CN100584320C - Chinese traditional medicine for treating rheumatoid disease and osteoarthritis and preparation method - Google Patents
Chinese traditional medicine for treating rheumatoid disease and osteoarthritis and preparation method Download PDFInfo
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Abstract
The present invention relates to a Chinese medicine compound preparation for effectively curing rheumatoid disease and osteoarthropathy with obvious therapeutic effect. It is made up by using 7 Chinese medicinal materials of wild aconite tuber, chaenomeles fruit, velvet deerhorn, bauhinia stem, Chinese angelica root, notopterygium root and achyranthes root through a certain preparation process.
Description
Technical field
The present invention relates to a kind of Chinese medicine, particularly relate to a kind of rheumatoid that the sick cold-damp resistance of numbness network causes and Chinese medicine of osteoarthritis for the treatment of.
Background technology
Rheumatism is the acquired chronic disease of a class, belongs to the sick category of motherland's medical science numbness.Rheumatoid arthritis (RA) be a kind of serve as the systemic autoimmune disease of main performance with chronic polyarthritis disease, mainly invade synovium of joint, be connective tissues such as serous coat, cardiopulmonary, tremulous pulse secondly.The worldwide average prevalence of primary disease is about 1%, and wherein the U.S. is about 3%, and Japan is about 0.3%, and China is about 2.9%.
Osteoarthritis is a kind of common degeneration rheumarthritis, and its pathological characteristic is an articular cartilage damage, edge, joint and subchondral bone reactive hyperplasia, and clinical manifestation is the arthralgia of slow sexual development, stiff, enlargement and limitation of activity.This sick incidence rate increases with the growth at age, find according to X line generaI investigation, 15-24 year the age group incidence rate be 10%, up to 80%, wherein have symptom and moving obstacle person to account for about 1/8 greater than 55 years old age group incidence rate.
Pain, swelling, dysfunction is three big primary symptoms of rheumatism.The most existence of the Chinese medicine preparation of treatment primary disease at present are difficult to rapid lenitive symptom in a short time, and wherein analgesic activity mainly is Radix Aconiti Lateralis Preparata, Herba Asari, Radix Aconiti, Radix Aconiti Kusnezoffii, but toxicity is also stronger, and unsuitable consumption is excessive.Though and chemicals effect is very fast, exist the treatment later stage to occur symptom " knock-on " easily, weak point such as side reaction is more obvious.
Summary of the invention
The technical problem to be solved in the present invention provides a kind of rheumatoid that the sick cold-damp resistance of treatment numbness network is caused and the Chinese medicine of osteoarthritis, and trade name is the Scobis Diospyroris Ebeni capsule.
The Scobis Diospyroris Ebeni capsule is on the basis, name side in ancient times of Chinese medicine arthromyodynia, in conjunction with the modern Chinese medicine compound preparation of modern medicine and pharmacology technological achievement development.This medicine is a prescription with Chinese medicines such as the Radix Aconiti Kusnezoffii Preparata of expelling cold and dampness, promoting blood circulation to remove obstruction in the collateral, Fructus Chaenomeliss; be used for the treatment of diseases such as rheumatoid arthritis and osteoarthritis; can improve symptom rapidly; effectively control inflammation; stop course of disease development, the protection function of joint reduces the joint deformity rate; treating both the principal and secondary aspects of a disease, curative effect is safe and reliable.
We have since two thousand two carried out the rheumatoid that the sick cold-damp resistance of numbness network causes and the study of tcm new drug of osteoarthritis.
