CN100574783C - an anti-inflammatory analgesic drug - Google Patents
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Abstract
Description
技术领域 technical field
本发明涉及一种外科用药物,特别是一种消炎止痛药物,它属于外用药物,适合于治疗因外伤引起的瘀肿、疼痛病症以及关节炎,特别是风湿性关节炎。The invention relates to a medicine for surgery, in particular to an anti-inflammatory and pain-relieving medicine, which belongs to external medicine and is suitable for treating bruises, pain symptoms and arthritis caused by trauma, especially rheumatoid arthritis.
背景技术 Background technique
通常,人们身体某部位的瘀肿、疼痛等病症,大多是因外伤造成的肌肉组织损伤、扭伤及挫伤所致;或者是因病菌侵害、机体发生变态反应等所引起的炎症所致。对于这类疾病的治疗,在临床上常采用的方法是服用消炎和解热镇痛类药物,再配以外用药物如驳骨水、红花油等,对患处进行涂擦,以达到消除炎症以及活血化瘀、通筋活络、消肿止痛的目的。采用上述方法虽然有一定的疗效,但是,若采用内服消炎类药物,特别是服用解热镇痛类药物,常常容易引起胃肠道不良反应以及药物过敏反应,严重者甚至会引起胃部出血或穿孔,给患者带来痛苦,而所采用的外用药物,疗效多较慢,治疗效果也多不理想。Usually, symptoms such as bruising and pain in certain parts of the body are mostly caused by muscle tissue damage, sprains and contusions caused by trauma; For the treatment of such diseases, the commonly used method in clinical practice is to take anti-inflammatory and antipyretic and analgesic drugs, and then mix them with external drugs such as bone bone water, safflower oil, etc., and rub the affected area to eliminate inflammation and The purpose of promoting blood circulation and removing blood stasis, dredging tendons and activating collaterals, reducing swelling and relieving pain. Although the above method has a certain curative effect, if anti-inflammatory drugs are taken orally, especially antipyretic and analgesic drugs, it is often easy to cause gastrointestinal adverse reactions and drug allergic reactions, and in severe cases, it may even cause gastric bleeding or Perforation brings misery to the patient, and the externally used medicine that adopts, curative effect is many slower, and therapeutic effect is also many unsatisfactory.
发明内容 Contents of the invention
本发明的目的在于提供一种消炎止痛药物,它能够克服已有技术的不足,可有效地治疗瘀肿、疼痛病症,且疗效快,治疗效果好。The object of the present invention is to provide an anti-inflammatory and analgesic drug, which can overcome the deficiencies of the prior art, can effectively treat bruises and pain symptoms, and has fast curative effect and good therapeutic effect.
其解决方案是:本发明的活性成分是由下列组分及其重量配比组成,并以医用乙醇为浸泡液,过滤提取浸泡液。其具体组分按重量计算如下:The solution is: the active ingredient of the present invention is composed of the following components and their weight proportions, and the soaking liquid is extracted by filtering with medical ethanol. Its specific components are calculated as follows by weight:
南星7-10g、半夏7-10g、川乌7-10g、草乌7-10g、毕拨7-10g、蟾酥6-8g、胡椒15-20g、细辛15-20g、无名异或自然铜7-10g、木鳖子10-15g。作为浸泡液的医用乙醇,其浓度为75%。Nanxing 7-10g, Pinellia 7-10g, Chuanwu 7-10g, Caowu 7-10g, Bibo 7-10g, Chansu 6-8g, Pepper 15-20g, Asarum 15-20g, Anonymous or natural copper 7-10g, wood turtle 10-15g. As the medical ethanol of soaking liquid, its concentration is 75%.
按照上述配方的规定量称取原料,经粉碎、混合制成散剂,该散剂浸泡75%医用乙醇中,浸泡时间为12个小时,且散剂与医用乙醇的配比是1∶10,而后,过滤、提取滤液,用该提取的滤液涂擦患处,每天5-6次,但严禁将药液直接涂擦在伤口上。According to the specified amount of the above formula, the raw materials are weighed, pulverized and mixed to make a powder, which is soaked in 75% medical ethanol for 12 hours, and the ratio of the powder to the medical ethanol is 1:10, and then filtered 1. Extract the filtrate, rub the affected part with the extracted filtrate, 5-6 times a day, but it is strictly forbidden to directly rub the medicinal liquid on the wound.
