CN101007090A - Health-preserving and growth-promoting Chinese medicinal additive for pig - Google Patents

Health-preserving and growth-promoting Chinese medicinal additive for pig Download PDF

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CN101007090A
CN101007090A CNA2006100423228A CN200610042322A CN101007090A CN 101007090 A CN101007090 A CN 101007090A CN A2006100423228 A CNA2006100423228 A CN A2006100423228A CN 200610042322 A CN200610042322 A CN 200610042322A CN 101007090 A CN101007090 A CN 101007090A
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pig
radix
weaned
group
siberian cocklebur
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CN100502907C (en
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黄一帆
姚金水
马玉芳
俞道远
黄小红
李清禄
刘建成
张中桥
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Fujian Wei ear Animal Pharmaceutical Co. Ltd.
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Fujian Agriculture and Forestry University
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Abstract

The invention relates to a kind of swine additive that has the function of health care and promoting growth. The traditional Chinese medicine additive ''swine toluylene I'' and ''swine toluylene Ibis the compound of radix astragal, hoelen, many prickle acanthopanax root, heartleaf houttuynia herb, floss lonicerae, dianthi,herba, Chinese hawthorn, magnolia bark and angelica; it can be used in the whole process of cultivating the pigs; it has special effects of resisting stress and promoting growth; it can substantially decrease the incidence of diarrhea for weaned son pigs, increase the son pigs' weight and the forage transformation efficiency; it can increase the amount of blood cells, the amount of white cells, the percentage of achroacyte, the percentage of ANAE+ achroacyte and the ratio of CD4/CD8; it can promote the generation of total serum protein, globulin, immune globulin and complement, improve the immunity, decrease the secretion of serum cortisol, release the stress, promote the synthesis of protein and promote the growth of son pigs.

Description

Pig health care and short long Chinese medicine additive
Technical field the present invention relates to the feed additive of a boar, particularly boar health care and short long Chinese medicine additive.
Background technology Chinese medicine has met the psychological need of consumers in general to green safety food as the feed additive of poultry health care, can actual reduce the drug residue of poultry meat simultaneously effectively, just more and more is subjected to people and pays close attention to.It is the technology of an extensive use in the modern Swine Production that swinery is used the short length of medicine diseases prevention, and particularly in the piglet stage, the health of piglet is most important to Swine Production, and the science medication has determined the health of swinery and the drug residue degree of pork product thereof.The extensive use on producing of Tri-Biocin commonly used and chemicals has exposed the defective of drug residue in various degree.People then pay close attention to and to have growth promotion, disease-resistant, health care, adjust body function, and the research and development of the Chinese medicine preparation that toxic and side effects is little, noresidue and being difficult for induces drug-resistant microorganism.Because most Chinese medicine derives from nature, people usually mention in the same breath Chinese medicine and natural product, so the Chinese medicine of the title of green additive is arranged, become the important channel that substitutes antibacterials and the production of research and development safe pork.Chinese medicine has multi-faceted adjusting and therapeutical effect, even medium-term and long-term the use because its low toxicity, side effect are little, meets the food safety requirements of people's increasingly stringent.Pharmacological research to the Chinese medicine immunization shows that many Chinese medicines and compound preparation can obviously be regulated the nonspecific immunity and the specific immunity of body, improves the premunition and the resistance of body.
Modern medicine proves, the generation of organism numerous disease is in the body on the unsaturated fatty acid covalent bond due to a series of free radicals reaction induced mostly, so Radical Metabolism mechanism is one of focus of studying both at home and abroad in recent years with damaging action and protection thereof.In recent years, the oxidative stress theory of oxygen-derived free radicals generation has been used for the etiology of some diseases.Studies show that in the animal body of stress state peroxidization has taken place, can cause radical damage thus and cause various diseases.Stress cause the pathologic damage of internal organs, tissue, its mechanism is relevant with harmful oxidation of oxygen-derived free radicals.Now can damage piglet body free radical resisting system and the reaction of acceleration bodies endoperoxides with clear and definite ablactation stress.Early weaning has very strong irritability to piglet, and along with the change of physiology, nutrition, environmental condition, piglet can be made stress at once, and the piglet immunological function is descended.
Xie Jiasheng, Wang Jianguo, He Guoyao equal 1991 in " Chinese veterinarian's medical magazine " the 6th phase publish an article " the Chinese medicine compound feed additive is to the effect of diarrhea of weaned piglets and weightening finish ", introduced physiological characteristics at the ablactational baby pig weakness of the spleen and stomach, use Chinese medicine compound feed additive that Rhizoma Atractylodis, Radix Sophorae Flavescentis, Maifanitum etc. have the invigorating the spleen and regulating the stomach effect ablactational baby pig of feeding, can reduce the piglet diarrhea sickness rate, increase daily gain.