Literature research: rheumatoid and osteoarthritis belong to traditional Chinese medical science arthromyodynia category together, are equivalent to " severe and migratory arthralgia ", " arthroncus of knee ", " insensitive impediment ", " rheumatism involving the bone " of the traditional Chinese medical science etc.Clinically mainly show as: limbs joint pain, swelling is bent and stretched and is changed one's position unfavorablely, and very the person is tetanic ossifys, joint deformity, movable function is limited.Localized pain, chance is trembled with fear and is increased the weight of; Or numbness of the skin is arranged, and symptom is shown effect repeatedly, and delay is difficult more, Tai Bai and be bored with stringy and tense pulse.Primary disease is many to be annotated in meridians because of body void wind-cold damp pathogen invasion and attack human body, stays in the joint, and venation is obstructed, and QI-blood circulation does not freely cause.Say as " element is asked the numbness opinion " " wet three gas of wind and cold are assorted extremely, close and be numbness also." " Lei Zheng Zhi Cai arthromyodynia " " all numbness ... very by the Wei Xianxu of battalion, interspaces of skin and muscles being loose, wind and cold wet and attack in an opponent's defence, and healthy energy is hindered by evil, can not declare row, thereby be detained, and QI and blood is puckery with fixed attention, forms numbness for a long time." cold-damp invasion and attack human body, to stay in limbs joint, venation is obstructed, and QI-blood circulation is not smooth, stagnation of QI and blood may bring about pain, disease is seen limbs joint pain, bends and stretches and changes one's position unfavorablely, very then movable function is limited; Cold having the property of coagulation, moist sticky so localized pain is met cold increasing the weight of, delay is difficult; Meet heat then QI and blood smoothness and alleviation of pain; Venation is obstructed, hematogenous blockage, and with the passing of time muscle arteries and veins, joint, muscle lose and support, so very then ankylosis ossifys, joint deformity, numbness of the skin; So the cold-evil presss from both sides wet arthroncus, and tongue is greasy in vain, stringy and tense pulse, the sign of attacking outward for cold-damp.
In addition, the course of disease of this class degeneration joint disease is longer, has the blood stasis symptom to take place more.Said as errors in Medicine Corrected: " pain must have blood stasis for a long time ".Many pharmacological research data show: collagen fiber generation puffing and recovery that drug for invigorating blood circulation and eliminating stasis can make the transparent homogenizing sample of generation become are normal, make the connective tissue absorption, recover normal morphology; And can improve blood microcirculation and connective tissue metabolism, particularly connective tissue be had emollescence.
This medicine is attacked outward at cold-damp, and the arthromyodynia due to the impatency meridians, hematogenous blockage is controlled with dispelling cold and removing dampness promoting blood circulation to remove obstruction in the collateral, the method for reducing swelling and alleviating pain.
New drug research determines that the technical scheme that adopts is:
A kind of Chinese medicine for the treatment of rheumatoid and osteoarthritis, be formulated by Radix Aconiti Kusnezoffii Preparata, Fructus Chaenomelis, Cornu Cervi Pantotrichum, Caulis Bauhihiae Championii, Radix Angelicae Sinensis, Rhizoma Et Radix Notopterygii, Radix Achyranthis Bidentatae, its raw medicinal herbs compatibility is: Radix Aconiti Kusnezoffii Preparata 150---170g, Fructus Chaenomelis 150---170g, Cornu Cervi Pantotrichum 20---30g, Caulis Bauhihiae Championii 150---170g, Radix Angelicae Sinensis 150---170g, Rhizoma Et Radix Notopterygii 130---150g, Radix Achyranthis Bidentatae 150---170g.
Producing a kind of manufacturing technique method for the treatment of rheumatoid and osteoarthritis Chinese medicine of the present invention is:
---170g, Fructus Chaenomelis 150---170g, Cornu Cervi Pantotrichum 20---30g, Caulis Bauhihiae Championii 150---170g, Radix Angelicae Sinensis 150---170g, Rhizoma Et Radix Notopterygii 130---150g, Radix Achyranthis Bidentatae 150---170g that need get Radix Aconiti Kusnezoffii Preparata 150 by compatibility.
