitable pressure output.
After step 712 or 714, logic is advanced to piece 716, wherein monitors the valve gear at peak value valve gear positions.In one embodiment, the following definite air-breathing threshold value of logical foundation:
Air-breathing threshold value=[(peak value-intermediate value) * 0.5]+intermediate value
Wherein " peak value " is the peak value valve gear positions from one or more breathing cycles formerly, and " intermediate value " is intermediate value valve gear positions, and 0.5 is the typical proportion factor.Can use other scale factor value in other embodiments.After current valve gear positions surpassed air-breathing threshold value, logic began to determine peak value valve gear positions.By comparing and select bigger value to determine peak value valve gear positions with valve gear positions formerly current valve gear positions.
At piece 718, the following definite unloading threshold value of logical foundation:
Unloading threshold value=[(peak value-intermediate value) * T]+intermediate value
Wherein " peak value " is the peak value valve gear positions from one or more breathing cycles formerly, and " intermediate value " is intermediate value valve gear positions, and " T " is the percentage ratio unloading trigger value of determining from question blank according to the per minute frequency of respiration of determining.Shown in the example table 1 below of per minute frequency of respiration:
Table 1
| The per minute frequency of respiration | T (% unloading) |
| 0 | -0.15 |
| 1 | -0.15 |
| 2 | -0.15 |
| 3 | -0.15 |
| 4 | -0.15 |
| 5 | -0.15 |
| 6 | -0.15 |
| 7 | -0.10 |
| 8 | -0.10 |
| 9 | -0.10 |
| 10 | 0.00 |
| 11 | 0.00 |
| 12 | 0.10 |
| 13 | 0.10 |
| 14 | 0.12 |
| 15 | 0.15 |
| 16 | 0.17 |
| 17 | 0.20 |
| 18 | 0.23 |
| 19 | 0.25 |
| 20 | 0.26 |
| 21 | 0.28 |
| 22 | 0.30 |
| 23 | 0.32 |
| 24 | 0.34 |
| 25 | 0.37 |
| 26 | 0.37 |
| 27 | 0.37 |
| 28 | 0.37 |
| 29 | 0.37 |
| 30 | 0.37 |
In form 1, that each " per minute frequency of respiration " value has is relative, corresponding " T (% unloading) " value of value " X ", " Y ", " Z " form, and it is generally equal to or less than 1.For any " per minute frequency of respiration " value that provides, being somebody's turn to do " T (% unloading) " value can be identical or different, and how soon definite unloading cycle begins with respect to intermediate value valve gear positions.For example, near 1 " T (% unloading) " value will promote the unloading threshold value far above intermediate value valve gear positions, so more promptly make with respect to the valve gear positions and to trigger the pressure minimizing." T (% the unloading) " value of approaching zero (0) will reduce the unloading threshold value makes it near intermediate value valve gear positions, so cause laterly that with respect to the valve gear positions triggering pressure reduces.Usually, " per minute frequency of respiration " value is big more, and " T (% unloading) " value is big more.Should also be noted that one or more " per minute frequency of respiration " value can have relative identical or different " T (% unloading) " value.
At piece 720, logic testing has been reduced to the unloading threshold value down to determine whether the valve gear positions.If not, logic loops turns back to piece 702 to continue effective PID SERVO CONTROL of valve gear positions.If logic advances to piece 722.At piece 722, logic determines that unloading pressure reduces control waveform and relevant pressure setting with pressure.Equally, be provided with the minimizing timer.In one embodiment, unloading pressure is following determines:
Unloading pressure=P
Set-[P
Set* ((Δ V*V
ScaleThe * of)/K) S]
" P wherein
Set" be the normal pressure of medical treatment regulation, " Δ V " is the variation by the valve gear positions of (peak value-intermediate value) definition, " V
Scale" be from the value of table 2 (infra) selection and based on P
Set, " K " is constant (for example, in the scope of 2000-4000, for example 3000), and " S " be among the scope 1-3 constant but can be less than 1 or greater than 3.If because some operating condition, logic only needs to keep simply the pressure stipulated, " S " thus constant can be set to the pressure that 0 unloading pressure equals to stipulate." V
Scale" value can based on the regulation pressure (P
Set), for example, as shown in table 2.