在本发明配方中的原料药材,南星(别名野芋头),具有消肿散结之功效;半夏,具有消痛及散疽、疖、肿的功效;毕拨(别名荜茇),具有温中散寒、下气止痛之功效;川乌(别名乌头),具有散寒止痛的功效,且有毒;草乌,具有止痛消肿的功效,且有毒;胡椒,具有温中祛寒的功效;细辛,具有强心止痛的功效;无名异(或自然铜),辛、平类入肝经,其中主含二硫化铁,并含有镍、砷、锑等微量元素,具有散瘀、止痛、解热毒、续筋接骨之功效;木鳖子,属葫芦科植物,有毒,具有麻醉功效。将上述原料配伍,具有活血化瘀、通筋活络、消肿止痛的综合功效,加之用75%医用乙醇为浸泡液,提取其浸泡液,以外用涂擦的方法,使药力直接作用于肿、痛的部位,通过皮肤作用于皮下损伤组织及发炎组织,可使肿痛症状逐渐消除,达到消肿止痛的效果。The raw medicinal material in the formula of the present invention, Nanxing (alias wild taro), has the effect of reducing swelling and dispelling stagnation; The effect of dispelling cold in the middle, lowering Qi and relieving pain; Chuanwu (also known as aconitum), has the effect of dispelling cold and relieving pain, and is poisonous; Asarum, has the effect of strengthening the heart and relieving pain; unnamed different (or natural copper), Xin and Ping enter the liver meridian, which mainly contains iron disulfide, and contains trace elements such as nickel, arsenic, antimony, etc., has the functions of dispelling blood stasis and relieving pain , antipyretic toxin, the effect of renewing tendons and bones; wood turtle, which belongs to Cucurbitaceae plant, is poisonous and has anesthetic effect. Combining the above raw materials has the comprehensive effects of promoting blood circulation and removing blood stasis, dredging tendons and activating collaterals, reducing swelling and relieving pain. In addition, 75% medical ethanol is used as the soaking solution, and the soaking solution is extracted and rubbed externally, so that the medicinal effect can directly act on swelling, swelling, and pain. Painful parts, acting on subcutaneous damaged tissue and inflamed tissue through the skin, can gradually eliminate swelling and pain symptoms, and achieve the effect of reducing swelling and relieving pain.
本发明主要是以天然的中药材为原料,采用外用涂擦的方法,治疗因肌肉组织损伤、韧带拉伤、扭伤、挫伤而造成的瘀血肿痛及红伤引起的痛肿、伤口不愈合,以及关节炎,既安全,无毒副作用,又见效快,疗效好,且费用低。对于较轻的一般肿、痛病症,只要用药10分钟,疼痛感会明显减轻,用药24小时内瘀肿病症会明显消退。一般情况下,用药三天临床症状会明显见轻,肿痛感逐渐减轻,基本好转;五天可以完全康复,治愈率达100%,但对于临床症状严重者,还需要在医生指导下并用其它药物。而对于破皮创伤,有伤口者,只允许在伤口周围红肿部位涂擦,严禁将该药液直接涂擦在伤口上,否则,会引起病情加重。The present invention mainly uses natural Chinese medicinal materials as raw materials and adopts the method of rubbing for external use to treat blood stasis, swelling and pain caused by muscle tissue injury, ligament strain, sprain and contusion, pain and swelling caused by red wound, and wound non-healing , and arthritis, both safe, non-toxic and side effects, quick results, good curative effect, and low cost. For mild general swelling and pain symptoms, as long as the medication takes 10 minutes, the pain will be significantly relieved, and the bruising symptoms will obviously disappear within 24 hours of medication. In general, after three days of medication, the clinical symptoms will be obviously relieved, the swelling and pain will be gradually relieved, and the symptoms will be basically improved; after five days, they will be fully recovered, and the cure rate will reach 100%. drug. For broken skin wounds, those with wounds are only allowed to rub the red and swollen parts around the wound, and it is strictly forbidden to rub the medicinal solution directly on the wound, otherwise, the condition will aggravate.
具体实施方式 Detailed ways
下面结合实施例详细描述本发明的具体实施方式。The specific implementation of the present invention will be described in detail below in conjunction with the examples.