Pulveratum Cornu Cervi Pantotrichum is broken into fine powder, standby; Radix Angelicae Sinensis, Rhizoma Et Radix Notopterygii add 6～10 times of water gagings, and water vapour distillation volatile oil 4～6 hours, the aqueous solution after the distillation device are in addition collected, and medicinal residues are standby; Volatile oil is made Benexate Hydrochloride.Radix Achyranthis Bidentatae, Fructus Chaenomelis, Caulis Bauhihiae Championii add 6～10 times of amounts (50～80) % ethanol extraction three times, each 1～2 hour, filter filtrate recycling ethanol and to be concentrated into relative density be 1.02～1.18 (50 ℃).Get Radix Aconiti Kusnezoffii Preparata and add 8～10 times of water gagings extraction secondaries, each 1～2 hour, merge with standby medicinal residues for the third time, adding 8～10 times of water gagings extracted 1～2 hour, filter, the aqueous solution after filtrate and the distillation merges, and being concentrated into relative density is 1.02～1.18 (50 ℃), merge spray drying with the alcohol extraction concentrated solution again and get fine powder, add Benexate Hydrochloride, velvet powder and appropriate amount of auxiliary materials, mixing incapsulates, make 1000, promptly.
Function cures mainly: dispelling cold and removing dampness, promoting blood circulation to remove obstruction in the collateral, reducing swelling and alleviating pain.Be used for rheumatoid and osteoarthritis that the sick cold-damp resistance of numbness network causes, clinical manifestation is a limbs joint pain, and swelling is bent and stretched and changed one's position unfavorablely, and very the person is tetanic ossifys, joint deformity, and movable function is limited, and symptom becomes work repeatedly, and delay is difficult, Tai Bai and be bored with stringy and tense pulse.
Usage: oral, 2～3 times on the one.
Consumption: at every turn take 1.2～1.8g.
The side separates: the rheumatoid and the osteoarthritis of cold-damp resistance network, Chinese medicine are thought because cold-damp invasion and attack human body stays in the limbs joint venation and is obstructed, and QI-blood circulation is not smooth, has caused limbs joint pain, bend and stretch or change one's position unfavorable, limitation of activity very then.The sticky disease difficulty of cold having the property of coagulation damp speed is more met then QI and blood smoothness of heat, the happiness temperature occurred and alleviation of pain, and chance is trembled with fear and increased the weight of, and delay is difficult, shows effect repeatedly.Venation is obstructed, and with the passing of time muscle arteries and veins, joint, muscle lose the rigid joint deformity numbness of the skin of foster very then ankylosis to hematogenous blockage.Radix Aconiti Kusnezoffii Preparata is hot product in the side, expelling wind and removing dampness, antalgic and subsiding a swelling; The contracture of treatment muscle arteries and veins is longer than in the removing dampness of Fructus Chaenomelis relaxing muscles and tendons and activating QI and blood in the collateral, and the two is monarch drug altogether.The Cornu Cervi Pantotrichum kidney-replenishing, benefiting essence-blood, bone and muscle strengthening, Caulis Bauhihiae Championii expelling wind and removing dampness, promoting blood circulation to remove obstruction in the collateral, Radix Angelicae Sinensis promoting blood circulation and stopping pain, and can enrich blood to make and invigorate blood circulation and blood trouble not, Xin Wen and non-impairment of YIN nourishing blood for moistening dryness, moistening the nourishing muscle and tendon bone is ministerial drug, the hot warm cold expelling wind-damp dispelling of Rhizoma Et Radix Notopterygii, sharp arthralgia relief tying-in is up, the Radix Achyranthis Bidentatae blood circulation promoting and blood stasis dispelling, bone and muscle strengthening, and can conducting blood to flow downwards be adjuvant.All medicines share, the disease combination, and giving consideration to both the incidental and fundamental is played dispelling cold and removing dampness altogether, promoting blood circulation to remove obstruction in the collateral, the effect of reducing swelling and alleviating pain.
Pharmacodynamic study:
1. analgesic activity: the Scobis Diospyroris Ebeni capsule has the pharmacological action of easing pain preferably, and this effect is tangible dose-effect relationship.