Table 2
| P set | V scale |
| 0 | 0 |
| 1 | 0 |
| 2 | 0 |
| 3 | 0 |
| 4 | 0.28 |
| 5 | 0.28 |
| 6 | 0.25 |
| 7 | 0.25 |
| 8 | 0.25 |
| 9 | 0.23 |
| 10 | 0.23 |
| 11 | 0.22 |
| 12 | 0.22 |
| 13 | 0.18 |
| 14 | 0.15 |
| 15 | 0.15 |
| 16 | 0.14 |
| 17 | 0.14 |
| 18 | 0.12 |
| 19 | 0.12 |
| 20 | 0.12 |
At form 2, P
SetThe scope from 0 to 20 of value, and the scope of the positive pressure value of expression medical treatment regulation.Each P
SetValue has relative corresponding V
ScaleValue (" A ", " B ", " C " etc.), it can be determined by the theoretical modeling of formerly experience or system.For example, if system 600 is configured to be operated in the relative broad range of patient interface 114, so every type patient interface 114 can be at setting pressure P
SetCause the Light Difference of the performance of system 600 down.Therefore, the technical staff can be chosen in and understand various patient interfaces to determining V after the influence of systematic function
ScaleValue.Usually, as shown in table 2, " V
Scale" scope of value can from 0 to 0.28, but other embodiment can exceed this scope.And, can adopt some to retouch safely to impose and do not allow unloading pressure to descend to exceed some rank.For example, if pressure P
SetBe the 4cm water column, logic cannot allow any discharge degree so, because the pressure of this setting has been the normal pressure of low-down medical treatment regulation.Yet as a rule, unloading pressure determines to have produced the value less than the normal pressure of medical treatment regulation.
In addition, in piece 722, logic is determined for example 195 pressure settings, and it has defined control waveform for the pressure setting reduces to unloading pressure setting.These pressure are provided with by effective PID SERVO CONTROL and use.In one embodiment, 195 pressure settings reduce timer (for example 780ms) acquisition by pressure.In one embodiment, can be for the control waveform of unloading cycle by the slope to lower part and retaining part definition.The slope can comprise 10 pressure settings to the lower part, and it sequentially reduces to the unloading pressure setting with the pressure setting from the setting of treatment pressure in the 40ms that for example is made of for example 10 4ms increments.Retaining part is through the 740ms that for example is made of for example 185 4ms cycles and keep pressure and be arranged on the unloading pressure setting.Should be noted that the value that can select other values and describe only means shows one embodiment of the present of invention.Shall also be noted that during the slope and/or retaining part of unloading cycle, pressure sensor can be used in and redefines or adjust control waveform.
In piece 724, adjust the valve gear positions to attempt making pressure sensor follow the pressure setting of fixed control waveform, wherein this control waveform is to be used for the pressure setting is reduced to the unloading pressure setting.In other words, piece 724 uses the logic identical with piece 706-714, because effectively the PID SERVO CONTROL is used to proofread and correct the valve gear positions, and the pressure of control waveform is provided for required pressure setting.For example, each pressure is provided with definition and " pressure is set ", and it is compared with pressure sensor to produce pressure error, and described pressure error is used by effective PID SERVO CONTROL.
In piece 726, logic testing is to determine whether that pressure reduces timer and (for example, 780ms) stops.If logic advances to piece 732.If not, logic advances to piece 728, and wherein it determines whether to reach the unloading pressure setting in the control waveform.Stop if pressure reduces timer, logic advances to piece 732, and wherein it prepares pressure is re-loaded to the normal pressure of medical treatment regulation.If also do not reach the unloading pressure setting in piece 728, logic loops turns back to piece 724 and proceeds effective PID SERVO CONTROL to the valve gear positions according to the pressure setting of control waveform.If reached the unloading pressure setting in piece 728, logic advances to piece 730, and wherein in whole effective PID SERVO CONTROL of valve gear positions, the unloading pressure setting is held, and reduces timer up to pressure and stops.
After pressure minimizing timer has stopped, logic execution block 732, wherein it determines that pressure increases control waveform and relevant pressure setting.Equally, be provided with pressure and increase timer.In one embodiment, logic is determined for example 100 pressure settings, and it has defined control waveform for the normal pressure (treatment pressure) that pressure is increased to the medical treatment regulation.This waveform is based on the normal pressure of pressure setting when reducing the timer termination and medical treatment regulation.In one embodiment, pressure increase timer can be set to 400ms.In one embodiment, the control waveform that is used for loading cycle can be defined to top by the slope.The slope can comprise 100 pressure settings to top, and it sequentially is increased to the setting of treatment pressure with the pressure setting from the unloading pressure setting in the 400ms that for example is made of for example 100 4ms increments.In another embodiment, the control waveform that is used for loading cycle can be defined to top and retaining part by the slope in the mode similar to the control waveform of describing in the above that is used for unloading cycle.Again, should be noted that can select other values and described value only to mean illustrates one embodiment of the present of invention.Should also be noted that pressure sensor can be used in the slope that redefines or adjust loading cycle and/or the control waveform during the retaining part.