实施例1:Example 1:
本发明是按如下配方称取原料,并粉碎、混合制成散剂,用医用75%乙醇为浸泡液,且该散剂与浸泡液的配比为1∶10,将所述的散剂置于浸泡液中,浸泡12个小时后,过滤,提取浸泡液,备用。可用备用的浸泡液涂擦患病部位进行治疗,每天可涂擦5-6次,但在涂擦该药物时,严禁将药液涂擦在破皮处及伤口上。其具体配方是:The present invention weighs the raw materials according to the following formula, pulverizes and mixes them to make a powder, uses medical 75% ethanol as the soaking liquid, and the ratio of the powder to the soaking liquid is 1:10, and puts the powder in the soaking liquid After soaking for 12 hours, filter, extract the soaking liquid, and set aside. The spare soaking liquid can be used to rub the diseased part for treatment, and it can be rubbed 5-6 times a day, but when rubbing the medicine, it is strictly forbidden to rub the medicine liquid on the broken skin and the wound. Its specific formula is:
南星7.5g、半夏8g、川乌7g、草乌7g、毕拨7.5g、蟾酥6.5g、胡椒15g细辛16g、无名异8g、木鳖子10g。Nanxing 7.5g, Pinellia 8g, Chuanwu 7g, Caowu 7g, Bibo 7.5g, Chansu 6.5g, Pepper 15g Asarum 16g, Anonymous 8g, Wood turtle 10g.
上述原料中药材在市场上均有售、易购。Above-mentioned raw material Chinese medicinal material is all available on the market, easy to buy.
实施例2:Example 2:
本发明是按如下配方称取原料,并粉碎、混合制成散剂,其具体配方是:The present invention weighs raw materials according to the following formula, and pulverizes and mixes them to make powder, and its specific formula is:
南星8g、半夏7.5g、川乌8.5g、草乌8.5g、毕拨8g、蟾酥6g、胡椒16g、细辛18g、无名异8.5g、木鳖子11g。其它均同实施例1。Nanxing 8g, Pinellia 7.5g, Chuanwu 8.5g, Caowu 8.5g, Bibo 8g, Chansu 6g, Pepper 16g, Asarum 18g, Anonymous 8.5g, Mu Biezi 11g. Others are all the same as in Example 1.
实施例3:Example 3:
本发明是按如下配方称取原料,并粉碎、混合制成散剂,其具体配方是:The present invention weighs raw materials according to the following formula, and pulverizes and mixes them to make powder, and its specific formula is:
南星9g、半夏8g、川乌9g、草乌7.5g、毕拨9g、蟾酥7g、胡椒17.5g、细辛18.5g、无名异9g、木鳖子12g。其它均同实施例1。Nanxing 9g, Pinellia 8g, Chuanwu 9g, Caowu 7.5g, Bibo 9g, Chansu 7g, Pepper 17.5g, Asarum 18.5g, Anonymous 9g, Wood turtle 12g. Others are all the same as in Example 1.
实施例4:Example 4:
本发明是按如下配方称取原料,并粉碎、混合制成散剂,其具体配方是:The present invention weighs raw materials according to the following formula, and pulverizes and mixes them to make powder, and its specific formula is:
南星10g、半夏8.5g、川乌9.5g、草乌9g、毕拨10g、蟾酥8g、胡椒18g、细辛19g、无名异10g、木鳖子14g。其它均同实施例1。Nanxing 10g, Pinellia 8.5g, Aconitum 9.5g, Aconitum 9g, Bibo 10g, Toad Su 8g, Pepper 18g, Asarum 19g, Anonymous 10g, Wood turtle 14g. Others are all the same as in Example 1.
实施例5:Example 5:
本发明是按如下配方称取原料,并粉碎、混合制成散剂,其具体配方是:The present invention weighs raw materials according to the following formula, and pulverizes and mixes them to make powder, and its specific formula is:
南星10g、半夏10g、川乌10g、草乌10g、毕拨10g、蟾酥7.5g、胡椒20g、细辛20g、自然铜10g、木鳖子15g。Nanxing 10g, Pinellia 10g, Chuanwu 10g, Caowu 10g, Bibo 10g, Chansu 7.5g, pepper 20g, asarum 20g, natural copper 10g, wood turtle 15g.
所述的自然铜为自制品,是采用如下方法制得的:将古铜币加热后,放入食用醋中热激,取出、刮取其表面的脱落层,将收集的脱落层研未,即可。其它均同实施例1。The natural copper is a self-made product, which is obtained by the following method: after heating the ancient copper coin, put it into edible vinegar for heat shock, take out and scrape the exfoliated layer on its surface, and grind the collected exfoliated layer, that is, Can. Others are all the same as in Example 1.