Table 1 Scobis Diospyroris Ebeni capsule is to the influence of the mice hot plate threshold of pain
※P＜0.05,
※ ※Compare with negative control group P＜0.01
The influence of table 2 Scobis Diospyroris Ebeni capsule Dichlorodiphenyl Acetate writhing method mouse writhing number of times
※P＜0.05,
※ ※Compare with negative control group P＜0.01
2. antiinflammatory action: the Scobis Diospyroris Ebeni capsule has the pharmacological action of anti-active chronic inflammation preferably.
Table 3 Scobis Diospyroris Ebeni capsule is to the influence of mice capillary permeability
※P＜0.05,
※ ※Compare with negative control group P＜0.01
The influence of table 4 Scobis Diospyroris Ebeni capsule xylol induced mice ear swelling
※P＜0.05,
※ ※Compare with negative control group P＜0.01
Table 5 Scobis Diospyroris Ebeni capsule is to the bullate influence of rat granuloma
※P＜0.05,
※ ※Compare with negative control group P＜0.01
3. immunosuppressive action: the Scobis Diospyroris Ebeni capsule has anti-mice delayed hypersensitivity, suppresses mice serum hemolysin content and suppresses the immune pharmacological action of mouse lymphocyte conversion percentage.
Table 6 Scobis Diospyroris Ebeni capsule is to the influence of mice delayed hypersensitivity
※P＜0.05,
※ ※Compare with negative control group P＜0.01
Table 7 Scobis Diospyroris Ebeni capsule is to the influence of antibody in the mice serum (hemolysin)
※P＜0.05,
※ ※Compare with negative control group P＜0.01
The influence that table 8 Scobis Diospyroris Ebeni capsule transforms mouse lymphocyte
※P＜0.05,
※ ※Compare with negative control group P＜0.01
4. the effect of Chinese People's Anti-Japanese Military and Political College Mus adjuvant-induced arthritis: the Scobis Diospyroris Ebeni capsule can significantly suppress the pharmacological action of the foot swelling of rat assist agent arthritis.This effect may be that the mechanism of action by inflammation-inhibiting medium NO and PGE2 produces.
The influence of table 9 pair rat assist agent arthritis Secondary cases foot swelling
△P＜0.05,
△ △Compare with the normal control group P＜0.01
※P＜0.05,
※ ※Compare with negative control group P＜0.01
Table 10 couple rat macrophage secretion NO amount and PGE
2The influence of content (x ± s)
△ △Compare with the normal control group P＜0.01
※P＜0.05,
※ ※Compare with negative control group P＜0.01
Table 11 general curative effect
As seen from Table 11, the sick syndrome of cold-dampness blocking collaterals patient of Scobis Diospyroris Ebeni capsule for treating numbness 60 examples are significantly improved after its general curative effect treatment (P＜0.01).
The comparison of erythrocyte sedimentation rate before and after table 12 treatment
As seen from Table 12, the sick syndrome of cold-dampness blocking collaterals patient of Scobis Diospyroris Ebeni capsule for treating numbness 60 examples are significantly improved after its erythrocyte sedimentation rate treatment (P＜0.01)
Untoward reaction: have 1 example to take medicine among the 60 routine patients and occurred in back 17 days feeling sick, stomach discomfort adheres to taking omnidistance medicine.Other patients find no allergy and untoward reaction.Safety detects (blood, urine, just conventional, hepatic and renal function, electrocardiogram) treatment all no abnormal change in front and back.
The toxicologic study data:
1, chmice acute toxicity: the capsular maximum dosage-feeding of Scobis Diospyroris Ebeni is 10.0g/kg, and mice does not have obvious poisoning manifestations, does not also have dead.
2, rat long term toxicity:, irritate stomach and give rat, continuous 12 weeks with 1.5g/kg/d, 4.5g/kg/d and three dosage of 13.5g/kg/d.In the test, after the experimental period end and after the convalescent period end, put to death the part rat respectively, carry out blood and blood biochemical and learn detection and pathological examination.The result: the every index of general performance, body weight, organ index, blood and blood biochemical and the pathological examination results of high, medium and low three the dosage groups of Scobis Diospyroris Ebeni capsule show no obvious abnormalities.