Wu Jinjie, Zhang Xiaorong, Wang Yong equals calendar year 2001 in " Anhui agricultural sciences " the 2nd phase publish an article " research that Chinese traditional compound medicine is prevented and treated early stage stress of baby pigs caused ablaction syndrome ", introduced and used Massa Medicata Fermentata, Fructus Hordei Germinatus, Fructus Crataegi, Radix Angelicae Sinensis, Radix Astragali Preparata, Fructus Psoraleae, prescriptions such as Flos Lonicerae, make decoction (every milliliter contains the 0.5g crude drug) according to a conventional method, give piglet oral during 21 ages in days, once a day, each 20ml, serve on 7 days, wean during 24 ages in days, the test group piglet average weight and the average daily gain utmost point increase significantly as a result, and the piglet diarrhea rate reduces by 62.5% than matched group.
Li Guoping, yellow the deep blue sea published an article in " Chinese veterinary's journal " the 1st phase in 2002 " Chinese herb on the prevention early weaning piglet diarrhoea ", introduced and used the Radix Astragali, Radix Codonopsis, Poria, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Herba Portulacae, Radix Angelicae Sinensis, Massa Medicata Fermentata, Fructus Crataegi prescription by a certain percentage, make 100% decoction, give and add 2% decoction in the 10 age in days DLY piglet diets, the interpolation time is 14 days, the wean of piglet 28 ages in days, test group piglet diarrhea rate, diarrhoea head reduce by 78.3% and 78.1% than matched group respectively, and the weightening finish of piglet are had certain facilitation as a result.
Yellow economic rights, Xu Haijun, Yang Su is bright in calendar year 2001 publish an article in " journal of Zhejiang university " the 2nd phase " the refreshing prevention early-weaned piglets diarrheal research preliminary study that looses of dysentery relieving ", introduced in wean and in the wean piglet diet in 2 weeks of back, added refreshing loose (compositions such as Fructus Psoraleae, Fructus Evodiae, Fructus Schisandrae Chinensis) of 1.5% dysentery relieving in preceding 1 day, test group piglet daily gain and feed conversion rate increase as a result, and diarrhea rate reduces.
Summary of the invention the objective of the invention is to develop boar health care and short long Chinese medicine additive.
Pig health care of the present invention and short long Chinese medicine additive are a kind of refining Chinese powder medicines, are flaxen powder, feeble QI perfume (or spice), sweet and slightly bitter taste.
Prescription one, select Herba Houttuyniae, the Radix Astragali, Poria, Radix Et Caulis Acanthopanacis Senticosi, Herba Dianthi, Fructus Crataegi, Cortex Magnoliae Officinalis, Radix Angelicae Sinensis combination, the shared weight percent of each medicine of distinguishing the flavor of is as follows:
Herba Houttuyniae 8%~12% Radix Astragali 15%~25% Poria 13%~17%
Radix Et Caulis Acanthopanacis Senticosi 9%~11% Herba Dianthi 7%~13% Fructus Crataegi 10%~20%
Cortex Magnoliae Officinalis 8%~12% Radix Angelicae Sinensis 8%~12%.
Prescription two, select Flos Lonicerae, the Radix Astragali, Poria, Herba Dianthi, Radix Et Caulis Acanthopanacis Senticosi, Fructus Crataegi, Cortex Magnoliae Officinalis, Radix Angelicae Sinensis combination, the shared weight percent of each medicine of distinguishing the flavor of is as follows:
Flos Lonicerae 8%~12% Radix Astragali 15%~25% Poria 13%~17%
Herba Dianthi 7%~13% Radix Et Caulis Acanthopanacis Senticosi 9%~112% Fructus Crataegi 10%~20%,
Cortex Magnoliae Officinalis 8%~12% Radix Angelicae Sinensis 8%~12%.
The preparation method of pig health care and short long Chinese medicine additive comprises raw material, extraction, concentrates, adds starch, drying, pulverizing, finished product.