试验例:Test example:
1、临床疗效观察:1. Observation of clinical efficacy:
采用本发明在临床应用中进行疗效观察30例,其中,因外伤造成的肌肉组织损伤,而发生红肿、疼痛病症的患者26例,关节炎4例。在治疗过程中,病症较轻者,只涂擦本发明药物,不再服用其它药物或外用贴剂,而对于病症较严重者,可在医生的指导下同时应用其它药物。患者在涂擦本发明药物前,患部肿、痛难忍,用药十分钟后,疼痛会明显见轻;用药24小时内瘀肿会明显消退;用药3天后,临床症状明显减轻,瘀肿基本消退,病情好转;用药5-10天,临床症状完全消失,即可痊愈。治愈率达100%。所述的治愈是指临床症状消失,患部恢复正常。但对于外伤造成骨折者,对骨折本身本发明药物无效。Adopt the present invention to carry out curative effect observation 30 cases in clinical application, wherein, because the muscular tissue injury that trauma causes, and the patient that occurs redness, pain symptoms 26 cases, 4 cases of arthritis. During the course of treatment, those with milder symptoms only apply the medicine of the present invention, and no longer take other medicines or external patches, and for those with more severe symptoms, other medicines can be applied simultaneously under the guidance of a doctor. Before the patient rubbed the medicine of the present invention, the affected part was swollen and painful, and after ten minutes of medication, the pain would be obviously lightened; within 24 hours of medication, the bruises would obviously subside; after 3 days of medication, the clinical symptoms were obviously alleviated, and the bruises basically subsided , the state of an illness takes a turn for the better; Medication 5-10 days, clinical symptom disappears completely, can recover from illness. The cure rate is 100%. Described cure refers to that clinical symptom disappears, and affected part returns to normal. But for fracture person caused by trauma, the medicine of the present invention is invalid to fracture itself.
1、典型病例举例:1. Examples of typical cases:
(1)、患者、男、46岁。因外伤致小腿前部伤口流血不止,但未造成骨折,虽到医院进行包扎处理,并服用消炎药物三天,症状不见好转,且出现小腿瘀肿严重,伤口感染化脓,疼痛。于是去掉包扎绷带,并停止服用原来药物,改用本发明外用药物,在伤口周围的瘀肿部位涂擦(严防涂擦在伤口上),每天涂擦5-8次,在涂擦本发明药物的当天疼痛减轻,用药到第3天,瘀肿明显消退,伤口处开始愈合,涂擦到第5天,伤口开始结痂,且肿痛症状消失;涂擦到第7天,伤口完全愈合,康复。至今仅留下一个疤痕。(1), patient, male, 46 years old. The wound on the front of the calf was bleeding because of the trauma, but no fracture was caused. Although he went to the hospital for bandage treatment and took anti-inflammatory drugs for three days, the symptoms did not improve, and the calf bruise was severe, the wound was infected and suppurated, and the pain was painful. Then remove the dressing bandage, and stop taking the original medicine, use the medicine for external use of the present invention instead, rub the ecchymosis position around the wound (prevent rubbing on the wound), rub 5-8 times every day, and rub the medicine of the present invention The pain relieved on the first day, and the bruising obviously subsided on the 3rd day after the medication, and the wound began to heal; on the 5th day of rubbing, the wound began to scab, and the swelling and pain symptoms disappeared; on the 7th day of rubbing, the wound healed completely, recover. Only one scar remains.
(2)、患者、男、67岁。因雪天外出滑倒,造成右侧两肋骨骨折。由于家中经济困难,只在医院进行了保守处理,无法住院治疗,在家静养,并服用一些活血化瘀、消肿止痛之类的药物,但疗效不明显。由于患侧疼痛,不能活动,被迫卧床。当卧床一个多月时,又出现了大、小便失禁。后采用本发明外用药物涂擦患处,每天局部涂擦6次,涂擦7天,临床症状明显减轻,可坐起在床上吃饭,半月后可以下床活动,并可在户外拄双拐进行练习活动。目前,患者身体健康,并能从事正常的体力劳动。(2), patient, man, 67 years old. She slipped and fell due to going out in the snow, resulting in fractures of two ribs on the right side. Due to financial difficulties at home, only conservative treatment was carried out in the hospital, and he could not be hospitalized. He rested at home and took some drugs such as promoting blood circulation, removing blood stasis, reducing swelling and relieving pain, but the curative effect was not obvious. Due to the pain on the affected side, he was unable to move and was forced to stay in bed. When lying in bed for more than a month, fecal and urinary incontinence occurred again. Afterwards, the topical medicine of the present invention is used to rub the affected part, 6 times a day, 7 days, and the clinical symptoms are obviously alleviated. You can sit up and eat on the bed, and you can get out of bed after half a month, and you can practice outdoors with double crutches. Activity. At present, the patient is in good health and can engage in normal physical labor.