The pharmacokinetic data:
When Scobis Diospyroris Ebeni capsule 5 is used ketoprofen, the cmax value the when Cmax of ketoprofen is significantly higher than the ketoprofen that gives Isodose separately in the beasle dog body, the AUC value also is higher than the ketoprofen that gives Isodose separately.Prompting compound Chinese medicinal preparation Scobis Diospyroris Ebeni capsule has the bioavailability that helps improve ketoprofen, but the t1/2 there was no significant difference illustrates that compound Chinese medicinal preparation Scobis Diospyroris Ebeni capsule does not have obviously influence to the metabolism and the elimination of ketoprofen.When Scobis Diospyroris Ebeni capsule for treating rheumatoid and osteoarthritis acute pain patient are used in prompting, can a spot of NSAID (non-steroidal anti-inflammatory drug) of 5 usefulness strengthening its analgesic activity, and can reduce the gastrointestinal side effect of NSAID (non-steroidal anti-inflammatory drug).
Clinical verification research: Scobis Diospyroris Ebeni capsule for treating rheumatoid arthritis, osteoarthritis (syndrome of cold-dampness blocking collaterals) patient amount to 60 examples, and male's 28 examples account for 46.7%; Women's 32 examples account for 53.3%, and the result shows that total effective rate is 86.67%.
The present invention is used for the treatment of the rheumatoid and the compound Chinese medicinal preparation of osteoarthritis that the sick cold-damp resistance of numbness network causes, has the rapid symptom of improving, and effectively controls inflammation, and protects function of joint, characteristics such as treating both the principal and secondary aspects of a disease.
The specific embodiment
Embodiment one
A kind of Chinese medicine for the treatment of rheumatoid and osteoarthritis is to be prepared into by Radix Aconiti Kusnezoffii Preparata 150g, Fructus Chaenomelis 150g, Cornu Cervi Pantotrichum 20g, Caulis Bauhihiae Championii 150g, Radix Angelicae Sinensis 150g, Rhizoma Et Radix Notopterygii 130g, Radix Achyranthis Bidentatae 150g.
Embodiment two
A kind of Chinese medicine for the treatment of rheumatoid and osteoarthritis is to be prepared into by Radix Aconiti Kusnezoffii Preparata 160g, Fructus Chaenomelis 165g, Cornu Cervi Pantotrichum 28g, Caulis Bauhihiae Championii 169g, Radix Angelicae Sinensis 154g, Rhizoma Et Radix Notopterygii 135g, Radix Achyranthis Bidentatae 162g.
Embodiment three
A kind of Chinese medicine for the treatment of rheumatoid and osteoarthritis is to be prepared into by Radix Aconiti Kusnezoffii Preparata 170g, Fructus Chaenomelis 170g, Cornu Cervi Pantotrichum 30g, Caulis Bauhihiae Championii 170g, Radix Angelicae Sinensis 170g, Rhizoma Et Radix Notopterygii 150g, Radix Achyranthis Bidentatae 170g.
Embodiment four
A kind of Chinese medicine for the treatment of rheumatoid and osteoarthritis is to be prepared into by Radix Aconiti Kusnezoffii Preparata 168g, Fructus Chaenomelis 159g, Cornu Cervi Pantotrichum 24g, Caulis Bauhihiae Championii 155g, Radix Angelicae Sinensis 164g, Rhizoma Et Radix Notopterygii 138g, Radix Achyranthis Bidentatae 151g.