(1) utilize prescription one prepare the pig health care and to urge the method for long Chinese medicine additive as follows:
1, raw material: the flavor of 8 in the one medicines oven dry of will filling a prescription, press prescription proportioning mixing for standby use;
2, extract: with above-mentioned raw materials through the multi-functional extraction unit of Chinese medicine under the condition of 60~70 ℃ of temperature, pressure 0.05Mpa, with concentration 70~75% ethanol, twice of continuous extraction, extraction time is 1.5hr for the first time, extraction time is 1.5hr still for the second time, merges the crude extract of twice lixiviate gained;
3, concentrate: with crude extract vacuum cock concentrator, be that being concentrated into proportion is 1.2~1.3 under the condition of 50~55 ℃ of-0.06~0.07Mpa, temperature in vacuum, must extractum;
4, add starch: press extractum: the weight ratio of starch=1: 1.8 is added starch in extractum, and stirs;
5, drying: the mixture of putting above-mentioned starch and extractum under the condition of 60~80 ℃ of temperature, is dried to moisture content≤8% in the electric heating hot air circulation drying oven;
6, pulverize: taking out above-mentioned dry thing, to be crushed to fineness with crushing and pelletizing machine be 50~60 orders;
7, finished product: add flavouring agent by 1~2% of above-mentioned ground product weight--the breast flavor is fragrant, and stirs, and is finished product.
(2) utilize prescription two prepare the pig health care and to urge the method for long Chinese medicine additive as follows:
1, raw material: the flavor of 8 in the two medicines oven dry of will filling a prescription, press behind the prescription proportioning mix homogeneously standby;
Remaining method prepares pig with utilization prescription one and keeps healthy identical with the method for short long Chinese medicine additive.
The suitable crude drug 4g of finished product 1g of pig health care of the present invention and short long Chinese medicine additive.It is Powdered that finished product is dark yellow in appearance, and granularity and bulk density are even, and it is strong to make an addition to the feedstuff adhesiveness, feedstuff dyeing variable color is coordinated and can not made to color and luster, do not influence the feedstuff primary colors, can use in the overall process of Swine Production, anti-stress and the short length to ablactational baby pig has original effect especially.Pig of the present invention health care and short long Chinese medicine additive also have the Olibanum flavor, are easy to the adaptation of feedstuff being distinguished the flavor of behind the weaned piglet, have the food calling effect.Adopt the Radix Astragali, Cortex Magnoliae Officinalis invigorating the spleen and replenishing QI, spleen invigorating consolidating superficial resistance; Poria, Herba Dianthi help Radix Astragali QI invigorating dampness removing, Radix Et Caulis Acanthopanacis Senticosi kidney and spleen invigorating, benefiting vital QI for tranquillizing, hawthorn digesting intestinal stasis relieving, the antidiarrheal that is good for the stomach, Radix Angelicae Sinensis temperature compensation liver blood; With Flos Lonicerae, Herba Houttuyniae heat-clearing and toxic substances removing, the silt pain relieving of loosing.
Belong to the body of the young sun of young the moon at piglet, internal organs are tender and lovely, and shape gas does not fill, the spleen tending to insufficiency usually, the wean back is because of raising condition changing and unhygienic diet, and injuring spleen-stomach often causes characteristics such as dysfunction of the spleen in transportation, abnormal ascending-descending of QI, according to air making-up and spleen enlivening, dyspepsia and intestinal stasis relieving, clearing away heat and eliminating dampness principle prescription.Prescription cooperates rigorous, does not have the incompatibility of eighteen incompatible medicaments, nineteen medicaments of mutual restraint, experimental results show that pig health care and short long Chinese medicine additive can obviously reduce the diarrhea of weaned piglets incidence rate, improve piglet daily gain and feed conversion rate; Can improve ablactational baby pig blood rbc number, leukocyte count, lymphocyte percentage, ANAE+ lymphocyte percentage and CD4/CD8 ratio, can promote the generation of ablactational baby pig total serum protein, globulin, immunoglobulin, complement, show pig health care and short long Chinese medicine additive immunological enhancement ablactational baby pig; Can reduce the secretion of ablactational baby pig serum cortisol, reduce stress of baby pigs caused ablaction, by improving serum 3 (T 3), thyroxine (T 4) content, promote proteinic syntheticly, improve the growth in piglets performance, promote the growth effect thereby play.
The specific embodiment is illustrated with F in conjunction with the embodiments in order fully to disclose pig health care of the present invention and short long Chinese medicine additive.
Embodiment boar health care in: one and short long Chinese medicine additive----" pig stilbene Siberian cocklebur I "
" pig stilbene Siberian cocklebur I " by Herba Houttuyniae, the Radix Astragali, Poria, Radix Et Caulis Acanthopanacis Senticosi, Herba Dianthi, Fructus Crataegi, Cortex Magnoliae Officinalis, when being grouped into, and the shared weight percent of each medicine of distinguishing the flavor of is as follows:
Herba Houttuyniae 10% Radix Astragali 20% Poria 15% Radix Et Caulis Acanthopanacis Senticosi 10%
Herba Dianthi 10% Fructus Crataegi 15% Cortex Magnoliae Officinalis 10% Radix Angelicae Sinensis 10%.