(3)、患者、男、51岁。患风湿性关节炎多年,临床症状主要是膝关节肿、痛,尤以天气变化时为著。曾采用服药、针剂、贴剂等进行治疗,临床症状也曾一度明显减轻,但一停止用药,病情常易复发,久治不愈。后来,采用本发明外用药物,每天在患处涂擦5-6次,用药3天后,自觉疼痛明显好转,用药10天后,局部红肿消退,疼痛消失。现已停用本发明药物一年多,没有任何临床症状,未见病情反复。(3), patient, man, 51 years old. Suffering from rheumatoid arthritis for many years, the main clinical symptoms are knee joint swelling and pain, especially when the weather changes. Once used medicine, injection, patch etc. to carry out treatment, clinical symptom once also once obviously relieved, but once stop taking medicine, the state of an illness often easily recurs, and long-term cure does not heal. Afterwards, adopt external medicine of the present invention, rub 5-6 times in affected part every day, after 3 days of medication, conscious pain obviously takes a turn for the better, and after 10 days of medication, local redness disappears, and pain disappears. The medicine of the present invention has been discontinued for more than one year, without any clinical symptoms, and no recurrence of the disease.
(4)、患者、男、42岁。其右手食指、中指、无名指皆被机器压断,而拇指被挤压骨折,经医院断指再植手术治疗,但食、中、无名指再植未成功,而拇指骨折处又化脓感染,并且局部瘀肿严重,虽经医院换药、内服消炎止痛类药物等处理,三个多月仍未见好转,后用本发明药物涂擦瘀肿患处,每天涂擦6次,7天后,瘀肿症状消失,化脓伤口已愈合结痂。(4), patient, male, 42 years old. The index finger, middle finger, and ring finger of his right hand were all broken by the machine, and the thumb was crushed and fractured. After replantation of the amputated finger in the hospital, the replantation of the index, middle, and ring fingers was unsuccessful, and the fractured thumb was suppurated and infected, and localized Severe bruises, though the hospital changed dressings, orally administered anti-inflammatory and pain-relieving drugs, etc., did not take a turn for the better in more than three months, and then rubbed the bruised affected part with the medicine of the present invention, and rubbed it 6 times a day. After 7 days, the symptoms of bruises disappeared. Disappeared, the purulent wound had healed and scabbed.
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| CN101337011B (en) * | 2008-07-09 | 2011-02-09 | 郭育然 | Traditional Chinese medicine formulation for treating herpes circunata |
| CN102274294A (en) * | 2011-08-10 | 2011-12-14 | 谷洪田 | Medicament for treating toothache |
| CN103920127A (en) * | 2014-05-03 | 2014-07-16 | 金丽秋 | External-use anesthetic used for adjuvant treatment of carbuncle and furunculosis toxins |
| CN104173643A (en) * | 2014-08-20 | 2014-12-03 | 覃洪质 | Liquid medicine for traumatic injury |
| CN105663534A (en) * | 2016-04-20 | 2016-06-15 | 广州益联健生物科技有限公司 | Composition for treating vital energy channel disease and preparation method thereof |
| CN106109704A (en) * | 2016-08-31 | 2016-11-16 | 罗丽葱 | A kind of narcotic analgesic medicine and preparation method thereof |
| CN108653512B (en) * | 2018-07-17 | 2020-11-24 | 河南中医药大学 | A kind of massage cream for treating various pains caused by soft tissue injury and preparation method thereof |
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Non-Patent Citations (1)
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| 中医药治疗晚期癌症疼痛概况. 田亚贤.河北中医,第14卷第(6)期. 1992 * |
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| CN101129640A (en) | 2008-02-27 |
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