In piece 734, adjust the valve gear positions to attempt making pressure sensor follow the pressure setting of fixed control waveform, wherein this control waveform is the normal pressure setting that is used for the pressure setting is increased to the medical treatment regulation.In other words, piece 734 uses and piece 706-714 and 724 identical logics, because effectively the PID SERVO CONTROL is used to proofread and correct the valve gear positions, and the pressure of control waveform is provided for required pressure setting.
In piece 736, logic testing is to determine whether that pressure increases timer and (for example, 400ms) stops.If logic advances to piece 700, wherein pressure is set to the normal pressure of medical treatment regulation.If not, logic advances to piece 738, and wherein it determines whether to reach the positive airway pressure setting (for example, treatment pressure setting) of the medical treatment regulation in the control waveform.If also do not reach the normal pressure setting of medical treatment regulation in piece 7 38, logic loops turns back to piece 734 and proceeds effective PID SERVO CONTROL to the valve gear positions according to the pressure setting of control waveform.If reached treatment pressure in piece 738, logic advances to piece 740, and wherein in whole effective PID SERVO CONTROL of valve gear positions, the normal pressure setting of medical treatment regulation is held, and increases timer up to pressure and stops.Stop in case pressure increases timer, logic loops turns back to piece 700 and repeats this processing for next breathing cycle.
With reference now to Fig. 8 A-8C,, shows the lung flow in time, valve gear positions, controlled pressure and the pressure sensor that are used for Fig. 6 illustrated embodiment.Fig. 8 A illustrates the flow of the breathing gas that enters lung and come out in time from lung.Fig. 8 B illustrates valve gear positions in time, and intermediate value valve gear, last or following breathing rate (BR) threshold value, air-breathing threshold value and unloading threshold value.The use of these values and threshold value has been described with reference to the logic of figure 7A-7C.Fig. 8 C illustrates the controlled pressure waveform, and it is by the pressure of determining pressure setting and system's sensing.In intake period, the PID servo controller is attempted to keep pressure is set, and it is the normal pressure that is used for patient's medical treatment regulation.Because patient demand, this causes that the valve gear positions changes, and it is increased to peak value valve gear positions and then reduces.During this stage, the peak value gear positions is monitored, and calculates intermediate value valve gear positions.In the time of under the valve gear positions drops to the unloading threshold value, unloading pressure reduces control waveform along with pressure and is used for reducing pressure by effective PID SERVO CONTROL and the related pressure setting that drops to unloading pressure is determined together.Pressure reduces timer and also begins.If because the patient respiratory feature, pressure sensor reaches unloading pressure before reducing the timer termination, then keep unloading pressure and stop up to reducing timer by effective PID servo controller.Stop in case reduce timer, no matter whether reach unloading pressure, the pressure sensor when all stopping according to the minimizing timer determines that with the normal pressure of medical treatment regulation pressure increases control waveform and relevant pressure setting.Increase control waveform during increasing the time cycle, set treatment pressure is got back in the pressure increase by effective PID servo controller working pressure.Because the effectively effect of PID servo controller and patient respiratory feature, before increasing the timer termination, pressure can be increased to required treatment rank.
Illustrated among Fig. 9 is further embodiment of this invention of system's 700 forms.System 700 is similar in appearance to system 600 (Fig. 6).Fig. 9 shows environment input 702 and filter 704, and it is provided to ambient air the input that links to each other with hair-dryer 106.Environment input 702 and filter 204 lie in the system of formerly describing and corresponding hair-dryer operation of Fig. 1 and 6.System 700 also comprises non-ambient input 704, and it receives the breathing gas that is shifted from flow channel 110 by variable position valve 108.This layout is different among Fig. 6, wherein shift breathing gas by variable position valve 108, but the gas that must will not shift is led the blowback blower fan.Otherwise system 700 operates in identical with system 600 mode of describing with reference to figure 6,7A-C and 8A-C in the above.And selection, variation and the replacement described about system 600 are suitable for system 700 equally, except they are not transferred to breathing gas in the non-ambient input 704.In other embodiments, can between filter 704 and hair-dryer 106, provide one or more additional filters.