Embodiment boar health care in two: one and short long Chinese herbal feed additive----" pig stilbene Siberian cocklebur II "
" pig stilbene Siberian cocklebur II " by Flos Lonicerae, the Radix Astragali, Poria, Radix Et Caulis Acanthopanacis Senticosi, Herba Dianthi, Fructus Crataegi, Cortex Magnoliae Officinalis, when being grouped into, and the shared weight percent of each medicine of distinguishing the flavor of is as follows:
Flos Lonicerae 10% Radix Astragali 20% Poria 15% Radix Et Caulis Acanthopanacis Senticosi 10%
Herba Dianthi 10% Fructus Crataegi 15% Cortex Magnoliae Officinalis 10% Radix Angelicae Sinensis 10%.
The raw material that " pig stilbene Siberian cocklebur I " and " pig stilbene Siberian cocklebur II " adopts is respectively as embodiment one and embodiment two, and remaining preparation method all comprises extraction, concentrates, adds starch, drying, pulverizing and finished product.
" pig stilbene Siberian cocklebur I " and " pig stilbene Siberian cocklebur II " function: air making-up and spleen enlivening, clearing away heat and eliminating dampness, enhancing immunity, alleviating ablactational baby pig stress.
" pig stilbene Siberian cocklebur I " and " pig stilbene Siberian cocklebur II " cures mainly: the control ablactational baby pig stress.
" pig stilbene Siberian cocklebur I " and " pig stilbene Siberian cocklebur II " usage and consumption: the amount of pressing 4kg/t~8kg/t in basal diet is added " pig stilbene Siberian cocklebur I " or " pig stilbene Siberian cocklebur II ", and 7 ages in days begin the food calling diet, until delivering for sale.
It below is the clinical trial result of " pig stilbene Siberian cocklebur I " and " pig stilbene Siberian cocklebur II ".
1, test material and method
1,1 trial drug " pig stilbene Siberian cocklebur I " and " pig stilbene Siberian cocklebur II ".
1, grouping of 2 experimental animals and processing
Choose parity close (3-5 tire), Du-length that age in days is identical-big suckling pig 12 nests (every nest 8-10 head), be divided into 3 groups at random, be respectively pig stilbene Siberian cocklebur I group, pig stilbene Siberian cocklebur II group, antibiotic group, every group 4 nest.7 ages in days begin food calling test diet, until wean back 28 ages in days.From every nest, choose the close piglet 4--5 head of body weight during the wean of 25 ages in days, merge in the group, jump, every group each 18.Wherein pig stilbene Siberian cocklebur I group, pig stilbene Siberian cocklebur II group are all added pig stilbene Siberian cocklebur I and pig stilbene Siberian cocklebur II respectively by the amount of 4kg/t in basal diet; The antibiotic group is added 15% chlortetracycline 70g/t and 15% bacitracin zinc 30g/t in basal diet.Each assembly is than all being made as graininess test diet after adding.
1, the mensuration of 3 fertility performance claims individual weight on an empty stomach in weaned piglet same day, wean back 28d, record daily feed intake, a diarrhoea number and diarrhoea piglet overbit; Calculate daily gain, feed conversion rate, diarrhea rate.
1, the mensuration of 4 other indexs
1, the mensuration of 4,1 hematology's project is when weaned piglet 14,28d, every group of piglet that selects 6 near average weight, the vena cava anterior of lying on the back blood sampling, add the EDTA-K2 anticoagulant, detect RBC number (RBC) with Sysmex K-1000 blood cell automatic analyzer, hemoglobin (HGB), hematid specific volume (HCT), mean corpuscular volume (MCV) (MCV), mean corpusular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC) (MCHC), leukocyte count (WBC), lymphocyte percentage (LYM).
1.4.2T the mensuration of lymphocyte subgroup and T total lymphocyte count when weaned piglet 28d, every group of piglet that selects 6 near average weight, the vena cava anterior of lying on the back blood sampling 1-2ml adds heparin sodium (25u/ml) anticoagulant, isolated lymphocytes, smear.Alkali phosphatase-alkali resistance phosphatase bridging immunoenzymatic staining (Alkaline phosphataseanti-alkaline phosphatase ELISA is adopted in t lymphocyte subset group's variation, APAAP-ELISA), test kit is provided by Beijing Bang Ding Biomedicines, Inc., and operating procedure is undertaken by product description; The T total lymphocyte count adopts acid α-naphthyl acetate esterase (Acid α-naphthyl acetate esterase, ANAE) staining.