Embodiment five
A kind of preparation method of Chinese medicine for the treatment of rheumatoid and osteoarthritis is: gets Cornu Cervi Pantotrichum 20g and is ground into fine powder, and standby; Get Radix Angelicae Sinensis 150g, Rhizoma Et Radix Notopterygii 130g and add 6 times of water gagings, water vapour distillation volatile oil 4 hours, the aqueous solution after the distillation device are in addition collected, and medicinal residues are standby; Volatile oil is made Benexate Hydrochloride.Getting Radix Achyranthis Bidentatae 150g, Fructus Chaenomelis 150g, Caulis Bauhihiae Championii 150g, to add 6 times of amount concentration be 80% ethanol extraction three times, each 2 hours, filters filtrate recycling ethanol and to be concentrated into relative density be 1.02～1.18 (50 ℃).Get Radix Aconiti Kusnezoffii Preparata 150g and add 8 times of water gagings, extract secondary, each 2 hours, merge with standby medicinal residues for the third time, add 8 times of water gagings and extracted 2 hours, filter, aqueous solution after filtrate and the distillation merges, being concentrated into relative density is 1.02～1.18 (50 ℃), merges spray drying with the alcohol extraction concentrated solution again and gets fine powder, adds Benexate Hydrochloride, velvet powder and appropriate amount of auxiliary materials, mixing, incapsulate, make 1000, promptly.
Claims (7)
1, a kind of Chinese medicine for the treatment of rheumatoid and osteoarthritis, its raw medicinal herbs compatibility is: Radix Aconiti Kusnezoffii Preparata 150---170g, Fructus Chaenomelis 150---170g, Cornu Cervi Pantotrichum 20---30g, Caulis Bauhihiae Championii 150---170g, Radix Angelicae Sinensis 150---170g, Rhizoma Et Radix Notopterygii 130---150g, Radix Achyranthis Bidentatae 150---170g.
2, a kind of production method for the treatment of the Chinese medicine of rheumatoid and osteoarthritis according to claim 1 is characterized in that: need get Radix Aconiti Kusnezoffii Preparata 150 by compatibility---170g, Fructus Chaenomelis 150---170g, Cornu Cervi Pantotrichum 20---30g, Caulis Bauhihiae Championii 150---170g, Radix Angelicae Sinensis 150---170g, Rhizoma Et Radix Notopterygii 130---150g, Radix Achyranthis Bidentatae 150---170g;
Pulveratum Cornu Cervi Pantotrichum is broken into fine powder, standby; Radix Angelicae Sinensis, Rhizoma Et Radix Notopterygii add 6～10 times of water gagings, and water vapour distillation volatile oil 4～6 hours, the aqueous solution after the distillation device are in addition collected, and medicinal residues are standby; Volatile oil is made Benexate Hydrochloride; Get Radix Achyranthis Bidentatae, Fructus Chaenomelis, it is 50～80% ethanol extraction three times that Caulis Bauhihiae Championii adds 6～10 times of amount concentration, each 1～2 hour, filter, filtrate recycling ethanol and to be concentrated into 50 ℃ of following relative densities be 1.02～1.18, get Radix Aconiti Kusnezoffii Preparata and add 8～10 times of water gagings extraction secondaries, each 1～2 hour, merge with standby medicinal residues for the third time, adding 8～10 times of water gagings extracted 1～2 hour, filter, the aqueous solution after filtrate and the distillation merges, and being concentrated into 50 ℃ of following relative densities is 1.02～1.18, merge spray drying with the alcohol extraction concentrated solution again and get fine powder, add Benexate Hydrochloride, velvet powder and appropriate amount of auxiliary materials, mixing incapsulates, make 1000, promptly.
3, a kind of Chinese medicine for the treatment of rheumatoid and osteoarthritis according to claim 1 is characterized in that being prepared into by Radix Aconiti Kusnezoffii Preparata 150g, Fructus Chaenomelis 150g, Cornu Cervi Pantotrichum 20g, Caulis Bauhihiae Championii 150g, Radix Angelicae Sinensis 150g, Rhizoma Et Radix Notopterygii 130g, Radix Achyranthis Bidentatae 150g.