Though show the present invention by the explanation embodiment, though and quite detailed description embodiment, the intention of description be not restriction or by any way the scope of the restriction claim of enclosing to this details.To be easy to find other advantages and modification for those skilled in the art.For example, the valve gear positions can change according to nonlinear function, and this nonlinear function is as the replacement of linear function, additional or make up with linear function.Replacement or additional parameter that can the sensing flowing gas comprise the flow velocity by use traffic sensor adjustment valve gear positions.More particularly, can also use the variation of mobile direction and/or flow velocity (for example, instant and average).Therefore, its wideer aspect, the present invention is not limited to specific detail, exemplary device and the illustrative example that illustrates and describe.Therefore, under the situation of the spirit and scope of the basic inventive concept that does not break away from the applicant, can break away from these details.
Claims (10)
1, a kind of method that breathing gas is provided comprises:
A) sensing and the relevant sensor parameter of conveying breathing gas;
B) in response to the difference between the sensor parameter during the first of current breathing cycle and the first predetermined sensor parameter value, change the control parameter relevant with the flow/pressure control element;
C) at least in part according to changing the control parameter, determine of the transformation of the first of current breathing cycle to second portion;
D), during the second portion of current breathing cycle, change the control parameter and change to cause first of sensor parameter at least in part according to fixed transformation; And
E), during the third part of current breathing cycle, change the control parameter and change to cause second of sensor parameter at least in part according to the first predetermined sensor parameter value.
2, according to the process of claim 1 wherein that sensor parameter is breathing gas pressure, breathing gas flow, breathing gas temperature or breathing gas composition.
3, according to the process of claim 1 wherein that the flow/pressure control element comprises the variable position valve, comprise the valve gear positions and control parameter.
4, according to the process of claim 1 wherein that the flow/pressure control element comprises variable speed blower, comprise blower speed and control parameter.
5, according to the process of claim 1 wherein b) in variation comprise:
F) determine valve gear error according to the sensor parameter and the first predetermined sensor parameter value at least in part; And
G) change the control parameter to minimize valve gear error.
6, according to the process of claim 1 wherein that the flow/pressure control element is the variable position valve, the control parameter is the valve gear positions, and c) in determine comprise:
F) determine the unloading threshold value; And
G) determine whether to change the valve gear positions less than the unloading threshold value.
Determining 7, according to the method for claim 6, f wherein) comprises:
H) determine breathing rate;
I) determine intermediate value valve gear positions;
J) determine peak value valve gear positions for one or more breathing cycles formerly;
K) the identification predetermined percentage ratio unloading factor relevant with fixed breathing rate; And
1) calculates the unloading threshold value according to fixed intermediate value valve gear positions at least in part.
8, according to the process of claim 1 wherein d) in variation comprise:
F) determine the second predetermined sensor parameter value;
G) the minimizing timer is set to predetermined discharge time;
H) at least in part according to the first and second predetermined sensor parameter values, for the second portion of current breathing cycle is determined a predetermined sensor parameter value sequence; And
I) basis should change the control parameter up to reducing the timer termination by predetermined sensor parameter value sequence at least in part.
9, method according to Claim 8, wherein the flow/pressure control element is the variable position valve, the control parameter is the valve gear positions, the first predetermined sensor parameter value is the pressure of regulation, the second predetermined sensor parameter value is a unloading pressure, and f) in determine comprise:
J) determine peak value valve gear positions;
K) determine intermediate value valve gear positions;
1) by deducting intermediate value valve gear positions from peak value valve gear positions obtaining first intermediate object program, multiply by first intermediate object program obtaining second intermediate object program with first constant, and multiply by second intermediate object program with the pressure of regulation, calculate the pressure skew thus; And
M) by from the pressure of regulation, deducting pressure calculations of offset unloading pressure.