1.4.3 the mensuration of other index is 3d, wean back 1,4,7,14,28d 7:30-9:30 in the morning before weaned piglet, 6 empty stomaches of every group of picked at random piglet (the pig unanimity of omnidistance blood sampling), the Baoding of lying on the back, vena cava anterior blood sampling, the conventional serum for preparing.Serum immune globulin (IgG, IgM, IgA), complement (C3, C4) are used immune turbidimetry, and test kit is provided by Zhejiang Province Yilikang Bioisystech Co., Ltd; Total serum protein (TP) adopts biuret method, and serum albumin (ALB) adopts bromocresol green (BCG) method, and serum globulin is total protein and albuminous difference, and test kit is provided by Shanghai Rongsheng Bioisystech Co., Ltd.Test instrunment is that last Hisoon reaches the XD-811L semi-automatic biochemical analyzer that Medical Instruments company produces.The mensuration of hydrocortisone is used radioimmunoassay box (lot number S20033008) mensuration of Isotope Research institute of China Atomic Energy Science Research Institute; The mensuration of T3, T4 uses Beijing Atom HighTech Co., Ltd.'s radioimmunoassay box (lot number S10930039, S1093004) to measure.
1.5 data analysis application SPSS11.5 statistical processing software carries out one factor analysis of variance and DUNCAN multiple comparisons.
2, result
2,1 " pig stilbene Siberian cocklebur " is to the influence (seeing Table 1) of ablactational baby pig growth performance
Table 1 pig stilbene Siberian cocklebur feed additive is to the influence of ablactational baby pig growth performance
The mensuration project Pig stilbene Siberian cocklebur I group Pig stilbene Siberian cocklebur II group The antibiotic group
Starting weight (Kg) 7.50±0.61 7.48±0.60 7.51±0.51
End heavy (Kg) 17.55±1.50b 17.53±1.77b 16.57±0.93a
Search for food day (Kg/d) 0.576±0.28 0.573±0.27 0.578±0.26
Daily gain (Kg/d) 0.359±0.05b 0.359±0.06b 0.324±0.03a
Feed conversion rate 1.61 1.60 1.79
Diarrhea rate (%) 2.78 2.18 4.76
Annotate: different lowercase alphabet significant differences (P<0.05) behind the same line number word
Diarrhea rate=diarrhoea sun is counted summation/(test piglet number * test natural law) * 100%
As shown in table 1, the piglet body weight gains of two pig stilbene Siberian cocklebur groups all is higher than the antibiotic group, daily gain improves 10.78% (p>0.05) and 11.68% (p>0.05) than antibiotic group respectively, feed conversion rate improves 10.09%, 10.54% than antibiotic group respectively, and diarrhea rate reduces by 41.67%, 45.83% than antibiotic group respectively.
2, the variation of 2 ablactational baby pig 14,28d blood project (see Table 2, table 3)
Back 14 days measurement results of table 2 wean for examination pig blood project
Project Pig stilbene Siberian cocklebur I group Pig stilbene Siberian cocklebur II group The antibiotic group
RBC(10^12/L) 6.40±0.67b 6.29±0.29b 5.77±0.34a
HGB(g/L) 112.5±7.42b 111.8±6.02b 104.2±2.39a
HCT 0.40±0.03b 0.41±0.01b 0.36±0.01a
MCV(fl) 63.80±1.79 65.04±2.69 63.86±1.69
MCH(pg) 18.13±0.57b 17.94±0.46b 17.80±0.37a
MCHC(g/L) 278.5±4.36 279.6±5.77 275.6±5.68
WBC(10^9/L) 18.35±0.97 18.86±1.88 17.04±2.09
LYM(%) 59.85±9.22b 58.16±4.18b 50.02±1.20a
As shown in table 2, during weaned piglet 14d, piglet RBC, HGB, the HCT of pig stilbene Siberian cocklebur of feeding all is significantly higher than the antibiotic group, pig stilbene Siberian cocklebur I, II group RBC improves 10.92% (P<0.05), 9.01% (P<0.05) than antibiotic group respectively, LYM improves 19.65% (P<0.05), 16.27% (P<0.05) than antibiotic group respectively, and WBC improves 7.69% (p>0.05), 10.68% (p>0.05) than antibiotic group respectively.