4, a kind of Chinese medicine for the treatment of rheumatoid and osteoarthritis according to claim 1 is characterized in that being prepared into by Radix Aconiti Kusnezoffii Preparata 160g, Fructus Chaenomelis 165g, Cornu Cervi Pantotrichum 28g, Caulis Bauhihiae Championii 169g, Radix Angelicae Sinensis 154g, Rhizoma Et Radix Notopterygii 135g, Radix Achyranthis Bidentatae 162g.
5, a kind of Chinese medicine for the treatment of rheumatoid and osteoarthritis according to claim 1 is characterized in that being prepared into by Radix Aconiti Kusnezoffii Preparata 170g, Fructus Chaenomelis 170g, Cornu Cervi Pantotrichum 30g, Caulis Bauhihiae Championii 170g, Radix Angelicae Sinensis 170g, Rhizoma Et Radix Notopterygii 150g, Radix Achyranthis Bidentatae 170g.
6, a kind of Chinese medicine for the treatment of rheumatoid and osteoarthritis according to claim 1 is characterized in that being prepared into by Radix Aconiti Kusnezoffii Preparata 168g, Fructus Chaenomelis 159g, Cornu Cervi Pantotrichum 24g, Caulis Bauhihiae Championii 155g, Radix Angelicae Sinensis 164g, Rhizoma Et Radix Notopterygii 138g, Radix Achyranthis Bidentatae 151g.
7, a kind of production method for the treatment of the Chinese medicine of rheumatoid and osteoarthritis according to claim 2 is characterized in that getting Cornu Cervi Pantotrichum 20g and is ground into fine powder, and is standby; Get Radix Angelicae Sinensis 150g, Rhizoma Et Radix Notopterygii 130g and add 6 times of water gagings, water vapour distillation volatile oil 4 hours, the aqueous solution after the distillation device are in addition collected, and medicinal residues are standby; Volatile oil is made Benexate Hydrochloride, get Radix Achyranthis Bidentatae 150g, Fructus Chaenomelis 150g, it is 80% ethanol extraction three times that Caulis Bauhihiae Championii 150g adds 6 times of amount concentration, each 2 hours, filter, filtrate recycling ethanol and to be concentrated into 50 ℃ of following relative densities be 1.02～1.18, get Radix Aconiti Kusnezoffii Preparata 150g and add 8 times of water gagings, extract secondary, each 2 hours, merge with standby medicinal residues for the third time, adding 8 times of water gagings extracted 2 hours, filter, the aqueous solution after filtrate and the distillation merges, and being concentrated into 50 ℃ of following relative densities is 1.02～1.18, merge spray drying with the alcohol extraction concentrated solution again and get fine powder, add Benexate Hydrochloride, velvet powder and appropriate amount of auxiliary materials, mixing incapsulates, make 1000, promptly.
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| CN102657742B (en) * | 2012-05-04 | 2014-06-04 | 刘来勤 | Traditional Chinese medicinal fumigant capable of expelling cold-dampness in in-vivo bones and muscles and preparation method and use method thereof |
| CN104840806B (en) * | 2015-04-17 | 2020-06-19 | 广西中医药大学 | Chinese medicinal preparation with anti-rheumatoid effect and production method thereof |
| CN111773295B (en) * | 2020-08-26 | 2021-12-10 | 广西中医药大学第一附属医院 | Sea salt bag for treating arthritis and preparation method and application thereof |
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Non-Patent Citations (4)
| Title |
|---|
| 中药外治法治疗膝关节骨性关节炎研究进展. 陈朝晖，曹日隆.安徽中医学院学报，第23卷第4期. 2004 |
| 中药外治法治疗膝关节骨性关节炎研究进展. 陈朝晖，曹日隆.安徽中医学院学报，第23卷第4期. 2004 * |
| 系列方药治疗类风湿性关节炎136 例观察. 王书勤，蔡胜秀，任子华.内蒙古中医药，第3期. 2000 |
| 系列方药治疗类风湿性关节炎136 例观察. 王书勤，蔡胜秀，任子华.内蒙古中医药，第3期. 2000 * |
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