10, according to the process of claim 1 wherein e) in variation comprise:
F) determine the second predetermined sensor parameter value;
G) the increase timer is set to the predetermined load time;
H) third part that is the current breathing cycle according to the first and second predetermined sensor parameter values is at least in part determined a predetermined sensor parameter value sequence; And
I) basis should change the control parameter up to increasing the timer termination by predetermined sensor parameter value sequence at least in part.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58084504P | 2004-06-18 | 2004-06-18 | |
| US60/580,845 | 2004-06-18 | ||
| PCT/US2005/021638 WO2006009939A2 (en) | 2004-06-18 | 2005-06-20 | System and method for providing a breathing gas |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010105225272A Division CN101982204B (en) | 2004-06-18 | 2005-06-20 | System and method for providing a breathing gas |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101014380A true CN101014380A (en) | 2007-08-08 |
| CN101014380B CN101014380B (en) | 2010-12-22 |
Family
ID=34972506
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010105225272A Expired - Fee Related CN101982204B (en) | 2004-06-18 | 2005-06-20 | System and method for providing a breathing gas |
| CN2005800285912A Expired - Fee Related CN101014380B (en) | 2004-06-18 | 2005-06-20 | System and method for providing a breathing gas |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010105225272A Expired - Fee Related CN101982204B (en) | 2004-06-18 | 2005-06-20 | System and method for providing a breathing gas |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1784237A1 (en) |
| JP (1) | JP2008503272A (en) |
| CN (2) | CN101982204B (en) |
| AU (1) | AU2005265201B2 (en) |
| CA (1) | CA2571164C (en) |
| WO (1) | WO2006009939A2 (en) |
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| CN101474446B (en) * | 2009-01-22 | 2011-06-15 | 北京航空航天大学 | Electric-controlled type breathing apparatus for supplying oxygen |
| CN102802710A (en) * | 2010-01-14 | 2012-11-28 | 皇家飞利浦电子股份有限公司 | Servo ventilation using negative pressure support |
| CN102920543A (en) * | 2007-08-17 | 2013-02-13 | 雷斯梅德有限公司 | Methods and apparatus for pressure therapy in the treatment of sleep disordered breathing |
| CN103608062A (en) * | 2011-03-18 | 2014-02-26 | 马奎特紧急护理公司 | Breathing apparatus and method for support ventilation |
| CN108211076A (en) * | 2017-12-15 | 2018-06-29 | 湖南明康中锦医疗科技发展有限公司 | A kind of lung ventilator pressure regulation method and system |
| CN110721386A (en) * | 2008-05-27 | 2020-01-24 | 菲舍尔和佩克尔保健有限公司 | Humidifier chamber temperature control for accurate humidity control |
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| US7152598B2 (en) | 2003-06-23 | 2006-12-26 | Invacare Corporation | System and method for providing a breathing gas |
| WO2008098586A1 (en) * | 2007-02-13 | 2008-08-21 | Dafra Pharma N.V. | Pharmaceutical carrier composition and pharmaceutical composition |
| US8261742B2 (en) | 2007-08-23 | 2012-09-11 | Invacare Corporation | Method and apparatus for adjusting desired pressure in positive airway pressure devices |
| DE102007046187A1 (en) | 2007-09-26 | 2009-04-09 | Bayer Materialscience Ag | roof module |
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| KR102203851B1 (en) * | 2018-11-12 | 2021-01-15 | 주식회사 케이티앤지 | Aerosol generating device and method of controlling same |
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| CN112274740A (en) * | 2020-09-14 | 2021-01-29 | 湖南明康中锦医疗科技发展有限公司 | Respiration support method and respiration support equipment for dynamically adjusting flow |
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| CN1024114C (en) * | 1989-02-24 | 1994-04-06 | 航天工业部第二研究院第四总体设计部 | Microcomputerized controller of respirator |
| US5259373A (en) * | 1989-05-19 | 1993-11-09 | Puritan-Bennett Corporation | Inspiratory airway pressure system controlled by the detection and analysis of patient airway sounds |
| JP3090468B2 (en) * | 1989-05-19 | 2000-09-18 | ピューリタン―ベネット・コーポレーション | Airway pressure system |
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- 2005-06-20 CN CN2010105225272A patent/CN101982204B/en not_active Expired - Fee Related
- 2005-06-20 CN CN2005800285912A patent/CN101014380B/en not_active Expired - Fee Related
- 2005-06-20 WO PCT/US2005/021638 patent/WO2006009939A2/en active Application Filing
- 2005-06-20 CA CA2571164A patent/CA2571164C/en not_active Expired - Fee Related
- 2005-06-20 EP EP05766008A patent/EP1784237A1/en not_active Withdrawn
- 2005-06-20 AU AU2005265201A patent/AU2005265201B2/en not_active Ceased
- 2005-06-20 JP JP2007516811A patent/JP2008503272A/en active Pending
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Also Published As
| Publication number | Publication date |
|---|---|
| CA2571164C (en) | 2015-09-01 |
| WO2006009939A2 (en) | 2006-01-26 |
| CA2571164A1 (en) | 2006-01-26 |
| AU2005265201B2 (en) | 2010-04-22 |
| CN101982204B (en) | 2012-09-05 |
| EP1784237A1 (en) | 2007-05-16 |
| AU2005265201A1 (en) | 2006-01-26 |
| CN101014380B (en) | 2010-12-22 |
| JP2008503272A (en) | 2008-02-07 |
| CN101982204A (en) | 2011-03-02 |
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