Table 3 wean supplied examination pig blood project measurement result in back 28 days
Project Pig stilbene Siberian cocklebur I group Pig stilbene Siberian cocklebur II group The antibiotic group
RBC(10^12/L) 5.65±0.34 5.68±0.23 5.55±0.32
HGB(g/L) 97.20±3.96a 98.60±2.70a 95.40±4.10a
HCT 0.34±0.01 0.34±0.03 0.33±0.02
MCV(fl) 62.00±2.26a 62.2±1.80a 59.14±1.65b
MCH(pg) 17.68±0.88 17.62±0.40 17.22±0.60
MCHC(g/L) 290.6±5.46a 287.4±6.73ab 289.6±6.95ab
WBC(10^9/L) 18.82±2.86 20.44±6.07 17.22±1.29
LYM(%) 63.88±3.68a 62.94±5.18a 56.54±2.90b
As shown in table 3,28d behind the weaned piglet, pig stilbene Siberian cocklebur I, II group MCV improves 4.84% (P<0.05), 5.17% (P<0.05) than antibiotic group respectively, RBC is respectively than antibiotic group high by 9.29% (p>0.05), 18.70% (p>0.05), and LYM improves 12.98% (P<0.05), 11.32% (P<0.05) than antibiotic group respectively.
2.3 the measurement result of ablactational baby pig t lymphocyte subset group and T lymphocyte percentage (seeing Table 4)
Table 4, pig stilbene Siberian cocklebur are to ablactational baby pig t lymphocyte subset group and ANAE +The influence of lymphocyte percentage
The mensuration project Pig stilbene Siberian cocklebur I group Pig stilbene Siberian cocklebur II group The antibiotic group
CD 3 61.50±1.96 60.88±1.4 60.63±2.09
CD 4 36.38±3.17 35.88±1.11 33.13±4.66
CD 8 22.00±2.16 22.25±1.26 21.75±2.63
CD 4/CD 8 1.66±0.0b 1.61±0.05b 1.52±0.11a
ANAE + 64.13±0.02b 64.00±0.03b 62.25±0.01a
Annotate: different lowercase alphabet significant differences (P<0.05) behind the same line number word.
As shown in table 4, in the time of around the weaned piglet, pig stilbene Siberian cocklebur group piglet lymphocyte subgroup CD 3, CD 4Content all be higher than the antibiotic group, pig stilbene Siberian cocklebur I organizes CD 3Content has improved 1.43% (p>0.05), CD than antibiotic group 4Content has then improved 9.81% (p>0.05), 16.42% (p>0.05) respectively; CD 8Content is close, but pig stilbene Siberian cocklebur group CD 4/ CD 8Ratio all is higher than the antibiotic group, and pig stilbene Siberian cocklebur group improves 9.21% (p>0.05), 5.92% (p>0.05) than antibiotic group respectively; T lymphocyte ANAE stained positive rate pig stilbene Siberian cocklebur group is higher.
2, the changes of contents of 4 ablactational baby pig total serum proteins, albumin and globulin (see Table 5, table 6, table 7)
Table 5 pig stilbene Siberian cocklebur is to the influence (g/L) of ablactational baby pig The Total albumen content
Time Pig stilbene Siberian cocklebur I group Pig stilbene Siberian cocklebur II group The antibiotic group
Weaned preceding 3 days 59.46±6.65 61.76±6.33 58.81±8.53
Weaned 1 day 54.91±1.97 55.54±6.70 53.82±3.28
Weaned 4 days 53.80±2.71ab 62.74±10.74b 51.13±5.90a
Weaned 7 days 53.33±3.79 59.17±9.86 51.88±9.09
Weaned 14 days 49.98±4.30 50.40±3.75 48.03±4.70
Weaned 28 days 69.07±9.08b 66.54±5.77b 64.69±6.20ab
Table 6 pig stilbene Siberian cocklebur is to the influence (g/L) of ablactational baby pig serum albumin levels
Time Pig stilbene Siberian cocklebur I group Pig stilbene Siberian cocklebur II group The antibiotic group
Weaned preceding 3 days 36.43±7.15 39.62±3.74 36.19±4.80
Weaned 1 day 32.27±1.78 34.71±6.00 31.84±2.93
Weaned 4 days 34.43±2.27ab 39.87±4.86b 32.32±2.63a
Weaned 7 days 31.57±2.88ab 36.65±5.30b 30.14±5.24a
Weaned 14 days 32.56±3.18 32.64±3.33 31.11±6.11
Weaned 28 days 35.01±4.68 34.41±3.86 33.77±5.80
Table 7 pig stilbene Siberian cocklebur is to the influence (g/L) of ablactational baby pig serum globulin content
Time Pig stilbene Siberian cocklebur I group Pig stilbene Siberian cocklebur II group The antibiotic group
Weaned preceding 3 days 23.30±3.74 22.23±1.99 22.63±1.67
Weaned 1 day 22.64±3.12 20.83±1.22 21.98±2.25
Weaned 4 days 19.37±3.02ab 22.87±7.33b 18.81±6.18ab
Weaned 7 days 21.77±4.14 22.52±12.26 21.74±5.87
Weaned 14 days 17.42±4.83 17.77±3.11 16.92±3.98
Weaned 28 days 34.06±8.46b 32.12±7.55b 30.93±9.68ab
Shown in table 5, table 6, table 7, it is on a declining curve respectively to organize piglet total serum protein, albumin, globulin content behind the weaned piglet, but pig stilbene Siberian cocklebur is organized above-mentioned three indexs all than antibiotic group height between whole weaning period.
2, the changes of contents of 5 ablactational baby pig serum immunoglobulin IgGs, IgM and IgA (see Table 8, table 9, table 10)
Table 8 pig stilbene Siberian cocklebur is to the influence (g/L) of ablactational baby pig serum immunoglobulin IgG content
Time Pig stilbene Siberian cocklebur I group Pig stilbene Siberian cocklebur II group The antibiotic group
Weaned preceding 3 days 0.61±0.03 0.65±0.08 0.61±0.07
Weaned 1 day 0.53±0.09 0.60±0.07 0.55±0.08
Weaned 4 days 0.57±0.18 0.60±0.09 0.59±0.14
Weaned 7 days 0.57±0.10ab 0.61±0.08b 0.55±0.06ab
Weaned 14 days 0.62±0.19b 0.63±0.08b 0.53±0.03ab
Weaned 28 days 0.66±0.12b 0.69±0.18b 0.59±0.06ab
Table 9 pig stilbene Siberian cocklebur is to the influence (g/L) of ablactational baby pig serum immune globulin IgM content
Time Pig stilbene Siberian cocklebur I group Pig stilbene Siberian cocklebur II group The antibiotic group
Weaned preceding 3 days 0.36±0.05 0.38±0.04 0.36±0.07
Weaned 1 day 0.34±0.07 0.36±0.06 0.35±0.05
Weaned 4 days 0.33±0.06 0.34±0.06 0.34±0.06
Weaned 7 days 0.31±0.03 0.36±0.07 0.32±0.06
Weaned 14 days 0.35±0.01ab 0.38±0.08b 0.33±0.06ab
Weaned 28 days 0.44±0.08 0.45±0.10 0.40±0.07
Table 10 pig stilbene Siberian cocklebur is to the influence (g/L) of ablactational baby pig serum immune globulin IgA content
Time Pig stilbene Siberian cocklebur I group Pig stilbene Siberian cocklebur II group The antibiotic group
Weaned preceding 3 days 0.17±0.04 0.16±0.04 0.15±0.02
Weaned 1 day 0.13±0.03 0.13±0.02 0.11±0.03
Weaned 4 days 0.13±0.02b 0.14±0.02b 0.09±0.01a
Weaned 7 days 0.12±0.01ab 0.14±0.03b 0.10±0.02a
Weaned 14 days 0.13±0.02 0.14±0.01 0.12±0.04
Weaned 28 days 0.23±0.06b 0.20±0.04ab 0.17±0.04a
Shown in table 8, table 9, table 10, behind the weaned piglet 1 day, each was compared before organizing piglet serum immune globulin content and wean, obviously descend, after maintain low level before the wean, wean is during 4 weeks, the piglet serum immune globulin raises, and surpasses the preceding level of wean.Pig stilbene Siberian cocklebur group piglet serum immune globulin content is all than antibiotic group height between whole weaning period.
2,6 pig stilbene Siberian cockleburs are to the influence (table 11, table 12, table 13) of ablactational baby pig endocrine function
Table 11 pig stilbene Siberian cocklebur is to the influence (ng/ml) of ablactational baby pig serum cortisol level
Time Pig stilbene Siberian cocklebur I group Pig stilbene Siberian cocklebur II group The antibiotic group
Weaned preceding 3 days 30.71±7.71 31.82±9.37 36.34±6.33
Weaned 1 day 48.00±12.82b 49.68±5.85b 71.86±4.91a
Weaned 4 days 32.70±11.80 37.57±7.38 38.64±12.56
Weaned 7 days 21.97±7.34 32.11±14.90 27.59±13.28
Weaned 14 days 24.57±5.50bc 33.51±4.37b 42.90±6.24ab
Weaned 28 days 29.30±5.32 35.21±9.45 39.63±10.90
As shown in table 11,1d behind the weaned piglet compares remarkable rising before each is organized piglet serum cortisol content and weans, and respectively organize hydrocortisone content afterwards and all slowly descend, but two pig stilbene Siberian cocklebur group hydrocortisone content is low than the antibiotic group all the time.Pig stilbene Siberian cocklebur I group piglet serum cortisol content reduces by 33.2% (p<0.05) than antibiotic group.
Table 12 pig stilbene Siberian cocklebur is to the influence (nmol/L) of ablactational baby pig serum T 3 levels
Time Pig stilbene Siberian cocklebur I group Pig stilbene Siberian cocklebur II group The antibiotic group
Weaned preceding 3 days 2.22±0.76 2.48±0.33 2.18±0.45
Weaned 1 day 1.50±0.32 1.55±0.22 1.35±0.13
Weaned 4 days 2.19±0.34 2.41±0.54 2.14±0.44
Weaned 7 days 2.11±0.51ab 2.35±0.38b 1.91±0.44ab
Weaned 14 days 1.94±0.24 2.10±0.36 2.05±0.46
Weaned 28 days 2.07±0.61 2.20±0.11 1.52±0.32
Table 13 pig stilbene Siberian cocklebur is to the ablactational baby pig serum T 4The influence of level (nmol/L)
Time Pig stilbene Siberian cocklebur I group Pig stilbene Siberian cocklebur II group The antibiotic group
Weaned preceding 3 days 86.39±19.63 88.51±15.54 81.95±16.98
Weaned 1 day 64.57±17.06 62.12±16.88 62.65±16.65
Weaned 4 days 88.53±12.96 91.12±20.27 91.27±5.98
Weaned 7 days 89.74±8.11ab 99.34±9.30b 82.34±12.04a
Weaned 14 days 87.73±9.99b 91.63±11.81b 82.34±12.04a
Weaned 28 days 70.50±9.15 74.43±9.09 60.93±23.29
Shown in table 12, table 13,1d behind the weaned piglet, each organizes the piglet serum T 3T 4Content with the wean before compare remarkable reduction, respectively organize T afterwards 3, T 4Content all raises, but two pig stilbene Siberian cocklebur group T 3, T 4Content is all the time than antibiotic group height.

Claims (4)

1, boar health care and short long Chinese medicine additive is characterized in that selecting Herba Houttuyniae, the Radix Astragali, Poria, Radix Et Caulis Acanthopanacis Senticosi, Herba Dianthi, Fructus Crataegi, Cortex Magnoliae Officinalis, Radix Angelicae Sinensis to make up, and the shared weight percent of each medicine of distinguishing the flavor of is as follows:
Herba Houttuyniae 8%~12% Radix Astragali 15%~25% Poria 13%~17%
Radix Et Caulis Acanthopanacis Senticosi 9%~11% Herba Dianthi 7%~13% Fructus Crataegi 10%~20%
Cortex Magnoliae Officinalis 8%~12% Radix Angelicae Sinensis 8%~12%.
2, boar health care according to claim 1 and short long Chinese medicine additive, the shared weight percent of medicine that it is characterized in that respectively distinguishing the flavor of is as follows:
Herba Houttuyniae 10% Radix Astragali 20% Poria 15% Radix Et Caulis Acanthopanacis Senticosi 10%
Herba Dianthi 10% Fructus Crataegi 15% Cortex Magnoliae Officinalis 10% Radix Angelicae Sinensis 10%.
3, boar health care and short long Chinese medicine additive is characterized in that selecting Flos Lonicerae, the Radix Astragali, Poria, Radix Et Caulis Acanthopanacis Senticosi, Herba Dianthi, Fructus Crataegi, Cortex Magnoliae Officinalis, Radix Angelicae Sinensis to make up, and the shared weight percent of each medicine of distinguishing the flavor of is as follows:
Flos Lonicerae 8%~12% Radix Astragali 15%~25% Poria 13%~17%
Herba Dianthi 7%~13% Radix Et Caulis Acanthopanacis Senticosi 9%~112% Fructus Crataegi 10%~20%,
Cortex Magnoliae Officinalis 8%~12% Radix Angelicae Sinensis 8%~12%.
4, boar health care according to claim 3 and short long Chinese medicine additive, the shared weight percent of medicine that it is characterized in that respectively distinguishing the flavor of is as follows:
Flos Lonicerae 10% Radix Astragali 20% Poria 15% Radix Et Caulis Acanthopanacis Senticosi 10%
Herba Dianthi 10% Fructus Crataegi 1 5% Cortex Magnoliae Officinalis 10% Radix Angelicae Sinensis 10%.
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